Perbaikan Tanah Dasar Menggunakan Pre-Fabricated Vertical Drain dengan Variasi Kedalaman dan Perkuatan Lereng dengan Turap Studi Kasus : Lapangan Penumpukan Peti Kemas, Pelabuhan Trisakti, Banjarmasin, Kalimantan Selatan

Metode perbaikan tanah dasar menggunakan preloading yang dikombinasikan dengan Pre-fabricated Vertical Drain (PVD) dipilih untuk proyek pengembangan lapangan penumpukan peti kemas di Pelabuhan Trisakti, Banjarmasin, Kalimantan Selatan. Selama masa preloading, ternyata kelongsoran selebar 37 meter terjadi di area penumpukan. Diketahui bahwa kelongsoran terjadi saat preloading setinggi 4,0 meter. Agar lapangan penumpukan dapat beroperasi kembali, diperlukan perencanaan untuk perkuatan lereng dan untuk menghilangkan pemampatan tanah dasar di area lapangan penumpukan. Perbaikan tanah dasar menggunakan preloading yang dikombinasikan dengan Pre-fabricated Vertical Drain (PVD) digunakan untuk Zona 3, 4, dan 5, dan perkuatan lereng dengan turap digunakan untuk Zona-1 dan Zona-2 yang merupakan bagian lereng dari lapangan penumpukan. Direncanakan PVD dipasang pada kedalaman yang berbeda: 1/3H, 2/3H, dan H (H adalah ketebalan lapisan tanah lunak) untuk melihat kondisi yang menghasilkan biaya paling murah. Dari hasil perencanaan yang dilakukan, diketahui bahwa turap yang digunakan adalah Corrugated Concrete sheet pile type W-600 A1000. Turap dipasang sedalam 18 meter di Zona-1 dan sedalam 22 meter di Zona-2; selain itu, angker dipasang pada turap untuk meningkatkan kekakuan turap. Hasil perencanaan juga menunjukkan bahwa biaya yang paling ekonomis adalah PVD dipasang sampai 2/3H di Zona-3, dan tanpa PVD di Zona-4 dan Zona-5. Total biaya konstruksi adalah sebesar Rp 843.106.053,00 untuk Zona-1 dan Zona-2; Rp 9.446.530.597,00 untuk Zona-3; Rp 1.869.613.200,00 untuk Zona 4; dan Rp 3.577.392.000,00 untuk Zona 5

Perbaikan Tanah Dasar Menggunakan Pre-Fabricated Vertical Drain dengan Variasi Kedalaman dan Perkuatan Lereng dengan Turap Studi Kasus : Lapangan Penumpukan Peti Kemas, Pelabuhan Trisakti, Banjarmasin, Kalimantan Selatan

Metode perbaikan tanah dasar menggunakan preloading yang dikombinasikan dengan Pre-fabricated Vertical Drain (PVD) dipilih untuk proyek pengembangan lapangan penumpukan peti kemas di Pelabuhan Trisakti, Banjarmasin, Kalimantan Selatan. Selama masa preloading, ternyata kelongsoran selebar 37 meter terjadi di area penumpukan. Diketahui bahwa kelongsoran terjadi saat preloading setinggi 4,0 meter. Agar lapangan penumpukan dapat beroperasi kembali, diperlukan perencanaan untuk perkuatan lereng dan untuk menghilangkan pemampatan tanah dasar di area lapangan penumpukan. Perbaikan tanah dasar menggunakan preloading yang dikombinasikan dengan Pre-fabricated Vertical Drain (PVD) digunakan untuk Zona 3, 4, dan 5, dan perkuatan lereng dengan turap digunakan untuk Zona-1 dan Zona-2 yang merupakan bagian lereng dari lapangan penumpukan. Direncanakan PVD dipasang pada kedalaman yang berbeda: 1/3H, 2/3H, dan H (H adalah ketebalan lapisan tanah lunak) untuk melihat kondisi yang menghasilkan biaya paling murah. Dari hasil perencanaan yang dilakukan, diketahui bahwa turap yang digunakan adalah Corrugated Concrete sheet pile type W-600 A1000. Turap dipasang sedalam 18 meter di Zona-1 dan sedalam 22 meter di Zona-2; selain itu, angker dipasang pada turap untuk meningkatkan kekakuan turap. Hasil perencanaan juga menunjukkan bahwa biaya yang paling ekonomis adalah PVD dipasang sampai 2/3H di Zona-3, dan tanpa PVD di Zona-4 dan Zona-5. Total biaya konstruksi adalah sebesar Rp 843.106.053,00 untuk Zona-1 dan Zona-2; Rp 9.446.530.597,00 untuk Zona-3; Rp 1.869.613.200,00 untuk Zona 4; dan Rp 3.577.392.000,00 untuk Zona 5

