Learning faster or more precisely? Strategic experimentation in networks

The paper analyzes a dynamic model of rational strategic learning in a network. It complements existing literature by providing a detailed picture of short-run dynamics in a game of strategic experimentation where agents are located in a social network. We show that the delay in information transmission caused by incomplete network structures may induce players to increase own experimentation efforts. As a consequence a complete network can fail to be optimal even if there are no costs for links. This means that in the design of networks there exists a trade-off between the speed of learning and accuracy

Critique of Creativity: Precarity, Subjectivity and Resistance in the ‘Creative Industries’

234 p. : il., Tablas.Libro ElectrónicoLa creatividad siempre está en movimiento: surge, se establece en el ente colectivo, palidece y desaparece a veces en el olvido; renace, vuelve con innovaciones, se reformula y resurge iniciando de nuevo el ciclo. Los viejos mitos de la creación y los creadores, los trabajos consagrados y los organismos privilegiados de los demiurgos están de nuevo en marcha, produciendo nuevos cambios. Los ensayos recogidos en este libro analizan ese resurgimiento complejo del mito de la creación y proponen una crítica contemporánea de la creatividad.Creativity is astir: reborn, re-conjured, re-branded, resurgent. The old myths of creation and creators – the hallowed labors and privileged agencies of demiurges and prime movers, of Biblical world-makers and self-fashioning artist-geniuses – are back underway, producing effects, circulating appeals. Much as the Catholic Church dresses the old creationism in the new gowns of ‘intelligent design’, the Creative Industries sound the clarion call to the Cultural Entrepreneurs. In the hype of the ‘creative class’ and the high flights of the digital bohemians, the renaissance of ‘the creatives’ is visibly enacted. The essays collected in this book analyze this complex resurgence of creation myths and formulate a contemporary critique of creativity.Contents vii Contributors ix Acknowledgements xv Introduction: On the Strange Case of ‘Creativity’ and its Troubled Resurrection 1 PART ONE: CREATIVITY 7 1 Immanent Effects: Notes on Cre-activity 9 2 The Geopolitics of Pimping 23 3 The Misfortunes of the ‘Artistic Critique’ and of Cultural Employment 41 4 ‘Creativity and Innovation’ in the Nineteenth Century: Harrison C. White and the Impressionist Revolution Reconsidered 57 PART TWO: PRECARIZATION 77 5 Virtuosos of Freedom: On the Implosion of Political Virtuosity and Productive Labour 79 6 Experiences Without Me, or, the Uncanny Grin of Precarity 91 7 Wit and Innovation 101 PART THREE: CREATIVITY INDUSTRIES 107 8 GovernCreativity, or, Creative Industries Austrian Style 109 9 The Los Angelesation of London: Three Short Waves of Young People’s Micro-Economies of Culture and Creativity in the UK 119 10 Unpredictable Outcomes / Unpredictable Outcasts: On Recent Debates over Creativity and the Creative Industries 133 11 Chanting the Creative Mantra: The Accelerating Economization of EU Cultural Policy 147 PART FOUR: CULTURE INDUSTRY 165 12 Culture Industry and the Administration of Terror 167 13 Add Value to Contents: The Valorization of Culture Today 183 14 Creative Industries as Mass Deception 191 Bibliography 20

The branched-chain amino acid transporter CD98 heavy chain facilitates the development of colonic macrophages associated with apoptosis in macrophage progenitors

CX3CR1+ mononuclear phagocytes extend processes into the intestinal lumen to monitor the intestinal microbiota as well as the chymus. Whether the constituents of the chymus are required for macrophages is not known. Moreover, the molecular mechanisms that control the intestinal ability to distinguish between "innocuous" and "dangerous" antigens remain poorly understood although macrophages play a key role in this process. A comprehensive macrophage development is critical for gut macrophages performing crucial tasks in the intestinal immune system. However, the underlying mechanisms of this development remain elusive. The amino acid transporter CD98, which was first identified as a lymphocyte activation marker, is a multifunctional protein and is associated with a variety of activities, such as those of amino acid transporters, integrin regulators, and fusion regulators. CD98hc interacts with certain integrin β-subunits to mediate signaling events and consequently controls cell migration, survival, and proliferation. To assess the role of branched-chain amino acids on the development of gut macrophages, we generated an inducible knock-out mouse model for the branched-chain amino acid transporter CD98hc specifically in CX3CR1+ intestinal macrophages. We showed that CD98 deficient macrophages attenuate the severity of dextran sodium sulfate-induced colitis clinically, endoscopically, and histologically. Single-cell RNA sequencing of colonic lamina propria macrophages obtained from unmanipulated and healthy mice revealed that silencing CD98 blocks the ‘monocyte waterfall’-development to mature macrophages. Further, we observed that the arrest in macrophage development is associated with increased expression of apoptotic genes. Moreover, patients with Crohn’s disease and ulcerative colitis are characterized by high CD98 expression. Our results demonstrate that CD98 plays a pivotal role in intestinal homeostasis by influencing the development of gut macrophages

Sprache und Struktur der Romane bei Carlo Cassola

Sprache und Struktur der Romane bei Carlo Cassol

IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis.

