Más allá del Concilio. El catolicismo holandés, un laboratorio de renovación eclesial (1960-1975)

Durante los años conciliares, la evolución de la sociedad holandesa hacia la izquierda está marcada por el desarrollo de una cultura joven y de flower power, pero también por las manifestaciones estudiantiles y por un endurecimiento de la acción sindical. Este cambio se traduce en la Iglesia católica en la aparición de comunidades de base y parroquias críticas. Los ejemplos analizados en el artículo, ponen de manifiesto sus preocupaciones: modernización de la liturgia pero también crítica de la sociedad y contestación del funcionamiento eclesial –particularmente el celibato eclesiástico y los obstáculos puesto a la intercomunión entre católicos y protestantes–. Ampliamente mediatizada, especialmente a través del grupo de sacerdotes contestatarios, la Septuaginta, la experiencia de izquierdas del catolicismo holandés tuvo un gran eco internacional alrededor de los años 60-70, antes de perder su base social y declinar rápidamente.Over the course of the conciliar years, progressive social movements arose in Dutch society. These were marked by the spread of youth culture and «flower power» as well as student demonstrations and the radicalization of trade unions. In the Catholic Church, this transformation was reflected in the emergence of grassroots communities and «critical parishes». Their main concerns were: the modernization of the liturgy, social critique and protest targeting the way the Church operated, particularly concerning ecclesiastical celibacy and the obstacles to intercommunion between Catholics and Protestants. Widely covered in the media, particularly thanks to the efforts of the Septuagint, a group of protesting priests, the experience of the Dutch Catholic left was closely observed abroad in the late 1960s and early 1970s. It subsequently lost its social basis and rapidly declined

The Pairing Mechanism in HTSC investigated by Electronic Raman Scattering

By means of electronic Raman scattering we investigated the symmetry of the energy gap Delta(k), its temperature dependence and its variation with doping of well characterized Bi2Sr2CaCu2O8+delta single crystals. The oxygen content delta was varied between the under- and the overdoped regime by subsequently annealing the same single crystal in Ar and O2, respectively. The symmetry analysis of the polarized electronic Raman scattering is consistent with a d_x^2-y^2-wave symmetry of the energy gap in both regimes. The gap ratio 2Delta_max/k_BT_c and its temperature dependence changes with doping similar to predictions of theories based on paramagnon coupling.Comment: 3 pages, LaTeX, 2 ps figures available on request to [email protected]

Анализ использования золошлакового материала Красноярской ТЭЦ-2 для получения товарного продукта

Объектом исследования в работе являются технологии утилизации золы с получением товарного продукта. Целью выпускной квалификационной работы является выполнение аналитического обзора литературных данных по использованию золошлаковых отходов, складируемых на золоотвале №2 Красноярской ТЭЦ -2, с целью производства товарного продукта. В процессе исследования проводился аналитический обзор по литературным источникам с целью выяснения достижений мировой науки техники в рассматриваемой области. В результате исследования разработана технологическая схема переработки золы и шлака в продукт для дальнейшего использования в отрасли производства строительных материалов.The object of research in the work are the technologies for the utilization of ash to obtain a marketable product. The aim of the final qualification work is to perform an analytical review of the literature on the use of ash and slag waste stored at ash dump No. 2 of the Krasnoyarsk power plant 2, with the aim of producing a marketable product. In the course of the study, an analytical review of literary sources was carried out in order to ascertain the achievements of the world science of technology in the field under consideration. As a result of the study, a technological scheme was developed for processing ash and slag into a product for further use in the building materials industry

ARF and p53 coordinate tumor suppression of an oncogenic IFN-β-STAT1-ISG15 signaling axis

SummaryThe ARF and p53 tumor suppressors are thought to act in a linear pathway to prevent cellular transformation in response to various oncogenic signals. Here, we show that loss of p53 leads to an increase in ARF protein levels, which function to limit the proliferation and tumorigenicity of p53-deficient cells by inhibiting an IFN-β-STAT1-ISG15 signaling axis. Human triple-negative breast cancer (TNBC) tumor samples with coinactivation of p53 and ARF exhibit high expression of both STAT1 and ISG15, and TNBC cell lines are sensitive to STAT1 depletion. We propose that loss of p53 function and subsequent ARF induction creates a selective pressure to inactivate ARF and propose that tumors harboring coinactivation of ARF and p53 would benefit from therapies targeted against STAT1 and ISG15 activation

Overexpression of a Prefoldin β subunit gene reduces biomass recalcitrance in the bioenergy crop Populus.