Perancangan Iklan Layanan Masyarakat Tentang Pola Kerja Yang Seimbang Dengan Media Animasi (Untuk Usia 20-26 Tahun)

Manusia pada umumnya bekerja untuk memenuhi kebutuhan materil. Namun aspek kehidupan yang lainnya seperti kesehatan terlupakan bahkan hilang. Istirahat serta pola makan menjadi berantakan. Melalui Iklan Layanan Masyarakat ini diharapkan para pekerja khususnya di Indonesia boleh diingatkan untuk bekerja dengan bijak dan tidak mengabaikan aspek kehidupan lain ketika bekerja. Khususnya aspek kesehatan. Penyajian cerita animasi yang simple akan membantu memudahkan para penonton untuk mengerti pesan yang akan disampaikan

The Ca2+ sensor protein Swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons

This work was supported by grants from the German Science Foundation (Deutsche Forschungsgemeinschaft, DFG; FOR832, to DM), the German Federal Ministry of Education and Research (01GQ113; to BW), the Bavarian Ministry of Sciences, Research and the Arts in the framework of the Bavarian Molecular Biosystems Reseach Network, the Interdisciplinary Center for Clinical Research (IZKF, Universitatsklinikum Erlangen; E8, to DM; NIII, to BW; Lab rotation to MR), the ELAN Fonds (Universitatsklinikum Erlangen; 11.08.19.1, to IP), and the Alzheimer’s Research UK (EB, FGM).Swiprosin-1/EFhd2 (EFhd2) is a cytoskeletal Ca2+ sensor protein strongly expressed in the brain. It has been shown to interact with mutant tau, which can promote neurodegeneration, but nothing is known about the physiological function of EFhd2 in the nervous system. To elucidate this question, we analyzed EFhd2-/-/lacZ reporter mice and showed that lacZ was strongly expressed in the cortex, the dentate gyrus, the CA1 and CA2 regions of the hippocampus, the thalamus, and the olfactory bulb. Immunohistochemistry and western blotting confirmed this pattern and revealed expression of EFhd2 during neuronal maturation. In cortical neurons, EFhd2 was detected in neurites marked by MAP2 and co-localized with preand post-synaptic markers. Approximately one third of EFhd2 associated with a biochemically isolated synaptosome preparation. There, EFhd2 was mostly confined to the cytosolic and plasma membrane fractions. Both synaptic endocytosis and exocytosis in primary hippocampal EFhd2-/- neurons were unaltered but transport of synaptophysin-GFP containing vesicles was enhanced in EFhd2-/- primary hippocampal neurons, and notably, EFhd2 inhibited kinesin mediated microtubule gliding. Therefore, we found that EFhd2 is a neuronal protein that interferes with kinesin-mediated transport.Peer reviewe

