“Tata, što si Ti radio u Velikom ratu” - Izravno učešće u neprijateljstvima i moguće rješenje za složenu pravnu poziciju

The issue of whether or not a civilian is culpable for having directly participated in hostilities, as per Article 51(3) of the First Additional Protocol to the Geneva Conventions is a complex and highly controversial issue. Further complexity is faced when considering the issue of targeting, and whether an individual may be legitimately targeted for his/her direct participation in hostilities. The aim of this paper is to examine the issue and to pose an alternative mechanism so as to provide a practical test to determine an individuals’ status. It also calls upon International jurists to provide much needed guidance.Prema članku 51. (3) Prvog dodatka protokolu ženevskih konvencija pitanje kažnjivosti za civile koji izravno sudjeluje u neprijateljstvima je složeno i nadasve kontroverzno pitanje. Daljnju poteškoću izaziva otvaranje pitanja cilja napada, odnosno da li se pojedinca može legitimno napadati zbog njegovog izravnog učešća u neprijateljstvima. Cilj ovog teksta je istražiti pitanje i postaviti alternativni mehanizam kako bi se osigurao praktični test određivanja statusa pojedinca. Istodobno njime se pozivaju međunarodni pravnici kako bi osigurali toliko potrebno usmjerenje

Life stage differences in mammary gland gene expression profile in non-human primates

Breast cancer (BC) is the most common malignancy of women in the developed world. To better understand its pathogenesis, knowledge of normal breast development is crucial, as BC is the result of disregulation of physiologic processes. The aim of this study was to investigate the impact of reproductive life stages on the transcriptional profile of the mammary gland in a primate model. Comparative transcriptomic analyses were carried out using breast tissues from 28 female cynomolgus macaques (Macaca fascicularis) at the following life stages: prepubertal (n=5), adolescent (n=4), adult luteal (n=5), pregnant (n=6), lactating (n=3), and postmenopausal (n=5). Mammary gland RNA was hybridized to Affymetrix GeneChip® Rhesus Macaque Genome Arrays. Differential gene expression was analyzed using ANOVA and cluster analysis. Hierarchical cluster analysis revealed distinct separation of life stage groups. More than 2,225 differentially expressed mRNAs were identified. Gene families or pathways that changed across life stages included those related to estrogen and androgen (ESR1, PGR, TFF1, GREB1, AR, 17HSDB2, 17HSDB7, STS, HSD11B1, AKR1C4), prolactin (PRLR, ELF5, STAT5, CSN1S1), insulin-like growth factor signaling (IGF1, IGFBP1, IGFBP5), extracellular matrix (POSTN, TGFB1, COL5A2, COL12A1, FOXC1, LAMC1, PDGFRA, TGFB2), and differentiation (CD24, CD29, CD44, CD61, ALDH1, BRCA1, FOXA1, POSTN, DICER1, LIG4, KLF4, NOTCH2, RIF1, BMPR1A, TGFB2). Pregnancy and lactation displayed distinct patterns of gene expression. ESR1 and IGF1 were significantly higher in the adolescent compared to the adult animals, whereas differentiation pathways were overrepresented in adult animals and pregnancy-associated life stages. Few individual genes were distinctly different in postmenopausal animals. Our data demonstrate characteristic patterns of gene expression during breast development. Several of the pathways activated during pubertal development have been implicated in cancer development and metastasis, supporting the idea that other developmental markers may have application as biomarkers for B

Language and Technology in Wales: Volume II

This ebook is based on some of the main papers presented during the Welsh Language Technologies Academic Symposium 2022 and 2023. It contains chapters dealing with the latest technology in the field of Artificial Intelligence (AI), natural language processing (NLP) and speech technology, techniques that continue to offer much to less-resourced languages. In addition to reporting on the latest technology available for the Welsh language, included are discussions on language technology tools for languages that are in a similar situation, namely Breton, Cornish and Irish

Microclimate drives shelter-seeking behaviour in lambing ewes

Silvopastoral agroforestry and the strategic placement of trees and hedgerows offers potential to improve livestock welfare and production efficiency through the provision of shelter in livestock farming systems. The aim of this study was to investigate the relationship between shelter-seeking behaviour of ewes during the lambing period and the microclimate influenced by landscape shelter features. Artificial and natural shelter was provided to Aberfield ewes (n = 15) on an upland sheep farm in Wales, UK, which were then continuously monitored for 14 days using global positioning system tracking devices. Modelling of microclimate influenced by topographical shelter features at the test site was used to generate a 1 m resolution wind field for geospatial statistical analysis of localised wind speed. Ewes demonstrated an increased preference for natural (3.4-fold; p < 0.01) and artificial (3.0-fold; p < 0.05) shelter zones five times the height of the shelter, compared to the exposed area of the trial site. Wind-chill and modelled local-scale wind speeds were found to have the greatest influence on shelter-seeking behaviour, with temperature and field-scale wind speed significantly influencing livestock behaviour. Mean wind-chill temperature during the trial was 3.7 °C (min −5.3 °C; max 13.1 °C), which is within the cold stress temperature threshold (−3 and 8 °C) that requires thermoregulatory strategies such as shelter-seeking behaviour. An improved understanding of the relationship between microclimate and shelter-seeking behaviour in sheep, demonstrated through the agent-based model developed in this project, shall better inform the economic incentives (e.g., reduction in lamb mortality and forage requirements) behind silvopastoral practices that benefit farm productivity, livestock welfare and the environment

A binary model for the UV-upturn of elliptical galaxies (MNRAS version)

The discovery of a flux excess in the far-ultraviolet (UV) spectrum of elliptical galaxies was a major surprise in 1969. While it is now clear that this UV excess is caused by an old population of hot helium-burning stars without large hydrogen-rich envelopes, rather than young stars, their origin has remained a mystery. Here we show that these stars most likely lost their envelopes because of binary interactions, similar to the hot subdwarf population in our own Galaxy. We have developed an evolutionary population synthesis model for the far-UV excess of elliptical galaxies based on the binary model developed by Han et al (2002, 2003) for the formation of hot subdwarfs in our Galaxy. Despite its simplicity, it successfully reproduces most of the properties of elliptical galaxies with a UV excess: the range of observed UV excesses, both in $(1550-V)$ and $(2000-V)$, and their evolution with redshift. We also present colour-colour diagrams for use as diagnostic tools in the study of elliptical galaxies. The model has major implications for understanding the evolution of the UV excess and of elliptical galaxies in general. In particular, it implies that the UV excess is not a sign of age, as had been postulated previously, and predicts that it should not be strongly dependent on the metallicity of the population, but exists universally from dwarf ellipticals to giant ellipticals.Comment: accepted for publication in MNRAS, 24 pages, 15 figures, 2 table