3,379 research outputs found
In My Dream Of The U. S. A.
https://digitalcommons.library.umaine.edu/mmb-vp/1845/thumbnail.jp
Suppression of intrinsic neutron background in the Multi-Grid detector
One of the key requirements for neutron scattering instruments is the
Signal-to-Background ratio (SBR). This is as well a design driving requirement
for many instruments at the European Spallation Source (ESS), which aspires to
be the brightest neutron source of the world. The SBR can be effectively
improved with background reduction. The Multi-Grid, a large-area thermal
neutron detector with a solid boron carbide converter, is a novel solution for
chopper spectrometers. This detector will be installed for the three
prospective chopper spectrometers at the ESS. As the Multi-Grid detector is a
large area detector with a complex structure, its intrinsic background and its
suppression via advanced shielding design should be investigated in its
complexity, as it cannot be naively calculated. The intrinsic scattered neutron
background and its effect on the SBR is determined via a detailed Monte Carlo
simulation for the Multi-Grid detector module, designed for the CSPEC
instrument at the ESS. The impact of the detector vessel and the neutron
entrance window on scattering is determined, revealing the importance of an
optimised internal detector shielding. The background-reducing capacity of
common shielding geometries, like side-shielding and end-shielding is
determined by using perfect absorber as shielding material, and common
shielding materials, like BC and Cd are also tested. On the basis of the
comparison of the effectiveness of the different shielding topologies and
materials, recommendations are given for a combined shielding of the Multi-Grid
detector module, optimised for increased SBR.Comment: 26 pages, 18 figures, revise
Scaffold searching: automated identification of similar ring systems for the design of combinatorial libraries
Rigid ring systems can be used to position receptor-binding functional groups in 3D space and they thus play an increasingly important role in the design of combinatorial libraries. This paper discusses the use of shape-similarity methods to identify ring systems that are structurally similar to, and aligned with, a user-defined target ring system. These systems can be used as alternative scaffolds for the construction of a combinatorial library
Study of leakage currents in pCVD diamonds as function of the magnetic field
pCVD diamond sensors are regularly used as beam loss monitors in accelerators
by measuring the ionization of the lost particles. In the past these beam loss
monitors showed sudden increases in the dark leakage current without beam
losses and these erratic leakage currents were found to decrease, if magnetic
fields were present. Here we report on a systematic study of leakage currents
inside a magnetic field. The decrease of erratic currents in a magnetic field
was confirmed. On the contrary, diamonds without erratic currents showed an
increase of the leakage current in a magnetic field perpendicular to the
electric field for fields up to 0.6T, for higher fields it decreases. A
preliminary model is introduced to explain the observations.Comment: 6 pages, 16 figures, poster at Hasselt Diamond Workshop, Mar 2009,
accepted version for publicatio
Exact harmonic coefficients for a magnetic ring head
©1999 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.The magnetic field of a ring head has been analyzed by Westmijze [1953], using a conformal mapping, and by Fan [1961], using Fourier techniques. Here these methods are reexamined and combined to give, for the first time, an explicit analytic expression for the harmonic coefficients in the Fan solution
Charge Transfer Properties Through Graphene Layers in Gas Detectors
Graphene is a single layer of carbon atoms arranged in a honeycomb lattice
with remarkable mechanical, electrical and optical properties. For the first
time graphene layers suspended on copper meshes were installed into a gas
detector equipped with a gaseous electron multiplier. Measurements of low
energy electron and ion transfer through graphene were conducted. In this paper
we describe the sample preparation for suspended graphene layers, the testing
procedures and we discuss the preliminary results followed by a prospect of
further applications.Comment: 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference
with the 21st Symposium on Room-Temperature Semiconductor X-Ray and Gamma-Ray
Detectors, 4 pages, 8 figure
Single exon skipping can address a multi-exon duplication in the dystrophin gene
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease typically caused by protein-truncating mutations that preclude synthesis of a functional dystrophin. Exonic deletions are the most common type of DMD lesion, however, whole exon duplications account for between 10–15% of all reported mutations. Here, we describe in vitro evaluation of antisense oligonucleotide-induced splice switching strategies to re-frame the transcript disrupted by a multi-exon duplication within the DMD gene. Phosphorodiamidate morpholino oligomers and phosphorodiamidate morpholino oligomers coupled to a cell penetrating peptide were evaluated in a Duchenne muscular dystrophy patient cell strain carrying an exon 14–17 duplication. Two strategies were employed; the conventional approach was to remove both copies of exon 17 in addition to exon 18, and the second strategy was to remove only the first copy of exon 17. Both approaches result in a larger than normal but in-frame DMD transcript, but surprisingly, the removal of only the first exon 17 appeared to be more efficient in restoring dystrophin, as determined using western blotting. The emergence of a normal sized DMD mRNA transcript that was not apparent in untreated samples may have arisen from back splicing and could also account for some of the dystrophin protein being produced
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