The Sexual Impact of Infertility Among Women Seeking Fertility Care.

IntroductionInfertility affects approximately 6.7 million women in the United States. Couples with infertility have significantly more anxiety, depression, and stress. This is compounded by the fact that almost 40% of couples undergoing assisted reproduction technology still cannot conceive, which can have an ongoing effect on quality of life, marital adjustment, and sexual impact.AimTo assess the sexual impact of infertility in women undergoing fertility treatment.MethodsThis study is a cross-sectional analysis of women in infertile couples seeking treatment at academic or private infertility clinics. Basic demographic information was collected. Respondents were surveyed regarding sexual impact and perception of their infertility etiology. Multivariate regression analyses were used to identify factors independently associated with increased sexual impact.Main outcome measureSexual impact of perceived fertility diagnosis.ResultsIn total, 809 women met the inclusion criteria, of whom 437 (54%) agreed to participate and 382 completed the sexual impact items. Most of the infertility was female factor only (58.8%), whereas 30.4% of infertility was a combination of male and female factors, 7.3% was male factor only, and 3.5% was unexplained infertility. In bivariate and multivariate analyses, women who perceived they had female factor only infertility reported greater sexual impact compared with woman with male factor infertility (P = .01). Respondents who were younger than 40 years experienced a significantly higher sexual impact than respondents older than 40 years (P < .01). When stratified by primary and secondary infertility, respondents with primary infertility overall reported higher sexual impact scores.ConclusionIn women seeking fertility treatment, younger age and female factor infertility were associated with increased sexual impact and thus these women are potentially at higher risk of sexual dysfunction. Providers should consider the role young age and an infertility diagnosis plays in a women's sexual well-being

On Writ of Certiorari to the United States Court of Appeals for the Ninth Circuit, Brief of Product Liability Advisory Council, Inc., National Association of Manufacturers, Business Roundtable, and Chemical Manufacturers Association as Amici Curiae in Support of Respondent, William Daubert and Joyce Daubert, Individually and as Guardians Ad Litem for Jason Daubert, and Anita De Young, Individually and as Gaurdian Ad Litem for Eric Schuller v. Merrell Dow Pharmaceuticals, Inc.

The Federal Rules of Evidence exclude expert scientific testimony when it has been developed without regard for accepted scientific methods. This case focuses on expert scientific evidence. Such evidence plays a vital and often dispositive role in modern litigation. For scientific evidence to be helpful to the factfinder it must meet some minimal threshold of reliability. To hold otherwise would be to allow a system of adjudication based more on chance than on reason

CO hydrogenation over K‐Co‐MoSₓ catalyst to mixed alcohols: A kinetic analysis

Higher alcohol synthesis (HAS) from syngas is one of the most promising approaches to produce fuels and chemicals. Our recent investigation on HAS showed that potassium‐promoted cobalt‐molybdenum sulfide is an effective catalyst system. In this study, the intrinsic kinetics of the reaction were studied using this catalyst system under realistic conditions. The study revealed the major oxygenated products are linear alcohols up to butanol and methane is the main hydrocarbon. The higher alcohol products (C3+) followed an Anderson‐Schultz‐Flory distribution while the catalyst suppressed methanol and ethanol formation. The optimum reaction conditions were estimated to be at temperature of 340°C, pressure of 117 bar, gas hourly space velocity of 27 000 mL g–1 h–1 and H2/CO molar feed ratio of 1. A kinetic network has been considered and kinetic parameters were estimated by nonlinear regression of the experimental data. The results indicated an increasing apparent activation energy of alcohols with the length of alcohols except for ethanol. The lower apparent activation energy of alcohols compared with hydrocarbon evidenced the efficiency of this catalyst system to facilitate the formation of higher alcohols

As instituições financeiras no direito pátrio : definição e caracterização da atividade própria ou exclusiva

Relaciona as atividades que caracterizam as instituições financeiras no Brasil. Argumenta que, segundo as normas, o Banco Central do Brasil não pode ser considerado, tecnicamente, uma instituição financeira, mas eventualmente age como tal. Esclarece que as pessoas jurídicas devem se organizar sob a forma de sociedade de crédito, financiamento e investimento se quiserem fazer concessão de financiamento (empréstimo a juros ou acima da taxa legal), caso contrário poderiam ser punidas por exercerem atividades próprias ou exclusivas de instituições financeiras ou por atuarem sem autorização do Banco Central

The High Impact of Astronomical Data Archives

Archives are widely recognized as a valuable resource for astronomy, but statistics on their use indicates they are even more important than most astronomers realize. Obviously much of the science from survey projects such as SDSS relies on the archive. Perhaps more surprisingly, archival data are also a major contributor to the science from targeted, PI-driven missions such as HST, Chandra, Spitzer and the ground-based observatories. Archival research currently accounts for half of the ~1200 Hubble and Chandra science papers published each year, and the use of the archive continues to increase. The archival data products are, in the long term, as important as the PI science programs. It is vital to recognize the large impact archives can have on the science generated by missions and observatories. The value of the archive should be an important factor in the establishment of new projects. Future missions and observatories should not only budget adequate resources to support a robust archive, but they also should consider the effects of mission design and operations decisions on the archive. Additional funding both for archive users and archive centers -- particularly with an eye to enabling cross-archive, multiwavelength science -- is a relatively inexpensive way to increase the science output from our major investments in large projects

Experimental and modeling studies on the absorption of NO in aqueous ferrous EDTA solutions

This work describes an experimental and modeling study on an industrial relevant process (i.e., the absorption of NO in aqueous Fe II (EDTA) solutions) to accurately determine the equilibrium constant of the reaction in the temperature range of 299-329 K. The experiments were carried out in a stirred cell contactor using a pH of 7 and an initial Fe II (EDTA) concentration of 7-9 mol/m 3 . A dynamic reactor model was developed to describe the experimental absorption profiles. Mass transfer effects were taken into account using the penetration theory for mass transfer. Excellent fits were obtained between measured and modeled profiles when assuming that the reaction takes place in the instantaneous regime. The following temperature dependence for the K value was obtained: K ) exp((4702/T) -8.534). Dynamic reactor modeling not only allowed calculation of the equilibrium constants of the reaction but also provided accurate values for the ratio of the diffusivity of Fe II (EDTA) and NO (r P ) at various temperatures. This ratio is of extreme importance for the design of a reactive NO absorption unit and could be expressed as: r P ) -1.775 × 10 -4 T 2 + 0.11T -16.93

Abnormalities of white matter integrity in the corpus callosum of adolescents with PTSD after childhood sexual abuse: a DTI study

This study seeks to determine whether white matter integrity in the brain differs between adolescents with post-traumatic stress disorder (PTSD) due to childhood sexual abuse (CSA) and matched healthy adolescents and whether there is a relationship between white matter integrity and symptom severity in the patient group. Using 3T diffusion tensor imaging, we examined fractional anisotropy (FA) in a group of adolescents with CSA-related PTSD (n = 20) and matched healthy controls (n = 20), in a region of interest consisting of the bilateral uncinate fasciculus (UF), the genu, splenium and body of the corpus callosum (CC), and the bilateral cingulum. In addition, we performed an exploratory whole brain analysis. Trauma symptomatology was measured with the Trauma Symptom Checklist for Children (TSCC) to enable correlational analyses between FA differences and trauma symptomatology. The PTSD group had significantly lower FA values in the genu, midbody and splenium of the CC in comparison with controls (p Multivariate analysis of psychological dat