Cosmic Microwave Background Observations as a Way to Discriminate Among Inflation Models

The upcoming satellite missions MAP and Planck will measure the spectrum of fluctuations in the Cosmic Microwave Background with unprecedented accuracy. We discuss the prospect of using these observations to distinguish among proposed models of inflationary cosmology.Comment: To appear in the proceedings of the XXXIIIrd Rencontres de Moriond, "Fundamental Parameters in Cosmology", 17-24 January, Les Arcs, France. 6 Pages, 2 figures, uses moriond.st

The Alaska Business Community\u27s View of the Development of Alaska

America has discovered Alaska!! Or maybe that’s just the way it seems to us Alaskans. Even though Secretary of State Seward bought the Great Land (that’s what Alaska means in native tongue) more than a hundred years ago, very little of its nature has drifted down to the “Lower 48”. That is until the great oil reserves were discovered on the now-famous North Slope. Only then was the fact of Alaska’s mineral wealth translated into something other than very general admissions that Alaska was the natural resource storehouse of the United States. Now one would naturally conclude that the Prudhoe Bay miracle, followed closely by the $900 million oil lease sale conducted by the State of Alaska in September 1969, has transformed an economic desert into a businessman’s bonanza. Well, that could have happened. Why hasn’t it? Simply because the same outside influences that have kept Alaska locked up for all these years have once again come into play to block or hinder the development of our state by Alaskans and for Alaskans

Understanding Net Benefits: A Citizen-Based Perspective on eGovernment Success

eGovernment promises more efficient services and a more responsive government. Despite substantial investment, increasing failure rates have prompted critics to argue that policy makers are not achieving this vision. Surprisingly, there is very little research on what citizens define as important in eGovernment services and how aspects of government web sites affect that perception. The inclusion of the citizen perspective has largely been absent, denying a deeper understanding of the factors that drive usage. This research proposes an important and unique development of the D&M IS Success Model. By combining elements from public administration research and eGovernment success, this study constructs a comprehensive model of Net Benefits centred on the perspective of the citizen. The novel paradigm of Public Value is used to create a balanced success model, tailored for the public sector and is situated within the D&M IS Success Model. This research therefore aims to understand what citizens regard as important in the success of eGovernment services and what aspects of IT Quality affect eGovernment success

Post-processing partitions to identify domains of modularity optimization

We introduce the Convex Hull of Admissible Modularity Partitions (CHAMP) algorithm to prune and prioritize different network community structures identified across multiple runs of possibly various computational heuristics. Given a set of partitions, CHAMP identifies the domain of modularity optimization for each partition ---i.e., the parameter-space domain where it has the largest modularity relative to the input set---discarding partitions with empty domains to obtain the subset of partitions that are "admissible" candidate community structures that remain potentially optimal over indicated parameter domains. Importantly, CHAMP can be used for multi-dimensional parameter spaces, such as those for multilayer networks where one includes a resolution parameter and interlayer coupling. Using the results from CHAMP, a user can more appropriately select robust community structures by observing the sizes of domains of optimization and the pairwise comparisons between partitions in the admissible subset. We demonstrate the utility of CHAMP with several example networks. In these examples, CHAMP focuses attention onto pruned subsets of admissible partitions that are 20-to-1785 times smaller than the sets of unique partitions obtained by community detection heuristics that were input into CHAMP.Comment: http://www.mdpi.com/1999-4893/10/3/9

Validation of a novel scoring system for changes in skeletal manifestations of hypophosphatasia in newborns, infants, and children: The Radiographic Global Impression of Change scale

Hypophosphatasia (HPP) is the heritable metabolic disease characterized by impaired skeletal mineralization due to low activity of the tissue-nonspecific isoenzyme of alkaline phosphatase. Although HPP during growth often manifests with distinctive radiographic skeletal features, no validated method was available to quantify them, including changes over time. We created the Radiographic Global Impression of Change (RGI-C) scale to assess changes in the skeletal burden of pediatric HPP. Site-specific pairs of radiographs of newborns, infants, and children with HPP from three clinical studies of asfotase alfa, an enzyme replacement therapy for HPP, were obtained at baseline and during treatment. Each pair was scored by three pediatric radiologists ( raters ), with nine raters across the three studies. Intrarater and interrater agreement was determined by weighted Kappa coefficients. Interrater reliability was assessed using intraclass correlation coefficients (ICCs) and by two-way random effects analysis of variance (ANOVA) and a mixed-model repeated measures ANOVA. Pearson correlation coefficients evaluated relationships of the RGI-C to the Rickets Severity Scale (RSS), Pediatric Outcomes Data Collection Instrument Global Function Parent Normative Score, Childhood Health Assessment Questionnaire Disability Index, 6-Minute Walk Test percent predicted, and Z-score for height in patients aged 6 to 12 years at baseline. Eighty-nine percent (8/9) of raters showed substantial or almost perfect intrarater agreement of sequential RGI-C scores (weighted Kappa coefficients, 0.72 to 0.93) and moderate or substantial interrater agreement (weighted Kappa coefficients, 0.53 to 0.71) in patients aged 0 to 12 years at baseline. Moderate-to-good interrater reliability was observed (ICC, 0.57 to 0.65). RGI-C scores were significantly (p ≤ 0.0065) correlated with the RSS and with measures of global function, disability, endurance, and growth in the patients aged 6 to 12 years at baseline. Thus, the RGI-C is valid and reliable for detecting clinically important changes in skeletal manifestations of severe HPP in newborns, infants, and children, including during asfotase alfa treatment. © 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc

Could Wild Pigs Impact Water Quality and Aquatic Biota in Floodplain Wetland and Stream Habitats at Congaree National Park, South Carolina?

2008 S.C. Water Resources Conference - Addressing Water Challenges Facing the State and Regio

The crustal dynamics intelligent user interface anthology

The National Space Science Data Center (NSSDC) has initiated an Intelligent Data Management (IDM) research effort which has, as one of its components, the development of an Intelligent User Interface (IUI). The intent of the IUI is to develop a friendly and intelligent user interface service based on expert systems and natural language processing technologies. The purpose of such a service is to support the large number of potential scientific and engineering users that have need of space and land-related research and technical data, but have little or no experience in query languages or understanding of the information content or architecture of the databases of interest. This document presents the design concepts, development approach and evaluation of the performance of a prototype IUI system for the Crustal Dynamics Project Database, which was developed using a microcomputer-based expert system tool (M. 1), the natural language query processor THEMIS, and the graphics software system GSS. The IUI design is based on a multiple view representation of a database from both the user and database perspective, with intelligent processes to translate between the views

An Empirical Evaluation of Statistical Matching Methodologies

Using known data, the methodologies available for microdata file merging are compared. Results indicate that various techniques work or do not work in specific circumstances. An optimal-constrined merge model with an absolute difference distance function provide the best results

Teacher Perceptions of Indigenous Representations in History: A Phenomenological Study

This phenomenological study addressed teacher perceptions of indigenous representations in United States history within a school district in East Tennessee. Teacher perceptions of indigenous representations in history were defined as teacher beliefs towards the inclusion and representation of indigenous peoples in United States history. Individual and focus group interviews were conducted from a purposeful sample of United States history teachers from multiple high schools in the school district. The analysis of data revealed three themes: (a) systemic challenges to multiculturalism within state course standards and textbooks, (b) teachers’ perceived self-efficacy in teaching their students using indigenous perspectives, (c) and the perpetuation of indigenous stereotypes. Furthermore, analysis revealed that U.S. history courses in the district perpetuate both the notion of indigenous peoples as historical bystanders and the racial stereotypes of Native Americans