Merck campañas de comunicación interna y global

If we realize, the communication is present in every moment of our lives, from the smallest point of view even in the most important situations. To achieve relate to other people we know to communicate is not just talk to one or more other persons, if don’t know how to get our message to the other person, making us understand more clearly. But we also found a communication outside of our personal lives, we find in our professional lives. To get a job, to achieve expose our work with our leaders to bring new ideas to the benefit of our company, we must know to communicate. But not only people, we also communicate organizations. To be able to sell both, their external customers interests should communicate who they are offering and benefit we can get to work with them. Additional, organizations must be clear about its strategy of both commercial and internal communication, so in this way they can take a clear organization in the area. Communication in all its terms is very important daily in our lives, no matter to which we devote or how old we are, from the day we are born is important to communicate with our environment, it is the only way to achieve our goals and maintain lasting relationships, whether marital, family or within a social circle.Si nos damos cuenta, la comunicación está presente en cada momento de la vida de las personas, desde el punto de vista más mínimo hasta en las situaciones más importantes. Para lograr relacionarnos con otras personas debemos saber comunicarnos, no es simplemente hablar con otra o más personas, si no saber llegar con nuestro mensaje hacia la otra persona, más claro hacernos entender. Pero también encontramos a la comunicación fuera de nuestra vida personal, la encontramos en nuestra vida profesional. Para conseguir trabajo, para lograr exponer nuestro trabajo con nuestros jefes, para aportar con nuevas ideas en beneficio de nuestra empresa, debemos saber comunicarnos. Pero no solo las personas nos comunicamos, también las organizaciones. Para poderse vender tanto con sus clientes internes como externos deben comunicar quienes son, que ofrecen y que beneficio podemos obtener al trabajar con ellos. Adicional, las organizaciones deben tener claro su estrategia de comunicación tanto comercial como interno, de esta forma podrán llevar una organización clara en esta área. La comunicación en todos sus términos es muy importante en el día a día de todas las personas, no importa a que nos dediquemos, ni qué edad tengamos, desde el día en que nacemos es importante saber comunicarnos con nuestro entorno, es la única manera de lograr nuestros objetivos y mantener relaciones duraderas, ya sea de pareja, en familia o dentro de un círculo social

'Just not knowing' can make life sweeter (and saltier): Reward uncertainty alters the sensory experience and consumption of palatable food and drinks

This project contains all of the data used for the paper "Reward uncertainty makes life sweeter (and saltier): Uncertainty can alter the sensory experience and consumption of palatable rewards

Review: The Journal of Dramaturgy, volume 23, issue 2

Contents include: Editor\u27s Note; LMDA Conference 2013 Re-defining Risk, A Keynote Address; Ellliott Hayes Award for Outstanding Achievement in Dramaturgy Introduction; Ellliott Hayes Award for Outstanding Achievement in Dramaturgy Staging Latina/o Classrooms and Culture: DNA and Dangerous Dramaturgy at the U.S.-Mexico Border; Early Career Dramaturgs Envision the Future of Dramaturgy: An Ensemble-Created Manifesto; What is the Future of Dramaturgy? A Manifesto; Juan Radigan and the Gringo, or Why Chilean Theatre Deserves our Attention; Behind the Scenes in Bollywood: An Interview with Brian Quirt; National Theatre: Center Stage\u27s My America Project; Crowdsourcing a New Hamburg Dramaturgy, A Preview of The Hamburg Dramaturgy: A New & Complete English Translation. Issue editors: Sydney Cheek-O\u27Donnell, Debra Cardona, Janine Sobeckhttps://soundideas.pugetsound.edu/lmdareview/1046/thumbnail.jp

Animal Research beyond the Laboratory:Report from a Workshop on Places Other than Licensed Establishments (POLEs) in the UK

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Research involving animals that occurs outside the laboratory raises an array of unique challenges. With regard to UK legislation, however, it receives only limited attention in terms of official guidelines, support, and statistics, which are unsurprisingly orientated towards the laboratory environment in which the majority of animal research takes place. In September 2019, four social scientists from the Animal Research Nexus program gathered together a group of 13 experts to discuss nonlaboratory research under the Animals (Scientific Procedures) Act (A(SP)A) of 1986 (mirroring European Union (EU) Directive 2010/63/EU), which is the primary mechanism for regulating animal research in the UK. Such nonlaboratory research under the A(SP)A often occurs at Places Other than Licensed Establishments (POLEs). The primary objective of the workshop was to assemble a diverse group with experience across a variety of POLEs (e.g., wildlife field sites, farms, fisheries, veterinary clinics, zoos) to explore the practical, ethical, and regulatory challenges of conducting research at POLEs. While consensus was not sought, nor reached on every point of discussion, we collectively identified five key areas that we propose require further discussion and attention. These relate to: (1) support and training; (2) ethical review; (3) cultures of care, particularly in nonregulated research outside of the laboratory; (4) the setting of boundaries; and (5) statistics and transparency. The workshop generated robust discussion and thereby highlighted the value of focusing on the unique challenges posed by POLEs, and the need for further opportunities for exchanging experiences and sharing best practice relating to research projects outside of the laboratory in the UK and elsewhere

Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours

Background Certain paediatric nervous system malignancies have dismal prognoses. Retinoic acid (RA) is used in neuroblastoma treatment, and preclinical data indicate potential benefit in selected paediatric brain tumour entities. However, limited single-agent efficacy necessitates combination treatment approaches. Methods We performed drug sensitivity profiling of 76 clinically relevant drugs in combination with RA in 16 models (including patient-derived tumouroids) of the most common paediatric nervous system tumours. Drug responses were assessed by viability assays, high-content imaging, and apoptosis assays and RA relevant pathways by RNAseq from treated models and patient samples obtained through the precision oncology programme INFORM (n = 2288). Immunoprecipitation detected BCL-2 family interactions, and zebrafish embryo xenografts were used for in vivo efficacy testing. Results Group 3 medulloblastoma (MBG3) and neuroblastoma models were highly sensitive to RA treatment. RA induced differentiation and regulated apoptotic genes. RNAseq analysis revealed high expression of BCL2L1 in MBG3 and BCL2 in neuroblastomas. Co-treatments with RA and BCL-2/XL inhibitor navitoclax synergistically decreased viability at clinically achievable concentrations. The combination of RA with navitoclax disrupted the binding of BIM to BCL-XL in MBG3 and to BCL-2 in neuroblastoma, inducing apoptosis in vitro and in vivo. Conclusions RA treatment primes MBG3 and NB cells for apoptosis, triggered by navitoclax cotreatment

Concert recording 2018-11-29

[Track 1]. French suite. I. Prelude [Track 2]. III. Gavotte / Yvonne Desportes -- [Track 3]. Flower duet from Lakmé / Léo Delibes -- [Track 4]. Hilltribe dance / Yos Vannesorn -- [Track 5]. Toccata and fugue in D minor, BMV 565 / J.S. Bach arranged by A. Brackett -- [Track 6]. Molly on the shore / Percy Grainger arranged by S. Knight -- [Track 7]. Chorale and danza / Vaclac Nelhybel -- [Track 8]. Klezmer suite / Alexis Ciesla

Identification of transdiagnostic psychiatric disorder subtypes using unsupervised learning

Psychiatric disorders show heterogeneous symptoms and trajectories, with current nosology not accurately reflecting their molecular etiology and the variability and symptomatic overlap within and between diagnostic classes. This heterogeneity impedes timely and targeted treatment. Our study aimed to identify psychiatric patient clusters that share clinical and genetic features and may profit from similar therapies. We used high-dimensional data clustering on deep clinical data to identify transdiagnostic groups in a discovery sample (N = 1250) of healthy controls and patients diagnosed with depression, bipolar disorder, schizophrenia, schizoaffective disorder, and other psychiatric disorders. We observed five diagnostically mixed clusters and ordered them based on severity. The least impaired cluster 0, containing most healthy controls, showed general well-being. Clusters 1-3 differed predominantly regarding levels of maltreatment, depression, daily functioning, and parental bonding. Cluster 4 contained most patients diagnosed with psychotic disorders and exhibited the highest severity in many dimensions, including medication load. Depressed patients were present in all clusters, indicating that we captured different disease stages or subtypes. We replicated all but the smallest cluster 1 in an independent sample (N = 622). Next, we analyzed genetic differences between clusters using polygenic scores (PGS) and the psychiatric family history. These genetic variables differed mainly between clusters 0 and 4 (prediction area under the receiver operating characteristic curve (AUC) = 81%;significant PGS: cross-disorder psychiatric risk, schizophrenia, and educational attainment). Our results confirm that psychiatric disorders consist of heterogeneous subtypes sharing molecular factors and symptoms. The identification of transdiagnostic clusters advances our understanding of the heterogeneity of psychiatric disorders and may support the development of personalized treatments

