Holocene Event Record of Aysen Fjord (Chilean Patagonia): An Interplay of Volcanic Eruptions and Crustal and Megathrust Earthquakes

In the first months of 2007, the Aysen region in southern Chile was affected by a crustal seismic swarm. Its largest earthquake (M-w 6.2) occurred in April and had its epicenter in Aysen Fjord. Seismic intensities became so high that hundreds of onshore mass movements were triggered, several of which entered into the fjord, resulting in mass transport deposits (MTDs) preserved at the fjord bottom. Here we present a Holocene record of paleo-earthquakes in the previously unstudied Patagonian fjordland based on MTD stratigraphy. High-resolution seismic data retrieved using two different seismic systems (sparker and TOPAS) reveal multiple older MTDs on different stratigraphic levels. Correlation of the seismic stratigraphy with sedimentological data obtained from a long Calypso core (MD07-3117) allows conclusion on the seismic origin of these deposits. Additionally, radiocarbon dating permits constructing an age model, validated by tephrochronology, providing an age for the different MTD levels. We thus present a highly detailed paleoseismological history of the Aysen region, including at least six major Holocene earthquakes, one of which is likely related to a known megathrust earthquake. Other earthquakes are related to activity of the Liquine-Ofqui Fault Zone (LOFZ), forming the main source of seismic hazard in the area. We can infer a general average recurrence time for LOFZ earthquakes of -2,100years in the vicinity of Aysen Fjord with clustered events during the early and late Holocene. Finally, we argue that cascading events (causal link between volcanic and seismic events) may be a frequent phenomenon along the LOFZ

Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis

Rinitis alérgica; Integridad epitelial; Furoato de mometasonaRinitis al·lèrgica; Integritat epitelial; Furoat de mometasonaAllergic rhinitis; Epithelial integrity; Mometasone furoateTight junction defects (TJ) have been associated with a defective epithelial barrier function in allergic rhinitis (AR). Intranasal corticosteroids are potent drugs frequently used to treat AR and are shown to restore epithelial integrity by acting on TJs and by reducing type 2 cytokine production. However, the effect of different classes of intranasal corticosteroids on the epithelial barrier has not been studied. Therefore, we compared the effect of 2 intranasal corticosteroids, ie, fluticasone furoate (FF) and mometasone furoate (MF) on epithelial barrier function. Both FF and MF similarly increased trans-epithelial electrical resistance of primary nasal epithelial cell cultures from AR patients. In a house dust mite-induced allergic asthma mouse model, FF and MF had similar beneficial effects on fluorescein isothiocyanate–dextran 4 kDa mucosal permeability, eosinophilic infiltration and IL-13 levels. Both molecules increased mRNA expression of the TJ proteins occludin and zonula occludens-1, thereby restoring epithelial barrier function. Lastly, we showed that long-term FF treatment also increased expression of occludin in AR patients compared to controls. In conclusion, both FF and MF effectively restore epithelial barrier function by increasing expression of TJ proteins in AR patients.This work was supported by an unrestricted grant from GSK. BS is supported by the Fund for Scientific Research Flanders (FWO), Belgium

Seismo‐turbidites in Aysén Fjord (Southern Chile) reveal a complex pattern of rupture modes along the 1960 megathrust earthquake segment

Grainsize analysis and end‐member modeling of a long sediment core from Aysén Fjord (southern Chile) allows to identify over 25 seismo‐turbidites in the last 9,000 years. Considering the shaking intensities required to trigger these turbidites (V½‐VI½), the majority can be related to megathrust earthquakes. Multiple studies in south‐central Chile have aimed at finding traces of giant, tsunamigenic megathrust earthquakes leading to the current 5,500‐year‐long paleoseismological record of the Valdivia segment. However, none of these cover the southern third of the segment. Aysén Fjord allows to fill this data gap and presents the first, crucial paleoseismic data to demonstrate that the 1960 event was not unique for the Valdivia segment, yielding a recurrence rate of 321 ± 116 years in the last two millennia. Moreover, the oldest identified events in Aysén Fjord date back to 9,000 cal years BP and, thus, also extend the regional paleoseismological record in time. We infer a large temporal variability in rupture modes, with successions of full‐segment ruptures alternating with partial and cascading ruptures. The latter seems to significantly postpone the occurrence of another full rupture when consecutively occurring in different parts of the segment. Additionally, one outstanding period of seismic quiescence ¿during which no megathrust earthquake evidence has been found at any paleoseismic site¿occurred after a full rupture in AD ~745 that presents an unusual uplift/subsidence pattern. Such variability makes it highly speculative to anticipate the rupture mode of the next megathrust earthquake along the Valdivia segment

Late Holocene current patterns in the northern Patagonian fjords recorded by sediment drifts in Aysén Fjord

Present-day circulation patterns in the southeastern Pacific Ocean are driven by the Antarctic Circumpolar Current, directing subantarctic surface water into the Patagonian fjords since at least the early Holocene. In this way, bottom current patterns in the area are regulated by the regional climate, although the complex bathymetry of the fjords has a significant impact as well. To understand the potential interplay of climate, seafloor topography and circulation patterns, we study the sedimentary infill of Aysén Fjord (~45°S) and reveal the first active sediment drifts in the region. These allow constraining the present-day circulation patterns in northern Patagonia and show an incoming (southward) as well as returning (northward) flow direction. While the general sedimentary evolution of the fjord (and thus also the sediment drifts) is climate-driven (i.e., it reflects variability in southern westerly wind strength), the onset of drift formation at ~3.7 ka does not seem to have originated from an abrupt change in regional climate. Instead, we propose that a megathrust earthquake described in paleoseismic records in the area could have resulted in subsidence of one (or more) of the many bathymetric highs in the Patagonian fjords, thus contributing to enhanced spilling of subantarctic water into the fjord. This study underscores the importance of multidisciplinary research to understand past and present bottom current circulation patterns and disentangle different possible feedback mechanisms

