253 research outputs found
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Structural studies of conformationally-restricted ligands binding to aspartic peptidases.
Layered architecture for quantum computing
We develop a layered quantum computer architecture, which is a systematic
framework for tackling the individual challenges of developing a quantum
computer while constructing a cohesive device design. We discuss many of the
prominent techniques for implementing circuit-model quantum computing and
introduce several new methods, with an emphasis on employing surface code
quantum error correction. In doing so, we propose a new quantum computer
architecture based on optical control of quantum dots. The timescales of
physical hardware operations and logical, error-corrected quantum gates differ
by several orders of magnitude. By dividing functionality into layers, we can
design and analyze subsystems independently, demonstrating the value of our
layered architectural approach. Using this concrete hardware platform, we
provide resource analysis for executing fault-tolerant quantum algorithms for
integer factoring and quantum simulation, finding that the quantum dot
architecture we study could solve such problems on the timescale of days.Comment: 27 pages, 20 figure
The Art of Hegel's Aesthetics. Hegelian Philosophy and the Perspectives of Art History
This volume explores one of modernity’s most profound and far-reaching philosophies of art: the Vorlesungen über die Ästhetik, delivered by Georg Friedrich Wilhelm Hegel in the 1820s. The book has two overriding objectives: first, to ask how Hegel’s work illuminates specific periods and artworks in light of contemporary art-historical discussions; second, to explore how art history helps us make better sense and use of Hegelian aesthetics.
In bringing together a range of internationally acclaimed critical voices, the volume establishes an important disciplinary bridge between aesthetics and art history. Given the recent resurgence of interest in ‘global’ art history, and calls for more comparative approaches to ‘visual culture’, contributors ask what role Hegel has played within the field – and what role he could play in the future. What can a historical treatment of art accomplish? How should we explain the ‘need’ for certain artistic forms at different historical junctures? Has art history been ‘Hegelian’ without fully acknowledging it? Indeed, have art historians shirked some of the fundamental questions that Hegel raised
Risk Factors for Post-ERCP Pancreatitis: A Prospective Multicenter Study
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75082/1/j.1572-0241.2006.00380.x.pd
A CESA from Griffithsia monilis (Rhodophyta, Florideophyceae) has a family 48 carbohydrate-binding module
Cellulose synthases form rosette terminal complexes in the plasma membranes of Streptophyta and various linear terminal complexes in other taxa. The sequence of a putative CESA from Griffithsia monilis (Rhodophyta, Floridiophyceae) was deduced using a cloning strategy involving degenerate primers, a cDNA library screen, and 5′ and 3′ rapid amplification of cDNA ends (RACE). RACE identified two alternative transcriptional starts and four alternative polyadenylation sites. The first translation start codon provided an open reading frame of 2610 bp encoding 870 amino acids and was PCR amplified without introns from genomic DNA. Southern hybridization indicated one strongly hybridizing gene with possible weakly related genes or pseudogenes. Amino acid sequence analysis identified a family 48 carbohydrate-binding module (CBM) upstream of the protein's first predicted transmembrane domain. There are broad similarities in predicted 3D structures of the family 48 modules from CESA, from several glycogen- and starch-binding enzymes, and from protein kinases, but there are substitutions at some residues thought to be involved in ligand binding. The module in G. monilis CESA will be on the cytoplasmic face of the plasma membrane so that it could potentially bind either low molecular weight ligands or starch which is cytosolic rather than inside membrane-bound plastids in red algae. Possible reasons why red algal CESAs have evolved family 48 modules perhaps as part of a system to regulate cellulose synthase activity in relation to cellular carbohydrate status are briefly discussed
Radio continuum observations of Class I protostellar disks in Taurus: constraining the greybody tail at centimetre wavelengths
We present deep 1.8 cm (16 GHz) radio continuum imaging of seven young
stellar objects in the Taurus molecular cloud. These objects have previously
been extensively studied in the sub-mm to NIR range and their SEDs modelled to
provide reliable physical and geometrical parametres.We use this new data to
constrain the properties of the long-wavelength tail of the greybody spectrum,
which is expected to be dominated by emission from large dust grains in the
protostellar disk. We find spectra consistent with the opacity indices expected
for such a population, with an average opacity index of beta = 0.26+/-0.22
indicating grain growth within the disks. We use spectra fitted jointly to
radio and sub-mm data to separate the contributions from thermal dust and radio
emission at 1.8 cm and derive disk masses directly from the cm-wave dust
contribution. We find that disk masses derived from these flux densities under
assumptions consistent with the literature are systematically higher than those
calculated from sub-mm data, and meet the criteria for giant planet formation
in a number of cases.Comment: submitted MNRA
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