Three-Centimeter Doppler Radar Observations of Wingtip-Generated Wake Vortices in Clear Air

This report documents a high risk, high pay-off experiment with the objective of detecting, for the first time, the presence of aircraft wake vortices in clear air using X-band Doppler radar. Field experiments were conducted in January 1995 at the Wallops Flight Facility (WFF) to demonstrate the capability of the 9.33 GHz (I=3 cm) radar, which was assembled using an existing nine-meter parabolic antenna reflector at VVTT and the receiver/transmitter from the NASA Airborne Windshear Radar-Program. A C-130-aircraft, equipped with wingtip smoke generators, created visually marked wake vortices, which were recorded by video cameras. A C-band radar also observed the wake vortices during detection attempts with the X-band radar. Rawinsonde data was used to calculate vertical soundings of wake vortex decay time, cross aircraft bearing wind speed, and water vapor mixing ratio for aircraft passes over the radar measurement range. This experiment was a pathfinder in predicting, in real time, the location and persistence of C-130 vortices, and in setting the flight path of the aircraft to optimize X-band radar measurement of the wake vortex core in real time. This experiment was conducted in support of the NASA Aircraft Vortex Spacing System (AVOSS)

The influence of laser relative intensity noise in the Laser Interferometer Space Antenna

LISA is an upcoming ESA mission that will detect gravitational waves in spaceby interferometrically measuring the separation between free-falling testmasses at picometer precision. To reach the desired performance, LISA willemploy the noise reduction technique time-delay interferometry (TDI), in whichmultiple raw interferometric readouts are time shifted and combined into thefinal scientific observables. Evaluating the performance in terms of these TDIvariables requires careful tracking of how different noise sources propagatethrough TDI, as noise correlations might affect the performance in unexpectedways. One example of such potentially correlated noise is the relativeintensity noise (RIN) of the six lasers aboard the three LISA satellites, whichwill couple into the interferometric phase measurements. In this article, wecalculate the expected RIN levels based on the current mission architecture andthe envisaged mitigation strategies. We find that strict requirements on thetechnical design reduce the effect from approximately 8.7 pm/rtHz perinter-spacecraft interferometer to that of a much lower sub-1 pm/rtHz noise,with typical characteristics of an uncorrelated readout noise after TDI. Ourinvestigations underline the importance of sufficient balanced detection of theinterferometric measurements.<br

The Impact of Pneumococcal Conjugate Vaccine (PCV) Coverage Heterogeneities on the Changing Epidemiology of Invasive Pneumococcal Disease in Switzerland, 2005–2019

Pneumococcal conjugate vaccines (PCVs) have lowered the incidence of invasive pneumococcal disease (IPD) worldwide. However, the influence of regional vaccine uptake differences on the changing epidemiology of IPD remains unclear. We aimed to examine the overall impact of both seven- and 13-valent PCVs (PCV7 and PCV13) on IPD in Switzerland. Three-year periods from 2005–2010 and 2011–2019 were considered, respectively, as (early and late) PCV7 eras and (early, mid and late) PCV13 eras. Vaccine coverage was estimated from a nationwide survey according to east (German-speaking) and west (French/Italian-speaking) regions for each period. Reported incidence rate ratios (IRRs) were compared between successive periods and regions using nationwide IPD surveillance data. Overall IPD incidence across all ages was only 16% lower in the late PCV13 era compared to the early PCV7 era (IRR 0.83, 95% CI 0.79–0.88), due to increasing incidence of non-PCV-type IPD (2.59, 2.37–2.83) in all age groups, except children <5 years. PCV uptake rates in swiss children were slightly higher in the west than the east (p < 0.001), and were accompanied by lower IPD incidences across all age groups in the former region. Post-PCV13, non-PCV serotypes 8, 22F and 9N were the major cause of IPD in adults ≥65 years. Increased PCV coverage in both areas of Switzerland resulted in a decrease in vaccine-type and overall IPD incidence across all age groups, in a regionally dependent manner. However, the rising incidence of non-vaccine-type IPD, exclusive to older adults, may undermine indirect beneficial effects

