A Cost-Benefit Analysis of Blockchain versus Relational Databases for Digitalising and Automating Information Flows in Cross-Border Supply Chains

Industrial Engineerin

RF-Separated Beam Project for the M2 Beam Line at CERN

Within the framework of the Physics Beyond Colliders initiative at CERN, discussions are underway on the feasibility of producing radio-frequency (RF) separated beams for Phase-2 of the AMBER experiment at the M2 beam line in the North experimental area of the CERN SPS. The technique of RF separation is applied to enrich the content of a certain particle type within a beam consisting of different species at the same momentum. It relies on the fact that each particle type has a different velocity, decreasing with rest mass. The successor of the COMPASS experiment, AMBER, requires for its Phase-2 measurements high-intensity, high-purity kaon (and antiproton) beams, which cannot be delivered with the currently existing conventional M2 beam line. The present contribution introduces the principle of RF separation and explains its dependence on different parameters of beam optics and hardware. The first examination of potential showstoppers for the RF-separated beam implementation is presented, based on the particle production rates, beam line transmission for specific optics settings, limitations for overall beam intensity and purity posed by beam line acceptance and radiation protection. Different beam optics settings have been examined, providing either focused or parallel beams inside the RF cavities. The separation and transmission capability of the different optics settings for realistic characteristics of RF cavities are discussed and the preliminary results of the potential purity and intensity of the RF-separated beam are presented. They illustrate the high importance of an RF-separated kaon beam for many of the AMBER Phase-2 data taking programs, such as spectroscopy, prompt-photon production, Primakoff reactions and kaon charge-radius measurement

Festschrift anläßlich der Emeritierung von Prof. Dr.-Ing. Walter Raab

Festschrift zum Festkolloquium am 8. April 1994 anläßlich der Emeritierung von Herrn Prof. Dr.-Ing. Walter Raab, Leiter des Fachgebiets Maschinenlemente und Mechanik an der Technischen Hochschule Darmstadt

Correcting 4sU induced quantification bias in nucleotide conversion RNA-seq data

Nucleoside analogues like 4-thiouridine (4sU) are used to metabolically label newly synthesized RNA. Chemical conversion of 4sU before sequencing induces T-to-C mismatches in reads sequenced from labelled RNA, allowing to obtain total and labelled RNA expression profiles from a single sequencing library. Cytotoxicity due to extended periods of labelling or high 4sU concentrations has been described, but the effects of extensive 4sU labelling on expression estimates from nucleotide conversion RNA-seq have not been studied. Here, we performed nucleotide conversion RNA-seq with escalating doses of 4sU with short-term labelling (1h) and over a progressive time course (up to 2h) in different cell lines. With high concentrations or at later time points, expression estimates were biased in an RNA half-life dependent manner. We show that bias arose by a combination of reduced mappability of reads carrying multiple conversions, and a global, unspecific underrepresentation of labelled RNA emerging during library preparation and potentially global reduction of RNA synthesis. We developed a computational tool to rescue unmappable reads, which performed favourably compared to previous read mappers, and a statistical method, which could fully remove remaining bias. All methods developed here are freely available as part of our GRAND-SLAM pipeline and grandR package

Durchflusskennwerte und Querbauwerke: Leitfaden zur Web-Anwendung „Ausgewählte Durchflusskennwerte und Querbauwerke sächsischer Fließgewässer, Stand 2015“

Der Leitfaden informiert über Methodik und Ergebnisse der Regionalisierung von ausgewählten Durchflusskennwerten. Über die Internet-Anwendung »Durchflusskennwerte und Querbauwerke« können für beliebige Querschnitte der sächsischen Fließgewässer die Durchflusskennwerte abgefragt werden (Stand 2015). Die Kennwerte werden u. a. benötigt bei der Ermittlung von Mindestwasserführungen und mittleren Durchflussdargeboten sowie bei der Planung wasserbaulicher Anlagen und der Ausweisung von Überschwemmungsgebieten. Die Publikation richtet sich an Wasserbehörden und Planungsbüros, aber auch an Gewässernutzer in Sachsen. Redaktionsschluss: 21.06.201

