Magnetic shell enhancements during magnetic disturbances

Magnetic shell enhancements during magnetic field disturbances from Langmuir probe observations of electron density on Ariel I satellit

Variability of the Vela Pulsar-wind Nebula Observed with Chandra

The observations of the pulsar-wind nebula (PWN) around the Vela pulsar with the Advanced CCD Imaging Spectrometer aboard the Chandra X-ray Observatory, taken on 2000 April 30 and November 30, reveal its complex morphology reminiscent of that of the Crab PWN. Comparison of the two observations shows changes up to 30% in the surface brightness of the PWN features. Some of the PWN elements show appreciable shifts, up to a few arcseconds (about 10^{16} cm), and/or spectral changes. To elucidate the nature of the observed variations, further monitoring of the Vela PWN is needed.Comment: 7 pages (incl. 3 embedded PS figures), AASTEX, uses emulateapj5.sty. Submitted to ApJ Lett. For a high-resolution color PS image of Figure 3 (6.3 Mby), see http://www.astro.psu.edu/users/divas/velaneb_fig3.p

Modelling cell motility and chemotaxis with evolving surface finite elements

We present a mathematical and a computational framework for the modelling of cell motility. The cell membrane is represented by an evolving surface, with the movement of the cell determined by the interaction of various forces that act normal to the surface. We consider external forces such as those that may arise owing to inhomogeneities in the medium and a pressure that constrains the enclosed volume, as well as internal forces that arise from the reaction of the cells' surface to stretching and bending. We also consider a protrusive force associated with a reaction-diffusion system (RDS) posed on the cell membrane, with cell polarization modelled by this surface RDS. The computational method is based on an evolving surface finite-element method. The general method can account for the large deformations that arise in cell motility and allows the simulation of cell migration in three dimensions. We illustrate applications of the proposed modelling framework and numerical method by reporting on numerical simulations of a model for eukaryotic chemotaxis and a model for the persistent movement of keratocytes in two and three space dimensions. Movies of the simulated cells can be obtained from http://homepages.warwick.ac.uk/maskae/CV_Warwick/Chemotaxis.html

Surfaces immersed in Lie algebras associated with elliptic integrals

The main aim of this paper is to study soliton surfaces immersed in Lie algebras associated with ordinary differential equations (ODE's) for elliptic functions. That is, given a linear spectral problem for such an ODE in matrix Lax representation, we search for the most general solution of the wave function which satisfies the linear spectral problem. These solutions allow for the explicit construction of soliton surfaces by the Fokas-Gel'fand formula for immersion, as formulated in (Grundland and Post 2011) which is based on the formalism of generalized vector fields and their prolongation structures. The problem has been reduced to examining three types of symmetries, namely, a conformal symmetry in the spectral parameter (known as the Sym-Tafel formula), gauge transformations of the wave function and generalized symmetries of the associated integrable ODE. The paper contains a detailed explanation of the immersion theory of surfaces in Lie algebras in connection with ODE's as well as an exposition of the main tools used to study their geometric characteristics. Several examples of the Jacobian and P-Weierstrass elliptic functions are included as illustrations of the theoretical results.Comment: 22 pages, 3 sets of figures. Keywords: Generalized symmetries, integrable models, surfaces immersed in Lie algebra

Smooth Random Surfaces from Tight Immersions?

We investigate actions for dynamically triangulated random surfaces that consist of a gaussian or area term plus the {\it modulus} of the gaussian curvature and compare their behavior with both gaussian plus extrinsic curvature and ``Steiner'' actions.Comment: 7 page

Hamiltonians for curves

We examine the equilibrium conditions of a curve in space when a local energy penalty is associated with its extrinsic geometrical state characterized by its curvature and torsion. To do this we tailor the theory of deformations to the Frenet-Serret frame of the curve. The Euler-Lagrange equations describing equilibrium are obtained; Noether's theorem is exploited to identify the constants of integration of these equations as the Casimirs of the euclidean group in three dimensions. While this system appears not to be integrable in general, it {\it is} in various limits of interest. Let the energy density be given as some function of the curvature and torsion, $f(\kappa,\tau)$. If $f$ is a linear function of either of its arguments but otherwise arbitrary, we claim that the first integral associated with rotational invariance permits the torsion $\tau$ to be expressed as the solution of an algebraic equation in terms of the bending curvature, $\kappa$. The first integral associated with translational invariance can then be cast as a quadrature for $\kappa$ or for $\tau$.Comment: 17 page

