Developmental divergence: motor trajectories in children with fragile X syndrome with and without co-occurring autism.

BackgroundAutism spectrum disorder (ASD) is highly prevalent in fragile X syndrome (FXS), affecting 50-70% of males. Motor impairments are a shared feature across autism and FXS that may help to better characterize autism in FXS. As motor skills provide a critical foundation for various language, cognitive, and social outcomes, they may serve an important mechanistic role for autism in FXS. As such, this study aimed to identify differences in motor trajectories across direct assessment and parent-report measures of fine and gross motor development between FXS with and without autism, and typical development, while controlling for cognitive functioning.MethodsThis prospective longitudinal study included 42 children with FXS, 24 of whom also had ASD (FXS + ASD), as well as 40 typically developing children. The Mullen Scales of Early Learning provided a direct measure of fine and gross motor skills, and the Vineland Adaptive Behavior Scales provided a measure of parent-reported fine and gross motor skills. Random slopes and random intercepts multilevel models were tested to determine divergence in developmental motor trajectories between groups when controlling for cognitive level.ResultsModel results indicated the children with FXS + ASD diverged from TD children by 9-months on all measures of gross and fine motor skills, even when controlling for cognitive level. Results also indicated an early divergence in motor trajectories of fine and gross motor skills between the FXS + ASD and FXS groups when controlling for cognitive level. This divergence was statistically significant by 18 months, with the FXS + ASD showing decelerated growth in motor skills across direct observation and parent-report measures.ConclusionsThis study is the first to examine longitudinal trends in motor development in children with FXS with and without comorbid ASD using both direct assessment and parent-report measures of fine and gross motor. Furthermore, it is among the first to account for nonverbal cognitive delays, a step towards elucidating the isolated role of motor impairments in FXS with and without ASD. Findings underscore the role of motor impairments as a possible signal representing greater underlying genetic liability, or as a potential catalyst or consequence, of co-occurring autism in FXS

A new approach to the pulsed thermocouple for high gas temperature measurements

Pulsed thermocouple systems can be used to measure gas temperatures above the melting point of the thermocouple by various techniques of short term of intermittent exposure of the thermocouple operating at lower temperatures. An approach is described which uses a thermocouple cooled by a small jet of inert gas. When a measurement is to be made, the cooling jet is turned off and the thermocouple allowed to heat up to near its melting point, at which time the cooling is reapplied. The final temperature which the thermocouple should have attained is then calculated by extrapolating an exponential curve fit to the data. Temperature measurements can be recorded and displayed in near real time by using modern high-speed computing systems to perform these calculations. Examples of the technique applied to high temperature jet engine combustor development are presented

Testing Alternative Theories of Gravity using LISA

We investigate the possible bounds which could be placed on alternative theories of gravity using gravitational wave detection from inspiralling compact binaries with the proposed LISA space interferometer. Specifically, we estimate lower bounds on the coupling parameter \omega of scalar-tensor theories of the Brans-Dicke type and on the Compton wavelength of the graviton \lambda_g in hypothetical massive graviton theories. In these theories, modifications of the gravitational radiation damping formulae or of the propagation of the waves translate into a change in the phase evolution of the observed gravitational waveform. We obtain the bounds through the technique of matched filtering, employing the LISA Sensitivity Curve Generator (SCG), available online. For a neutron star inspiralling into a 10^3 M_sun black hole in the Virgo Cluster, in a two-year integration, we find a lower bound \omega > 3 * 10^5. For lower-mass black holes, the bound could be as large as 2 * 10^6. The bound is independent of LISA arm length, but is inversely proportional to the LISA position noise error. Lower bounds on the graviton Compton wavelength ranging from 10^15 km to 5 * 10^16 km can be obtained from one-year observations of massive binary black hole inspirals at cosmological distances (3 Gpc), for masses ranging from 10^4 to 10^7 M_sun. For the highest-mass systems (10^7 M_sun), the bound is proportional to (LISA arm length)^{1/2} and to (LISA acceleration noise)^{-1/2}. For the others, the bound is independent of these parameters because of the dominance of white-dwarf confusion noise in the relevant part of the frequency spectrum. These bounds improve and extend earlier work which used analytic formulae for the noise curves.Comment: 16 pages, 9 figures, submitted to Classical & Quantum Gravit

Adjustment of model parameters to estimate distribution transformers remaining lifespan

