Amadeus käyttöohje Helin Matkoille

Toiminnallisessa opinnäytetyössäni toteutettiin Amadeus käyttöohje Helin Matkatoimisto Oy:lle. Olen työskennellyt Helin Matkoilla lipunkirjoittajana vuodesta 2006 ja pääasiallinen työkaluni on ollut Amadeus varausjärjestelmä. Näin tarpeelliseksi luoda Helin Matkoille oman Amadeus käyttöohjeistuksen, johon on sisällytetty kaikki ne asiat mitä Helin Matkojen virkailijat eniten käyttävät työssään. Opinnäytetyöni tavoite oli helpottaa virkailijoiden työtä, tehostaa sitä ja vähentää virheiden määrää. Käyttöohjeen teolla halusin nopeuttaa uusien työntekijöiden perehdytystä sekä helpottaa pitkän poissaolon jälkeen alalle palaavia virkailijoita. Opinnäytetyön produkti haluttiin toteuttaa kohderyhmän näkemysten mukaan. Tästä syystä opinnäytetyössä on hyödynnetty sen aineistokeruussa laadulliselle tutkimusmenetelmälle yleisesti käytettyä teemahaastattelumallia. Teemahaastattelu toteutettiin Jyväskylän toimipisteessä kolmelle virkailijalle. Teoriaosan tieto on hankittu käytettävyyttä sekä tekniikasta kirjoittamista käsittelevästä kirjallisuudesta. Opinnäytetyön tulokset olivat hyvinkin positiiviset ja itse produkti otettiin myönteisesti vastaan. Opinnäytetyön tuloksena toteutettu Amadeus käyttöohje Helin Matkoille oli onnistunut. Käyttöohjeeseen saatiin sisällytettyä kaikki haluttu, selkeässä ja ymmärrettävässä muodossa. Käyttöohje tulee olemaan virkailijoiden tukena ja apuvälineenä jokapäiväisessä työssä. Uuden työntekijän perehdytys Amadeuksen käyttöön helpottuu myös käyttöohjeen myötä.This functional thesis created an Amadeus user manual for Heli's Travel Agency Ltd. I have worked at Heli's Travel as a ticketing specialist since 2006 and my main tool has always been the Amadeus flight booking system. I saw a need to create an Amadeus user manual for Heli's Travel which included only the specific advice and methods needed by the employees. The goal of the thesis was to ease and optimize the employees’ work and to help reduce errors. It was also intended that the thesis would accelerate the new employee orientation process. In addition, the user manual will be helpful to employees returning to the industry after a long absence. The product of the thesis was based on the views of the target group. Thus, the material used was based on the theme interview model, which is commonly used in qualitative research. The theme interview was conducted with three employees in the Jyvaskylä office. The material for the theory part of this thesis was acquired from literature concerning usability and technique. The outcome of the thesis was very positive and the product itself has been received well. The end product and result of the thesis, the Amadeus user manual for Heli's Travel, was a success. In the user manual I was able to include all the necessary information, presented in a clear and user friendly way. The user manual will be a resource in and support the everyday work of the employees. Also, teaching new employees how to use Amadeus is now considerably easier due to the manual

sj-docx-1-jdr-10.1177_00220345221138517 – Supplemental material for Apical Papilla Regulates Dental Follicle Fate via the OGN-Hh Pathway

Supplemental material, sj-docx-1-jdr-10.1177_00220345221138517 for Apical Papilla Regulates Dental Follicle Fate via the OGN-Hh Pathway by X. Lin, Q. Li, L. Hu, C. Jiang, S. Wang and X. Wu in Journal of Dental Research</p

Multi-mode Heterodyne Laser Interferometry Realized via Software Defined Radio

The agile generation and control of multiple optical frequency modes combined with the realtime processing of multi-mode data provides access to experimentation in domains such as optomechanical systems, optical information processing, and multi-mode spectroscopy. The latter, specifically spectroscopy of spectral-hole burning (SHB), has motivated our development of a multi-mode heterodyne laser interferometric scheme centered around a software-defined radio platform for signal generation and processing, with development in an entirely open-source environment. A challenge to SHB is the high level of shot noise due to the laser power constraint imposed by the spectroscopic sample. Here, we have demonstrated the production, detection, and separation of multiple optical frequency modes to the benefit of optical environment sensing for realtime phase noise subtraction as well as shot noise reduction through multi-mode averaging. This has allowed us to achieve improved noise performance in low-optical-power interferometry. Although our target application is laser stabilization via SHB in cryogenic temperature rare-earth doped crystals, these techniques may be employed in a variety of different contexts

sj-docx-1-jdr-10.1177_00220345231182052 – Supplemental material for Fibulin-1 Regulates Initiation of Successional Dental Lamina

Supplemental material, sj-docx-1-jdr-10.1177_00220345231182052 for Fibulin-1 Regulates Initiation of Successional Dental Lamina by G. Li, Q. Li, Z. Shen, X. Lin, X. Li, J. Wang, B. Zhao, Y. Feng, L. Feng, W. Guo, L. Hu, J. Wang, C. Zhang, Z. Fan, S. Wang and X. Wu in Journal of Dental Research</p

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study

Importance: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. Objective: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. Data Sources: Genomewide association studies (GWAS) published up to January 15, 2015. Study Selection: GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. Data Extraction and Synthesis: Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. Main Outcomes and Measures: Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. Results: Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [95% CI, 0.05-0.15]). Conclusions and Relevance: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases

Rare and low-frequency coding variants alter human adult heigh

Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways