A participatory assessment of nitrified urine fertilizer use in Swayimane, South Africa: Crop production potential, farmer attitudes and smallholder challenges

Long-term nutrient mining of soil hampers agricultural production across Africa. However, emerging sanitation technologies afford a hygienically safe and ecologically sustainable solution to this development challenge by providing fertilizers derived from human excreta that could facilitate a socio-technical transition toward a more sustainable food system. To evaluate one such technology, nitrified urine fertilizer (NUF), we conducted participatory action research to assess the potential, from both a biophysical and social perspective, of NUF to serve as a soil fertilizer to support smallholder agricultural production in Swayimane, South Africa. To achieve this objective, we formed a stakeholder group comprised of a cooperative of smallholder farmers, a local NGO (Zimele), and researchers from ETH Zurich and the University of Kwazulu-Natal. Over the course of two growing seasons (2016 and 2017) this stakeholder group assessed the potential of NUF to support smallholder vegetable production (i.e., cabbage). First, we adopted a randomized complete block design incorporating five treatments in season 1 (unfertilized control, nitrified urine, nitrified urine+bone meal, urea, and urea+diammonium phosphate (DAP) and six treatments (unfertilized control, urea, urea+DAP, DAP, nitrified urine, and nitrified urine+DAP) in season 2 to assess cabbage yield and leaf nutrient concentration (sodium, phosphorus, potassium, carbon, nitrogen). Although we observed large variability in yields, the urine-based treatments were as effective as any of the chemical fertilizers. Second, beyond the biophysical analysis, we elicited the challenges and opportunities of the smallholder farmers in our stakeholder group, as well as their attitudes toward the use of NUF as a fertilizer. Through this qualitative work, farmers indicated that their attitudes about the use of NUF as a fertilizer improved and that they would be willing to incorporate this product into their production practices if it was available at scale. Thus, we demonstrate the potential of participatory action research to co-produce knowledge and awareness around an innovative technology. In so doing, we provide evidence that this approach can support a change toward nutrient recycling-based agriculture

Comment on `A scattering quantum circuit for measuring Bell's time inequality: a nuclear magnetic resonance demonstration using maximally mixed states'

A recent paper by Souza, Oliveira and Sarthour (SOS) reports the experimental violation of a Leggett-Garg inequality (sometimes referred to as a temporal Bell inequality). The inequality tests for quantum mechanical superposition: if the inequality is violated, the dynamics cannot be explained by a large class of classical theories under the heading of macrorealism. Experimental tests of the LG inequality are beset by the difficulty of performing the necessary so-called 'non-invasive' measurements (which for the macrorealist will extract information from a system of interest without disturbing it). SOS argue that they nevertheless achieve this difficult goal by putting the system in a maximally mixed state. The system then allegedly undergoes no perturbation during their experiment. Unfortunately the method is ultimately unconvincing to a skeptical macrorealist, and so the conclusions drawn by SOS are unjustified.Comment: 6 pages, 1 figur

Transplantation of Renal Allografts From Organ Donors Reactive for HCV Antibodies to HCV-Negative Recipients: Safety and Clinical Outcome

IntroductionBecause of the shortage of available organs for renal transplantation, strategies enabling the safe use of organs from donors with potential chronic infections such as hepatitis C are necessary. The aim of this study was to analyze the outcome of renal transplant donation from hepatitis C virus (HCV)-positive donors.MethodsBetween September 2002 and May 2007, 51 kidneys (34 donors) reactive for HCV antibodies were further evaluated. Six kidneys (5 donors) were transplanted to 6 recipients with known chronic HCV infection. The remaining 29 donors underwent extended virological testing. Nine donors were HCV RNA positive and thus not suitable for HCV-negative patients. Twenty donors (21 kidneys) did not have detectable HCV RNA copies and were transplanted into 21 HCV-negative recipients. Clinical outcomes focusing on safety, allograft function, and de novo HCV infection in the recipient were collected.ResultsThere were no de novo HCV infections detected in recipients who were HCV negative before transplantation. The extended virological donor screening did not have an impact on median cold ischemia time. Five-year graft survival was 75%.DiscussionOrgans from anti-HCV-reactive, nonviremic donors can be transplanted safely to HCV-negative recipients

Like a thief in the night : Agamben, Hobbes and the messianic transvaluation of security

