The effects of bilingualism on speakers who stutter during late childhood

Objectives: To examine stuttering by children speaking an alternative language exclusively (LE) or with English (BIL) and to study onset of stuttering, school performance and recovery rate relative to monolingual speakers who stutter (MONO). Design: Clinical referral sample with supplementary data obtained from speech recordings and interviews. Setting: South-East England, 1999–2007. Participants: Children aged 8–12 plus who stuttered (monolingual and bilingual) and fluent bilingual controls (FB). Main outcome measures: Participants’ stuttering history, SATS scores, measures of recovery or persistence of stuttering. Results: 69 (21.8%) of 317 children were bilingual. Of 38 children who used a language other than English at home, 36 (94.7%) stuttered in both languages. Fewer LE (15/38, 39.5%) than BIL (23/38, 60.5%) children stuttered at first referral to clinic, but more children in the fluent control sample were LE (28/38, 73.7%) than BIL (10/38, 26.3%). The association between stuttering and bilingual group (LE/BIL) was significant by x2 test; BIL speakers have more chance of stuttering than LE speakers. Age at stuttering onset and male/female ratio for LE, BIL and MONO speakers were similar (4 years 9 months, 4 years 10 months and 4 years 3 months, and 4.1:1, 4.75:1 and 4.43:1, respectively). Educational achievement was not affected by bilingualism relative to the MONO and FB groups. The recovery rate for the LE and MONO controls together (55%) was significantly higher by x2 test than for the BIL group (25%). Conclusions: BIL children had an increased risk of stuttering and a lower chance of recovery from stuttering than LE and MONO speakers

Continuous phase amplification with a Sagnac interferometer

We describe a weak value inspired phase amplification technique in a Sagnac interferometer. We monitor the relative phase between two paths of a slightly misaligned interferometer by measuring the average position of a split-Gaussian mode in the dark port. Although we monitor only the dark port, we show that the signal varies linearly with phase and that we can obtain similar sensitivity to balanced homodyne detection. We derive the source of the amplification both with classical wave optics and as an inverse weak value.Comment: 5 pages, 4 figures, previously submitted for publicatio

Challenges in the development of the orbiter radiator system

Major technical challenges which were met in the design and development of the Space Shuttle Orbiter Radiator System are discussed. This system rejects up to 30 kW of waste heat from eight individual radiators having a combined surface area of 175 sq m. The radiators, which are deployable, are mounted on the inside of the payload bay doors for protection from aerodynamic heating during ascent and re-entry. While in orbit the payload bay doors are opened to expose the radiators for operation. An R21 coolant loop accumulates waste heat from various components in the Orbiter and delivers the heat to the radiators for rejection to space. Specific challenges included high acoustically induced loads during lift-off, severe radiating area constraints, demanding heat load control requirements, and long life goals. Details of major design and analysis efforts are discussed. The success of the developed hardware in satisfying mission objectives showed how well the design challenge was met

The relationship of body weight to response to endocrine therapy, steroid hormone receptors and survival of patients with advanced cancer of the breast.

High body weight is associated with increased production of oestrogens which may influence the clinical behaviour of breast cancer. We have examined the influence of body weight on the response to endocrine therapy, steroid hormone receptor content and survival in 227 women who either presented with or developed advanced cancer of the breast. One hundred and thirty-three (59%) patients presented with operable disease and 94 (41%) with locally advanced tumours. Two hundred (88%) were treated by tamoxifen and 27 (12%) by ovarian ablation. High body weight was correlated with advanced tumour stage (P = 0.002) and progesterone receptor (PR) positivity (P = 0.01), but not with the presence of oestrogen receptor (ER P = 0.21). The association between high body weight and PR positivity was particularly noticeable among ER positive tumours. There was no significant relationship between the nature of the response to therapy and weight (P = 0.57). There was no significant difference in survival from the start of endocrine therapy (P = 0.95), nor the time to progression of disease (P = 0.29) between patients above and below the median weight of 64 kg. Among the patients with operable disease, there was no difference in overall survival (P = 0.42), relapse free survival (P = 0.69), and survival from the start of endocrine therapy (P = 0.85) according to body weight

X-Shooting EF Eridani: further evidence for a massive white dwarf and a sub-stellar secondary