Integrated engineering environments for large complex products

An introduction is given to the Engineering Design Centre at the University of Newcastle upon Tyne, along with a brief explanation of the main focus towards large made-to-order products. Three key areas of research at the Centre, which have evolved as a result of collaboration with industrial partners from various sectors of industry, are identified as (1) decision support and optimisation, (2) design for lifecycle, and (3) design integration and co-ordination. A summary of the unique features of large made-to-order products is then presented, which includes the need for integration and co-ordination technologies. Thus, an overview of the existing integration and co-ordination technologies is presented followed by a brief explanation of research in these areas at the Engineering Design Centre. A more detailed description is then presented regarding the co-ordination aspect of research being conducted at the Engineering Design Centre, in collaboration with the CAD Centre at the University of Strathclyde. Concurrent Engineering is acknowledged as a strategy for improving the design process, however design coordination is viewed as a principal requirement for its successful implementation. That is, design co-ordination is proposed as being the key to a mechanism that is able to maximise and realise any potential opportunity of concurrency. Thus, an agentoriented approach to co-ordination is presented, which incorporates various types of agents responsible for managing their respective activities. The co-ordinated approach, which is implemented within the Design Co-ordination System, includes features such as resource management and monitoring, dynamic scheduling, activity direction, task enactment, and information management. An application of the Design Co-ordination System, in conjunction with a robust concept exploration tool, shows that the computational design analysis involved in evaluating many design concepts can be performed more efficiently through a co-ordinated approach

Analisis Geoteknik Terhadap Kerusakan Dan Peningkatan Jalan Kolonel Imam Suparto Kecamatan Tembalang Sta. 4+700

Kolonel Imam Suparto street has an important role for the economic growth in Subdistric of Tembalang. Recently, this road has catastrophic landslide. It is quite alarming. Degradation of this road as an impact of landslide is very danger for the safety of driver who pass through this way. After slope stability analysis using Fellenius method is performed, it is shown that the SF or safety factor of the slope is 0,891. By using PLAXIS 8.2 , it is shown that the SF is 1,37. Both of this point indicated that the slope stability is in a critical condition or very risk for landslide. So, a precise solution is needed to push the landslide risk by increased the safety factor of that slope. The alternatives that used for this case by using Retaining Wall (DPT) type Cantilever Wall and Bronjong DPT or Bronjong is quite good for solving the landslide. It is founded that after reparation by using DPT type cantilever wall the safety factor is 1,93 and 1,77 by using Bronjong. DPT type cantilever wall is decided as the best solution between both alternatives. It is because the safety factor of DPT is higher than Bronjong

Favorable outcome of early treatment of new onset child and adolescent migraine-implications for disease modification.

There is evidence that the prevalence of migraine in children and adolescents may be increasing. Current theories of migraine pathophysiology in adults suggest activation of central cortical and brainstem pathways in conjunction with the peripheral trigeminovascular system, which ultimately results in release of neuropeptides, facilitation of central pain pathways, neurogenic inflammation surrounding peripheral vessels, and vasodilatation. Although several risk factors for frequent episodic, chronic, and refractory migraine have been identified, the causes of migraine progression are not known. Migraine pathophysiology has not been fully evaluated in children. In this review, we will first discuss the evidence that early therapeutic interventions in the child or adolescent new onset migraineur, may halt or limit progression and disability. We will then review the evidence suggesting that many adults with chronic or refractory migraine developed their migraine as children or adolescents and may not have been treated adequately with migraine-specific therapy. Finally, we will show that early, appropriate and optimal treatment of migraine during childhood and adolescence may result in disease modification and prevent progression of this disease

An Investigation of the Security Designs of a Structured Query Language (Sql) Database and its Middleware Application and their Secure Implementation Within Thinclient Environments

The Information Portability and Accountability Act (HIPAA) and The SarbanesOxley (SOX) regulations greatly influenced the health care industry regarding the means of securing financial and private data within information and technology. With the introduction of thinclient technologies into medical information systems (IS), data security and regulation compliancy becomes more problematic due to the exposure to the World Wide Web (WWW) and malicious activity. This author explores the best practices of the medical industry and information technology industry for securing electronic data within the thinclient environment at the three levels of architecture: the SQL database, its middleware application, and Web interface. Designing security within the SQL database is not good enough as breaches can occur through unintended consequences during data access within the middleware application design and data exchange design over computer networks. For example, a hospital\u27s medical records, which are routinely exchanged over computer networks, are subject to the audit control an encryption requirements mandated for data security. (Department of, 2008). While there is an overlapping of security techniques within each of the three layers of architectural security design, the use of 18 methodologies greatly enhances the ability to protect electronic information. Due to the variety of IS used within a medical facility, security conscientiousness, consistency of security design, excellent communication between designers, developers and system engineers, and the use of standardized security techniques within each of the three layers of architecture are required

