Wer ist zukünftig noch im Büro? : Erfahrungen mit Remote Work in Pandemiezeiten und ein Blick in die Zukunft

Der Programmbereich A – Bestandsentwicklung und Metadaten mit seinen zwei Abteilungen A1 – Wissenschaftliche Dienste und A2 – Integrierte Erwerbung und Katalogisierung ist mit über 80 Beschäftigten der größte Programmbereich der ZBW – Leibniz Informationszentrum Wirtschaft. Auch wenn die ZBW seit Jahren im Rahmen einer modernen familienorientierten Personalpolitik Telearbeit als flexible Arbeitsform zur Vereinbarkeit von Beruf und Privatleben fördert, waren die Voraussetzungen der einzelnen Beschäftigten Mitte März 2020 mit dem pandemiebedingten Eintritt in 100 % Homeoffice sehr unterschiedlich. Es gab Beschäftigte, bei deren Aufgaben Remote Work problemlos möglich war, von denen einige bereits Telearbeit praktiziert hatten. Doch gab es auch Mitarbeiter*innen, deren Tätigkeiten nur vor Ort zu erledigen waren, die bis März 2020 noch nie Telearbeit ausgeübt hatten. Der Bericht schildert die Erfahrungen mit Remote Work aus über zwei Jahren Pandemie, wie es z.B. gelungen ist, den Kontakt zum Team zu halten, welche organisatorischen Maßnahmen zur Unterstützung getroffen wurden und wie der Zusammenhalt und das Wir-Gefühl gestärkt werden konnten. Zum Schluss wird diskutiert, wie die Arbeit in Zukunft organisiert werden kann, nachdem die Teams zumindest teilweise wieder in die Büros zurückgekehrt sind – und welche Arbeitsweisen aus den zwei Jahren in der ZBW bleiben werden.The division A – Collection Management and Metadata with its two departments A1 – Scientific Services and A2 – Integrated Acquisition and Cataloguing is the largest division of the ZBW – Leibniz Information Centre for Economics with more than 80 employees. Even though the ZBW has promoted teleworking as a flexible way to balance work and private life for years as part of a modern, family-oriented staff policy, the conditions of the individual employees varied greatly in mid-March 2020, when everybody had to work from home full time due to the pandemic. There were employees who had already practiced telework when their tasks had permitted it. However, there were also employees whose tasks could only be done on site and who had had no experience with telework until March 2020. The report describes the experiences with telework from more than two pandemic years, e.g., how it was possible to keep in touch with the team, which organizational measures were taken to support the teleworking staff and how the team spirit and the sense of togetherness were strengthened. What remains after many teams return to the offices at least partially and how work in the ZBW will be organized in the future will be discussed at the end of this paper

Universitätsbibliothek Kiel: Jahresbericht 2018

Der Jahresbericht informiert über die wichtigsten Aktivitäten der Universitätsbibliothek Kiel und stellt ausgewählte Daten, Zahlen und Fakten zur Verfügung. Als wichtiger Eckpfeiler im Berichtswesen der Bibliothek beschreibt er unser vielfältiges Spektrum an Services und Projekten

Bevoelkerungsentwicklung im Landesteil Schleswig bis zum Jahr 2000: Auswirkungen u. Perspektiven

Includes 2 articlesAvailable from Bibliothek des Instituts fuer Weltwirtschaft, ZBW, Duesternbrook Weg 120, D-24105 Kiel B 229875 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Strategien der Wirtschaftsfoerderung fuer den Kreis Schleswig-Flensburg: Studie ueber d. Moeglichkeiten u. Erfolgsaussichten, neue Arbeitsplaetze im Kreis Schleswig-Flensburg zu schaffen

Available from Bibliothek des Instituts fuer Weltwirtschaft, ZBW, Duesternbrook Weg 120, D-24105 Kiel C 137859 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Case Report—An Inherited Loss-of-Function <i>NRXN3</i> Variant Potentially Causes a Neurodevelopmental Disorder with Autism Consistent with Previously Described 14q24.3-31.1 Deletions

