An Evening with Tim Wise, an Anti-Racist Essayist, Author and Educator.

Wise, who began his career as Youth Coordinator and Associate Director of the Louisiana Coalition Against Racism and Nazism, now tours the country speaking to students on over 1,000 college and high school campuses. He also speaks to professional institutions on ways to remove racism from within their ranks. Wise\u27s memoir White Like Me: Reflections on Race from a Privileged Son, is widely regarded for its depiction of how racism creates privilege for Whites, while negatively impacting persons of color. His five other works, including Dear White America: Letter to a New Minority, have also earned critical acclaimed. His seventh work Culture of Cruelty: How America\u27s Elite Demonize the Poor, Valorize the Rich and Jeopardize the Future, is scheduled for release in early 2015

Wireless Kick Pedal

The goal of the project is to build a wireless kick pedal that allows accessibility to drummers that have leg or foot disabilities and add versatility to multi-instrumentalists looking to add percussion while playing another instrument. The proposed pedal is designed in two main parts, a wearable band that tracks the player’s movement, and a hammer mechanism that receives actuation commands from the wearable band to move the hammer and deliver a drumbeat. The band is designed to be worn on several parts of the body, including the ankle, knee, thigh, or even the arm depending on the user’s situation. This is to allow compatibility for musicians of differing ability. The team plans to communicate from the band to the hammer mechanism over a short-range wireless communication protocol, so that the response time to deliver a beat is as close to human response time as possible. The hammer mechanism for physically delivering the drumbeat is to be designed such that the hammer strikes the drum similarly to how a commercial pedal would. With this pedal design, the team hopes to invite more people to play the drums and spark new ideas in the future of instrument innovations

Margaret Wise Brown Correspondence

Entries include hand written letters from Brown and a humorous poodle chase publisher advertismen

On the Short Distance Part of the QCD Anomaly Contribution to the b --> s eta' Amplitude

In addressing the B --> eta' K puzzle, there has been a considerable hope in the literature to resolve it by the QCD anomaly contribution to the b --> s eta' amplitude. This contribution corresponds to the electroweak b --> s g* g* transition followed by the off-shell gluon fusion g* g* --> eta'. In the present paper we perform a critical reassessment of this issue. We show that for the hard virtual gluons in a loop there is a well defined short distance amplitude corresponding to a remnant of the QCD anomaly. However, we find that it cannot account for the measured amplitude. In addition, we point out that the reduction of the gluon fusion vertex for the off-shell gluons is compensated by an absence of the claimed suppression in the electroweak vertex, and that some nonperturbative contributions related to the QCD anomaly may still be viable in explaining the physical B --> eta' K amplitude.Comment: 11 pages, 4 figures, LaTeX + elsart.cls, to appear in Phys. Lett.

Temporal Gene Expression Profiling during Rat Femoral Marrow Ablation-Induced Intramembranous Bone Regeneration

Enhanced understanding of differential gene expression and biological pathways associated with distinct phases of intramembranous bone regeneration following femoral marrow ablation surgery will improve future advancements regarding osseointegration of joint replacement implants, biomaterials design, and bone tissue engineering. A rat femoral marrow ablation model was performed and genome-wide microarray data were obtained from samples at 1, 3, 5, 7, 10, 14, 28, and 56 days post-ablation, with intact bones serving as controls at Day 0. Bayesian model-based clustering produced eight distinct groups amongst 9,062 significant gene probe sets based on similar temporal expression profiles, which were further categorized into three major temporal classes of increased, variable, and decreased expression. Osteoblastic- and osteoclastic-associated genes were found to be significantly expressed within the increased expression groups. Chondrogenesis was not detected histologically. Adipogenic marker genes were found within variable/decreased expression groups, emphasizing that adipogenesis was inhibited during osteogenesis. Differential biological processes and pathways associated with each major temporal group were identified, and significantly expressed genes involved were visually represented by heat maps. It was determined that the increased expression group exclusively contains genes involved in pathways for matrix metalloproteinases (MMPs), Wnt signaling, TGF-β signaling, and inflammatory pathways. Only the variable expression group contains genes associated with glycolysis and gluconeogenesis, the notch signaling pathway, natural killer cell mediated cytotoxicity, and the B cell receptor signaling pathway. The decreased group exclusively consists of genes involved in heme biosynthesis, the p53 signaling pathway, and the hematopoietic cell lineage. Significant biological pathways and transcription factors expressed at each time point post-ablation were also identified. These data present the first temporal gene expression profiling analysis of the rat genome during intramembranous bone regeneration induced by femoral marrow ablation

Differential expression and prognostic value of long nonâ coding RNA in HPVâ negative head and neck squamous cell carcinoma

BackgroundLong nonâ coding RNA (lncRNA) has emerged as a new avenue of interest due to its various biological functions in cancer. Abnormal expression of lncRNA has been reported in other malignancies but has been understudied in head and neck squamous cell carcinoma (HNSCC).MethodsThe lncRNA expression was interrogated via quantitative realâ time polymerase chain reaction (qRTâ PCR) array for 19 human papillomavirus (HPV)â negative HNSCC tumorâ normal pairs. The Cancer Genome Atlas (TCGA) was used to validate these results. The association between differentially expressed lncRNA and survival outcomes was analyzed.ResultsDifferential expression was validated for 5 lncRNA (SPRY4â IT1, HEIH, LUCAT1, LINC00152, and HAND2â AS1). There was also an inverse association between MEG3 expression (not significantly differentially expressed in TCGA tumors but highly variable expression) and 3â year recurrenceâ free survival (RFS).ConclusionWe identified and validated differential expression of 5 lncRNA in HPVâ negative HNSCC. Low MEG3 expression was associated with favorable 3â year RFS, although the significance of this finding remains unclear.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144638/1/hed25136_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144638/2/hed25136.pd

A diffuse bubble-like radio-halo source MRC 0116+111: imprint of AGN feedback in a low-mass cluster of galaxies

We present detailed observations of MRC 0116+111, revealing a luminous, mini radio-halo of ~240 kpc diameter located at the centre of a cluster of galaxies at redshift z = 0.131. Our optical and multi-wavelength GMRT and VLA radio observations reveal a highly unusual radio source: showing a pair of giant (~100 kpc diameter) bubble-like diffuse structures, that are about three times larger than the analogous extended radio emission observed in M87 - the dominant central radio galaxy in the Virgo Cluster. However, in MRC 0116+111 we do not detect any ongoing Active Galactic Nucleus (AGN) activity, such as a compact core or active radio jets feeding the plasma bubbles. The radio emitting relativistic particles and magnetic fields were probably seeded in the past by a pair of radio-jets originating in the AGN of the central cD galaxy. The extremely steep high-frequency radio spectrum of the north-western bubble, located ~100 kpc from cluster centre, indicates radiation losses, possibly because having detached, it is rising buoyantly and moving away into the putative hot intra-cluster medium. The other bubble, closer to the cluster centre, shows signs of ongoing particle re-acceleration. We estimate that the radio jets which inflated these two bubbles might have also fed enough energy into the intra-cluster medium to create an enormous system of cavities and shock fronts, and to drive a massive outflow from the AGN, which could counter-balance and even quench a cooling flow. Therefore, this source presents an excellent opportunity to understand the energetics and the dynamical evolution of radio-jet inflated plasma bubbles in the hot cluster atmosphere.Comment: 15 pages, 8 figures. Accepted for publication in MNRA