307 research outputs found
Racial Differences Among LGBT Adults in the US: LGBT Well-Being at the Intersection of Race
This final report in the series, LGBT Well-Being at the Intersection of Race, uses data from the 2012-2017 Gallup Survey and the Generations/Transpop studies to assess whether LGBT people of color (POC) differ from White LGBT people on several areas of health and socioeconomic well-being. We find that more LGBT people of color report economic instability compared to White LGBT people on many indicators. Additionally, disparities for POC LGBT adults persist in the health domain, except for measures of depression where more White LGBT adults report having depression compared with POC LGBT adults. Further, more women of color who identify as LGBT reported living in a low-income household, and experiencing unemployment and food insecurity compared to all other groups. We also found differences in outcomes among LGBT POC on some economic and health indicators. Overall, the series of papers demonstrate that the relationship between race and LGBT status is a complicated one that differs by outcome and racialized group. Regardless of these complexities, the data point to the need for social and policy interventions that address economic and health disparities along racial, gender and LGBT statuses, separately and at their intersection
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Growers say cannabis legalization excludes small growers, supports illicit markets, undermines local economies
H. Bodwitch is Postdoctoral Fellow, Department of Natural Resource Sciences, McGill University, Quebec, Canada; J. Carah is Senior Freshwater Ecologist, The Nature Conservancy, San Francisco; K.M. Daane is UC Cooperative Extension Specialist, Department of Environmental Science, Policy, and Management, UC Berkeley; C. Getz is Associate Cooperative Extension Specialist, Department of Environmental Science, Policy, and Management, UC Berkeley; T.E. Grantham is Assistant Cooperative Extension Specialist and Adjunct Professor, Department of Environmental Science, Policy, and Management, UC Berkeley; G.M. Hickey is Associate Professor, Department of Natural Resource Sciences, McGill University, Quebec, Canada; H. Wilson is Assistant Cooperative Extension Specialist, Department of Entomology, UC Riverside
Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor
Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution
Drug-gene interactions of antihypertensive medications and risk of incident cardiovascular disease: a pharmacogenomics study from the CHARGE consortium
Background
Hypertension is a major risk factor for a spectrum of cardiovascular diseases (CVD), including myocardial infarction, sudden death, and stroke. In the US, over 65 million people have high blood pressure and a large proportion of these individuals are prescribed antihypertensive medications. Although large long-term clinical trials conducted in the last several decades have identified a number of effective antihypertensive treatments that reduce the risk of future clinical complications, responses to therapy and protection from cardiovascular events vary among individuals.
Methods
Using a genome-wide association study among 21,267 participants with pharmaceutically treated hypertension, we explored the hypothesis that genetic variants might influence or modify the effectiveness of common antihypertensive therapies on the risk of major cardiovascular outcomes. The classes of drug treatments included angiotensin-converting enzyme inhibitors, beta-blockers, calcium channel blockers, and diuretics. In the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, each study performed array-based genome-wide genotyping, imputed to HapMap Phase II reference panels, and used additive genetic models in proportional hazards or logistic regression models to evaluate drug-gene interactions for each of four therapeutic drug classes. We used meta-analysis to combine study-specific interaction estimates for approximately 2 million single nucleotide polymorphisms (SNPs) in a discovery analysis among 15,375 European Ancestry participants (3,527 CVD cases) with targeted follow-up in a case-only study of 1,751 European Ancestry GenHAT participants as well as among 4,141 African-Americans (1,267 CVD cases).
Results
Although drug-SNP interactions were biologically plausible, exposures and outcomes were well measured, and power was sufficient to detect modest interactions, we did not identify any statistically significant interactions from the four antihypertensive therapy meta-analyses (Pinteraction > 5.0×10−8). Similarly, findings were null for meta-analyses restricted to 66 SNPs with significant main effects on coronary artery disease or blood pressure from large published genome-wide association studies (Pinteraction ≥ 0.01). Our results suggest that there are no major pharmacogenetic influences of common SNPs on the relationship between blood pressure medications and the risk of incident CVD
Light-cone QCD Sum Rules for the Baryon Electromagnetic Form Factors and its magnetic moment
We present the light-cone QCD sum rules up to twist 6 for the electromagnetic
form factors of the baryon. To estimate the magnetic moment of the
baryon, the magnetic form factor is fitted by the dipole formula. The numerical
value of our estimation is , which is in
accordance with the experimental data and the existing theoretical results. We
find that it is twist 4 but not the leading twist distribution amplitudes that
dominate the results.Comment: 13 page, 7 figures, accepted for publication in Euro. Phys. J.
Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor
Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution
Rapid Downregulation of DAB2 by Toll-Like Receptor Activation Contributes to a Pro-Inflammatory Switch in Activated Dendritic Cells
Dendritic cells (DCs) are pivotal in regulating tolerogenic as well as immunogenic responses against microorganisms by directing both the innate and adaptive immune response. In health, phenotypically different DC subsets found in the gut mucosa are maintained in their tolerogenic state but switch to a pro-inflammatory phenotype during infection or chronic autoinflammatory conditions such as inflammatory bowel disease (IBD). The mechanisms that promote the switch among the mucosal DCs from a tolerogenic to an immunogenic, pro-inflammatory phenotype are incompletely understood. We hypothesized that disabled homolog 2 (DAB2), recently described as a negative regulator of DC immunogenicity during their development, is regulated during intestinal inflammation and modulates mucosal DC function. We show that DAB2 is highly expressed in colonic CD11b+CD103− DCs, a subset known for its capacity to induce inflammatory Th1/Th17 responses in the colon, and is downregulated predominantly in this DC subset during adoptive T cell transfer colitis. Administration of Dab2-deficient DCs (DC2.4Dab2−/− cells) modulated the course of DSS colitis in wild-type mice, enhanced mucosal expression of Tnfa, Il6, and Il17a, and promoted neutrophil recruitment. In bone-marrow derived dendritic cells (BMDC), DAB2 expression correlated with CD11b levels and DAB2 was rapidly and profoundly inhibited by TLR ligands in a TRIF- and MyD88-dependent manner. The negative modulation of DAB2 was biphasic, initiated with a quick drop in DAB2 protein, followed by a sustained reduction in Dab2 mRNA. DAB2 downregulation promoted a more functional and activated DC phenotype, reduced phagocytosis, and increased CD40 expression after TLR activation. Furthermore, Dab2 knockout in DCs inhibited autophagy and promoted apoptotic cell death. Collectively, our results highlight the immunoregulatory role for DAB2 in the intestinal dendritic cells and suggest that DAB2 downregulation after microbial exposure promotes their switch to an inflammatory phenotype
RR-Lyrae-type pulsations from a 0.26-solar-mass star in a binary system
RR Lyrae pulsating stars have been extensively used as tracers of old stellar
populations for the purpose of determining the ages of galaxies, and as tools
to measure distances to nearby galaxies. There was accordingly considerable
interest when the RR Lyr star OGLE-BLG-RRLYR-02792 was found to be a member in
an eclipsing binary system4, as the mass of the pulsator (hitherto constrained
only by models) could be unambiguously determined. Here we report that
RRLYR-02792 has a mass of 0.26 M_sun and therefore cannot be a classical RR
Lyrae star. Through models we find that its properties are best explained by
the evolution of a close binary system that started with 1.4 M_sun and 0.8
M_sun stars orbiting each other with an initial period of 2.9 days. Mass
exchange over 5.4 Gyr produced the observed system, which is now in a very
short-lived phase where the physical properties of the pulsator happen to place
it in the same instability strip of the H-R diagram occupied by RR Lyrae stars.
We estimate that samples of RR Lyr stars may contain a 0.2 percent
contamination with systems similar to this one, implying that distances
measured with RR Lyrae stars should not be significantly affected by these
binary interlopers
The Vehicle, Fall 1987
Table of Contents
Sketches in the SunRodger L. Patiencepage 3
Reflecting PoolRob Montgomerypage 5
Grandpa\u27s Porcelain DollRichard E. Hallpage 6
Tintype 1837Catherine Friemannpage 6
PhotographSteven M. Beamerpage 7
Washerwoman\u27s SongBob Zordanipage 8
Scrambled Eggs for D.O.Lynne A. Rafoolpage 8
my mother would sayMonica Grothpage 9
Retired by His ChildrenDan Von Holtenpage 10
I am the oldestMonica Grothpage 11
Ice on WheatRob Montgomerypage 12
The Nature of the RoseTroy Mayfieldpage 12
Past NebraskaDan Hornbostelpage 13
Five Minute Jamaican VacationChristy Dunphypage 14
PhotographSteven M. Beamerpage 14
The Angry PoemChristy Dunphypage 15
Road UnfamiliarChristy Dunphypage 15
raised voicesMonica Grothpage 16
Old Ladies & MiniskirtsKara Shannonpage 17
FreakspeakBob Zordanipage 18
PortraitDan Von Holtenpage 18
Mobile VacuumKathleen L. Fairfieldpage 19
Rev. Fermus DickSteve Hagemannpage 20
PhotographSteven M. Beamerpage 21
What\u27s the Name of That Flower?Richard Jesse Davispage 22
RequestChristy Dunphypage 23
SketchPaul Seabaughpage 24
ExperiencedMarilyn Wilsonpage 26
Leaving: Two ViewsTina Phillipspage 27
AntaeusDan Von Holtenpage 28
Misogyny at 19J. D. Finfrockpage 29
A Mental CrippleSteve Hagemannpage 32
AssociationsRhonda Ealypage 33
Banana BreadGail Bowerpage 34
Bill and JackBradford B. Autenpage 35
After Image No. 2Rob Montgomerypage 35
VrrooomBeth Goodmanpage 36
Mr. Modern LoverMolly Maddenpage 36
TravelogueRodger L. Patiencepage 37
Down the HighwayJoan Sebastianpage 38
A Retread HeavenRob Montgomerypage 41
StuporDan Von Holtenpage 42
Love Poem After a Seizure in Your BedBob Zordanipage 43
PalsyChristy Dunphypage 44
Interview with Mr. MatthewsBob Zordanipage 45
Chasing Down Hot Air Balloons on a Sunday MorningRob Montgomerypage 48https://thekeep.eiu.edu/vehicle/1049/thumbnail.jp
An Infrared Nebula Associated with Delta Cephei: Evidence of Mass Loss?
We present the discovery of an infrared nebula around the Cepheid prototype
delta Cephei and its hot companion HD 213307. Large scale (~2.1x10^4 AU)
nebulosity is detected at 5.8, 8.0, 24 and 70 um. Surrounding the two stars,
the 5.8 and 8.0 um emission is largely attributable to Polycyclic Aromatic
Hydrocarbon (PAH) emission swept from the ISM by a wind originating from delta
Cephei and/or its companion. Stochastically heated small dust grains are the
most likely source of the 24 and 70 um extended emission. The 70 um emission,
in particular, resembles a bow shock aligned in the direction of the proper
motion of delta Cephei. This discovery supports the hypothesis that delta
Cephei may be currently losing mass, at a rate in the range ~ 5x10^-9 to
6x10^-8 Mo/yr.Comment: Published on The Astrophysical Journa
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