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall (total N = 2196), verbal (total N = 2206) and non-verbal cognitive scores (total N = 3300). The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that variation in cord blood DNA methylation at single CpG sites is associated with cognitive skills and further studies are needed to confirm the association at DUSP22.Peer reviewe

The Immune Landscape of Undifferentiated Pleomorphic Sarcoma

INTRODUCTION: Undifferentiated pleomorphic sarcoma (UPS) can be associated with a relatively dense immune infiltration. Immune checkpoint inhibitors (anti-PD1, anti-PDL1, and anti-CTLA4) are effective in 20% of UPS patients. We characterize the immune microenvironment of UPS and its association with oncologic outcomes. MATERIAL AND METHODS: Surgically resected UPS samples were stained by immunohistochemistry (IHC) for the following: tumor-associated immune cells (CD3, CD8, CD163, CD20), immune checkpoints (stimulatory: OX40, ICOS; inhibitory: PD-L1, LAG3, IDO1, PD1), and the adenosine pathway (CD73, CD39). Sections were reviewed for the presence of lymphoid aggregates (LA). Clinical data were retrospectively obtained for all samples. The Wilcoxon rank-sum and Kruskal-Wallis tests were used to compare distributions. Correlations between biomarkers were measured by Spearman correlation. Univariate and multivariate Cox models were used to identify biomarkers associated with overall survival (OS) and disease-free survival (DFS). Unsupervised clustering was performed, and Kaplan-Meier curves and log-rank tests used for comparison of OS and DFS between immune clusters. RESULTS: Samples analyzed (n=105) included 46 primary tumors, 34 local recurrences, and 25 metastases. LA were found in 23% (n=10/43), 17% (n=4/24), and 30% (n=7/23) of primary, recurrent, and metastatic samples, respectively. In primary UPS, CD73 expression was significantly higher after preoperative radiation therapy (p=0.009). CD39 expression was significantly correlated with PD1 expression (primary: p=0.002, recurrent: p=0.004, metastatic: p=0.001), PD-L1 expression (primary: p=0.009), and CD3+ cell densities (primary: p=0.016, recurrent: p=0.043, metastatic: p=0.028). In recurrent tumors, there was a strong correlation between CD39 and CD73 (p=0.015), and both were also correlated with CD163+ cell densities (CD39 p=0.013; CD73 p\u3c0.001). In multivariate analyses, higher densities of CD3+ and CD8+ cells (Cox Hazard Ratio [HR]=0.33; p=0.010) were independently associated with OS (CD3+, HR=0.19, p\u3c0.001; CD8+, HR= 0.33, p=0.010) and DFS (CD3+, HR=0.34, p=0.018; CD8+, HR=0.34, p= 0.014). Unsupervised clustering of IHC values revealed three immunologically distinct clusters: immune high, intermediate, and low. In primary tumors, these clusters were significantly associated with OS (log-rank p\u3c0.0001) and DFS (p\u3c0.001). CONCLUSION: We identified three immunologically distinct clusters of UPS Associated with OS and DFS. Our data support further investigations of combination anti-PD-1/PD-L1 and adenosine pathway inhibitors in UPS

Quality of Life of Short-Statured Children Born Small for Gestational Age or Idiopathic Growth Hormone Deficiency Within 1 Year of Growth Hormone Treatment

Aside from clinical endpoints like height gain, health-related quality of life has also become an important outcome indicator in the medical field. However, the data on short stature and health-related quality of life is inconsistent. Therefore, we examined changes in health-related quality of life in German children with idiopathic growth hormone deficiency or children born small for gestational age before and after 12 months of human growth hormone treatment. Children with idiopathic short stature without treatment served as a comparison group. At baseline, health-related quality of life data of 154 patients with idiopathic growth hormone deficiency (n = 65), born small for gestational age (n = 58), and idiopathic short stature (n = 31) and one parent each was collected. Of these, 130 completed health-related quality of life assessments after 1-year of human growth hormone treatment. Outcome measures included the Quality of Life in Short Stature Youth questionnaire, as well as clinical and sociodemographic data. Our results showed that the physical, social, and emotional health-related quality of life of children treated with human growth hormone significantly increased, while untreated patients with idiopathic short stature reported a decrease in these domains. Along with this, a statistically significant increase in height in the treated group can be observed, while the slight increase in the untreated group was not significant. In conclusion, the results showed that human growth hormone treatment may have a positive effect not only on height but also in improving patient-reported health-related quality of life of children with idiopathic growth hormone deficiency and children born small for gestational age