1,017 research outputs found
An observational constraint on gravitational lensing by objects of mass 10^(9.5) - 10^(10.9) Mo
A radio-based search for strong gravitational lensing, with image separations
in the range 160-300 milliarcsec (mas), has yielded a null result for a sample
of 1665 sources (Augusto, Wilkinson & Browne 1998) whose mean redshift is
estimated to be ~1.3. The lensing rate for this previously-unexplored
separation range, <1:555 at the 95% confidence level, is less than on
arcsecond-scales - as expected from models of lensing galaxy populations.
Lensing on 160-300 mas scales is expected to arise predominantly from spiral
galaxies at a rate dependent on the disk-halo mass ratio and the evolving
number density of the population with redshift. While the present sample is too
small for there to be a high probability of finding spiral galaxy lenses, our
work is a pilot survey for a much larger search based on the full CLASS
database which would provide useful information on galactic structure at z~0.5.
We examine other possible lens populations relevant to our present search, in
particular dwarf galaxies and supermassive black holes in galactic nuclei, and
conclude that none of them are likely to be detected. Our null result enables
us formally to rule out a cosmologically significant population of
uniformly-distributed compact objects: Omega (CO)<0.1 (95% confidence) in the
mass range 10^(9.5) - 10^(10.9) Mo.Comment: Accepted for publication in MNRAS (Letters) 5 pages, 2 Figure
HI intensity mapping with FAST
We discuss the detectability of large-scale HI intensity fluctuations using
the FAST telescope. We present forecasts for the accuracy of measuring the
Baryonic Acoustic Oscillations and constraining the properties of dark energy.
The FAST -beam L-band receivers (-- GHz) can provide
constraints on the matter power spectrum and dark energy equation of state
parameters () that are comparable to the BINGO and CHIME
experiments. For one year of integration time we find that the optimal survey
area is . However, observing with larger frequency coverage
at higher redshift (-- GHz) improves the projected errorbars on the
HI power spectrum by more than confidence level. The combined
constraints from FAST, CHIME, BINGO and Planck CMB observations can provide
reliable, stringent constraints on the dark energy equation of state.Comment: 7 pages, 3 figures, submitted to "Frontiers in Radio Astronomy and
FAST Early Sciences Symposium 2015" conference proceedin
Uncovering the origin of Z-configured double bonds in polyketides: intermediate E-double bond formation during borrelidin biosynthesis
Formation of Z-configured double bonds in reduced polyketides is uncommon and their origins have not been extensively studied. To investigate the origin of the Z-configured double bond in the macrolide borrelidin, the recombinant dehydratase domains BorDH2 and B0rDH3 were assayed with a synthetic analogue of the predicted tetraketide substrate. The configuration of the dehydrated products was determined to be E in both cases by comparison to synthetic standards. Detailed NMR spectroscopic analysis of the biosynthetic intermediate pre-borrelidin confirmed the E,E-configuration of the fulllength polyketide synthase product. In contrast to a previously-proposed hypothesis, our results show that in this case the Z-configured double bond is not formed via dehydration from a 3 L-configured precursor, but rather as the result of a later isomerization process.Marie Curie programme of the European UnionEmmy Noether programme of the Deutsche ForschungsgemeinschaftDAA
Fibroadenoma in vulval ectopic breast tissue in a patient with PTEN Hamartoma Tumour Syndrome
PTEN is a tumour suppressor gene involved in regulating cell division. Pathogenic germline variants in PTEN predispose to benign and malignant growths of numerous organs, including of the breast. In the following report, we describe the first documented case of a fibroadenoma developing in ectopic breast tissue of the vulva in a patient with a germline pathogenic variant in PTEN. This highlights the risk of hyperplasia developing in any breast tissue, including rare ectopic sites, particularly in patients with underlying germline variants in cancer susceptibility genes
Galaxy redshift surveys selected by neutral hydrogen using FAST
We discuss the possibility of performing a substantial spectroscopic galaxy
redshift survey selected via the 21cm emission from neutral hydrogen using the
Five-hundred metre Aperture Spherical Telescope (FAST) to be built in China. We
consider issues related to the estimation of the source counts and
optimizations of the survey, and discuss the constraints on cosmological models
that such a survey could provide. We find that a survey taking around two years
could detect ~10^7 galaxies with an average redshift of ~0.15 making the survey
complementary to those already carried out at optical wavelengths. These
conservative estimates have used the z=0 HI mass function and have ignored the
possibility of evolution. The results could be used to constrain Gamma =
(Omega_m h) to 5 per cent and the spectral index, n_s, to 7 per cent
independent of cosmic microwave background data. If we also use simulated power
spectra from the Planck satellite, we can constrain w to be within 5 per cent
of -1.Comment: 13 pages, 15 figures, Accepted by MNRAS, minor correction
Prospects for local co-governance