Background: Heterozygous, large-scale deletions at 14q24.3-31.1 affecting the neurexin-3 gene have been associated with neurodevelopmental disorders such as autism. Both “de novo” occurrences and inheritance from a healthy parent suggest incomplete penetrance and expressivity, especially in autism spectrum disorder. NRXN3 encodes neurexin-3, a neuronal cell surface protein involved in cell recognition and adhesion, as well as mediating intracellular signaling. NRXN3 is expressed in two distinct isoforms (alpha and beta) generated by alternative promoters and splicing. MM/Results: Using exome sequencing, we identified a monoallelic frameshift variant c.159_160del (p.Gln54AlafsTer50) in the NRXN3 beta isoform (NM_001272020.2) in a 5-year-old girl with developmental delay, autism spectrum disorder, and behavioral issues. This variant was inherited from her mother, who did not have any medical complaints. Discussion: This is the first detailed report of a loss-of-function variant in NRXN3 causing an identical phenotype, as reported for heterozygous large-scale deletions in the same genomic region, thereby confirming NRXN3 as a novel gene for neurodevelopmental disorders with autism

Evaluation des arbeitsmarktpolitischen Sonderprogramms der Bundesregierung in Hamburg Entwurf Bericht Dezember 1993

IAB-90-0HH0-309000 BB 589 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Bacteriophages targeting protective commensals impair resistance against Salmonella Typhimurium infection in gnotobiotic mice.

Gut microbial communities protect the host against a variety of major human gastrointestinal pathogens. Bacteriophages (phages) are ubiquitous in nature and frequently ingested via food and drinking water. Moreover, they are an attractive tool for microbiome engineering due to the lack of known serious adverse effects on the host. However, the functional role of phages within the gastrointestinal microbiome remain poorly understood. Here, we investigated the effects of microbiota-directed phages on infection with the human enteric pathogen Salmonella enterica serovar Typhimurium (S. Tm), using a gnotobiotic mouse model (OMM14) for colonization resistance (CR). We show, that phage cocktails targeting Escherichia coli and Enterococcus faecalis acted in a strain-specific manner. They transiently reduced the population density of their respective target before establishing coexistence for up to 9 days. Infection susceptibility to S. Tm was markedly increased at an early time point after challenge with both phage cocktails. Surprisingly, OMM14 mice were also susceptible 7 days after a single phage inoculation, when the targeted bacterial populations were back to pre-phage administration density. Concluding, our work shows that phages that dynamically modulate the density of protective members of the gut microbiota can provide opportunities for invasion of bacterial pathogens, in particular at early time points after phage application. This suggests, that phages targeting protective members of the microbiota may increase the risk for Salmonella infection

Expanding the phenotypic spectrum of BCS1L-related mitochondrial disease

Publisher Copyright: © 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological AssociationObjective: To delineate the full phenotypic spectrum of BCS1L-related disease, provide better understanding of the genotype–phenotype correlations and identify reliable prognostic disease markers. Methods: We performed a retrospective multinational cohort study of previously unpublished patients followed in 15 centres from 10 countries. Patients with confirmed biallelic pathogenic BCS1L variants were considered eligible. Clinical, laboratory, neuroimaging and genetic data were analysed. Patients were stratified into different groups based on the age of disease onset, whether homozygous or compound heterozygous for the c.232A>G (p.Ser78Gly) variant, and those with other pathogenic BCS1L variants. Results: Thirty-three patients were included. We found that growth failure, lactic acidosis, tubulopathy, hepatopathy and early death were more frequent in those with disease onset within the first month of life. In those with onset after 1 month, neurological features including movement disorders and seizures were more frequent. Novel phenotypes, particularly involving movement disorder, were identified in this group. The presence of the c.232A>G (p.Ser78Gly) variant was associated with significantly worse survival and exclusively found in those with disease onset within the first month of life, whilst other pathogenic BCS1L variants were more frequent in those with later symptom onset. Interpretation: The phenotypic spectrum of BCS1L-related disease comprises a continuum of clinical features rather than a set of separate syndromic clinical identities. Age of onset defines BCS1L-related disease clinically and early presentation is associated with poor prognosis. Genotype correlates with phenotype in the presence of the c.232A>G (p.Ser78Gly) variant.Peer reviewe