9,279 research outputs found
Reference Distorted Prices
I show that when consumers (mis)perceive prices relative to reference prices,
budgets turn out to be soft, prices tend to be lower and the average quality of
goods sold decreases. These observations provide explanations for decentralized
purchase decisions, for people being happy with a purchase even when they have
paid their evaluation, and for why trade might affect high quality local firms
'unfairly'
Second-line agents in myositis: 1-year factorial trial of additional immunosuppression in patients who have partially responded to steroids.
Ciclosporin and MTX are used in idiopathic inflammatory myopathies (DM and PM) when patients incompletely respond to glucocorticoids. Their effectiveness is unproved in randomized controlled trials (RCTs). We evaluated their benefits in a placebo-controlled factorial RCT
Global Standards in Action: Insights from Anti-Money Laundering Regulation
As organizations have come under the increasing influence of global rules of all sorts, organization scholars have started studying the dynamics of global regulation. The purpose of this article is to identify and evaluate the contribution to this interdisciplinary field by the ‘Stockholm Centre for Organisational Research’. The latter’s key proposition is that while global regulation often consists of voluntary best practice rules it can nevertheless become highly influential under certain conditions. We assess how innovative this approach is using as a benchmark the state of the art in another field of relevance to the study of global regulation, i.e. ‘International Relations’. Our discussion is primarily theoretical but we draw on the case of global anti-money laundering regulation to illustrate our arguments and for inspirations of how to further elaborate the approach
The impact of chorionicity on pregnancy outcome and neurodevelopment at 2 years old among twins born preterm: the EPIPAGE-2 cohort study
OBJECTIVE
To compare the short‐ and mid‐term outcomes of preterm twins by chorionicity of pregnancy.
DESIGN
Prospective nationwide population‐based EPIPAGE‐2 cohort study.
SETTING
546 maternity units in France, between March and December 2011.
POPULATION
A total of 1700 twin neonates born between 24 and 34 weeks of gestation.
METHODS
The association of chorionicity with outcomes was analysed using multivariate regression models.
MAIN OUTCOME MEASURES
First, survival at 2‐year corrected age with or without neurosensory impairment, and second, perinatal, short‐, and mid‐term outcomes (survival at discharge, survival at discharge without severe morbidity) were described and compared by chorionicity.
RESULTS
In the EPIPAGE 2 cohort, 1700 preterm births were included (850 twin pregnancies). In all, 1220 (71.8%) were from dichorionic (DC) pregnancies and 480 from monochorionic (MC) pregnancies. MC pregnancies had three times more medical terminations than DC pregnancies (1.67 versus 0.51%, P < 0.001), whereas there were three times more stillbirths in MC than in DC pregnancies (10.09 versus 3.78%, P < 0.001). Both twins were alive at birth in 86.6% of DC pregnancies compared with 80.0% among MC pregnancies (P = 0.008). No significant difference according to chorionicity was found regarding neonatal deaths and morbidities. Likewise, for children born earlier than 32 weeks, the 2‐year follow‐up neurodevelopmental results were not significantly different between DC and MC twins.
CONCLUSIONS
This study confirms that MC pregnancies have a higher risk of adverse outcomes. However, the outcomes among preterm twins admitted to neonatal intensive care units are similar irrespective of chorionicity
Constraints on dark matter models from a Fermi LAT search for high-energy cosmic-ray electrons from the Sun
During its first year of data taking, the Large Area Telescope (LAT) onboard
the Fermi Gamma-Ray Space Telescope has collected a large sample of high-energy
cosmic-ray electrons and positrons (CREs). We present the results of a
directional analysis of the CRE events, in which we searched for a flux excess
correlated with the direction of the Sun. Two different and complementary
analysis approaches were implemented, and neither yielded evidence of a
significant CRE flux excess from the Sun. We derive upper limits on the CRE
flux from the Sun's direction, and use these bounds to constrain two classes of
dark matter models which predict a solar CRE flux: (1) models in which dark
matter annihilates to CREs via a light intermediate state, and (2) inelastic
dark matter models in which dark matter annihilates to CREs.Comment: 18 pages, 8 figures, accepted for publication in Physical Review D -
contact authors: Francesco Loparco ([email protected]), M. Nicola Mazziotta
([email protected]) and Jennifer Siegal-Gaskins ([email protected]
Finding robust solutions for constraint satisfaction problems with discrete and ordered domains by coverings
Constraint programming is a paradigm wherein relations between variables are
stated in the form of constraints. Many real life problems come from uncertain and dynamic
environments, where the initial constraints and domains may change during its execution.