The article addresses the reinterpretation of the problematic of security in the messianic turn in contemporary continental political thought. I focus on Giorgio Agamben's reinterpretation of Hobbes's Leviathan in Stasis, which restores an eschatological dimension to this foundational text of modern security politics. Hobbes's commonwealth has been traditionally read as a secularized version of the katechon, a force that restrains the state of nature while drawing on its resources. Instead, Agamben argues that for Hobbes, the state is neither the analogue of God's kingdom on earth nor the katechon that delays its arrival, but the profane power that will disappear when the kingdom of God is established on earth. It is thus in principle incapable of attaining the peace and security that it claims to provide, perpetually producing insecurity and violence in the guise of protection. In Agamben's reading, it is precisely this failure of the state's security apparatuses that assists the advent of the messianic event in an oblique fashion. The exposure of this failure does not aspire to the improvement of the apparatuses of security or resign us to inescapable insecurity but only affirms the need to render the present apparatuses inoperative, bringing forth a future without them.Peer reviewe

European recommendations integrating genetic testing into multidisciplinary management of sudden cardiac death.

Sudden cardiac death (SCD) accounts for 10-20% of total mortality, i.e., one in five individuals will eventually die suddenly. Given the substantial genetic component of SCD in younger cases, postmortem genetic testing may be particularly useful in elucidating etiological factors in the cause of death in this subset. The identification of genes responsible for inherited cardiac diseases have led to the organization of cardiogenetic consultations in many countries worldwide. Expert recommendations are available, emphasizing the importance of genetic testing and appropriate information provision of affected individuals, as well as their relatives. However, the context of postmortem genetic testing raises some particular ethical, legal, and practical (including economic or financial) challenges. The Public and Professional Policy Committee of the European Society of Human Genetics (ESHG), together with international experts, developed recommendations on management of SCD after a workshop sponsored by the Brocher Foundation and ESHG in November 2016. These recommendations have been endorsed by the ESHG Board, the European Council of Legal Medicine, the European Society of Cardiology working group on myocardial and pericardial diseases, the ERN GUARD-HEART, and the Association for European Cardiovascular Pathology. They emphasize the importance of increasing the proportion of both medical and medicolegal autopsies and educating the professionals. Multidisciplinary collaboration is of utmost importance. Public funding should be allocated to reach these goals and allow public health evaluation

Risk of depression, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis:a multinational network cohort study

Objectives: Concern has been raised in the rheumatology community regarding recent regulatory warnings that HCQ used in the coronavirus disease 2019 pandemic could cause acute psychiatric events. We aimed to study whether there is risk of incident depression, suicidal ideation or psychosis associated with HCQ as used for RA.Methods: We performed a new-user cohort study using claims and electronic medical records from 10 sources and 3 countries (Germany, UK and USA). RA patients ≥18 years of age and initiating HCQ were compared with those initiating SSZ (active comparator) and followed up in the short (30 days) and long term (on treatment). Study outcomes included depression, suicide/suicidal ideation and hospitalization for psychosis. Propensity score stratification and calibration using negative control outcomes were used to address confounding. Cox models were fitted to estimate database-specific calibrated hazard ratios (HRs), with estimates pooled where I2 &lt;40%.Results: A total of 918 144 and 290 383 users of HCQ and SSZ, respectively, were included. No consistent risk of psychiatric events was observed with short-term HCQ (compared with SSZ) use, with meta-analytic HRs of 0.96 (95% CI 0.79, 1.16) for depression, 0.94 (95% CI 0.49, 1.77) for suicide/suicidal ideation and 1.03 (95% CI 0.66, 1.60) for psychosis. No consistent long-term risk was seen, with meta-analytic HRs of 0.94 (95% CI 0.71, 1.26) for depression, 0.77 (95% CI 0.56, 1.07) for suicide/suicidal ideation and 0.99 (95% CI 0.72, 1.35) for psychosis.Conclusion: HCQ as used to treat RA does not appear to increase the risk of depression, suicide/suicidal ideation or psychosis compared with SSZ. No effects were seen in the short or long term. Use at a higher dose or for different indications needs further investigation.Trial registration: Registered with EU PAS (reference no. EUPAS34497; http://www.encepp.eu/encepp/viewResource.htm? id=34498). The full study protocol and analysis source code can be found at https://github.com/ohdsi-studies/Covid19EstimationHydroxychloroquine2.</p