Official Proclamation by Geo. A. Wilson, June 15, 1942

Official Proclamation by Geo. A. Wilson, Governor of the State of Iowa. Officially declares June 21, 1942 to be celebrated in the state as the holiday Father\u27s Day. George A. Wilson served as Governor of Iowa from 1939 to 1943.https://digitalcommons.whitworth.edu/fathers-day-correspondence/1080/thumbnail.jp

A PERFORMANCE EVALUATION OF FIVE SWEETPOTATO SHIPPING CONTAINERS

Using a six x six latin square experimental design, five box types in two different markets were evaluated over a six-week period in 1986 to determine if sweetpotato arrival damage could be reduced through use of alternative shipping containers. Findings indicated that skinning, cut and break damage, and bruising could be reduced through use of either a 40-pound container or the 45-pound MUM box rather than using the current 50-pound box. Economic considerations, receiver preferences, and the actions of shippers resulted in the selection of a 40-pound shipping carton as the new standard for the North Carolina sweetpotato industry.Agribusiness,

A dc model for power switching transistors suitable for computer-aided design and analysis

A model for bipolar junction power switching transistors whose parameters can be readily obtained by the circuit design engineer, and which can be conveniently incorporated into standard computer-based circuit analysis programs is presented. This formulation results from measurements which may be made with standard laboratory equipment. Measurement procedures, as well as a comparison between actual and computed results, are presented

Bulletin No. 211 - Silage Corn Varieties for Utah

Utah is rapidly developing an important dairy industry. In addition to homegrown hay and grain, there must be some form of succulence. Pasturage is the common way of furnishing fresh feed in summer. In certain regions, silage and beet pulp are the winter forms. With a scarcity of beet pulp, silage corn is likely to be an important crop in the Great Salt Lake and Utah Lake Valleys, where corn does well. The data presented in this publication are related to the choice of a corn variety for ensilage

Behavioral Sensitivity of Temporally Modulated Striatal Neurons

Recent investigations into the neural mechanisms that underlie temporal perception have revealed that the striatum is an important contributor to interval timing processes, and electrophysiological recording studies have shown that the firing rates of striatal neurons are modulated by the time in a trial at which an operant response is made. However, it remains unclear whether striatal firing rate modulations are related to the passage of time alone (i.e., whether temporal information is represented in an “abstract” manner independent of other attributes of biological importance), or whether this temporal information is embedded within striatal activity related to co-occurring contextual information, such as motor behaviors. This study evaluated these two hypotheses by recording from striatal neurons while rats performed a temporal production task. Rats were trained to respond at different nosepoke apertures for food reward under two simultaneously active reinforcement schedules: a variable-interval (VI-15 s) schedule and a fixed-interval (FI-15 s) schedule of reinforcement. Responding during a trial occurred in a sequential manner composing three phases; VI responding, FI responding, VI responding. The vast majority of task-sensitive striatal neurons (95%) varied their firing rates associated with equivalent behaviors (e.g., periods in which their snout was held within the nosepoke) across these behavioral phases, and 96% of cells varied their firing rates for the same behavior within a phase, thereby demonstrating their sensitivity to time. However, in a direct test of the abstract timing hypothesis, 91% of temporally modulated “hold” cells were further modulated by the overt motor behaviors associated with transitioning between nosepokes. As such, these data are inconsistent with the striatum representing time in an “abstract’ manner, but support the hypothesis that temporal information is embedded within contextual and motor functions of the striatum

Safety and efficacy of a Labisia pumila var alata water extract on sexual well being and lipid profile of pre- and postmenopausal women: A randomized double-blind pilot study

