Magnetic order and frustrated dynamics in Li(Ni0.8Co0.1Mn0.1)O2: a study by {\mu}+SR and SQUID magnetometry

Recently, the mixed transition metal oxides of the form Li(Ni1-y-zCoyMnz)O2, have become the center of attention as promising candidates for novel battery material. These materials have also revealed very interesting magnetic properties due to the alternate stacking of planes of metal oxides on a 2D triangular lattice and the Li-layers. The title compound, Li(Ni0.8Co0.1Mn0.1)O2, has been investigated by both magnetometry and measurements and {\mu}+SR. We find the evolution of localized magnetic moments with decreasing temperature below 70 K. The magnetic ground state (T = 2 K) is, however, shown to be a frustrated system in 3D, followed by a transition into a possible 2D spinglass above 22 K. With further increasing temperature the compound show the presence of remaining correlations with increasing effective dimensionality all the way up to the ferrimagnetic transition at TC = 70 K.Comment: Accepted for publication in Physics Procedia (muSR2011 Conference

The Pfaffian quantum Hall state made simple--multiple vacua and domain walls on a thin torus

We analyze the Moore-Read Pfaffian state on a thin torus. The known six-fold degeneracy is realized by two inequivalent crystalline states with a four- and two-fold degeneracy respectively. The fundamental quasihole and quasiparticle excitations are domain walls between these vacua, and simple counting arguments give a Hilbert space of dimension $2^{n-1}$ for $2n-k$ holes and $k$ particles at fixed positions and assign each a charge $\pm e/4$. This generalizes the known properties of the hole excitations in the Pfaffian state as deduced using conformal field theory techniques. Numerical calculations using a model hamiltonian and a small number of particles supports the presence of a stable phase with degenerate vacua and quarter charged domain walls also away from the thin torus limit. A spin chain hamiltonian encodes the degenerate vacua and the various domain walls.Comment: 4 pages, 1 figure. Published, minor change

Spin chain description of rotating bosons at ν=1\nu=1

We consider bosons at Landau level filling $\nu=1$ on a thin torus. In analogy with previous work on fermions at filling $\nu =1/2$, we map the low-energy sector onto a spin-1/2 chain. While the fermionic system may realize the gapless XY-phase, we show that typically this does not happen for the bosonic system. Instead, both delta function and Coulomb interaction lead to gapped phases in the bosonic system, and in particular we identify a phase corresponding to the non-abelian Moore-Read state. In the spin language, the hamiltonian is dominated by a ferromagnetic next-nearest neighbor interaction, which leads to a description consistent with the non-trivial degeneracies of the ground and excited states of this phase of matter. In addition we comment on the similarities and differences of the two systems mentioned above and fermions at $\nu=5/2$.Comment: Published. 19 pages, 4 figure

Lithium Diffusion & Magnetism in Battery Cathode Material LixNi1/3Co1/3Mn1/3O2

We have studied low-temperature magnetic properties as well as high-temperature lithium ion diffusion in the battery cathode materials LixNi1/3Co1/3Mn1/3O2 by the use of muon spin rotation/relaxation. Our data reveal that the samples enter into a 2D spin-glass state below TSG=12 K. We further show that lithium diffusion channels become active for T>Tdiff=125 K where the Li-ion hopping-rate [nu(T)] starts to increase exponentially. Further, nu(T) is found to fit very well to an Arrhenius type equation and the activation energy for the diffusion process is extracted as Ea=100 meV.Comment: Submitted to Journal of Physics: Conference Series (2014

Fractional domain walls from on-site softening in dipolar bosons

We study dipolar bosons in a 1D optical lattice and identify a region in parameter space---strong coupling but relatively weak on-site repulsion---hosting a series of stable charge-density-wave (CDW) states whose low-energy excitations, built from "fractional domain walls," have remarkable similarities to those of non-Abelian fractional quantum Hall states. Here, a conventional domain wall between translated CDW's may be split by inserting strings of degenerate, but inequivalent, CDW states. Outside these insulating regions, we find numerous supersolids as well as a superfluid regime. The mentioned phases should be accessible experimentally and, in particular, the fractional domain walls can be created in the ground state using single-site addressing, i.e., by locally changing the chemical potential.Comment: 6 pages, 3 figures. Extended discussion. As publishe

Identification of an N-hydroxyguanidine reducing activity of xanthine oxidase

A guanoxabenz [1-(2,6-dichlorobenzylideneamino)-3-hydroxyguanidine; an N-hydroxyguanidine] reducing enzymatic activity of rat spleen cytosol was investigated by means of protein purification and N-terminal amino acid sequencing, the reducing activity was shown to reside in xanthine oxidase. The action of the enzyme on guanoxabenz resulted in the formation of guanabenz [1-(2,6-dichlorobenzylideneamino) -3-guanidine]; the product formation could be monitored by HPLC and its identity was confirmed by NMR analysis. The reduction of guanoxabenz required xanthine or NADH as reducing substrates, while the process could be blocked by allopurinol, a selective inhibitor of xanthine oxidase. By using bovine milk xanthine oxidase, the guanoxabenz reducing activity of the enzyme was also verified. We conclude that guanoxabenz is a novel electron acceptor structure for xanthine oxidase.publishersversionPeer reviewe

