М.К. Янгель біля витоків вітчизняного ракетобудування

Висвітлено життєвий шлях академіка М.К.Янгеля, його внесок у розвиток вітчизняного ракетобудування, забезпечення обороноздатності СРСР.Освещены жизненный путь академика М.К.Янгеля и его вклад в развитие отечественного ракетостроения, обеспечение обороноспособности СССР.An account of the life path of the academician М. К. Yangel, his contribution in the national spacecraft and of defense capacity building of the USSR is contained

BMI Development of Normal Weight and Overweight Children in the PIAMA Study

Background: There is evidence that rapid weight gain during the first year of life is associated with overweight later in life. However, results from studies exploring other critical periods for the development of overweight are inconsistent. Objective: The objective was to investigate BMI development to assess at what ages essential differences between normal weight and overweight children occur, and to assess which age intervals the most strongly influence the risk of overweight at 8 years of age. Methods: Longitudinal weight and height data

Public health impacts of city policies to reduce climate change:Findings from the URGENCHE EU-China project

Climate change is a global threat to health and wellbeing. Here we provide findings of an international research project investigating the health and wellbeing impacts of policies to reduce greenhouse gas emissions in urban environments.; Five European and two Chinese city authorities and partner academic organisations formed the project consortium. The methodology involved modelling the impact of adopted urban climate-change mitigation transport, buildings and energy policy scenarios, usually for the year 2020 and comparing them with business as usual (BAU) scenarios (where policies had not been adopted). Carbon dioxide emissions, health impacting exposures (air pollution, noise and physical activity), health (cardiovascular, respiratory, cancer and leukaemia) and wellbeing (including noise related wellbeing, overall wellbeing, economic wellbeing and inequalities) were modelled. The scenarios were developed from corresponding known levels in 2010 and pre-existing exposure response functions. Additionally there were literature reviews, three longitudinal observational studies and two cross sectional surveys.; There are four key findings. Firstly introduction of electric cars may confer some small health benefits but it would be unwise for a city to invest in electric vehicles unless their power generation fuel mix generates fewer emissions than petrol and diesel. Second, adopting policies to reduce private car use may have benefits for carbon dioxide reduction and positive health impacts through reduced noise and increased physical activity. Third, the benefits of carbon dioxide reduction from increasing housing efficiency are likely to be minor and co-benefits for health and wellbeing are dependent on good air exchange. Fourthly, although heating dwellings by in-home biomass burning may reduce carbon dioxide emissions, consequences for health and wellbeing were negative with the technology in use in the cities studied.; The climate-change reduction policies reduced CO2 emissions (the most common greenhouse gas) from cities but impact on global emissions of CO2 would be more limited due to some displacement of emissions. The health and wellbeing impacts varied and were often limited reflecting existing relatively high quality of life and environmental standards in most of the participating cities; the greatest potential for future health benefit occurs in less developed or developing countries

Hitte-overlast en luchtverontreiniging versterken elkaar

Periodes met hitte gekoppeld aan stedelijke luchtverontreiniging hebben gevolgen voor de gezondheid en het welzijn van de inwoners in de stad. ze leiden tot hittestress en in het extreme geval tot vroegtijdige sterfte. Onderzoek uit 2011 liet zien dat temperatuur en luchtvervuiling vaak tegelijk verhoogd zijn. Of de twee elkaar versterken in hun effect op vroegtijdige sterfte kon toen niet worden bewezen. Uit een gedetailleerd onderzoek voor Rotterdam is die interactie nu wel vastgesteld. Hieruit blijkt ook dat de luchtkwaliteit en het aantal dagen met hittestress sterk per buurt kunnen verschillen

Traffic noise and cardiovascular health in Sweden: The roadside study

Long-term exposure to traffic noise has been suggested to increase the risk of cardiovascular diseases (CVD). However, few studies have been performed in the general population and on railway noise. This study aimed to investigate the cardiovascular effects of living near noisy roads and railways. This cross-sectional study comprised 25,851 men and women, aged 18-80 years, who had resided in Sweden for at least 5 years. All subjects participated in a National Environmental Health Survey, performed in 2007, in which they reported on health, annoyance reactions and environmental factors. Questionnaire data on self-reported doctor′s diagnosis of hypertension and/or CVD were used as outcomes. Exposure was assessed as Traffic Load (millions of vehicle kilometres per year) within 500 m around each participant′s residential address. For a sub-population (n = 2498), we also assessed road traffic and railway noise in L den at the dwelling façade. Multiple logistic regression models were used to assess Prevalence Odds Ratios (POR) and 95% Confidence Intervals (CI). No statistically significant associations were found between Traffic Load and self-reported hypertension or CVD. In the sub-population, there was no association between road traffic noise and the outcomes; however, an increased risk of CVD was suggested among subjects exposed to railway noise ≥50 dB(A); POR 1.55 (95% CI 1.00-2.40). Neither Traffic Load nor road traffic noise was, in this study, associated with self-reported cardiovascular outcomes. However, there was a borderline-significant association between railway noise and CVD. The lack of association for road traffic may be due to methodological limitations

