The liminal leisure of disadvantaged young people in the UK before and during the COVID-19 pandemic

The global COVID-19 pandemic has created, exposed and exacerbated inequalities and differences around access to—and experiences and representations of—the physical and virtual spaces of young people’s leisure cultures and practices. Drawing on longstanding themes of continuity and change in youth leisure scholarship, this paper contributes to our understandings of ‘liminal leisure’ as experienced by some young people in the UK before and during the COVID-19 pandemic. To do this, we place primary pre-pandemic research on disadvantaged young people’s leisure spaces and practices in dialogue with secondary data on lockdown and post-lockdown leisure. Subsequently, we argue that existing and emergent forms of youth ‘leisure liminality’ are best understood through the lens of intersectional disadvantages. Specifically, pre-existing intersectional disadvantages are being compounded by disruptions to youth leisure, as the upheaval of the pandemic continues to be differentially experienced. To understand this process, we deploy the concept of liminal leisure spaces used by Swaine et al Leisure Studies 37:4,440-451, (2018) in their ethnography of Khat-chewing among young British Somali urban youth ‘on the margins’. Similarly, our focus is on young people’s management and negotiation of substance use ‘risks’, harms and pleasures when in ‘private-in-public’ leisure spaces. We note that the UK government responses to the pandemic, such as national and regional lockdowns, meant that the leisure liminality of disadvantaged young people pre-pandemic became the experience of young people more generally, with for example the closure of night-time economies (NTEs). Yet despite some temporary convergence, intersectionally disadvantaged young people ‘at leisure’ have been subject to a particularly problematic confluence of criminalisation, exclusion and stigmatisation in COVID-19 times, which will most likely continue into the post-pandemic future

Biology and management of river herring and shad in Virginia : Annual report, Anadromous Fish Project 1974

This annual report covers the period October, .1973 through September, 1974. It is the seventh report generated by\u27 the project, with 3-year completion reports prepared in 1970 and 1973. The project· is continuing at VIMS and each year allows stronger conclusions to be made concerning trends in the basic population parameters studied. The 1970-1973 completion report was widely distributed in Virginia, libraries at fishery science institutes, and throughout the National Marine Fisheries Service. The completion report analyzed data from the entire history of the project. In many cases the entire summarized data core for a particular segment was presented, e.g. mortality rates and age composition of the run since 1966. Some jobs were presented in final. analysis form, because they were made inactive after 1973. The history of the foreign fleet activities was presented with an analysis of their effect on the anadromous alosids. \u2

Impact of \u3cem\u3eMYH6\u3c/em\u3e Variants in Hypoplastic Left Heart Syndrome

Hypoplastic left heart syndrome (HLHS) is a clinically and anatomically severe form of congenital heart disease (CHD). Although prior studies suggest that HLHS has a complex genetic inheritance, its etiology remains largely unknown. The goal of this study was to characterize a risk gene in HLHS and its effect on HLHS etiology and outcome. We performed next-generation sequencing on a multigenerational family with a high prevalence of CHD/HLHS, identifying a rare variant in the α-myosin heavy chain (MYH6) gene. A case-control study of 190 unrelated HLHS subjects was then performed and compared with the 1000 Genomes Project. Damaging MYH6 variants, including novel, missense, in-frame deletion, premature stop, de novo, and compound heterozygous variants, were significantly enriched in HLHS cases (P \u3c 1 × 10−5). Clinical outcomes analysis showed reduced transplant-free survival in HLHS subjects with damaging MYH6 variants (P \u3c 1 × 10−2). Transcriptome and protein expression analyses with cardiac tissue revealed differential expression of cardiac contractility genes, notably upregulation of the β-myosin heavy chain (MYH7) gene in subjects with MYH6 variants (P \u3c 1 × 10−3). We subsequently used patient-specific induced pluripotent stem cells (iPSCs) to model HLHS in vitro. Early stages of in vitro cardiomyogenesis in iPSCs derived from two unrelated HLHS families mimicked the increased expression of MYH7 observed in vivo (P \u3c 1 × 10−2), while revealing defective cardiomyogenic differentiation. Rare, damaging variants in MYH6 are enriched in HLHS, affect molecular expression of contractility genes, and are predictive of poor outcome. These findings indicate that the etiology of MYH6-associated HLHS can be informed using iPSCs and suggest utility in future clinical applications

Nitrogen supply and cyanide concentration influence the enrichment of nitrogen from cyanide in wheat (Triticum aestivum L.) and sorghum (Sorghum bicolor L.)

Cyanide assimilation by the beta-cyanoalanine pathway produces asparagine, aspartate and ammonium, allowing cyanide to serve as alternate or supplemental source of nitrogen. Experiments with wheat and sorghum examined the enrichment of (15)N from cyanide as a function of external cyanide concentration in the presence or absence of nitrate and/or ammonium. Cyanogenic nitrogen became enriched in plant tissues following exposure to (15)N-cyanide concentrations from 5 to 200 microm, but when exposure occurred in the absence of nitrate and ammonium, (15)N enrichment increased significantly in sorghum shoots at solution cyanide concentrations of \u3e or =50 microm and in wheat roots at 200 microm cyanide. In an experiment with sorghum using (13)C(15)N, there was also a significant difference in the tissue (13)C:(15)N ratio, suggestive of differential metabolism and transport of carbon and nitrogen under nitrogen-free conditions. A reciprocal (15)N labelling study using KC(15)N and (15)NH(4)(+) and wheat demonstrated an interaction between cyanide and ammonium in roots in which increasing solution ammonium concentrations decreased the enrichment from 100 microm cyanide. In contrast, with increasing solution cyanide concentrations there was an increase in the enrichment from ammonium. The results suggest increased transport and assimilation of cyanide in response to decreased nitrogen supply and perhaps to ammonium supply

Sensory Input to Cortex Encoded on Low-dimensional Periphery-correlated Subspaces

As information about the world is conveyed from the sensory periphery to central neural circuits, it mixes with complex ongoing cortical activity. How do neural populations keep track of sensory signals, separating them from noisy ongoing activity? Here, we show that sensory signals are encoded more reliably in certain low-dimensional subspaces. These coding subspaces are defined by correlations between neural activity in the primary sensory cortex and upstream sensory brain regions; the most correlated dimensions were best for decoding. We analytically show that these correlation-based coding subspaces improve, reaching optimal limits (without an ideal observer), as noise correlations between cortex and upstream regions are reduced. We show that this principle generalizes across diverse sensory stimuli in the olfactory system and the visual system of awake mice. Our results demonstrate an algorithm the cortex may use to multiplex different functions, processing sensory input in low-dimensional subspaces separate from other ongoing functions

Illinoian and Late Wisconsin Tills in Eastern New England: a Transect from Northeastern Massachusetts to West-Central Maine

Guidebook for field trips in southern and west-central Maine, October 13, 14 and 15, 1989: New England Intercollegiate Geological Conference 81st annual meeting: Trip A-