Modernist literature at the museum: history, memory, and aesthetics in Proust, James, and Joyce

This thesis brings together three well-known authors of the early 20th century, Henry James, Marcel Proust, and James Joyce, in order to explore the similarities and divergences in their work when it comes to the treatment and depiction of museums and galleries. Each author differs in their interpretations of such spaces but, significantly, engages with a number of related discourses: the consequence of a rising materialism in society, the risks (and rewards) of collecting, and the importance of history for both societies and individuals. As each of these authors has been extensively studied since rising to renown, the scope of my investigations is broad and spans a number of areas of scholarship in order to draw together what I see as their responses to what Peter McIsaac calls the ‘museum function’. I also make use of their correspondence and nonfiction writings in order to build as comprehensive a picture as possible. The Introduction provides a short history of the development of museums in the Western world, as well as looking at the work of several authors such as H. G. Wells and Edith Wharton, in order to assess the cultural impact of museums throughout their rise and heyday towards the turn of the 20th century. My first chapter looks at the work of Henry James, especially his interest in collectors and their motivations, as well as questions of aesthetics and historicity, as expressed in such signal texts as The Portrait of a Lady and The Golden Bowl. I have endeavoured to engage with ‘minor’ texts of James’s such as The Spoils of Poynton and The Sense of the Past. My second chapter is concerned with exploring James Joyce’s construction of an aesthetic practice predicated around resistance (in many forms) to the power of institutions such as the National Library of Ireland and, in a more abstract sense, the legacy of colonialism as exemplified in monuments such as the Duke of Wellington’s obelisk which still stands in Dublin’s Phoenix Park. I demonstrate how Joyce uses humour as his main weapon in the dismantling of such spaces and sites in order to argue for the primacy of individual agency. My third chapter deals with Marcel Proust’s multifaceted interest in museums, galleries, and the visual arts, which he makes use of in sometimes contradictory ways throughout his writing, both fictional and otherwise. I contend that Proust believes a ‘Museum of Memory’, built along exacting lines, to be the solution to a wider memory crisis afflicting French society as typified by the upper classes at the end of the 19th century. In my conclusion I discuss the possible legacies of these literary treatments of museums, bringing modern-day writers such as Orhan Pamuk and Daljit Nagra to the fore

Quantifying cellular dynamics in mice using a novel fluorescent division reporter system

The dynamics of cell populations are frequently studied in vivo using pulse-chase DNA labeling techniques. When combined with mathematical models, the kinetic of label uptake and loss within a population of interest then allows one to estimate rates of cell production and turnover through death or onward differentiation. Here we explore an alternative method of quantifying cellular dynamics, using a cell fate-mapping mouse model in which dividing cells can be induced to constitutively express a fluorescent protein, using a Ki67 reporter construct. We use a pulse-chase approach with this reporter mouse system to measure the lifespans and division rates of naive CD4 and CD8 T cells using a variety of modeling approaches, and show that they are all consistent with estimates derived from other published methods. However we propose that to obtain unbiased parameter estimates and full measures of their uncertainty one should simultaneously model the timecourses of the frequencies of labeled cells within both the population of interest and its precursor. We conclude that Ki67 reporter mice provide a promising system for modeling cellular dynamics

Current Fertility Status Does Not Predict Sociosexual Attitudes and Desires in Normally Ovulating Women

Previous research has found that women at peak fertility show greater interest in extra-pair sex. However, recent replications have failed to detect this effect. In this study, we add to this ongoing debate by testing whether sociosexuality (the willingness to have sex in the absence of commitment) is higher in women who are at peak fertility. A sample of normally ovulating women (N = 773) completed a measure of sociosexuality and had their current fertility status estimated using the backward counting method. Contrary to our hypothesis, current fertility was unrelated to sociosexual attitudes and desires, even when relationship status was included as a moderator. These findings raise further doubts about the association between fertility and desire for extra-pair sex

Socio-legal studies and the humanities – law, interdisciplinarity and integrity

publication-status: Publishedtypes: ArticleInaugural lecture delivered at the SLSA Socio-Legal Studies and the Humanities Conference, at the Institute of Advanced Legal Studies, London, 5 November 2008.Published version; Published online by Cambridge University Press. Copyright © Cambridge University Press, 2009. Available online at http://journals.cambridge.org/This paper was delivered as a plenary lecture, designed to respond to the one-day special conference focus upon links between socio-legal studies and the humanities. The paper focuses in particular upon the relationship between law and the humanities. It may be argued that the role of empirically sourced socio-legal research is well accepted, given its tangible utility in terms of producing hard data which can inform and transform policy perspectives. However, scholarly speculation about the relationship between law and the humanities ranges from the indulgent to the hostile. In particular, legal scholars aligning themselves as ‘black letter’ commentators express strong opinions about such links, suggesting that scholarship purporting to establish links between the two fields is essentially spurious, bearing in mind the purposive role of law as a problem-solving mechanism. The paper sets out to challenge such assertions, indicating the natural connections between the two fields and the philosophical necessity of continued interaction, given the fact that certain aspects of human experience and nature cannot be plumbed by doctrine or empiricism or even by combinations of the two. Law must be understood to stand at the nexus of human experience, in a relationship of integrity, where the word is understood to mean both morally principled and culturally integrated. In particular, the development of human qualities, of character and moral sensibility informing normative values – and, ultimately, engagement with the world of law – is a process of subtle cultural as well as psychological significance, and may benefit from interrogation deriving from the wider fields of human discourse

Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation

With antigen stimulation, naïve CD4+ T cells differentiate to several effector or memory cell populations, and cytokines contribute to differentiation outcome. Several proteins on these cells receive costimulatory signals, but a systematic comparison of their differential effects on naïve T cell differentiation has not been conducted. Two costimulatory proteins, CD28 and ICAM-1, resident on human naïve CD4+ T cells were compared for participation in differentiation. Under controlled conditions, and with no added cytokines, costimulation through either CD3+CD28 or CD3+ICAM-1 induced differentiation to T effector and T memory cells. In contrast, costimulation through CD3+ICAM-1 induced differentiation to Treg cells whereas costimulation through CD3+CD28 did not

Branching out: redox strategies towards the synthesis of acyclic α-tertiary ethers

Acyclic α-tertiary ethers represent a highly prevalent functionality, common to high-value bioactive molecules, such as pharmaceuticals and natural products, and feature as crucial synthetic handles in their construction. As such their synthesis has become an ever-more important goal in synthetic chemistry as the drawbacks of traditional strong base- and acid-mediated etherifications have become more limiting. In recent years, the generation of highly reactive intermediates via redox approaches has facilitated the synthesis of highly sterically-encumbered ethers and accordingly these strategies have been widely applied in α-tertiary ether synthesis. This review summarises and appraises the state-of-the-art in the application of redox strategies enabling acyclic α-tertiary ether synthesis

The Nature of the Strong 24 micron Spitzer Source J222557+601148: Not a Young Galactic Supernova Remnant

The nebula J222557+601148, tentatively identified by Morris et al. (2006) as a young Galactic supernova remnant (SNR) from Spitzer Galactic First Look Survey images and a follow-up mid-infrared spectrum, is unlikely to be a SNR remnant based on Halpha, [O III], [S II] images and low dispersion optical spectra. The object is seen in Halpha and [O III] 5007 images as a faint, roughly circular ring nebula with dimensions matching that seen in 24 micron Spitzer images. Low-dispersion optical spectra show it to have narrow Halpha and [N II] 6548, 6583 line emissions with no evidence of broad or high-velocity (v > 300 km/s) line emissions. The absence of any high-velocity optical features, the presence of relatively strong [N II] emissions, a lack of detected [S II] emission which would indicate the presence of shock-heated gas, plus no coincident X-ray or nonthermal radio emissions indicate the nebula is unlikely to be a SNR, young or old. Instead, it is likely a faint, high-excitation planetary nebula (PN) as its elliptical morphology would suggest, lying at a distance of approximately 2 - 3 kpc with unusual but not extraordinary mid-IR colors and spectrum. We have identified a m_r' = 22.4 +/- 0.2 star as a PN central star candidate.Comment: 6 pages, 3 figures, accepted to The Astronomical Journa

Effects of the COVID-19 pandemic on people experiencing incarceration: a systematic review

Objective: To assess the effect of the COVID-19 pandemic on people experiencing incarceration (PEI), focusing particularly on clinical outcomes compared with the general population. Design: Systematic review with narrative synthesis in accordance with the Centre for Reviews and Dissemination’s good practice guidelines. Data sources: Medline, Social Policy and Practice, Criminology Connection, ASSIA, EMBASE, SCOPUS, Web Of Science, CINAHL, Cochrane Library, Cochrane COVID-19 reviews, COVID-19 Evidence Reviews and L*OVE COVID-19 Evidence databases were searched up to 21 October 2022. Eligibility criteria for selecting studies: We included studies presenting data specific to adults ≥18 years experiencing incarceration, with exposure to SARS-CoV-2 infection. All studies with a comparison group, regardless of study design and country were included. Studies with no comparison group data or not measuring clinical outcomes/health inequalities were excluded. Studies focussing on detained migrants, forensic hospitals, prison staff and those not in English were also excluded. Data extraction and synthesis: Two reviewers extracted data and assessed risk of bias. Data underwent narrative synthesis using a framework analysis based on the objectives, for infection rates, testing, hospitalisation, mortality, vaccine uptake rates and mental health outcomes. There was no scope for meta-analysis, due to the heterogeneity of evidence available. Results: 4516 references were exported from the databases and grey literature searched, of which 55 met the inclusion criteria. Most were from the USA and were retrospective analyses. Compared with the general population, PEI were usually found to have higher rates of SARS-CoV-2 infection and poorer clinical outcomes. Conflicting data were found regarding vaccine uptake and testing rates compared with the general population. The mental health of PEI declined during the pandemic. Certain subgroups were more adversely affected by the COVID-19 pandemic, such as ethnic minorities and older PEI. Conclusion: PEI have poorer COVID-19 clinical outcomes than the general public, as shown by largely low-quality heterogenous evidence. Further high-quality research of continuing clinical outcomes and appropriate mitigating interventions is required to assess downstream effects of the pandemic on PEI. However, performing such research in the context of incarceration facilities is highly complex and potentially challenging. Prioritisation of resources for this vulnerable group should be a focus of national policy in the event of future pandemics. PROSPERO registration number: CRD42022296968

The ACS Nearby Galaxy Survey Treasury III: Cepheids in the Outer Disk of M81

The ACS Nearby Galaxy Survey Treasury (ANGST) has acquired deep ACS imaging of a field in the outer disk of the large spiral galaxy M81. These data were obtained over a total of 20 HST orbits, providing a baseline long enough to reliably identify Cepheid variable stars in the field. Fundamental mode and first overtone types have been distinguished through comparative fits with corresponding Cepheid light curve templates derived from principal component analysis of confirmed Cepheids in the LMC, SMC, and Milky Way. A distance modulus of 27.78 pm 0.05_random pm 0.14_systematic with a corresponding distance of 3.60 pm 0.23 Mpc has been calculated from a sample of 11 fundamental mode and 2 first overtone Cepheids (assuming an LMC distance modulus of mu_LMC=18.41 pm 0.10_r pm 0.13_s).Comment: 10 pages, 9 figures. Accepted for publication in AJ Fixed typo