Commissioning of the vacuum system of the KATRIN Main Spectrometer

The KATRIN experiment will probe the neutrino mass by measuring the beta-electron energy spectrum near the endpoint of tritium beta-decay. An integral energy analysis will be performed by an electro-static spectrometer (Main Spectrometer), an ultra-high vacuum vessel with a length of 23.2 m, a volume of 1240 m^3, and a complex inner electrode system with about 120000 individual parts. The strong magnetic field that guides the beta-electrons is provided by super-conducting solenoids at both ends of the spectrometer. Its influence on turbo-molecular pumps and vacuum gauges had to be considered. A system consisting of 6 turbo-molecular pumps and 3 km of non-evaporable getter strips has been deployed and was tested during the commissioning of the spectrometer. In this paper the configuration, the commissioning with bake-out at 300{\deg}C, and the performance of this system are presented in detail. The vacuum system has to maintain a pressure in the 10^{-11} mbar range. It is demonstrated that the performance of the system is already close to these stringent functional requirements for the KATRIN experiment, which will start at the end of 2016.Comment: submitted for publication in JINST, 39 pages, 15 figure

Efficacy of UVC-treated, pathogen-reduced platelets versus untreated platelets: a randomized controlled non-inferiority trial

Pathogen reduction (PR) technologies for blood components have been established to reduce the residual risk of known and emerging infectious agents. THERAFLEX UVPlatelets, a novel UVC light-based PR technology for platelet concentrates, works without photoactive substances. This randomized, controlled, double-blind, multicenter, noninferiority trial was designed to compare the efficacy and safety of UVC-treated platelets to that of untreated platelets in thrombocytopenic patients with hematologic-oncologic diseases. Primary objective was to determine non-inferiority of UVC-treated platelets, assessed by the 1-hour corrected count increment (CCI) in up to eight per-protocol platelet transfusion episodes. Analysis of the 171 eligible patients showed that the defined non-inferiority margin of 30% of UVC-treated platelets was narrowly missed as the mean differences in 1-hour CCI between standard platelets versus UVC-treated platelets for intention-to-treat and perprotocol analyses were 18.2% (95% confidence interval [CI]: 6.4%; 30.1) and 18.7% (95% CI: 6.3%; 31.1%), respectively. In comparison to the control, the UVC group had a 19.2% lower mean 24-hour CCI and was treated with an about 25% higher number of platelet units, but the average number of days to next platelet transfusion did not differ significantly between both treatment groups. The frequency of low-grade adverse events was slightly higher in the UVC group and the frequencies of refractoriness to platelet transfusion, platelet alloimmunization, severe bleeding events, and red blood cell transfusions were comparable between groups. Our study suggests that transfusion of pathogen-reduced platelets produced with the UVC technology is safe but non-inferiority was not demonstrated. (The German Clinical Trials Register number: DRKS00011156)

Commissioning of the vacuum system of the KATRIN Main Spectrometer

The KATRIN experiment will probe the neutrino mass by measuring the beta-electron energy spectrum near the endpoint of tritium beta-decay. An integral energy analysis will be performed by an electro-static spectrometer (Main Spectrometer), an ultra-high vacuum vessel with a length of 23.2 m, a volume of 1240 m^3, and a complex inner electrode system with about 120000 individual parts. The strong magnetic field that guides the beta-electrons is provided by super-conducting solenoids at both ends of the spectrometer. Its influence on turbo-molecular pumps and vacuum gauges had to be considered. A system consisting of 6 turbo-molecular pumps and 3 km of non-evaporable getter strips has been deployed and was tested during the commissioning of the spectrometer. In this paper the configuration, the commissioning with bake-out at 300{\deg}C, and the performance of this system are presented in detail. The vacuum system has to maintain a pressure in the 10^{-11} mbar range. It is demonstrated that the performance of the system is already close to these stringent functional requirements for the KATRIN experiment, which will start at the end of 2016