Nurturing the young shoots of talent: Using action research for exploration and theory building

This is an Author's Accepted Manuscript of an article published in European Early Childhood Education Research Journal, 19(4), 433-450, 2011, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/1350293X.2011.623515.This paper reports the outcomes of a set of action research projects carried out by teacher researchers in 14 local education authorities in England, working collaboratively with university tutors, over a period of three years. The common aim of all the projects was to explore practical ways of nurturing the gifts and talents of children aged four–seven years. The project was funded by the Department of Education and Skills in England as part of the government's gifted and talented programme. The project teachers felt that their understanding of issues relating to nurturing the gifts and talents of younger children was enhanced through their engagement in the project. It was possible to map the findings of the projects to the English government's National Quality Standards for gifted and talented education which include: (1) identification; (2) effective provision in the classroom; (3) enabling curriculum entitlement and choice; (4) assessment for learning; (5) engaging with community, families and beyond. The findings are also analysed within the framework of good practice in educating children in the first years of schooling. Participating practitioners felt that action research offered them a suitable methodology to explore the complexity of the topic of giftedness through cycles of planning, action and reflection and personal theory building

Effects of preservation methods of muscle tissue from upper-trophic level reef fishes on stable isotope values (δ13C and δ15N)

© The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PeerJ 3 (2015): e874, doi:10.7717/peerj.874.Research that uses stable isotope analysis often involves a delay between sample collection in the field and laboratory processing, therefore requiring preservation to prevent or reduce tissue degradation and associated isotopic compositions. Although there is a growing literature describing the effects of various preservation techniques, the results are often contextual, unpredictable and vary among taxa, suggesting the need to treat each species individually. We conducted a controlled experiment to test the effects of four preservation methods of muscle tissue from four species of upper trophic-level reef fish collected from the eastern Gulf of Mexico (Red Grouper Epinephelus morio, Gag Mycteroperca microlepis, Scamp Mycteroperca phenax, and Red Snapper Lutjanus campechanus). We used a paired design to measure the effects on isotopic values for carbon and nitrogen after storage using ice, 95% ethanol, and sodium chloride (table salt), against that in a liquid nitrogen control. Mean offsets for both δ13C and δ15N values from controls were lowest for samples preserved on ice, intermediate for those preserved with salt, and highest with ethanol. Within species, both salt and ethanol significantly enriched the δ15N values in nearly all comparisons. Ethanol also had strong effects on the δ13C values in all three groupers. Conversely, for samples preserved on ice, we did not detect a significant offset in either isotopic ratio for any of the focal species. Previous studies have addressed preservation-induced offsets in isotope values using a mass balance correction that accounts for changes in the isotope value to that in the C/N ratio. We tested the application of standard mass balance corrections for isotope values that were significantly affected by the preservation methods and found generally poor agreement between corrected and control values. The poor performance by the correction may have been due to preferential loss of lighter isotopes and corresponding low levels of mass loss with a substantial change in the isotope value of the sample. Regardless of mechanism, it was evident that accounting for offsets caused by different preservation methods was not possible using the standard correction. Caution is warranted when interpreting the results from specimens stored in either ethanol or salt, especially when using those from multiple preservation techniques. We suggest the use of ice as the preferred preservation technique for muscle tissue when conducting stable isotope analysis as it is widely available, inexpensive, easy to transport and did not impart a significant offset in measured isotopic values. Our results provide additional evidence that preservation effects on stable isotope analysis can be highly contextual, thus requiring their effects to be measured and understood for each species and isotopic ratio of interest before addressing research questions.Funding was provided by a grant to CD Stallings and TS Switzer from the National Oceanic and Atmospheric Administration, Cooperative Research Program (NA12NMF4540081)