Development Toward a Ground-Based Interferometric Phased Array for Radio Detection of High Energy Neutrinos

The in-ice radio interferometric phased array technique for detection of high energy neutrinos looks for Askaryan emission from neutrinos interacting in large volumes of glacial ice, and is being developed as a way to achieve a low energy threshold and a large effective volume at high energies. The technique is based on coherently summing the impulsive Askaryan signal from multiple antennas, which increases the signal-to-noise ratio for weak signals. We report here on measurements and a simulation of thermal noise correlations between nearby antennas, beamforming of impulsive signals, and a measurement of the expected improvement in trigger efficiency through the phased array technique. We also discuss the noise environment observed with an analog phased array at Summit Station, Greenland, a possible site for an interferometric phased array for radio detection of high energy neutrinos.Comment: 13 Pages, 14 Figure

Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies.

Three mitochondria-encoded subunits form the catalytic core of cytochrome c oxidase, the terminal enzyme of the respiratory chain. COX1 and COX2 contain heme and copper redox centers, which are integrated during assembly of the enzyme. Defects in this process lead to an enzyme deficiency and manifest as mitochondrial disorders in humans. Here we demonstrate that COA6 is specifically required for COX2 biogenesis. Absence of COA6 leads to fast turnover of newly synthesized COX2 and a concomitant reduction in cytochrome c oxidase levels. COA6 interacts transiently with the copper-containing catalytic domain of newly synthesized COX2. Interestingly, similar to the copper metallochaperone SCO2, loss of COA6 causes cardiomyopathy in humans. We show that COA6 and SCO2 interact and that corresponding pathogenic mutations in each protein affect complex formation. Our analyses define COA6 as a constituent of the mitochondrial copper relay system, linking defects in COX2 metallation to cardiac cytochrome c oxidase deficiency

Beyond the required LISA free-fall performance: new LISA pathfinder results down to 20 μHz

In the months since the publication of the first results, the noise performance of LISA Pathfinder has improved because of reduced Brownian noise due to the continued decrease in pressure around the test masses, from a better correction of noninertial effects, and from a better calibration of the electrostatic force actuation. In addition, the availability of numerous long noise measurement runs, during which no perturbation is purposely applied to the test masses, has allowed the measurement of noise with good statistics down to 20  μHz. The Letter presents the measured differential acceleration noise figure, which is at (1.74±0.05)  fm s^{-2}/sqrt[Hz] above 2 mHz and (6±1)×10  fm s^{-2}/sqrt[Hz] at 20  μHz, and discusses the physical sources for the measured noise. This performance provides an experimental benchmark demonstrating the ability to realize the low-frequency science potential of the LISA mission, recently selected by the European Space Agency

LISA Pathfinder closed-loop analysis: a model breakdown of the in-loop observables

This paper describes a methodology to analyze, in the frequency domain, the steady-state control performances of the LISA Pathfinder mission. In particular, it provides a technical framework to give a comprehensive understanding of the spectra of all the degrees of freedom by breaking them down into their various physical origins, hence bringing out the major contributions of the control residuals. A reconstruction of the measured in-loop output, extracted from a model of the closed-loop system, is shown as an instance to illustrate the potential of such a model breakdown of the data

LISA Pathfinder: First steps to observing gravitational waves from space

LISA Pathfinder, the European Space Agency's technology demonstrator mission for future spaceborne gravitational wave observatories, was launched on 3 December 2015, from the European space port of Kourou, French Guiana. After a short duration transfer to the final science orbit, the mission has been gathering science data since. This data has allowed the science community to validate the critical technologies and measurement principle for low frequency gravitational wave detection and thereby confirming the readiness to start the next generation gravitational wave observatories, such as LISA. This paper will briefly describe the mission, followed by a description of the science operations highlighting the performance achieved. Details of the various experiments performed during the nominal science operations phase can be found in accompanying papers in this volume