Thus, the solution found for the problem may become invalid. The search forrobustsolutions
for constraint satisfaction problems (CSPs) has become an important issue in the ¿eld of
constraint programming. In some cases, there exists knowledge about the uncertain and
dynamic environment. In other cases, this information is unknown or hard to obtain. In
this paper, we consider CSPs with discrete and ordered domains where changes only involve
restrictions or expansions of domains or constraints. To this end, we model CSPs as weighted
CSPs (WCSPs) by assigning weights to each valid tuple of the problem constraints and
domains. The weight of each valid tuple is based on its distance from the borders of the
space of valid tuples in the corresponding constraint/domain. This distance is estimated by
a new concept introduced in this paper: coverings. Thus, the best solution for the modeled
WCSP can be considered as a most robust solution for the original CSP according to these
assumptionsThis work has been partially supported by the research projects TIN2010-20976-C02-01 (Min. de Ciencia e Innovacion, Spain) and P19/08 (Min. de Fomento, Spain-FEDER), and the fellowship program FPU.Climent Aunés, LI.; Wallace, RJ.; Salido Gregorio, MA.; Barber Sanchís, F. (2013). Finding robust solutions for constraint satisfaction problems with discrete and ordered domains by coverings. Artificial Intelligence Review. 1-26. https://doi.org/10.1007/s10462-013-9420-0S126Climent L, Salido M, Barber F (2011) Reformulating dynamic linear constraint satisfaction problems as weighted csps for searching robust solutions. In: Ninth symposium of abstraction, reformulation, and approximation (SARA-11), pp 34–41Dechter R, Dechter A (1988) Belief maintenance in dynamic constraint networks. In: Proceedings of the 7th national conference on, artificial intelligence (AAAI-88), pp 37–42Dechter R, Meiri I, Pearl J (1991) Temporal constraint networks. Artif Intell 49(1):61–95Fargier H, Lang J (1993) Uncertainty in constraint satisfaction problems: a probabilistic approach. In: Proceedings of the symbolic and quantitative approaches to reasoning and uncertainty (EC-SQARU-93), pp 97–104Fargier H, Lang J, Schiex T (1996) Mixed constraint satisfaction: a framework for decision problems under incomplete knowledge. In: Proceedings of the 13th national conference on, artificial intelligence, pp 175–180Fowler D, Brown K (2000) Branching constraint satisfaction problems for solutions robust under likely changes. In: Proceedings of the international conference on principles and practice of constraint programming (CP-2000), pp 500–504Goles E, Martínez S (1990) Neural and automata networks: dynamical behavior and applications. Kluwer Academic Publishers, DordrechtHays W (1973) Statistics for the social sciences, vol 410, 2nd edn. Holt, Rinehart and Winston, New YorkHebrard E (2006) Robust solutions for constraint satisfaction and optimisation under uncertainty. PhD thesis, University of New South WalesHerrmann H, Schneider C, Moreira A, Andrade Jr J, Havlin S (2011) Onion-like network topology enhances robustness against malicious attacks. J Stat Mech Theory Exp 2011(1):P01,027Larrosa J, Schiex T (2004) Solving weighted CSP by maintaining arc consistency. Artif Intell 159:1–26Larrosa J, Meseguer P, Schiex T (1999) Maintaining reversible DAC for Max-CSP. J Artif Intell 107(1):149–163Mackworth A (1977) On reading sketch maps. In: Proceedings of IJCAI’77, pp 598–606Sam J (1995) Constraint consistency techniques for continuous domains. These de doctorat, École polytechnique fédérale de LausanneSchiex T, Fargier H, Verfaillie G (1995) Valued constraint satisfaction problems: hard and easy problems. In: Proceedings of the 14th international joint conference on, artificial intelligence (IJCAI-95), pp 631–637Taillard E (1993) Benchmarks for basic scheduling problems. Eur J Oper Res 64(2):278–285Verfaillie G, Jussien N (2005) Constraint solving in uncertain and dynamic environments: a survey. Constraints 10(3):253–281Wallace R, Freuder E (1998) Stable solutions for dynamic constraint satisfaction problems. In: Proceedings of the 4th international conference on principles and practice of constraint programming (CP-98), pp 447–461Wallace RJ, Grimes D (2010) Problem-structure versus solution-based methods for solving dynamic constraint satisfaction problems. In: Proceedings of the 22nd international conference on tools with artificial intelligence (ICTAI-10), IEEEWalsh T (2002) Stochastic constraint programming. In: Proceedings of the 15th European conference on, artificial intelligence (ECAI-02), pp 111–115William F (2006) Topology and its applications. Wiley, New YorkWiner B (1971) Statistical principles in experimental design, 2nd edn. McGraw-Hill, New YorkYorke-Smith N, Gervet C (2009) Certainty closure: reliable constraint reasoning with incomplete or erroneous data. J ACM Trans Comput Log (TOCL) 10(1):