Bioclipse-R: integrating management and visualization of life science data with statistical analysis

SUMMARY: Bioclipse, a graphical workbench for the life sciences, provides functionality for managing and visualizing life science data. We introduce Bioclipse-R, which integrates Bioclipse and the statistical programming language R. The synergy between Bioclipse and R is demonstrated by the construction of a decision support system for anticancer drug screening and mutagenicity prediction, which shows how Bioclipse-R can be used to perform complex tasks from within a single software system. Availability and implementation: Bioclipse-R is implemented as a set of Java plug-ins for Bioclipse based on the R-package rj. Source code and binary packages are available from https://github.com/bioclipse and http://www.bioclipse.net/bioclipse-r, respectively. CONTACT: [email protected] SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online

Cryogenic and vacuum sectorisation of the LHC arcs

Following the recommendation of the LHC TC of June 20th, 1995 to introduce a separate cryogenic distribution line (QRL), which opened the possibility to have a finer cryogenic and vacuum sectorisation of the LHC machine than the original 8 arcs scheme, a working group was set up to study the implications: technical feasibility, advantages and drawbacks as well as cost of such a sectorisation (DG/DI/LE/dl, 26 July 1995). This report presents the conclusions of the Working Group. In the LHC Conceptual Design Report, ref. CERN/AC/95-05 (LHC), 20 October 1995, the so-called "Yellow Book", a complete cryostat arc (~ 2.9 km) would have to be warmed up in order to replace a defective cryomagnet. Even by coupling the two large refrigerators feeding adjacent arcs at even points to speed up the warm-up and cool down of one arc, the minimum down-time of the machine needed to replace a cryomagnet would be more than a full month (and even 52 days with only one cryoplant). Cryogenic and vacuum sectorisation of an arc into smaller sectors is technically feasible and would allow to reduce the down-times considerably (by one to three weeks with four sectors of 750 m in length, with respectively two or one cryoplants). In addition, sectorisation of the arcs may permit a more flexible quality control and commissioning of the main machine systems, including cold testing of small magnet strings. Sectorisation, described in detail in the following paragraphs, consists essentially of installing several additional cryogenic and vacuum valves as well as some insulation vacuum barriers. Additional cryogenic valves are needed in the return lines of the circuits feeding each half-cell in order to complete the isolation of the cryoline QRL from the machine, allowing intervention (i.e. venting to atmospheric pressure) on machine sectors without affecting the rest of an arc. Secondly, and for the same purpose, special vacuum and cryogenic valves must be installed, at the boundaries of machine sectors, for the circuits not passing through the cryoline QRL. Finally, some additional vacuum barriers must be installed around the magnet cold masses to divide the insulation vacuum of the magnet cryostats into independent sub-sectors, permitting to keep under insulating vacuum the cryogenically floating cold masses, while a sector (or part of it) is warmed up and opened to atmosphere. A reasonable scenario of sectorisation, namely with four 650-750 m long sectors per arc, and each consisting of 3 or 4 insulation vacuum sub-sectors with two to four half-cells, would represent an additional total cost of about 6.6 MCHF for the machine. It is estimated that this capital investment would be paid off by time savings in less than three long unscheduled interventions such as the change of a cryomagnet

Epigenetic alterations in skin homing CD4+CLA+ T cells of atopic dermatitis patients

T cells expressing the cutaneous lymphocyte antigen (CLA) mediate pathogenic inflammation in atopic dermatitis (AD). The molecular alterations contributing to their dysregulation remain unclear. With the aim to elucidate putative altered pathways in AD we profiled DNA methylation levels and miRNA expression in sorted T cell populations (CD4+, CD4+CD45RA+ naïve, CD4+CLA+, and CD8+) from adult AD patients and healthy controls (HC). Skin homing CD4+CLA+ T cells from AD patients showed significant differences in DNA methylation in 40 genes compared to HC (p < 0.05). Reduced DNA methylation levels in the upstream region of the interleukin-13 gene (IL13) in CD4+CLA+ T cells from AD patients correlated with increased IL13 mRNA expression in these cells. Sixteen miRNAs showed differential expression in CD4+CLA+ T cells from AD patients targeting genes in 202 biological processes (p < 0.05). An integrated network analysis of miRNAs and CpG sites identified two communities of strongly interconnected regulatory elements with strong antagonistic behaviours that recapitulated the differences between AD patients and HC. Functional analysis of the genes linked to these communities revealed their association with key cytokine signaling pathways, MAP kinase signaling and protein ubiquitination. Our findings support that epigenetic mechanisms play a role in the pathogenesis of AD by affecting inflammatory signaling molecules in skin homing CD4+CLA+ T cells and uncover putative molecules participating in AD pathways. © 2020, The Author(s).Peer reviewe