The clinical relevance and newsworthiness of NIHR HTA-funded research: a cohort study

ObjectiveTo assess the clinical relevance and newsworthiness of the UK National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme funded reports.Study designRetrospective cohort study.SettingThe cohort included 311 NIHR HTA Programme funded reports publishing in HTA in the period 1 January 2007–31 December 2012. The McMaster Online Rating of Evidence (MORE) system independently identified the clinical relevance and newsworthiness of NIHR HTA publications and non-NIHR HTA publications. The MORE system involves over 4000 physicians rating publications on a scale of relevance (the extent to which articles are relevant to practice) and a scale of newsworthiness (the extent to which articles contain news or something clinicians are unlikely to know).Main outcome measuresThe proportion of reports published in HTA meeting MORE inclusion criteria and mean average relevance and newsworthiness ratings were calculated and compared with publications from the same studies publishing outside HTA and non-NIHR HTA funded publications.Results286/311 (92.0%) of NIHR HTA reports were assessed by MORE, of which 192 (67.1%) passed MORE criteria. The average clinical relevance rating for NIHR HTA reports was 5.48, statistically higher than the 5.32 rating for non-NIHR HTA publications (mean difference=0.16, 95% CI 0.04 to 0.29, p=0.01). Average newsworthiness ratings were similar between NIHR HTA reports and non-NIHR HTA publications (4.75 and 4.70, respectively; mean difference=0.05, 95% CI ?0.18 to 0.07, p=0.402). NIHR HTA-funded original research reports were statistically higher for newsworthiness than reviews (5.05 compared with 4.64) (mean difference=0.41, 95% CI 0.18 to 0.64, p=0.001).ConclusionsFunding research of clinical relevance is important in maximising the value of research investment. The NIHR HTA Programme is successful in funding projects that generate outputs of clinical relevance

The evaluation of Federal Fabrics-Fibers electrochemical capacitors

The electrochemical capacitor devices described in this report were deliverables from the US Department of Energy-Idaho Operations Office (DOE-ID) as part of the US Department of Energy`s (DOE) High Power Energy Storage Program. The Idaho National Engineering and Environmental Laboratory (INEEL) has the responsibility for technical management, testing, and evaluation of high-power batteries and electrochemical capacitors under this Program. The DOE is currently developing various electrochemical capacitors as candidate power assist devices for the Partnership for a New Generation of Vehicles (PNGV) fast response engine requirement. This contract with Federal Fabrics-Fibers was intended to evaluate the use of their novel Z-axis carbon fiber materials as candidate electrodes for electrochemical capacitors. Deliverables were sent to the INEEL`s Energy Storage Technologies (EST) Laboratory for independent testing and evaluation. This report describes performance testing on four selected devices delivered over a 2-year period. Due to the highly experimental nature of the packages, life cycle testing was not conducted

The Borexino Thermal Monitoring & Management System and simulations of the fluid-dynamics of the Borexino detector under asymmetrical, changing boundary conditions

A comprehensive monitoring system for the thermal environment inside the Borexino neutrino detector was developed and installed in order to reduce uncertainties in determining temperatures throughout the detector. A complementary thermal management system limits undesirable thermal couplings between the environment and Borexino's active sections. This strategy is bringing improved radioactive background conditions to the region of interest for the physics signal thanks to reduced fluid mixing induced in the liquid scintillator. Although fluid-dynamical equilibrium has not yet been fully reached, and thermal fine-tuning is possible, the system has proven extremely effective at stabilizing the detector's thermal conditions while offering precise insights into its mechanisms of internal thermal transport. Furthermore, a Computational Fluid-Dynamics analysis has been performed, based on the empirical measurements provided by the thermal monitoring system, and providing information into present and future thermal trends. A two-dimensional modeling approach was implemented in order to achieve a proper understanding of the thermal and fluid-dynamics in Borexino. It was optimized for different regions and periods of interest, focusing on the most critical effects that were identified as influencing background concentrations. Literature experimental case studies were reproduced to benchmark the method and settings, and a Borexino-specific benchmark was implemented in order to validate the modeling approach for thermal transport. Finally, fully-convective models were applied to understand general and specific fluid motions impacting the detector's Active Volume.Comment: arXiv admin note: substantial text overlap with arXiv:1705.09078, arXiv:1705.0965

Land resource assessment of Northern Belize (NRI Bulletin 43, Volume 1 of 2)

