Neural Network based Electron Identification in the ZEUS Calorimeter

We present an electron identification algorithm based on a neural network approach applied to the ZEUS uranium calorimeter. The study is motivated by the need to select deep inelastic, neutral current, electron proton interactions characterized by the presence of a scattered electron in the final state. The performance of the algorithm is compared to an electron identification method based on a classical probabilistic approach. By means of a principle component analysis the improvement in the performance is traced back to the number of variables used in the neural network approach.Comment: 20 pages, latex, 16 figures appended as uuencoded fil

Scarlet & Silver Jubilee

Program listing performers and works performe

Identifying predictors of attitudes towards local onshore wind development with reference to an English case study

The threats posed by climate change are placing governments under increasing pressure to meet electricity demand from low-carbon sources. In many countries, including the UK, legislation is in place to ensure the continued expansion of renewable energy capacity. Onshore wind turbines are expected to play a key role in achieving these aims. However, despite high levels of public support for onshore wind development in principle, specific projects often experience local opposition. Traditionally this difference in general and specific attitudes has been attributed to NIMBYism (not in my back yard), but evidence is increasingly calling this assumption into question. This study used multiple regression analysis to identify what factors might predict attitudes towards mooted wind development in Sheffield, England. We report on the attitudes of two groups; one group (target) living close to four sites earmarked for development and an unaffected comparison group (comparison). We found little evidence of NIMBYism amongst members of the target group; instead, differences between general and specific attitudes appeared attributable to uncertainty regarding the proposals. The results are discussed with respect to literature highlighting the importance of early, continued and responsive community involvement in combating local opposition and facilitating the deployment of onshore wind turbines. (C) 2009 Elsevier Ltd. All rights reserved

Optimisation of Car Park Designs

The problem presented by ARUP to the UK Study Group 2014 was to investigate methods for maximising the number of car parking spaces that can be placed within a car park. This is particularly important for basement car parks in residential apartment blocks or offices where parking spaces command a high value. Currently the job of allocating spaces is done manually and is very time intensive. The Study Group working on this problem split into teams examining different aspects of the car park design process There were three approaches taken. These approaches include a so-called "tile-and-trim" method in which an optimal layout of cars from an `infinite car park' are overlaid onto the actual car park domain; adjustments are then made to accommodate access from one lane to the next. A second approach seeks to develop an algorithm for optimising the road within a car park on the assumption that car parking spaces should fill the space and that any space needs to be adjacent to the network. A third similar approach focused on schemes for assessing the potential capacity of a small selection of specified road networks within the car park to assist the architect in selecting the optimal road network(s). The problem is a variant of the "bin packing" problem, well known in computer science. It is further complicated by the fact that two different classes of item need to be packed (roads and cars), with both local (immediate access to a road) and global (connectivity of the road network) constraints. Bin-packing is known to be NP-hard, and hence the problem at hand has at least this level of computational complexity. None of the approaches produced a complete solution to the problem posed. Indeed, it was quickly determined by the group that this was a very hard problem (a view reinforced by the many different possible approaches considered) requiring far longer than a week to really make significant progress. All approaches rely to differing degrees on optimisation algorithms which are inherently unreliable unless designed specifically for the intended purpose. It is also not clear whether a relatively simple automated computer algorithm will be able to "beat the eye of the architect"; additional sophistication may be required due to subtle constraints. Apart from determining that the problem is hard, positive outcomes have included: Determining that parking perpendicular to the road in long aisles provides the most efficient packing of cars. Provision of code which "tiles and trims" from an infinite car park onto the given car park with interactive feedback on the number of cars in the packing. Provision of code for optimal packing in a parallel-walled car park. Methods for optimising a road within a given domain based on developing cost functions ensuring that cars fill the car park and have access to the road. Provision of code for optimising a single road in a given (square) space. Description of methods for assessing the capacity of a car park for a set of given road network in order to select optimal road networks. Some ideas for developing possible solutions further

Intradermal substance P as a challenge agent in healthy individuals

Pharmacological challenge models are deployed to evaluate drug effects during clinical development. Intradermal injection of Substance P (SP) neuropeptide, a potential challenge agent for investigating local mediators, is associated with wheal and flare response mediated by the MRGPRX2 receptor. Although dose-dependent data on SP effects exist, full characterization and information on potential carryover effect after repeated challenge are lacking. This open-label, two-part, prospective enabling study of SP intradermal challenge in healthy participants aimed to understand and distinguish between wheal and flare responses following various SP doses. Part 1 included one challenge visit to determine optimum SP dose range for evaluation in part 2, which determined variability in 20 participants and used intradermal microdialysis (IDM) for SP-challenged skin sampling. At 5, 15, 50, and 150 pmol doses, respectively, posterior median area under the curve (AUC; AUC0-2h ) was 4090.4, 5881.2, 8846.8, and 9212.8 mm2 /min, for wheal response, and 12020.9, 38154.3, 65470.6, and 67404.4 mm2 /min for flare response (SP-challenge visit 2). When the challenge was repeated ~2 weeks later, no carryover effect was observed. IDM histamine levels were relatively low, resulting in low confidence in the data to define temporal characteristics for histamine release following SP challenge. No safety concerns were identified using SP. Wheal and flare responses following intradermal SP challenge were dose-dependent and different. The results indicate that this challenge model is fit-for-purpose in future first-in-human studies and further assessment of novel drugs targeting dermal inflammatory disease responses, such as chronic spontaneous urticaria, chronic inducible urticaria, and pseudo-allergic reactions.Drug Delivery Technolog

Serum paraoxonase-1 activity is inversely related to free thyroxine in euthyroid subjects:The PREVEND Cohort Study

BACKGROUND: Low-normal thyroid function within the euthyroid range has been suggested to enhance atherosclerosis susceptibility. Paraoxonase-1 (PON-1), may protect against atherosclerotic cardiovascular disease development by attenuating oxidative stress. We evaluated relationships of PON-1 with TSH, free T4 , free T3 , lipids and apolipoprotein (apo)A-I in euthyroid subjects, and assessed whether such relationships are modified in the context of the metabolic syndrome (MetS). MATERIALS AND METHODS: Serum PON-1 activity (arylesterase activity), TSH, free T4 , free T3 , lipids and apoA-I were measured in 2206 euthyroid subjects (aged 28 to75 years; 1138 men (age 49 ± 13 years) and 1068 women (age 46 ± 12 years), recruited from the general population (PREVEND cohort). RESULTS: In age- and sex-adjusted analysis, PON-1 activity (divided into tertiles) was positively related to TSH (β=-0.045, P=0.036) and inversely to free T4 (β=-0.042, P=0.050), but not to free T3 (β=-0.027, P=0.20). PON-1 activity was positively related to total cholesterol, non-HDL cholesterol and triglycerides, as well as to HDL cholesterol and apoA-I (P<0.01 to <0.001). The inverse relationship of PON-1 activity with free T4 remained present after adjustment for lipids and other potential confounders (β=-0.066, P=0.002), but the positive relationship with TSH lost significance (β=0.034, P=0.11). The inverse relationship of PON-1 activity with free T4 was not different in subjects with vs. without MetS (P=0.94), nor modified by the presence of its individual components (P≥0.22 for each). CONCLUSIONS: Serum PON-1 activity is inversely associated with free T4 in euthyroid subjects, suggesting that low-normal thyroid function may affect PON-1 regulation

A high density linkage map of the bovine genome

<p>Abstract</p> <p>Background</p> <p>Recent technological advances have made it possible to efficiently genotype large numbers of single nucleotide polymorphisms (SNPs) in livestock species, allowing the production of high-density linkage maps. Such maps can be used for quality control of other SNPs and for fine mapping of quantitative trait loci (QTL) via linkage disequilibrium (LD).</p> <p>Results</p> <p>A high-density bovine linkage map was constructed using three types of markers. The genotypic information was obtained from 294 microsatellites, three milk protein haplotypes and 6769 SNPs. The map was constructed by combining genetic (linkage) and physical information in an iterative mapping process. Markers were mapped to 3,155 unique positions; the 6,924 autosomal markers were mapped to 3,078 unique positions and the 123 non-pseudoautosomal and 19 pseudoautosomal sex chromosome markers were mapped to 62 and 15 unique positions, respectively. The linkage map had a total length of 3,249 cM. For the autosomes the average genetic distance between adjacent markers was 0.449 cM, the genetic distance between unique map positions was 1.01 cM and the average genetic distance (cM) per Mb was 1.25.</p> <p>Conclusion</p> <p>There is a high concordance between the order of the SNPs in our linkage map and their physical positions on the most recent bovine genome sequence assembly (Btau 4.0). The linkage maps provide support for fine mapping projects and LD studies in bovine populations. Additionally, the linkage map may help to resolve positions of unassigned portions of the bovine genome.</p