Prefoldin (PFD) is a group II chaperonin that is ubiquitously present in the eukaryotic kingdom. Six subunits (PFD1-6) form a jellyfish-like heterohexameric PFD complex and function in protein folding and cytoskeleton organization. However, little is known about its function in plant cell wall-related processes. Here, we report the functional characterization of a PFD gene from Populus deltoides, designated as PdPFD2.2. There are two copies of PFD2 in Populus, and PdPFD2.2 was ubiquitously expressed with high transcript abundance in the cambial region. PdPFD2.2 can physically interact with DELLA protein RGA1_8g, and its subcellular localization is affected by the interaction. In P. deltoides transgenic plants overexpressing PdPFD2.2, the lignin syringyl/guaiacyl ratio was increased, but cellulose content and crystallinity index were unchanged. In addition, the total released sugar (glucose and xylose) amounts were increased by 7.6% and 6.1%, respectively, in two transgenic lines. Transcriptomic and metabolomic analyses revealed that secondary metabolic pathways, including lignin and flavonoid biosynthesis, were affected by overexpressing PdPFD2.2. A total of eight hub transcription factors (TFs) were identified based on TF binding sites of differentially expressed genes in Populus transgenic plants overexpressing PdPFD2.2. In addition, several known cell wall-related TFs, such as MYB3, MYB4, MYB7, TT8 and XND1, were affected by overexpression of PdPFD2.2. These results suggest that overexpression of PdPFD2.2 can reduce biomass recalcitrance and PdPFD2.2 is a promising target for genetic engineering to improve feedstock characteristics to enhance biofuel conversion and reduce the cost of lignocellulosic biofuel production

Anticancer Gene Transfer for Cancer Gene Therapy

Gene therapy vectors are among the treatments currently used to treat malignant tumors. Gene therapy vectors use a specific therapeutic transgene that causes death in cancer cells. In early attempts at gene therapy, therapeutic transgenes were driven by non-specific vectors which induced toxicity to normal cells in addition to the cancer cells. Recently, novel cancer specific viral vectors have been developed that target cancer cells leaving normal cells unharmed. Here we review such cancer specific gene therapy systems currently used in the treatment of cancer and discuss the major challenges and future directions in this field

Early Detection of Erlotinib Treatment Response in NSCLC by 3′-Deoxy-3′-[18F]-Fluoro-L-Thymidine ([18F]FLT) Positron Emission Tomography (PET)

Background: Inhibition of the epidermal growth factor receptor (EGFR) has shown clinical success in patients with advanced non-small cell lung cancer (NSCLC). Somatic mutations of EGFR were found in lung adenocarcinoma that lead to exquisite dependency on EGFR signaling; thus patients with EGFR-mutant tumors are at high chance of response to EGFR inhibitors. However, imaging approaches affording early identification of tumor response in EGFR-dependent carcinomas have so far been lacking. Methodology/Principal Findings: We performed a systematic comparison of 3′-Deoxy-3′-[$^{18}F$]-fluoro-L-thymidine ([$^{18}F$]FLT) and 2-[$^{18}F$]-fluoro-2-deoxy-D-glucose ([$^{18}F$]FDG) positron emission tomography (PET) for their potential to identify response to EGFR inhibitors in a model of EGFR-dependent lung cancer early after treatment initiation. While erlotinib-sensitive tumors exhibited a striking and reproducible decrease in [$^{18}F$]FLT uptake after only two days of treatment, [$^{18}F$]FDG PET based imaging revealed no consistent reduction in tumor glucose uptake. In sensitive tumors, a decrease in [$^{18}F$]FLT PET but not [$^{18}F$]FDG PET uptake correlated with cell cycle arrest and induction of apoptosis. The reduction in [$^{18}F$]FLT PET signal at day 2 translated into dramatic tumor shrinkage four days later. Furthermore, the specificity of our results is confirmed by the complete lack of [$^{18}F$]FLT PET response of tumors expressing the T790M erlotinib resistance mutation of EGFR. Conclusions: [$^{18}F$]FLT PET enables robust identification of erlotinib response in EGFR-dependent tumors at a very early stage. [$^{18}F$]FLT PET imaging may represent an appropriate method for early prediction of response to EGFR TKI treatment in patients with NSCLC