61,532 research outputs found
An investigation of the grindability of two torrefied energy crops
The process of torrefaction alters the physical properties of biomass, reducing its fibrous tenacious nature. This could allow increased rates of co-milling and therefore co-firing in coal fired power stations, which in turn would enable a reduction in the amount of coal used and an increase in the use of sustainable fuels, without the need for additional plant. This paper presents an experimental investigation of the pulverisation behaviour of two torrefied energy crops, namely: willow and Miscanthus. A multifactorial method approach was adopted to investigate the three process parameters of temperature, residence time and particle size, producing fuels treated using four different torrefaction conditions. The untreated and torrefied fuels were subjected to standard fuel analysis techniques including ultimate analysis, proximate analysis and calorific value determination. The grindability of these fuels was then determined using a laboratory ball mill and by adapting the Hardgrove Grindability Index (HGI) test for hard coals. After grinding, two sets of results were obtained. Firstly a determination similar to the HGI test was made, measuring the proportion of sample passing through a 75 mu m sieve and plotting this on a calibrated HGI chart determined using four standard reference coals of known HGI values. Secondly the particle size distributions of the entire ground sample were measured and compared with the four standard reference coals. The standard fuel tests revealed that temperature was the most significant parameter in terms of mass loss, changes in elemental composition and energy content increase. The first grindability test results found that the untreated fuels and fuels treated at low temperatures showed very poor grindability behaviour. However, more severe torrefaction conditions caused the fuels to exhibit similar pulverisation properties as coals with low HGI values. Miscanthus was found to have a higher HGI value than willow. On examining the particle size distributions it was found that the particle size distributions of torrefied Miscanthus differed significantly from the untreated biomass and had comparable profiles to those of the standard reference coals with which they had similar HGI values. However, only the torrefied willow produced at the most severe conditions investigated exhibited this behaviour, and the HGI of torrefied willow was not generally a reliable indicator of grindability performance for this energy crop. Overall it was concluded that torrefied biomass can be successfully pulverised and that torrefied Miscanthus was easier to grind than torrefied willow
Study of foldable elastic tubes for large space structure applications
Various modifications were made to the tube design. The tubes were retested and analyzed, and the results are presented. One type of modified tube, the slotted tube, deployed successfully and reliably, and became the focus of detailed tests. Optimal design criteria, taking into consideration deployment as well as strength and buckling behavior were established
Comparison of Compression Schemes for CLARA
CLARA (Compact Linear Advanced Research Accelerator)at Daresbury Laboratory
is proposed to be the UK's national FEL test facility. The accelerator will be
a ~250 MeV electron linac capable of producing short, high brightness electron
bunches. The machine comprises a 2.5cell RF photocathode gun, one 2 m and three
5 m normal conducting S-band (2998MHz) accelerating structures and a variable
magnetic compression chicane. CLARA will be used as a test bed for novel FEL
configurations. We present a comparison of acceleration and compression schemes
for the candidate machine layout.Comment: 3 pages, 5 figures, IPAC 201
Do adverts increase the probability of finding online cognitive behavioural therapy for depression? Cross-sectional study
Objective To estimate the effect of online adverts on the probability of finding online cognitive behavioural therapy (CBT) for depression.
Design Exploratory online cross-sectional study of search experience of people in the UK with depression in 2011. (1) The authors identified the search terms over 6 months entered by users who subsequently clicked on the advert for online help for depression. (2) A panel of volunteers across the UK recorded websites presented by normal Google search for the term ‘depression’. (iii) The authors examined these websites to estimate probabilities of knowledgeable and naive internet users finding online CBT and the improved probability by addition of a Google advert.
Participants (1) 3868 internet users entering search terms related to depression into Google. (2) Panel, recruited online, of 12 UK participants with an interest in depression.
Main outcome measures Probability of finding online CBT for depression with/without an advert.
