873 research outputs found
Finitely generated free Heyting algebras via Birkhoff duality and coalgebra
Algebras axiomatized entirely by rank 1 axioms are algebras for a functor and
thus the free algebras can be obtained by a direct limit process. Dually, the
final coalgebras can be obtained by an inverse limit process. In order to
explore the limits of this method we look at Heyting algebras which have mixed
rank 0-1 axiomatizations. We will see that Heyting algebras are special in that
they are almost rank 1 axiomatized and can be handled by a slight variant of
the rank 1 coalgebraic methods
Neurogenesis Drives Stimulus Decorrelation in a Model of the Olfactory Bulb
The reshaping and decorrelation of similar activity patterns by neuronal
networks can enhance their discriminability, storage, and retrieval. How can
such networks learn to decorrelate new complex patterns, as they arise in the
olfactory system? Using a computational network model for the dominant neural
populations of the olfactory bulb we show that fundamental aspects of the adult
neurogenesis observed in the olfactory bulb -- the persistent addition of new
inhibitory granule cells to the network, their activity-dependent survival, and
the reciprocal character of their synapses with the principal mitral cells --
are sufficient to restructure the network and to alter its encoding of odor
stimuli adaptively so as to reduce the correlations between the bulbar
representations of similar stimuli. The decorrelation is quite robust with
respect to various types of perturbations of the reciprocity. The model
parsimoniously captures the experimentally observed role of neurogenesis in
perceptual learning and the enhanced response of young granule cells to novel
stimuli. Moreover, it makes specific predictions for the type of odor
enrichment that should be effective in enhancing the ability of animals to
discriminate similar odor mixtures
First principles theory of inelastic currents in a scanning tunneling microscope
A first principles theory of inelastic tunneling between a model probe tip
and an atom adsorbed on a surface is presented, extending the elastic tunneling
theory of Tersoff and Hamann. The inelastic current is proportional to the
change in the local density of states at the center of the tip due to the
addition of the adsorbate. We use the theory to investigate the vibrational
heating of an adsorbate below an STM tip. We calculate the desorption rate of H
from Si(100)-H(21) as function of the sample bias and tunnel current,
and find excellent agreement with recent experimental data.Comment: 5 pages, RevTeX, epsf file
Static charged perfect fluid spheres in general relativity
Interior perfect fluid solutions for the Reissner-Nordstrom metric are
studied on the basis of a new classification scheme. General formulas are found
in many cases. Explicit new global solutions are given as illustrations. Known
solutions are briefly reviewed.Comment: 23 pages, Revtex (galley), journal version, to appear in Phys.Rev.
The impact of different DNA extraction kits and laboratories upon the assessment of human gut microbiota composition by 16S rRNA gene sequencing
Peer reviewedPublisher PD
Routine screening of harmful microorganisms in beach sands: implications to public health
Beaches worldwide provide recreational opportunities to hundreds of millions of people and serve as important components of coastal economies. Beach water is often monitored for microbiological quality to detect the presence of indicators of human sewage contamination so as to prevent public health outbreaks associated with water contact. However, growing evidence suggests that beach sand can harbor microbes harmful to human health, often in concentrations greater than the beach water. Currently, there are no standards for monitoring, sampling, analyzing, or managing beach sand quality. In addition to indicator microbes, growing evidence has identified pathogenic bacteria, viruses, and fungi in a variety of beach sands worldwide. The public health threat associated with these populations through direct and indirect contact is unknown because so little research has been conducted relating to health outcomes associated with sand quality. In this manuscript, we present the consensus findings of a workshop of experts convened in Lisbon, Portugal to discuss the current state of knowledge on beach sand microbiological quality and to develop suggestions for standardizing the evaluation of sand at coastal beaches. The expert group at the "Microareias 2012" workshop recommends that 1) beach sand should be screened for a variety of pathogens harmful to human health, and sand monitoring should then be initiated alongside regular water monitoring; 2) sampling and analysis protocols should be standardized to allow proper comparisons among beach locations; and 3) further studies are needed to estimate human health risk with exposure to contaminated beach sand. Much of the manuscript is focused on research specific to Portugal, but similar results have been found elsewhere, and the findings have worldwide implications
Principles of Glomerular Organization in the Human Olfactory Bulb – Implications for Odor Processing
Olfactory sensory neurons (OSN) in mice express only 1 of a possible 1,100 odor receptors (OR) and axons from OSNs expressing the same odor receptor converge into ∼2 of the 1,800 glomeruli in each olfactory bulb (OB) in mice; this yields a convergence ratio that approximates 2∶1, 2 glomeruli/OR. Because humans express only 350 intact ORs, we examined human OBs to determine if the glomerular convergence ratio of 2∶1 established in mice was applicable to humans. Unexpectedly, the average number of human OB glomeruli is >5,500 yielding a convergence ratio of ∼16∶1. The data suggest that the initial coding of odor information in the human OB may differ from the models developed for rodents and that recruitment of additional glomeruli for subpopulations of ORs may contribute to more robust odor representation