OBJECTIVE Disruption of the epithelial barrier plays an essential role in developing eosinophilic oesophagitis (EoE), a disease defined by type 2 helper T cell (Th2)-mediated food-associated and aeroallergen-associated chronic inflammation. Although an increased expression of interleukin (IL)-20 subfamily members, IL-19, IL-20 and IL-24, in Th2-mediated diseases has been reported, their function in EoE remains unknown. DESIGN Combining transcriptomic, proteomic and functional analyses, we studied the importance of the IL-20 subfamily for EoE using patient-derived oesophageal three-dimensional models and an EoE mouse model. RESULTS Patients with active EoE have increased expression of IL-20 subfamily cytokines in the oesophagus and serum. In patient-derived oesophageal organoids stimulated with IL-20 cytokines, RNA sequencing and mass spectrometry revealed a downregulation of genes and proteins forming the cornified envelope, including filaggrins. On the contrary, abrogation of IL-20 subfamily signalling in Il20R2 -/- animals resulted in attenuated experimental EoE reflected by reduced eosinophil infiltration, lower Th2 cytokine expression and preserved expression of filaggrins in the oesophagus. Mechanistically, these observations were mediated by the mitogen-activated protein kinase (MAPK); extracellular-signal regulated kinases (ERK)1/2) pathway. Its blockade prevented epithelial barrier impairment in patient-derived air-liquid interface cultures stimulated with IL-20 cytokines and attenuated experimental EoE in mice. CONCLUSION Our findings reveal a previously unknown regulatory role of the IL-20 subfamily for oesophageal barrier function in the context of EoE. We propose that aberrant IL-20 subfamily signalling disturbs the oesophageal epithelial barrier integrity and promotes EoE development. Our study suggests that specific targeting of the IL-20 subfamily signalling pathway may present a novel strategy for the treatment of EoE

Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice

Comprehensive development is critical for gut macrophages being essential for the intestinal immune system. However, the underlying mechanisms of macrophage development in the colon remain elusive. To investigate the function of branched-chain amino acids in the development of gut macrophages, an inducible knock-out mouse model for the branched-chain amino acid transporter CD98hc in CX3CR1+ macrophages was generated. The relatively selective deletion of CD98hc in macrophage populations leads to attenuated severity of chemically-induced colitis that we assessed by clinical, endoscopic, and histological scoring. Single-cell RNA sequencing of colonic lamina propria macrophages revealed that conditional deletion of CD98hc alters the "monocyte waterfall"-development to MHC II+ macrophages. The change in the macrophage development after deletion of CD98hc is associated with increased apoptotic gene expression. Our results show that CD98hc deletion changes the development of colonic macrophages

Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1⁺ Macrophages Regulates Intestinal Homeostasis.

Single-nucleotide polymorphisms in the gene encoding G protein-coupled receptor 35 (GPR35) are associated with increased risk of inflammatory bowel disease. However, the mechanisms by which GPR35 modulates intestinal immune homeostasis remain undefined. Here, integrating zebrafish and mouse experimental models, we demonstrate that intestinal Gpr35 expression is microbiota dependent and enhanced upon inflammation. Moreover, murine GPR35 <sup>+</sup> colonic macrophages are characterized by enhanced production of pro-inflammatory cytokines. We identify lysophosphatidic acid (LPA) as a potential endogenous ligand produced during intestinal inflammation, acting through GPR35 to induce tumor necrosis factor (Tnf) expression in macrophages. Mice lacking Gpr35 in CX3CR1 <sup>+</sup> macrophages aggravate colitis when exposed to dextran sodium sulfate, which is associated with decreased transcript levels of the corticosterone-generating gene Cyp11b1 and macrophage-derived Tnf. Administration of TNF in these mice restores Cyp11b1 expression and intestinal corticosterone production and ameliorates DSS-induced colitis. Our findings indicate that LPA signals through GPR35 in CX3CR1 <sup>+</sup> macrophages to maintain TNF-mediated intestinal homeostasis

Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity.

Goblet cells secrete mucin to create a protective mucus layer against invasive bacterial infection and are therefore essential for maintaining intestinal health. However, the molecular pathways that regulate goblet cell function remain largely unknown. Although GPR35 is highly expressed in colonic epithelial cells, its importance in promoting the epithelial barrier is unclear. In this study, we show that epithelial Gpr35 plays a critical role in goblet cell function. In mice, cell-type-specific deletion of Gpr35 in epithelial cells but not in macrophages results in goblet cell depletion and dysbiosis, rendering these animals more susceptible to Citrobacter rodentium infection. Mechanistically, scRNA-seq analysis indicates that signaling of epithelial Gpr35 is essential to maintain normal pyroptosis levels in goblet cells. Our work shows that the epithelial presence of Gpr35 is a critical element for the function of goblet cell-mediated symbiosis between host and microbiota

Investigating how the attributes of live theatre productions influence consumption choices using conjoint analysis : the example of the National Arts Festival, South Africa

While there is a fair amount of work on determinants of demand for the live performing arts, results have often been contradictory with little explanatory power. This may be because of the difficulty in describing the attributes of a performance, particularly in terms of its quality, and the heterogeneity of consumer preferences. This article uses conjoint analysis, also called choice experiments, to investigate the impact of the attributes of live theatre performances on demand, using data collected from 483 randomly chosen attenders at live theatre performances at the 2008 South African National Arts Festival. Attributes include the type of cast (professional, semi-professional or amateur), reputation of the producer/director, the context or setting, production type and ticket price of the show. Results largely support the a priori expectations based on the results of other demand studies. For example, it is found that the age of consumers affects the type of show chosen, that utility and willingness to pay increase for shows with professional and semi-professional casts and that 93% of the potential audience prefer shows with a South African context. It is concluded that the method could prove useful to both event organisers and policy makers, especially where the goal is to broaden access to the arts