Currently, the electrical system in Argentina is working at its maximum capacity, decreasing the margin between the installed power and demanded consumption, and drastically reducing the service life of transformer substations due to overload (since the margin for summer peaks is small). The advent of the Smart Grids allows electricity distribution companies to apply data analysis techniques to manage resources more efficiently at different levels (avoiding damages, better contingency management, maintenance planning, etc.). The Smart Grids in Argentina progresses slowly due to the high costs involved. In this context, the estimation of the lifespan reduction of distribution transformers is a key tool to efficiently manage human and material resources, maximizing the lifetime of this equipment. Despite the current state of the smart grids, the electricity distribution companies can implement it using the available data. Thermal models provide guidelines for lifespan estimation, but the adjustment to particular conditions, brands, or material quality is done by adjusting parameters. In this work we propose a method to adjust the parameters of a thermal model using Genetic Algorithms, comparing the estimation values of top-oil temperature with measurements from 315 kVA distribution transformers, located in the province of Tucumán, Argentina. The results show that, despite limited data availability, the adjusted model is suitable to implement a transformer monitoring system.Fil: Jimenez, Victor Adrian. Universidad Tecnológica Nacional. Facultad Regional Tucumán. Centro de Investigación en Tecnologías Avanzadas de Tucumán; ArgentinaFil: Will, Adrian L. E.. Universidad Tecnológica Nacional. Facultad Regional Tucumán. Centro de Investigación en Tecnologías Avanzadas de Tucumán; ArgentinaFil: Gotay Sardiñas, Jorge. Universidad Tecnológica Nacional. Facultad Regional Tucumán. Centro de Investigación en Tecnologías Avanzadas de Tucumán; ArgentinaFil: Rodriguez, Sebastian Alberto. Universidad Tecnológica Nacional. Facultad Regional Tucumán. Centro de Investigación en Tecnologías Avanzadas de Tucumán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentin

Cosmological test of gravity with polarizations of stochastic gravitational waves around 0.1-1 Hz

In general relativity, a gravitational wave has two polarization modes (tensor mode), but it could have additional polarizations (scalar and vector modes) in the early stage of the universe, where the general relativity may not strictly hold and/or the effect of higher-dimensional gravity may become significant. In this paper, we discuss how to detect extra-polarization modes of stochastic gravitational wave background (GWB), and study the separability of each polarization using future space-based detectors such as BBO and DECIGO. We specifically consider two plausible setups of the spacecraft constellations consisting of two and four clusters, and estimate the sensitivity to each polarization mode of GWBs. We find that a separate detection of each polarization mode is rather sensitive to the geometric configuration and distance between clusters and that the clusters should be, in general, separated by an appropriate distance. This seriously degrades the signal sensitivity, however, for suitable conditions, space-based detector can separately detect scalar, vector and tensor modes of GWBs with energy density as low as ~10^-15.Comment: 16 pages, 11 figure

An operating system for future aerospace vehicle computer systems

The requirements for future aerospace vehicle computer operating systems are examined in this paper. The computer architecture is assumed to be distributed with a local area network connecting the nodes. Each node is assumed to provide a specific functionality. The network provides for communication so that the overall tasks of the vehicle are accomplished. The O/S structure is based upon the concept of objects. The mechanisms for integrating node unique objects with node common objects in order to implement both the autonomy and the cooperation between nodes is developed. The requirements for time critical performance and reliability and recovery are discussed. Time critical performance impacts all parts of the distributed operating system; e.g., its structure, the functional design of its objects, the language structure, etc. Throughout the paper the tradeoffs - concurrency, language structure, object recovery, binding, file structure, communication protocol, programmer freedom, etc. - are considered to arrive at a feasible, maximum performance design. Reliability of the network system is considered. A parallel multipath bus structure is proposed for the control of delivery time for time critical messages. The architecture also supports immediate recovery for the time critical message system after a communication failure

Head-on collision of compact objects in general relativity: comparison of post-newtonian and perturbation approaches

The gravitational-wave energy flux produced during the head-on infall and collision of two compact objects is calculated using two approaches: (i) a post-Newtonian method, carried to second post-Newtonian order beyond the quadrupole formula, valid for systems of arbitrary masses; and (ii) a black-hole perturbation method, valid for a test-body falling radially toward a black hole. In the test-body case, the methods are compared. The post-Newtonian method is shown to converge to the ``exact'' perturbation result more slowly than expected {\it a priori\/}. A surprisingly good approximation to the energy radiated during the infall phase, as calculated by perturbation theory, is found to be given by a Newtonian, or quadrupole, approximation combined with the exact test-body equations of motion in the Schwarzschild spacetime

A Spinor Theory of Gravity and the Cosmological Framework

Recently we have presented a new formulation of the theory of gravity based on an implementation of the Einstein Equivalence Principle distinct from General Relativity. The kinetic part of the theory - that describes how matter is affected by the modified geometry due to the gravitational field - is the same as in General Relativity. However, we do not consider the metric as an independent field. Instead, it is an effective one, constructed in terms of two fundamental spinor fields $\Psi$ and $\Upsilon$ and thus the metric does not have a dynamics of its own, but inherits its evolution through its relation with the fundamental spinors. In the first paper it was shown that the metric that describes the gravitational field generated by a compact static and spherically symmetric configuration is very similar to the Schwarzschild metric. In the present paper we describe the cosmological framework in the realm of the Spinor Theory of Gravity

Gravitational Self-Force Correction to the Binding Energy of Compact Binary Systems

Using the first law of binary black-hole mechanics, we compute the binding energy E and total angular momentum J of two non-spinning compact objects moving on circular orbits with frequency Omega, at leading order beyond the test-particle approximation. By minimizing E(Omega) we recover the exact frequency shift of the Schwarzschild innermost stable circular orbit induced by the conservative piece of the gravitational self-force. Comparing our results for the coordinate invariant relation E(J) to those recently obtained from numerical simulations of comparable-mass non-spinning black-hole binaries, we find a remarkably good agreement, even in the strong-field regime. Our findings confirm that the domain of validity of perturbative calculations may extend well beyond the extreme mass-ratio limit.Comment: 5 pages, 1 figure; matches the published versio