Splicing Modulation Results in Aberrant Isoforms and Protein Products of p53 Pathway Genes and the Sensitization of B Cells to Non-Genotoxic MDM2 Inhibition

Several molecular subtypes of cancer are highly dependent on splicing for cell survival. There is a general interest in the therapeutic targeting of splicing by small molecules. E7107, a first-in-class spliceosome inhibitor, showed strong growth inhibitory activities against a large variety of human cancer xenografts. Chronic lymphocytic leukaemia (CLL) is a clinically heterogeneous hematologic malignancy, with approximately 90% of cases being TP53 wild-type at diagnosis. An increasing number of studies are evaluating alternative targeted agents in CLL, including MDM2–p53 binding antagonists. In this study, we report the effect of splicing modulation on key proteins in the p53 signalling pathway, an important cell death pathway in B cells. Splicing modulation by E7107 treatment reduced full-length MDM2 production due to exon skipping, generating a consequent reciprocal p53 increase in TP53WT cells. It was especially noteworthy that a novel p21WAF1 isoform with compromised cyclin-dependent kinase inhibitory activity was produced due to intron retention. E7107 synergized with the MDM2 inhibitor RG7388, via dual MDM2 inhibition; by E7107 at the transcript level and by RG7388 at the protein level, producing greater p53 stabilisation and apoptosis. This study provides evidence for a synergistic MDM2 and spliceosome inhibitor combination as a novel approach to treat CLL and potentially other haematological malignancies

Conformally invariant bending energy for hypersurfaces

The most general conformally invariant bending energy of a closed four-dimensional surface, polynomial in the extrinsic curvature and its derivatives, is constructed. This invariance manifests itself as a set of constraints on the corresponding stress tensor. If the topology is fixed, there are three independent polynomial invariants: two of these are the straighforward quartic analogues of the quadratic Willmore energy for a two-dimensional surface; one is intrinsic (the Weyl invariant), the other extrinsic; the third invariant involves a sum of a quadratic in gradients of the extrinsic curvature -- which is not itself invariant -- and a quartic in the curvature. The four-dimensional energy quadratic in extrinsic curvature plays a central role in this construction.Comment: 16 page

Periodic Variability During the X-ray Decline of 4U 1636-53

We report the onset of a large amplitude, statistically significant periodicity (~46 d) in the RXTE/ASM data of the prototype X-ray burster 4U 1636-53, the X-ray flux of which has been gradually declining over the last four years. This behaviour is remarkably similar to that observed in the neutron star LMXB KS 1731-260, which is a long-term transient. We also report on an INTEGRAL/IBIS observation of 4U 1636-53 during its decline phase, and find that the hard X-ray flux (20-100 keV) indicates an apparent anti-correlation with soft X-rays (2-12 keV). We argue that 4U 1636-53 is transiting from activity to quiescence, as occurred in KS 1731-260. We also suggest that the variability during the X-ray decline is the result of an accretion rate variability related to the X-ray irradiation of the disc.Comment: 6 pages. Accepted by MNRA

Shape selection in non-Euclidean plates

We investigate isometric immersions of disks with constant negative curvature into $\mathbb{R}^3$, and the minimizers for the bending energy, i.e. the $L^2$ norm of the principal curvatures over the class of $W^{2,2}$ isometric immersions. We show the existence of smooth immersions of arbitrarily large geodesic balls in $\mathbb{H}^2$ into $\mathbb{R}^3$. In elucidating the connection between these immersions and the non-existence/singularity results of Hilbert and Amsler, we obtain a lower bound for the $L^\infty$ norm of the principal curvatures for such smooth isometric immersions. We also construct piecewise smooth isometric immersions that have a periodic profile, are globally $W^{2,2}$, and have a lower bending energy than their smooth counterparts. The number of periods in these configurations is set by the condition that the principal curvatures of the surface remain finite and grows approximately exponentially with the radius of the disc. We discuss the implications of our results on recent experiments on the mechanics of non-Euclidean plates