Arterial-portal fistula treated with hepatic arterial embolization and portal venous aneurysm stent-graft exclusion complicated by type 2 endoleak.

Intrahepatic arterioportal fistulas may be complicated by portal hypertension. An associated portal venous aneurysm (PVA) may impinge upon adjacent structures or rupture. We present a 65-year-old man with an intrahepatic Intrahepatic arterioportal fistula and 6.4 × 5.8 cm right portal vein aneurysm extending within 0.4 cm of the hepatic margin, associated with pain concerning for impending rupture. The PVA was refractory to transarterial embolization due to recruitment of arterial collaterals. Therefore, it was additionally excluded from the portal vein with a 12 mm × 9.5 cm venous stent graft. Although endovascular therapy thrombosed the aneurysm and improved symptoms, it was complicated by a type 2 endoleak into the PVA

Immune-Boosting Functional Foods: A Potential Remedy for Chinese Consumers Living Under Polluted Air

The deterioration of air quality in China has resulted in many people looking for remedies to counteract the impact that air pollution is perceived to be having on their health. As the importance of diet on immune health is becoming increasingly well recognised, a narrative literature review was undertaken to elucidate Chinese consumers’ acceptance of functional food products designed to help the immune system recover from pollution-driven impact and to assess their market potential. Consumers’ attitude towards immune-boosting functional foods were mainly positive, with scientific validation being important in determining the credibility of a product. This was despite the fact that the effectiveness of the functional food products currently in the market that purported to be remedies for pollution-driven impacts on the lung did not appear to be supported by scientific evidence. Numerous studies have reported functional foods could provide a wide range of benefits to immune health, including helping pollution-driven immune issues. This review highlights the market demand for effective and scientifically-proven functional food products that help Chinese consumers’ immune system recover from the impact of air pollution

Notes

Notes by Saverio Alonzi, William J. Obermiller, James H. Neu, Thomas F. Bremer, Francis J. Paulson, Robert T. Fanning, Robert A. Oberfell, Hal E. Hunter, Jr., William Bodden, and Charles M. Boynton

Data-driven model for divertor plasma detachment prediction

We present a fast and accurate data-driven surrogate model for divertor plasma detachment prediction leveraging the latent feature space concept in machine learning research. Our approach involves constructing and training two neural networks. An autoencoder that finds a proper latent space representation (LSR) of plasma state by compressing the multi-modal diagnostic measurements, and a forward model using multi-layer perception (MLP) that projects a set of plasma control parameters to its corresponding LSR. By combining the forward model and the decoder network from autoencoder, this new data-driven surrogate model is able to predict a consistent set of diagnostic measurements based on a few plasma control parameters. In order to ensure that the crucial detachment physics is correctly captured, highly efficient 1D UEDGE model is used to generate training and validation data in this study. Benchmark between the data-driven surrogate model and UEDGE simulations shows that our surrogate model is capable to provide accurate detachment prediction (usually within a few percent relative error margin) but with at least four orders of magnitude speed-up, indicating that performance-wise, it has the potential to facilitate integrated tokamak design and plasma control. Comparing to the widely used two-point model and/or two-point model formatting, the new data-driven model features additional detachment front prediction and can be easily extended to incorporate richer physics. This study demonstrates that the complicated divertor and scrape-off-layer plasma state has a low-dimensional representation in latent space. Understanding plasma dynamics in latent space and utilizing this knowledge could open a new path for plasma control in magnetic fusion energy research.Comment: 24 pages, 15 figure

Chinese consumers’ perceptions of immune health and immune-boosting remedies including functional foods

To facilitate the successful design of functional foods designed to boost immunity and to guide the successful promotion of such products, to Chinese consumers, fundamental knowledge is required on how consumers perceive the concept of immunity, the steps they take to improve their immunity and what their general attitudes are toward new functional food products. To explore these issues, focus groups (n = 4) and in-home semi-structured interviews (n = 12) were conducted in Shanghai. Immunity was understood to be the defense system that protects the body, with perceived causes for poor immunity including irregular lifestyles, polluted air, and increased age. Participants believed that immunity could be changed by modifying their diet with either conventional or functional foods (including TCM-based foods), supplements (TCM or non-TCM containing), TCM medical gels, TCM patent medicine, and Western medicine all playing varying roles at enhancing immunity and protecting health at different stages of wellbeing

Regulation of the Escherichia coli water channel gene aqpZ

Osmotic movement of water across bacterial cell membranes is postulated to be a homeostatic mechanism for maintaining cell turgor. The molecular water transporter remained elusive until discovery of the Escherichia coli water channel, AqpZ, however the regulation of the aqpZ gene expression and physiological function of the AqpZ protein are unknown. Northern analysis revealed a transcript of 0.7 kb, confirming the monocistronic nature of aqpZ. Regulatory studies performed with an aqpZ::lacZ low copy plasmid demonstrate enhanced expression during mid-logarithmic growth, and expression of the gene is dependent upon the extracellular osmolality, which increased in hypoosmotic environments but strongly reduced in hyperosmolar NaCl or KCl. While disruption of the chromosomal aqpZ is not lethal for E. coli, the colonies of the aqpZ knockout mutant are smaller than those of the parental wild-type strain. When cocultured with parental wild-type E. coli, the aqpZ knockout mutant exhibits markedly reduced colony formation when grown at 39 degrees C. Similarly, the aqpZ knockout mutant also exhibits greatly reduced colony formation when grown at low osmolality, but this phenotype is reversed by overexpression of AqpZ protein. These results implicate AqpZ as a participant in the adaptive response of E. coli to hypoosmotic environments and indicate a requirement for AqpZ by rapidly growing cells