High resolution spectral observations of the polar EF Eridani obtained in a low state with X-Shooter revealed narrow emission lines from the irradiated secondary. The lines were most prominent in the near-IR Ca2-triplet, the more intensive Halpha line had additional emission likely originating from an accretion stream. The lines with a radial velocity amplitude, K2' = 385 +- 4 kmps, serve as tracer of the otherwise unseen companion. The mass function implies a massive white dwarf with Mwd > 0.65 Msun at 3sigma confidence, and a short distance to the binary, d ~ 111 pc (<145pc at 3sigma confidence). The spectral energy distribution from the UV to the IR together with the high mass ratio gives further strong evidence of EF Eri being a post period-minimum object with M2 < 0.06 MsunComment: Astron, Astrophys., in pres

Herpesvirus pan encodes a functional homologue of BHRF1, the Epstein-Barr virus v-Bcl-2

BACKGROUND: Epstein-Barr virus (EBV) latently infects about 90% of the human population and is associated with benign and malignant diseases of lymphoid and epithelial origin. BHRF1, an early lytic cycle antigen, is an apoptosis suppressing member of the Bcl-2 family. In vitro studies imply that BHRF1 is dispensable for both virus replication and transformation. However, the fact that BHRF1 is highly conserved not only in all EBV isolates studied to date but also in the analogous viruses Herpesvirus papio and Herpesvirus pan that infect baboons and chimpanzees respectively, suggests BHRF1 may play an important role in vivo. RESULTS: Herpesvirus papio BHRF1 has been shown to function in an analogous manner to EBV BHRF1 in response to DNA damaging agents in human keratinocytes. In this study we show that the heterologous expression of the previously uncharacterised Herpesvirus pan BHRF1 in the human Burkitt's lymphoma cell line Ramos-BL provides similar anti-apoptotic functions to that of EBV BHRF1 in response to apoptosis triggered by serum withdrawal, etoposide treatment and ultraviolet (UV) radiation. We also map the amino acid changes onto the recently solved structure of the EBV BHRF1 and reveal that these changes are unlikely to alter the 3D structure of the protein. CONCLUSIONS: These findings show that the functional conservation of BHRF1 extends to a lymphoid background, suggesting that the primate virus proteins interact with cellular proteins that are themselves highly conserved across the higher primates. Further weight is added to this suggestion when we show that the difference in amino acid sequences map to regions on the 3D structure of EBV BHRF1 that are unlikely to change the conformation of the protein

Time-resolved, multi-color photometry and spectroscopy of Virgo 4 (OU Vir): a high orbital inclination, short orbital period dwarf nova

We present multi-color photometry and time resolved spectroscopy of OU Vir. The analysis of the quiescent light curve shows that OU Vir is characterized by i) strong cycle-to-cycle brightness variations, and ii) hot spot modulated light curve with grazing eclipse of the impact region. Colors are derived both in- and out- of eclipse. The time-resolved spectroscopy allows us to produce the radial velocity curve from the H$\alpha$ accretion disk emission line which possibly reveals only weak evidence for hot spot line emission. The hot spot is believed to be a turbulent optically thick region, producing mostly continuum emission.Comment: 8 pages (including figures), 7 figures. To Be published in A&

Margery Kempe and Perfectionism

Late fourteenth, early fifteenth-century mystic Margery Kempe (1373 ca. 1439) was an extraordinary lay Christian who sought spiritual perfection-sand did so outside the confines of traditional religious orders. However, understanding Kempe\u27s quest is, as evidenced by scholars having classified her as everything from a hysteric, anorexic, heretic, or self-centered egocentric to a revered saint. Kempe\u27s life cannot be exclusively categorized into anyone of these classifications. Instead, she was on a general quest to understand the suffering of Christ. Her life pursuits may well be illustrated by using the broader psychoanalytical term spiritual perfection. This thesis examines the effects of this behavior on her

A Binary Orbit for the Massive, Evolved Star HDE 326823, a WR+O System Progenitor

The hot star HDE 326823 is a candidate transition-phase object that is evolving into a nitrogen-enriched Wolf-Rayet star. It is also a known low-amplitude, photometric variable with a 6.123 d period. We present new, high and moderate resolution spectroscopy of HDE 326823, and we show that the absorption lines show coherent Doppler shifts with this period while the emission lines display little or no velocity variation. We interpret the absorption line shifts as the orbital motion of the apparently brighter star in a close, interacting binary. We argue that this star is losing mass to a mass gainer star hidden in a thick accretion torus and to a circumbinary disk that is the source of the emission lines. HDE 326823 probably belongs to a class of objects that produce short-period WR+O binaries.Comment: 32 pages, 10 figures, accepted to the Astronomical Journa