The land resource assessment was undertaken from July 1989 to June 1990 by the Natural Resources Institute (NRI) of the Overseas Development Administration (ODA), assisted by Mr. A. C. S. Wright, and Dr. M. Holder of Central Farm. The main object of the survey was to produce an updated land suitability assessment of Orange Walk, Corozal, Belize and Cayo districts which had not already been surveyed by Jenkin et al. (1976) and King et al. (1989). In addition, this survey would provide a land suitability assessment for the Belize Valley based on the soil mapping of )en kin et al. Thus, together with the land resource assessments of Toledo and Stann Creek districts (King et al., 1986, 1989 respectively), a land suitability assessment for the whole of Belize is now available

Land resource assessment of Northern Belize (NRI Bulletin 43, Volume 2 of 2)

The land resource assessment was undertaken from July 1989 to June 1990 by the Natural Resources Institute (NRI) of the Overseas Development Administration (ODA), assisted by Mr. A. C. S. Wright, and Dr. M. Holder of Central Farm. The main object of the survey was to produce an updated land suitability assessment of Orange Walk, Corozal, Belize and Cayo districts which had not already been surveyed by Jenkin et al. (1976) and King et al. (1989). In addition, this survey would provide a land suitability assessment for the Belize Valley based on the soil mapping of )en kin et al. Thus, together with the land resource assessments of Toledo and Stann Creek districts (King et al., 1986, 1989 respectively), a land suitability assessment for the whole of Belize is now available

Bonding mechanism from the impact of thermally sprayed solid particles

Power particles are mainly in solid state prior to impact on substrates from high velocity oxy-fuel (HVOF) thermal spraying. The bonding between particles and substrates is critical to ensure the quality of coating. Finite element analysis (FEA) models are developed to simulate the impingement process of solid particle impact on substrates. This numerical study examines the bonding mechanism between particles and substrates and establishes the critical particle impact parameters for bonding. Considering the morphology of particles, the shear-instability–based method is applied to all the particles, and the energy-based method is employed only for spherical particles. The particles are given the properties of widely used WC-Co powder for HVOF thermally sprayed coatings. The numerical results confirm that in the HVOF process, the kinetic energy of the particle prior to impact plays the most dominant role in particle stress localization and melting of the interfacial contact region. The critical impact parameters, such as particle velocity and temperature, are shown to be affected by the shape of particles, while higher impact velocity is required for highly nonspherical powder

A Study of the Residual 39Ar Content in Argon from Underground Sources

The discovery of argon from underground sources with significantly less 39Ar than atmospheric argon was an important step in the development of direct-detection dark matter experiments using argon as the active target. We report on the design and operation of a low background detector with a single phase liquid argon target that was built to study the 39Ar content of the underground argon. Underground argon from the Kinder Morgan CO2 plant in Cortez, Colorado was determined to have less than 0.65% of the 39Ar activity in atmospheric argon.Comment: 21 pages, 10 figure

Measurement of the solar 8B neutrino rate with a liquid scintillator target and 3 MeV energy threshold in the Borexino detector

We report the measurement of electron neutrino elastic scattering from 8B solar neutrinos with 3 MeV energy threshold by the Borexino detector in Gran Sasso (Italy). The rate of solar neutrino-induced electron scattering events above this energy in Borexino is 0.217 +- 0.038 (stat) +- 0.008 (syst) cpd/100 t, which corresponds to the equivalent unoscillated flux of (2.4 +- 0.4 (stat) +- 0.1 (syst))x10^6 cm^-2 s^-1, in good agreement with measurements from SNO and SuperKamiokaNDE. Assuming the 8B neutrino flux predicted by the high metallicity Standard Solar Model, the average 8B neutrino survival probability above 3 MeV is measured to be 0.29+-0.10. The survival probabilities for 7Be and 8B neutrinos as measured by Borexino differ by 1.9 sigma. These results are consistent with the prediction of the MSW-LMA solution of a transition in the solar electron neutrino survival probability between the low energy vacuum-driven and the high-energy matter-enhanced solar neutrino oscillation regimes.Comment: 10 pages, 8 figures, 6 table

Observational constraints on Horava-Lifshitz cosmology

We use observational data from Type Ia Supernovae (SNIa), Baryon Acoustic Oscillations (BAO), and Cosmic Microwave Background (CMB), along with requirements of Big Bang Nucleosynthesis (BBN), to constrain the cosmological scenarios governed by Horava-Lifshitz gravity. We consider both the detailed and non-detailed balance versions of the gravitational sector, and we include the matter and radiation sectors. We conclude that the detailed-balance scenario cannot be ruled out from the observational point of view, however the corresponding likelihood contours impose tight constraints on the involved parameters. The scenario beyond detailed balance is compatible with observational data, and we present the corresponding stringent constraints and contour-plots of the parameters. Although this analysis indicates that Horava-Lifshitz cosmology can be compatible with observations, it does not enlighten the discussion about its possible conceptual and theoretical problems.Comment: 11 pages, 6 figures, version published in JCA