A conserved juxtacrine signal regulates synaptic partner recognition in Caenorhabditis elegans

<p>Abstract</p> <p>Background</p> <p>An essential stage of neural development involves the assembly of neural circuits via formation of inter-neuronal connections. Early steps in neural circuit formation, including cell migration, axon guidance, and the localization of synaptic components, are well described. However, upon reaching their target region, most neurites still contact many potential partners. In order to assemble functional circuits, it is critical that within this group of cells, neurons identify and form connections only with their appropriate partners, a process we call synaptic partner recognition (SPR). To understand how SPR is mediated, we previously developed a genetically encoded fluorescent trans-synaptic marker called NLG-1 GRASP, which labels synaptic contacts between individual neurons of interest in dense cellular environments in the genetic model organism <it>Caenorhabditis elegans</it>.</p> <p>Results</p> <p>Here, we describe the first use of NLG-1 GRASP technology, to identify SPR genes that function in this critical process. The NLG-1 GRASP system allows us to assess synaptogenesis between PHB sensory neurons and AVA interneurons instantly in live animals, making genetic analysis feasible. Additionally, we employ a behavioral assay to specifically test PHB sensory circuit function. Utilizing this approach, we reveal a new role for the secreted UNC-6/Netrin ligand and its transmembrane receptor UNC-40/Deleted in colorectal cancer (DCC) in SPR. Synapses between PHB and AVA are severely reduced in <it>unc-6 </it>and <it>unc-40 </it>animals despite normal axon guidance and subcellular localization of synaptic components. Additionally, behavioral defects indicate a complete disruption of PHB circuit function in <it>unc-40 </it>mutants. Our data indicate that UNC-40 and UNC-6 function in PHB and AVA, respectively, to specify SPR. Strikingly, overexpression of UNC-6 in postsynaptic neurons is sufficient to promote increased PHB-AVA synaptogenesis and to potentiate the behavioral response beyond wild-type levels. Furthermore, an artificially membrane-tethered UNC-6 expressed in the postsynaptic neurons promotes SPR, consistent with a short-range signal between adjacent synaptic partners.</p> <p>Conclusions</p> <p>These results indicate that the conserved UNC-6/Netrin-UNC-40/DCC ligand-receptor pair has a previously unknown function, acting in a juxtacrine manner to specify recognition of individual postsynaptic neurons. Furthermore, they illustrate the potential of this new approach, combining NLG-1 GRASP and behavioral analysis, in gene discovery and characterization.</p

CGM-measured glucose values have a strong correlation with C-peptide, HbA1c and IDAAC, but do poorly in predicting C-peptide levels in the two years following onset of diabetes

AIMS/HYPOTHESIS: The aim of this work was to assess the association between continuous glucose monitoring (CGM) data, HbA1c, insulin-dose-adjusted HbA1c (IDAA1c) and C-peptide responses during the first 2 years following diagnosis of type 1 diabetes. METHODS: A secondary analysis was conducted of data collected from a randomised trial assessing the effect of intensive management initiated within 1 week of diagnosis of type 1 diabetes, in which mixed-meal tolerance tests were performed at baseline and at eight additional time points through 24 months. CGM data were collected at each visit. RESULTS: Among 67 study participants (mean age [± SD] 13.3 ± 5.7 years), HbA1c was inversely correlated with C-peptide at each time point (p < 0.001), as were changes in each measure between time points (p < 0.001). However, C-peptide at one visit did not predict the change in HbA1c at the next visit and vice versa. Higher C-peptide levels correlated with increased proportion of CGM glucose values between 3.9 and 7.8 mmol/l and lower CV (p = 0.001 and p = 0.02, respectively) but not with CGM glucose levels <3.9 mmol/l. Virtually all participants with IDAA1c < 9 retained substantial insulin secretion but when evaluated together with CGM, time in the range of 3.9-7.8 mmol/l and CV did not provide additional value in predicting C-peptide levels. CONCLUSIONS/INTERPRETATION: In the first 2 years after diagnosis of type 1 diabetes, higher C-peptide levels are associated with increased sensor glucose levels in the target range and with lower glucose variability but not hypoglycaemia. CGM metrics do not provide added value over the IDAA1c in predicting C-peptide levels

14th Annual Seminar on Estate Planning

Outlines of speaker presentations from the 14th Annual Seminar on Estate Planning held by UK/CLE on July 17-18, 1987