British local authorities and their partners are increasingly developing new ways of working together with local communities. The nature of this co-working, however, is complex, multi-faceted and little understood. This article argues for greater clarity of thinking on the topic, by analysing this co-working as a form of political co-governance, and drawing attention in particular to issues of scale and democracy. Using evidence from a study of 43 local authority areas, 16 authorities are identified where co-governance is practised, following three main types of approach: service-influencing, service-delivering and parish council developing. It is concluded that strengthening political co-governance is essential for a healthy democracy
Canonical thermalization
For quantum systems that are weakly coupled to a much 'bigger' environment,
thermalization of possibly far from equilibrium initial ensembles is
demonstrated: for sufficiently large times, the ensemble is for all practical
purposes indistinguishable from a canonical density operator under conditions
that are satisfied under many, if not all, experimentally realistic conditions
Past as global trade governance prelude: reconfiguring debate about reform of the multilateral trading system
This paper peers backwards into the history of the multilateral trading system and its development over the past half century as a means of considering what may lie beyond the horizon for the future of global trade governance. Its purpose is to underscore the necessity and urgency for root-and-branch reform of the multilateral trading system. It achieves this by comparing and contrasting the global trading system of 50 years ago with its modern-day equivalent and its likely future counterpart half-a-century hence. In so doing, the paper throws into sharp relief not only the inadequacies of global trade governance today but also the damaging consequences of not fundamentally reforming the system in the near future, with a particular emphasis on the past, present and future development of the world’s poorest and most marginalised countries
Time-sequenced Multi-Radio-Frequency Observations of Cygnus X-3 in Flare
Multifrequency observations from the VLA, VLBA and OVRO Millimeter Array of a
major radio outburst of Cygnus X-3 in 2001 September are presented, measuring
the evolution of the spectrum of the source over three decades in frequency,
over a period of six days. Following the peak of the flare, as the intensity
declines the high-frequency spectrum at frequency nu steepens from nu^{-0.4} to
nu^{-0.6}, after which the spectral index remains at this latter terminal
value; a trend previously observed but hitherto not satisfactorily explained.
VLBA observations, for the first time, track over several days the expansion of
a sequence of knots whose initial diameters are approximately 8
milliarcseconds. The light-crossing time within these plasmons is of the same
order as the time-scale over which the spectrum is observed to evolve. We
contend that properly accounting for light-travel time effects in and between
plasmons which are initially optically thick, but which after expansion become
optically thin, explains the key features of the spectral evolution, for
example the observed timescale. Using the VLBA images, we have directly
measured for the first time the proper motions of individual knots, analysis of
which shows a two-sided jet whose axis is precessing. The best-fit jet speed is
roughly beta = 0.63 and the precession period is about 5 days, significantly
lower than fitted for a previous flare. Extrapolation of the positions of the
knots measured by the VLBA back to zero-separation shows this to occur
approximately 2.5 days after the detection of the rise in flux density of
Cygnus X-3.Comment: 23 pages, 10 figures, accepted by Ap
A reassuring presence: An evaluation of Bradford District Hospice at Home service
Within the United Kingdom, a developing role for primary care services in cancer and palliative care has resulted in an increase in palliative home care teams. The provision of professional care in the home setting seeks to provide necessary services and enhanced choice for patients whose preference is to die at home.
A mismatch between patient preference for home death and the actual number of people who died at home was identified within Bradford, the locality of this study. In response to this mismatch, and reflecting the policy environment of wishing to enhance community service provision, the four Primary Care Trusts (PCTs) in the city sought to offer support to patients who wished to remain in their own homes through the final stages of a terminal illness. To offer this support they set up a dedicated hospice at home team. This would provide services and support for patients in achieving a dignified, symptom free and peaceful death, allowing families to maximise time spent together. The aim of the study was to evaluate the Bradford hospice at home service from the perspective of carers, nurses and General Practitioners.
Postal questionnaires were sent to carers (n = 289), district nurses (n = 508) and GP's (n = 444) using Bradford's hospice at home service. Resulting quantitative data was analysed using the Statical Package for Social Sciences (SPSS) and qualitative data was analysed using grounded theory techniques.
The data from carers, district nurses and GPs provide general support for the Bradford hospice at home service. Carers valued highly the opportunity to 'fulfil a promise' to the individual who wished to be cared for at home. District nurses and GPs cited the positive impact of access to specialist expertise. This was a 'reassuring presence' for primary healthcare teams and offered 'relief of carer anxiety' by providing prompt, accessible and sensitive care.
Carers and health professionals welcomed the increased possibility of patients being cared for at home. The study identified the need to focus on improving skill levels of staff and on ensuring continuity of care
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