Probabilistic evaluation of fault sources based on paleoseismic evidence from mass-transport deposits : the example of Aysen Fjord, Chile

Contemporaneous mass-transport deposits (MTDs) recorded in lake and fjord sediments provide evidence of past seismic shaking. However, because they are usually not connected to a fault rupture, assessment of the earthquake source remains difficult. Based on observed coseismic mass wasting and associated seismic shaking, previous studies assigned minimum intensities required to trigger them. Attempts to infer their earthquake source relied on methods developed to estimate the location and magnitude of historical earthquakes using intensity prediction equations, but considered these thresholds as actual intensities. Here we develop a probabilistic method to infer the most likely earthquake sources from the spatial distribution (or absence) of MTDs. This approach simultaneously allows the triggering intensity to exceed the assumed threshold and takes into account intensity prediction equation uncertainties, two shortcomings of existing methods. Additionally, we consider known active faults rather than a grid of possible epicenters. We apply this method to Aysen Fjord (southern Chile), which is intersected by the Liquine-Ofqui Fault Zone. In 2007, an M-W=6.2 earthquake hit the fjord with intensities of VIII+, causing major landslides entering the fjord. Seismic-reflection profiles show that its sedimentary fill contains nine prehistoric MTD levels. Following a sensitivity analysis, application of the method to the MTD record allows identifying the most likely fault sections and magnitude range for most events, confirming that they are mainly attributed to crustal earthquakes on the Liquine-Ofqui Fault Zone. We conclude that the method has good potential to constrain the size and location of paleoearthquakes for which only shaking evidence is available. Plain Language Summary Strong earthquakes often cause landslides that may be preserved as typical deposits in lakes and fjords. Previous studies have linked the triggering of different types of landslides to minimum shaking intensities and used empirical relations with earthquake magnitude and distance in a simple way to derive the most likely location and magnitude of the earthquake. We developed an alternative method that takes into account the uncertainties in these intensity relations and also the possibility that the actual intensity was higher than the minimum triggering intensity. We extend the method by using information on known active faults in the area, and apply it to a fjord in Chile that is intersected by several faults. An earthquake on one of these faults in 2007 caused various landslides, which are preserved in the fjord's sedimentary record, along with nine older landslide events. In most cases, our method appears to perform better than previous methods to identify the faults that most likely caused the observed landslide pattern. Our results confirm that most landslides are the result of earthquakes on faults in or around the fjord and that only a few could be the result of larger earthquakes on the subduction zone off the coast

Holocene Event Record of Aysén Fjord (Chilean Patagonia): An Interplay of Volcanic Eruptions and Crustal and Megathrust Earthquakes

International audienceIn the first months of 2007, the Aysén region in southern Chile was affected by a crustal seismic swarm. Its largest earthquake (M w 6.2) occurred in April and had its epicenter in Aysén Fjord. Seismic intensities became so high that hundreds of onshore mass movements were triggered, several of which entered into the fjord, resulting in mass transport deposits (MTDs) preserved at the fjord bottom. Here we present a Holocene record of paleo-earthquakes in the previously unstudied Patagonian fjordland based on MTD stratigraphy. High-resolution seismic data retrieved using two different seismic systems (sparker and TOPAS) reveal multiple older MTDs on different stratigraphic levels. Correlation of the seismic stratigraphy with sedimentological data obtained from a long Calypso core (MD07-3117) allows conclusion on the seismic origin of these deposits. Additionally, radiocarbon dating permits constructing an age model, validated by tephrochronology, providing an age for the different MTD levels. We thus present a highly detailed paleoseismological history of the Aysén region, including at least six major Holocene earthquakes, one of which is likely related to a known megathrust earthquake. Other earthquakes are related to activity of the Liquiñe-Ofqui Fault Zone (LOFZ), forming the main source of seismic hazard in the area. We can infer a general average recurrence time for LOFZ earthquakes of~2,100 years in the vicinity of Aysén Fjord with clustered events during the early and late Holocene. Finally, we argue that cascading events (causal link between volcanic and seismic events) may be a frequent phenomenon along the LOFZ

Mometasone furoate and fluticasone furoate are equally effective in restoring nasal epithelial barrier dysfunction in allergic rhinitis

Tight junction defects (TJ) have been associated with a defective epithelial barrier function in allergic rhinitis (AR). Intranasal corticosteroids are potent drugs frequently used to treat AR and are shown to restore epithelial integrity by acting on TJs and by reducing type 2 cytokine production. However, the effect of different classes of intranasal corticosteroids on the epithelial barrier has not been studied. Therefore, we compared the effect of 2 intranasal corticosteroids, ie, fluticasone furoate (FF) and mometasone furoate (MF) on epithelial barrier function. Both FF and MF similarly increased trans-epithelial electrical resistance of primary nasal epithelial cell cultures from AR patients. In a house dust mite-induced allergic asthma mouse model, FF and MF had similar beneficial effects on fluorescein isothiocyanate–dextran 4 kDa mucosal permeability, eosinophilic infiltration and IL-13 levels. Both molecules increased mRNA expression of the TJ proteins occludin and zonula occludens-1, thereby restoring epithelial barrier function. Lastly, we showed that long-term FF treatment also increased expression of occludin in AR patients compared to controls. In conclusion, both FF and MF effectively restore epithelial barrier function by increasing expression of TJ proteins in AR patients