186 research outputs found
Chinaâs Rising Sea Power: The PLA Navyâs Submarine Challenge,
Peter Howarth, an Australian former diplomat and intelligence analyst, pres- ents an excellent mix of strategic the- ory, political dynamics, and tactical detail in considering the Chinese sub- marine fleet. His treatment demon- strates a keen understanding of both parts of the phrase âpolitico-military strategy,â and it is the type of thinking that Jeffrey Record of the Air War Col- lege recently opined is too often miss- ing in the American community
The Role of Strategy in Great Power Decline
The transformation of world order is commonly linked to the decline of one or more great powers and the rise of others. The cause of the decline of great powen and the rise of their successon is of special interest to social scientists and othen who seek to identify patterns in history. It is also of interest to attentive citizens and to policy maken who wish to avoid what are perceived to be the mistakes of the past. Therefore, analyses of great-power decline must eventually focus on more than economic mega-trends, abstract models, or mere correlations as explanations for decline, else there be scant room for policy prescription and little to be harvested for the use of either statesmen or citizens
HadISD: a quality-controlled global synoptic report database for selected variables at long-term stations from 1973--2011
[Abridged] This paper describes the creation of HadISD: an automatically
quality-controlled synoptic resolution dataset of temperature, dewpoint
temperature, sea-level pressure, wind speed, wind direction and cloud cover
from global weather stations for 1973--2011. The full dataset consists of over
6000 stations, with 3427 long-term stations deemed to have sufficient sampling
and quality for climate applications requiring sub-daily resolution. As with
other surface datasets, coverage is heavily skewed towards Northern Hemisphere
mid-latitudes.
The dataset is constructed from a large pre-existing ASCII flatfile data bank
that represents over a decade of substantial effort at data retrieval,
reformatting and provision. These raw data have had varying levels of quality
control applied to them by individual data providers. The work proceeded in
several steps: merging stations with multiple reporting identifiers;
reformatting to netCDF; quality control; and then filtering to form a final
dataset. Particular attention has been paid to maintaining true extreme values
where possible within an automated, objective process. Detailed validation has
been performed on a subset of global stations and also on UK data using known
extreme events to help finalise the QC tests. Further validation was performed
on a selection of extreme events world-wide (Hurricane Katrina in 2005, the
cold snap in Alaska in 1989 and heat waves in SE Australia in 2009). Although
the filtering has removed the poorest station records, no attempt has been made
to homogenise the data thus far. Hence non-climatic, time-varying errors may
still exist in many of the individual station records and care is needed in
inferring long-term trends from these data.
A version-control system has been constructed for this dataset to allow for
the clear documentation of any updates and corrections in the future.Comment: Published in Climate of the Past, www.clim-past.net/8/1649/2012/. 31
pages, 23 figures, 9 pages. For data see
http://www.metoffice.gov.uk/hadobs/hadis
The Dipole Coupling of Atoms and Light in Gravitational Fields
The dipole coupling term between a system of N particles with total charge
zero and the electromagnetic field is derived in the presence of a weak
gravitational field. It is shown that the form of the coupling remains the same
as in flat space-time if it is written with respect to the proper time of the
observer and to the measurable field components. Some remarks concerning the
connection between the minimal and the dipole coupling are given.Comment: 10 pages, LaTe
A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure
Aims
Heart failure (HF) is frequently caused by an ischaemic event (e.g. myocardial infarction) but might also be caused by a primary disease of the myocardium (cardiomyopathy). In order to identify targeted therapies specific for either ischaemic or nonâischaemic HF, it is important to better understand differences in underlying molecular mechanisms.
Methods and results
We performed a biological physical proteinâprotein interaction network analysis to identify pathophysiological pathways distinguishing ischaemic from nonâischaemic HF. First, differentially expressed plasma protein biomarkers were identified in 1160 patients enrolled in the BIOSTATâCHF study, 715 of whom had ischaemic HF and 445 had nonâischaemic HF. Second, we constructed an enriched physical proteinâprotein interaction network, followed by a pathway overârepresentation analysis. Finally, we identified key network proteins. Data were validated in an independent HF cohort comprised of 765 ischaemic and 100 nonâischaemic HF patients. We found 21/92 proteins to be upâregulated and 2/92 downâregulated in ischaemic relative to nonâischaemic HF patients. An enriched network of 18 proteins that were specific for ischaemic heart disease yielded six pathways, which are related to inflammation, endothelial dysfunction superoxide production, coagulation, and atherosclerosis. We identified five key network proteins: acid phosphatase 5, epidermal growth factor receptor, insulinâlike growth factor binding proteinâ1, plasminogen activator urokinase receptor, and secreted phosphoprotein 1. Similar results were observed in the independent validation cohort.
Conclusions
Pathophysiological pathways distinguishing patients with ischaemic HF from those with nonâischaemic HF were related to inflammation, endothelial dysfunction superoxide production, coagulation, and atherosclerosis. The five key pathway proteins identified are potential treatment targets specifically for patients with ischaemic HF
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