Results The 3868 users entered 1748 different search terms but the single keyword ‘depression’ resulted in two-thirds of the presentations of, and over half the ‘clicks’ on, the advert. In total, 14 different websites were presented to our panel in the first page of Google results for ‘depression’. Four of the 14 websites had links enabling access to online CBT in three clicks for knowledgeable users. Extending this approach to the 10 most frequent search terms, the authors estimated probabilities of finding online CBT as 0.29 for knowledgeable users and 0.006 for naive users, making it unlikely CBT would be found. Adding adverts that linked directly to online CBT increased the probabilities to 0.31 (knowledgeable) and 0.02 (naive).
Conclusions In this case, online CBT was not easy to find and online adverts substantially increased the chance for naive users. Others could use this approach to explore additional impact before committing to long-term Google AdWords advertising budgets
Prior in vitro exposure to voriconazole confers resistance to amphotericin B in aspergillus fumigatus biofilms
Triazoles are the mainstay of treatment for aspergillosis, although resistance to these antifungal agents may be associated with treatment failure. Refractory infections often necessitate a switch to other antifungal agents, including amphotericin B (AmB), although these infections may not resolve. The aim of this study was to investigate the effect of prior azole exposure on AmB sensitivity in Aspergillus fumigatus biofilms. It was hypothesised that sequential antifungal therapy has the potential to impact adaptive resistance mechanisms. Antifungal sensitivity was determined for each isolate against AmB ± voriconazole (VRZ) exposure by a broth microdilution method and an XTT metabolic assay. To analyse the role of extracellular DNA (eDNA) and Hsp90 activation, sensitivity to AmB ± DNA-digesting enzyme (DNase) or Hsp90 inhibitor [geldanamycin (GDA)] was also tested. Finally, scanning electron microscopy was performed to assess phenotypic changes. The in vitro data revealed that A. fumigatus sensitivity to AmB was decreased when it was tested in combination with VRZ. In addition, a two- to four-fold decreased sensitivity to AmB was recorded against VRZ-exposed germlings compared with controls. It was also shown that depletion of eDNA by DNase treatment enhanced AmB activity against VRZ-exposed cells by eight-fold, which visually could be explained by destabilisation of the biofilm when examined microscopically. Pharmacological inhibition of Hsp90 by GDA significantly improved biofilm susceptibility to AmB by four- to eight-fold. In conclusion, A. fumigatus pre-exposure to VRZ concomitantly induces eDNA release and activates the stress response, which collectively confers AmB resistance in vitro
Study of foldable elastic tubes for large space structure applications, phase 1
Structural members that might be suitable for strain energy deployable structures, are discussed with emphasis on a thin-walled cylindrical tube with a cross-section that is called 'bi-convex'. The design of bi-convex tube test specimens and their fabrication are described as well as the design and construction of a special purpose testing machine to determine the deployment characteristics. The results of the first series of tests were quite mixed, but clearly revealed that since most of the specimens failed to deploy completely, due to a buckling problem, this type of tube requires some modification in order to be viable
Arithmeticity of Orbifold Generalised Triangle Groups
Maclachlan and Martin have proved that only finitely many arithmetic Kleinian groups can be generated by 2 elliptic elements, and have classified these groups in the non-cocompact case. Here, we investigate the cocompact case, restricting to a class of generalisedtrianglegroups considered by Jones and Reid which arise as the fundamental groups of hyperbolic 3-dimensional orbifolds. We obtain 21 arithmetic groups and provide a description of the corresponding orbifolds
Choosing Thesis Juries: The Costs of Taking a Strict Line on Conflicts of Interest
Étude de cas / Case studyCette étude de cas examine les conflits d'intérêts (CI) qui peuvent survenir lors de la sélection des membres du jury pour évaluer une thèse de doctorat et les coûts (temps, personnel, expertise) associés aux tentatives d'éviter les CI.This case study examines the conflicts of interest (COI) that can arise in the selection of jury members to evaluate a PhD thesis, and the costs (time, personnel, expertise) associated with trying to avoid COI
Canadian Bioethics Research and Scholarship: A Need for Explicit Leadership and Support by Research Funders
La tribune de l'éditeur / Editor's Soapbo
BioéthiqueOnline: Towards a Bilingual (English-French) Bioethics Community / Vers une communauté bilingue (anglais-français) en bioéthique
Éditorial / Editoria
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