This randomized double-blind, placebo-controlled study investigated the safety and efficacy of Labisia pumila (LP) water extract on sexual health, lipid profile and inflammatory markers in 36 healthy pre-and post-menopausal North American women. Participants were randomized to either LP (200 mg) or placebo for 12 weeks. The female sexual function index (FSFI) and short form-36 health survey (SF-36) were completed, and lipid profiles, anti-inflammatory markers, urinary antioxidants and safetyparameters were assessed. There were no significant differences in FSFI and SF-36 scores after 12 weeks. Compared to placebo, women on Labisia pumila trended towards a reduction in total cholesterol after 12 weeks (p=0.077). Urinary 8-isoprostane concentrations from baseline to week 12 decreased for both groups, with women on L. pumila demonstrating a greater decrease (Δ= -144.4nmol/L) versus placebo (Δ= -125.9nmol/L). Significant decreases in serum IL-6 from baseline to week 6 were observedin Labisia pumila and placebo (p=0.006 and p=0.012 respectively) but these differences were not sustained through week 12. LP demonstrated a trend towards an improvement in TC, urinary 8-isoprostane and significant within group improvement in IL-6 and IL-1β suggesting a role for LP inimproving inflammation. Future research should focus on older subjects that are sexually dysfunctional.Key words: Labisia pumila, women’s health, randomized double-blind trial, female sexual function index, blood lipid profile, cytokines

Balancing neurotrophin pathway and sortilin function: its role in human disease

Neurotensin receptor-3 or sortilin is a vacuolar protein sorting 10 protein domain (Vps10p) has been firstly discovered in the human brain, it acts as receptor or co-receptor of the cell and traffics different proteins within the cell. Sortilin deregulation contributes to the development of several diseases, including neurological diseases and cancer. On the other hand, neurotrophins which are a family of proteins essential for the nervous system development, function and plasticity. The first discovered member is the nerve growth factor; other members are brain-derived growth factor, neurotrophin-3 and neurotrophin-4. Nerve growth factor and brain-derived growth factor are the common neurotrophins that have a role in cancer. Neurotrophins initiate their signals through interaction with tyrosine receptor kinases TrkA, TrkB, and TrkC; each member has an affinity for a specific receptor to stimulate cell survival, while the interaction with p75NTR initiates cell apoptosis pathway by forming a complex with sortilin and neurotrophin precursors. A number of therapeutic approaches are emerging to target the neurotrophins pathway as well as sortilin

Bulk Viscosity, Decaying Dark Matter, and the Cosmic Acceleration

We discuss a cosmology in which cold dark-matter particles decay into relativistic particles. We argue that such decays could lead naturally to a bulk viscosity in the cosmic fluid. For decay lifetimes comparable to the present hubble age, this bulk viscosity enters the cosmic energy equation as an effective negative pressure. We investigate whether this negative pressure is of sufficient magnitude to account fo the observed cosmic acceleration. We show that a single decaying species in a flat, dark-matter dominated cosmology without a cosmological constant cannot reproduce the observed magnitude-redshift relation from Type Ia supernovae. However, a delayed bulk viscosity, possibly due to a cascade of decaying particles may be able to account for a significant fraction of the apparent cosmic acceleration. Possible candidate nonrelativistic particles for this scenario include sterile neutrinos or gauge-mediated decaying supersymmetric particles.Comment: 7 pages, 4 figure

miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities

MicroRNAs (miRNAs) are a type of non-coding RNA whose dysregulation is frequently associated with the onset and progression of human cancers. miR-142, an ultra-conserved miRNA with both active -3p and -5p mature strands and wide-ranging physiological targets, has been the subject of countless studies over the years. Due to its preferential expression in hematopoietic cells, miR-142 has been found to be associated with numerous types of lymphomas and leukemias. This review elucidates the multifaceted role of miR-142 in human physiology, its influence on hematopoiesis and hematopoietic cells, and its intriguing involvement in exosome-mediated miR-142 transport. Moreover, we offer a comprehensive exploration of the genetic and molecular landscape of the miR-142 genomic locus, highlighting its mutations and dysregulation within hematological malignancies. Finally, we discuss potential avenues for harnessing the therapeutic potential of miR-142 in the context of hematological malignancies

The Genomic and Transcriptomic Landscape of Ultra-Conserved miR-142 in Hematological Malignancies

Department of Translational Molecular Pathology Department of Experimental Therapeutics Department of Translational Molecular Pathology, Department of Experimental Therapeutics, Center for RNA Interference and Non-Coding RNAs, Department of Leukemia, Division of Cancer Medicinehttps://openworks.mdanderson.org/sumexp22/1053/thumbnail.jp