Acridine-decorated cyclometallated gold(III) complexes: synthesis and anti-tumour investigations

(C^N) and (C^N^C) cyclometalated Au(III) represent a highly promising class of potential anticancer agents. We report here the synthesis of seven new cyclometalated Au(III) complexes with five of them bearing an acridine moiety attached via (N^O) or (N^N) chelates, acyclic amino carbenes (AAC) and N-heterocyclic carbenes (NHC). The antiproliferative properties of the different complexes were evaluated in vitro on a panel of cancer cells including leukaemia, lung and breast cancer cells. We observed a trend between the cytotoxicity and the intracellular gold uptake of some representative compounds of the series. Some of the acridine-decorated complexes were demonstrated to interact with ds-DNA using FRET-melting techniques

Central Retinal Artery Occlusion With Subsequent Central Retinal Vein Occlusion in Biopsy-Proven Giant Cell Arteritis

We performed bilateral optic nerve sheath fenestrations on a patient with the syndrome of acquired hyperopia and choroidal folds. We are unaware of previous reports of this procedure being performed in this clinical setting. Despite the incomplete resolution of his posterior segment findings postoperatively, the results of the procedure, along with an understanding of the relevant anatomy, may help to shed light on the pathogenesis of this rare entity

Central Retinal Artery Occlusion With Subsequent Central Retinal Vein Occlusion in Biopsy-Proven Giant Cell Arteritis

Central retinal artery occlusion with subsequent central retinal vein occlusion in the same eye is a rare entity. We present a 72-year-old man with biopsy-proven giant cell arteritis who developed bilateral arteritic anterior ischemic optic neuropathy and a left central retinal artery occlusion. Subsequently, he developed a left central retinal vein occlusion within 2 weeks of his initial vision loss. His vision did not improve with corticosteroids

Adaptive Optics Imaging With Histopathologic Correlation in Cancer-Associated Retinopathy

We describe the first report of in vivo adaptive optics imaging in cancer-associated retinopathy as correlated with histopathology

Survival of retinal ganglion cells after damage to the occipital lobe in humans is activity dependent

Damage to the optic radiations or primary visual cortex leads to blindness in all or part of the contralesional visual field. Such damage disconnects the retina from its downstream targets and, over time, leads to trans-synaptic retrograde degeneration of retinal ganglion cells. To date, visual ability is the only predictor of retinal ganglion cell degeneration that has been investigated after geniculostriate damage. Given prior findings that some patients have preserved visual cortex activity for stimuli presented in their blind field, we tested whether that activity explains variability in retinal ganglion cell degeneration over and above visual ability. We prospectively studied 15 patients (four females, mean age = 63.7 years) with homonymous visual field defects secondary to stroke, 10 of whom were tested within the first two months after stroke. Each patient completed automated Humphrey visual field testing, retinotopic mapping with functional magnetic resonance imaging, and spectral-domain optical coherence tomography of the macula. There was a positive relation between ganglion cell complex (GCC) thickness in the blind field and early visual cortex activity for stimuli presented in the blind field. Furthermore, residual visual cortex activity for stimuli presented in the blind field soon after the stroke predicted the degree of retinal GCC thinning six months later. These findings indicate that retinal ganglion cell survival after ischaemic damage to the geniculostriate pathway is activity dependent

Distal ash fall from the mid-Holocene eruption of Mount Hudson (H2) discovered in the Falkland Islands: New possibilities for Southern Hemisphere archive synchronisation

Cryptotephra deposits (microscopic volcanic ash) are important geochronological tools that can be used to synchronize records of past environmental change. Here we report a distal cryptotephra from a Holocene peat sequence (Canopus Hill) in the Falkland Islands, in the South Atlantic. Using geochemical analysis (major- and trace-element) of individual volcanic glass shards, we provide a robust correlation between this cryptotephra and the large mid-Holocene explosive eruption of Mt. Hudson in Patagonia, Chile (H2; ∼3.9 ka cal BP). The occurrence of H2 as a cryptotephra in the Falkland Islands significantly increases the known distribution of this marker horizon to more than 1200 km from the volcano, a threefold increase of its previous known extent. A high-resolution radiocarbon chronology, based on terrestrial plant macrofossils, dates the H2 tephra to 4265 ± 65 cal yr BP, suggesting that the eruption may have occurred slightly earlier than previously reported. The refined age and new geochemical reference dataset will facilitate the identification of the H2 tephra in other distal locations. The high concentration of glass shards in our peat sequence indicates that the H2 tephra may extend well beyond the Falkland Islands and we recommend future studies search for its presence across the sub-Antarctic islands and Antarctic Peninsula as a potentially useful chronological marker