Gamma-ray flaring activity from the gravitationally lensed blazar PKS 1830-211 observed by Fermi LAT
The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope
routinely detects the highly dust-absorbed, reddened, and MeV-peaked flat
spectrum radio quasar PKS 1830-211 (z=2.507). Its apparent isotropic gamma-ray
luminosity (E>100 MeV) averaged over 3 years of observations and peaking
on 2010 October 14/15 at 2.9 X 10^{50} erg s^{-1}, makes it among the brightest
high-redshift Fermi blazars. No published model with a single lens can account
for all of the observed characteristics of this complex system. Based on radio
observations, one expects time delayed variability to follow about 25 days
after a primary flare, with flux about a factor 1.5 less. Two large gamma-ray
flares of PKS 1830-211 have been detected by the LAT in the considered period
and no substantial evidence for such a delayed activity was found. This allows
us to place a lower limit of about 6 on the gamma rays flux ratio between the
two lensed images. Swift XRT observations from a dedicated Target of
Opportunity program indicate a hard spectrum and with no significant
correlation of X-ray flux with the gamma-ray variability. The spectral energy
distribution can be modeled with inverse Compton scattering of thermal photons
from the dusty torus. The implications of the LAT data in terms of variability,
the lack of evident delayed flare events, and different radio and gamma-ray
flux ratios are discussed. Microlensing effects, absorption, size and location
of the emitting regions, the complex mass distribution of the system, an
energy-dependent inner structure of the source, and flux suppression by the
lens galaxy for one image path may be considered as hypotheses for
understanding our results.Comment: 14 pages, 6 figures, 2 tables. Accepted by the The Astrophysical
Journal. Corresponding authors: S. Ciprini (ASI ASDC & INAF OAR, Rome,
Italy), S. Buson (INAF Padova & Univ. of Padova, Padova, Italy), J. Finke
(NRL, Washington, DC, USA), F. D'Ammando (INAF IRA, Bologna, Italy
Fermi Large Area Telescope Observations of the Cosmic-Ray Induced gamma-ray Emission of the Earth's Atmosphere
We report on measurements of the cosmic-ray induced gamma-ray emission of
Earth's atmosphere by the Large Area Telescope onboard the Fermi Gamma-ray
Space Telescope. The LAT has observed the Earth during its commissioning phase
and with a dedicated Earth-limb following observation in September 2008. These
measurements yielded 6.4 x 10^6 photons with energies >100MeV and ~250hours
total livetime for the highest quality data selection. This allows the study of
the spatial and spectral distributions of these photons with unprecedented
detail. The spectrum of the emission - often referred to as Earth albedo
gamma-ray emission - has a power-law shape up to 500 GeV with spectral index
Gamma = 2.79+-0.06.Comment: Accepted for publication in PR
Mutation update and genotype-phenotype correlations of novel and previously described mutations in TPM2 and TPM3 causing congenital myopathies
Mutations affecting skeletal muscle isoforms of the tropomyosin genes may cause nemaline myopathy, cap myopathy, core-rod myopathy, congenital fiber-type disproportion, distal arthrogryposes, and Escobar syndrome. We correlate the clinical picture of these diseases with novel (19) and previously reported (31) mutations of the TPM2 and TPM3 genes. Included are altogether 93 families: 53 with TPM2 mutations and 40 with TPM3 mutations. Thirty distinct pathogenic variants of TPM2 and 20 of TPM3 have been published or listed in the Leiden Open Variant Database (http://www.dmd.nl/). Most are heterozygous changes associated with autosomal-dominant disease. Patients with TPM2 mutations tended to present with milder symptoms than those with TPM3 mutations, DA being present only in the TPM2 group. Previous studies have shown that five of the mutations in TPM2 and one in TPM3 cause increased Ca2+ sensitivity resulting in a hypercontractile molecular phenotype. Patients with hypercontractile phenotype more often had contractures of the limb joints (18/19) and jaw (6/19) than those with nonhypercontractile ones (2/22 and 1/22), whereas patients with the non-hypercontractile molecular phenotype more often (19/22) had axial contractures than the hypercontractile group (7/19). Our in silico predictions show that most mutations affect tropomyosin–actin association or tropomyosin head-to-tail binding
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