Routine screening of harmful microorganisms in beach sands: implications to public health
Beaches worldwide provide recreational opportunities to hundreds of millions of people and serve as important components of coastal economies. Beach water is often monitored for microbiological quality to detect the presence of indicators of human sewage contamination so as to prevent public health outbreaks associated with water contact. However, growing evidence suggests that beach sand can harbor microbes harmful to human health, often in concentrations greater than the beach water. Currently, there are no standards for monitoring, sampling, analyzing, or managing beach sand quality. In addition to indicator microbes, growing evidence has identified pathogenic bacteria, viruses, and fungi in a variety of beach sands worldwide. The public health threat associated with these populations through direct and indirect contact is unknown because so little research has been conducted relating to health outcomes associated with sand quality. In this manuscript, we present the consensus findings of a workshop of experts convened in Lisbon, Portugal to discuss the current state of knowledge on beach sand microbiological quality and to develop suggestions for standardizing the evaluation of sand at coastal beaches. The expert group at the "Microareias 2012" workshop recommends that 1) beach sand should be screened for a variety of pathogens harmful to human health, and sand monitoring should then be initiated alongside regular water monitoring; 2) sampling and analysis protocols should be standardized to allow proper comparisons among beach locations; and 3) further studies are needed to estimate human health risk with exposure to contaminated beach sand. Much of the manuscript is focused on research specific to Portugal, but similar results have been found elsewhere, and the findings have worldwide implications
Triangleland. I. Classical dynamics with exchange of relative angular momentum
In Euclidean relational particle mechanics, only relative times, relative
angles and relative separations are meaningful. Barbour--Bertotti (1982) theory
is of this form and can be viewed as a recovery of (a portion of) Newtonian
mechanics from relational premises. This is of interest in the absolute versus
relative motion debate and also shares a number of features with the
geometrodynamical formulation of general relativity, making it suitable for
some modelling of the problem of time in quantum gravity. I also study
similarity relational particle mechanics (`dynamics of pure shape'), in which
only relative times, relative angles and {\sl ratios of} relative separations
are meaningful. This I consider firstly as it is simpler, particularly in 1 and
2 d, for which the configuration space geometry turns out to be well-known,
e.g. S^2 for the `triangleland' (3-particle) case that I consider in detail.
Secondly, the similarity model occurs as a sub-model within the Euclidean
model: that admits a shape--scale split. For harmonic oscillator like
potentials, similarity triangleland model turns out to have the same
mathematics as a family of rigid rotor problems, while the Euclidean case turns
out to have parallels with the Kepler--Coulomb problem in spherical and
parabolic coordinates. Previous work on relational mechanics covered cases
where the constituent subsystems do not exchange relative angular momentum,
which is a simplifying (but in some ways undesirable) feature paralleling
centrality in ordinary mechanics. In this paper I lift this restriction. In
each case I reduce the relational problem to a standard one, thus obtain
various exact, asymptotic and numerical solutions, and then recast these into
the original mechanical variables for physical interpretation.Comment: Journal Reference added, minor updates to References and Figure
Foundations of Relational Particle Dynamics
Relational particle dynamics include the dynamics of pure shape and cases in
which absolute scale or absolute rotation are additionally meaningful. These
are interesting as regards the absolute versus relative motion debate as well
as discussion of conceptual issues connected with the problem of time in
quantum gravity. In spatial dimension 1 and 2 the relative configuration spaces
of shapes are n-spheres and complex projective spaces, from which knowledge I
construct natural mechanics on these spaces. I also show that these coincide
with Barbour's indirectly-constructed relational dynamics by performing a full
reduction on the latter. Then the identification of the configuration spaces as
n-spheres and complex projective spaces, for which spaces much mathematics is
available, significantly advances the understanding of Barbour's relational
theory in spatial dimensions 1 and 2. I also provide the parallel study of a
new theory for which positon and scale are purely relative but orientation is
absolute. The configuration space for this is an n-sphere regardless of the
spatial dimension, which renders this theory a more tractable arena for
investigation of implications of scale invariance than Barbour's theory itself.Comment: Minor typos corrected; references update
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