System for and method of freezing biological tissue

Biological tissue is frozen while a polyethylene bag placed in abutting relationship against opposed walls of a pair of heaters. The bag and tissue are cooled with refrigerating gas at a time programmed rate at least equal to the maximum cooling rate needed at any time during the freezing process. The temperature of the bag, and hence of the tissue, is compared with a time programmed desired value for the tissue temperature to derive an error indication. The heater is activated in response to the error indication so that the temperature of the tissue follows the desired value for the time programmed tissue temperature. The tissue is heated to compensate for excessive cooling of the tissue as a result of the cooling by the refrigerating gas. In response to the error signal, the heater is deactivated while the latent heat of fusion is being removed from the tissue while the tissue is changing phase from liquid to solid

Electron temperature in electrically isolated Si double quantum dots

Charge-based quantum computation can be attained through reliable control of single electrons in lead-less quantum systems. Single-charge transitions in electrically-isolated double quantum dots (DQD) realised in phosphorus-doped silicon can be detected via capacitively coupled single-electron tunnelling devices. By means of time-resolved measurements of the detector's conductance, we investigate the dots' occupancy statistics in temperature. We observe a significant reduction of the effective electron temperature in the DQD as compared to the temperature in the detector's leads. This sets promises to make isolated DQDs suitable platforms for long-coherence quantum computation.Comment: 4 pages, 3 figure

Design of a blood-freezing system for leukemia research

Leukemia research involves the use of cryogenic freezing and storage equipment. In a program being carried out at the National Cancer Institute (NCI), bone marrow (white blood cells) was frozen using a standard cryogenic biological freezer. With this system, it is difficult to maintain the desired rate of freezing and repeatability from sample to sample. A freezing system was developed that satisfies the requirements for a repeatable, constant freezing rate. The system was delivered to NIC and is now operational. This report describes the design of the major subsystems, the analyses, the operating procedure, and final system test results

Ion Exchange-Precipitation for Nutrient Recovery from Dilute Wastewater

Regulated phosphorus (P) and nitrogen (N) discharges and the cost of fertilizer provide economic drivers for nutrient removal and recovery from wastewater. This study used ion exchange (IX) in dilute (domestic) wastewater to concentrate nutrients with subsequent recovery by struvite precipitation. This is the first tertiary wastewater treatment study directly comparing P removal using a range of Fe, Cu, and Al-based media followed by clinoptilolite IX columns for N removal and precipitation using the combined regenerants. Phosphate removal prior to breakthrough was 0.5–2.0 g P Lmedia−1, providing effluent concentrations −1 PO4-P and −1 NH4-N for ≥80 bed volumes. Dow-FeCu resin provided effective P removal, efficient neutral pH regeneration and 560 mg P L−1 in the regeneration eluate (≥100× concentration factor). Exchange capacity of clinoptilolite in column mode was 3.9–6.1 g N Lmedia−1 prior to breakthrough. Precipitation using the combined cation and anion regenerants resulted in a maximum of 74% P removal using Dow-FeCu. Precipitates contained impurities, including Al3+, Ca2+, and Fe. Overall, the IX-precipitation recovery process removed ≥98% P and 95% N and precipitates contained 13% P and 1.6% N. This sequential process can satisfy increasingly stringent wastewater standards and offers an effective alternative to traditional treatment technologies that simply remove nutrients. Approximately 84% of total P and 97% of total Kjeldahl N entering a treatment plant can be captured (accounting for primary clarifier removal), whereas most existing technologies target side streams that typically contain only 20–30% of influent P and 15–20% of influent N

Charge Detection in Phosphorus-doped Silicon Double Quantum Dots

We report charge detection in degenerately phosphorus-doped silicon double quantum dots (DQD) electrically connected to an electron reservoir. The sensing device is a single electron transistor (SET) patterned in close proximity to the DQD. Measurements performed at 4.2K show step-like behaviour and shifts of the Coulomb Blockade oscillations in the detector's current as the reservoir's potential is swept. By means of a classical capacitance model, we demonstrate that the observed features can be used to detect single-electron tunnelling from, to and within the DQD, as well as to reveal the DQD charge occupancy.Comment: 4 pages, 3 figure

Chemical reaction of atomic oxygen with evaporated films of copper, part 4

Evaporated copper films were exposed to an atomic oxygen flux of 1.4 x 10(exp 17) atoms/sq cm per sec at temperatures in the range 285 to 375 F (140 to 191 C) for time intervals between 2 and 50 minutes. Rutherford backscattering spectroscopy (RBS) was used to determine the thickness of the oxide layers formed and the ratio of the number of copper to oxygen atoms in the layers. Oxide film thicknesses ranged from 50 to 3000 A (0.005 to 0.3 microns, or equivalently, 5 x 10(exp -9) to 3 x 10(exp -7); it was determined that the primary oxide phase was Cu2O. The growth law was found to be parabolic (L(t) varies as t(exp 1/2)), in which the oxide thickness L(t) increases as the square root of the exposure time t. The analysis of the data is consistent with either of the two parabolic growth laws. (The thin-film parabolic growth law is based on the assumption that the process is diffusion controlled, with the space charge within the growing oxide layer being negligible. The thick-film parabolic growth law is also based on a diffusion controlled process, but space-charge neutrality prevails locally within very thick oxides.) In the absence of a voltage measurement across the growing oxide, a distinction between the two mechanisms cannot be made, nor can growth by the diffusion of neutral atomic oxygen be entirely ruled out. The activation energy for the reaction is on the order of 1.1 eV (1.76 x 10(exp -19) joule, or equivalently, 25.3 kcal/mole)

Neutrino Electromagnetic Form Factor and Oscillation Effects on Neutrino Interaction With Dense Matter

The mean free path of neutrino - free electron gas interaction has been calculated by taking into account the neutrino electromagnetic form factors and the possibility of neutrino oscillation. It is shown that the form factor effect becomes significant for a neutrino magnetic moment \mu_\nu > 10^{-10} mu_B and for a neutrino radius R > 10^{-6} MeV^{-1}. The mean free path is found to be sensitive to the nu_e-nu_mu and nu_e-nu_e^R transition probabilities.Comment: 4 pages, 3 eps figures, accepted for publication in Phys. Rev.

Neutron Fraction and Neutrino Mean Free Path Predictions in Relativistic Mean Field Models

The equation of state (EOS) of dense matter and neutrino mean free path (NMFP) in a neutron star have been studied by using relativistic mean field models motivated by effective field theory (ERMF). It is found that the models predict too large proton fractions, although one of the models (G2) predicts an acceptable EOS. This is caused by the isovector terms. Except G2, the other two models predict anomalous NMFP. In order to minimize the anomaly, besides an acceptable EOS, a large M* is favorable. A model with large M* retains the regularity in the NMFP even for a small neutron fraction.Comment: 4 pages, 5 figures, accepted for publication in Phys. Rev.

The control of nonlinear stochastic control systems under discounted performance criteria

Control algorithm for optimization of nonlinear stochastic processes with discounted performance criteri