Improvements in air quality in the Netherlands during the corona lockdown based on observations and model simulations

The lockdown measures in response to the SARS-CoV-2 virus outbreak in 2020 have resulted in reductions in emissions of air pollutants and corresponding ambient concentrations. In the Netherlands, the most stringent lockdown measures were in effect from March to May 2020. These measures coincided with a period of unusual meteorological conditions with wind from the north-east and clear-sky conditions, which complicates the quantification of the effect of the lockdown measures on the air quality. Here we quantify the lockdown effects on the concentrations of nitrogen oxides (NOx and NO2), particulate matter (PM10 and PM2.5) and ozone (O3) in the Netherlands, by analyzing observations and simulations with the atmospheric chemistry-transport model EMEP/MSC-W in its EMEP4NL configuration, after eliminating the effects of meteorological conditions during the lockdown. Based on statistical analyses with a Random Forest method, we estimate that the lockdown reduced observed NO2 concentrations by 30% (95% confidence interval 25–35%), 26% (21–32%), and 18% (10–25%) for traffic, urban, and rural background locations, respectively. Slightly smaller reductions of 8–28% are found with the EMEP4NL simulations for urban and regional background locations based on estimates in reductions in economic activity and emissions of traffic and industry in the Netherlands and other European countries. Reductions in observed PM2.5 concentrations of about 20% (10–25%) are found for all locations, which is somewhat larger than the estimates of 5–16% based on the model simulations. A comparison of the calculated NO2 traffic contributions with observations shows a substantial drop of about 35% in traffic contributions during the lockdown period, which is similar to the estimated reductions in mobility data as reported by Apple and Google. Since the largest health effects related to air pollution in the Netherlands are associated with exposure to PM10 and PM2.5, the lockdown measures in spring of 2020 have temporarily improved the air quality in the Netherlands. The concentrations of the most health relevant compounds have only been reduced by about 10–25%

High resolution exposure modelling of heat and air pollution and the impact on mortality

Background: Elevated temperature and air pollution have been associated with increased mortality. Exposure to heat and air pollution, as well as the density of vulnerable groups varies within cities. The objective was to investigate the extent of neighbourhood differences in mortality risk due to heat and air pollution in a city with a temperate maritime climate. Methods: A case-crossover design was used to study associations between heat, air pollution and mortality. Different thermal indicators and air pollutants (PM10, NO2, O-3) were reconstructed at high spatial resolution to improve exposure classification. Daily exposures were linked to individual mortality cases over a 15 year period. Results: Significant interaction between maximum air temperature (Ta-max) and PM10 was observed. During "summer smog" days (Ta-max > 25 degrees C and PM10 > 50 mu g/m(3)), the mortality risk at lag 2 was 7% higher compared to the reference (Ta-max 15 degrees C and PM10 15 mu g/m(3)). Persons above age 85 living alone were at highest risk. Conclusion: We found significant synergistic effects of high temperatures and air pollution on mortality. Single living elderly were the most vulnerable group. Due to spatial differences in temperature and air pollution, mortality risks varied substantially between neighbourhoods, with a difference up to 7%. (C) 2016 Elsevier Ltd. All rights reserved

Maternal food consumption during pregnancy and the longitudinal development of childhood asthma

Rationale Maternal diet during pregnancy has the potential to affect airway development and to promote T-helper-2-cell responses during fetal life. This might increase the risk of developing childhood asthma or allergy. Objectives: We investigated the influence of maternal food consumption during pregnancy on childhood asthma outcomes from 1 to 8 years of age. Methods: A birth cohort study consisting of a baseline of 4,146 pregnant women (1,327 atopic and 2,819 nonatopic). These women were asked about their frequency of consumption of fruit, vegetables, fish, egg, milk, milk products, nuts, and nut products during the last month. Their children were followed until 8 years of age. Longitudinal analyses were conducted to assess associations between maternal diet during pregnancy and childhood asthma outcomes over 8 years. Measurements and Main Results: Complete data were obtained for 2,832 children. There were no associations between maternal vegetable, fish, egg, milk or milk products, and nut consumption and longitudinal childhood outcomes. Daily consumption of nut products increased the risk of childhood wheeze (odds ratio [OR] daily versus rare consumption, 1.42; 95% confidence interval [95% CI], 1.06-1.89), dyspnea (OR, 1.58, 95% CI, 1.16-2.15), steroid use (OR, 1.62; 95% CI, 1.06-2.46), and asthma symptoms (OR, 1.47; 95% CI, 1.08-1.99). Conclusions: Results of this study indicate an increased risk of daily versus rare consumption of nut products during pregnancy on childhood asthma outcomes. These findings need to be replicated by other studies before dietary advice can be given to pregnant women