Atomic Faraday filter with equivalent noise bandwidth less than 1 GHz

We demonstrate an atomic bandpass optical filter with an equivalent noise bandwidth less than 1 GHz using the D1 line in a cesium vapor. We use the ElecSus computer program to find optimal experimental parameters and find that, for important quantities, the cesium D1 line clearly outperforms other alkali metals on either D-lines. The filter simultaneously achieves a peak transmission of 77%, a passband of 310 MHz, and an equivalent noise bandwidth of 0.96 GHz, for a magnetic field of 45.3 G and a temperature of 68.0°C. Experimentally, the prediction from the model is verified. The experiment and theoretical predictions show excellent agreement

A novel, efficient synthesis of N-aryl pyrroles via reaction of 1-boronodienes with arylnitroso compounds

A one-pot hetero-Diels–Alder/ring contraction cascade is presented from the reaction of 1-boronodienes and arylnitroso derivatives to derive N-arylpyrroles in moderate to good yields (up to 82%)

An experimental and computational approach to understanding the reactions of acyl nitroso compounds in [4+2]-cycloadditions

Catalytic aerobic oxidation of phenyl hydroxycarbamate 1 and 1-hydroxy-3-phenylurea 2 using CuCl2 and 2-ethyl-2-oxazoline in methanol gave acyl nitroso species in situ, which were trapped in nitroso-Diels–Alder (NDA) reactions with various dienes to afford the corresponding cycloadducts in high yields (90–98%). Competing ene products were also present for dienes containing both alkene π-bonds and allylic σ-bonds, and the ene yields are higher with 1 than with 2. The use of the chiral hydroxamic acid, (R)-1-hydroxy-3-(1-phenylethylurea) 3 (same conditions) gave NDA cycloadducts in high yields (97–99%) with no ene product from 2,3-dimethyl-1,3-butadiene. NDA cycloadducts were not obtained from other hydroxamic acid analogues [RCONHOH (R = PhCH2 4; Ph(CH2)2 5; Ph(CH2)3 6; Ph(CH2)4 7; Ph 8; 2-pyridyl 9; 3-pyridyl 10] with various dienes using copper-oxidation but rather were obtained using sodium periodate, resulting in variable NDA yields (13–51%) from hydroxamic acids 1–10 with cyclohexa-1,3-diene and 2,3-dimethyl-1,3-butadiene (several cycloadducts characterized by X-ray crystallography). The NDA and nitroso-ene reaction pathways of nitroso intermediates with dienes were mapped by DFT computations (B3LYP/6-31G*), which showed that the acyl nitroso species are super-reactive and that activation energies in the NDA processes are lower than the isomerization barriers between some cis- and trans-butadienes

Reconstruction of subgrid scale topographic variability and its effect upon the spatial structure of three dimensional river flow

A new approach to describing the associated topography at different scales in computational fluid dynamic applications to gravel bed rivers was developed. Surveyed topographic data were interpolated, using geostatistical methods, into different spatial discretizations, and grain-size data were used with fractal methods to reconstruct the microtopography at scales finer than the measurement (subgrid) scale. The combination of both scales of topography was then used to construct the spatial discretization of a three-dimensional finite volume Computational Fluid Dynamics (CFD) scheme where the topography was included using a mass flux scaling approach. The method was applied and tested on a 15 m stretch of Solfatara Creek, Wyoming, United States, using spatially distributed elevation and grain-size data. Model runs were undertaken for each topography using a steady state solution. This paper evaluates the impact of the model spatial discretization and additional reconstructed-variability upon the spatial structure of predicted three-dimensional flow. The paper shows how microtopography modifies the spatial structure of predicted flow at scales finer than measurement scale in terms of variability whereas the characteristic scale of predicted flow is determined by the CFD scale. Changes in microtopography modify the predicted mean velocity value by 3.6% for a mesh resolution of 5 cm whereas a change in the computational scale modifies model results by 60%. The paper also points out how the spatial variability of predicted velocities is determined by the topographic complexity at different scales of the input topographic model

KRAS mutation testing of tumours in adults with metastatic colorectal cancer: a systematic review and cost-effectiveness analysis

__Abstract__ Background: Bowel cancer is the third most common cancer in the UK. Most bowel cancers are initially treated with surgery, but around 17% spread to the liver. When this happens, sometimes the liver tumour can be treated surgically, or chemotherapy may be used to shrink the tumour to make surgery possible. Kirsten rat sarcoma viral oncogene (KRAS) mutations make some tumours less responsive to treatment with biological therapies such as cetuximab. There are a variety of tests available to detect these mutations. These vary in the specific mutations that they detect, the amount of mutation they detect, the amount of tumour cells needed, the time to give a result, the error rate and cost. Objectives: To compare the performance and cost-effectiveness of KRAS mutation tests in differentiating adults with metastatic colorectal cancer whose metastases are confined to the liver and are unresectable and who may benefit from first-line treatment with cetuximab in combination with standard chemotherapy from those who should receive standard chemotherapy alone

High-sensitivity troponin assays for the early rule-out or diagnosis of acute myocardial infarction in people eith acute chest pain: a systematic review and cost-effectiveness analysis

Background: Early diagnosis of acute myocardial infarction (AMI) can ensure quick and effective treatment but only 20% of adults with emergency admissions fo

Translation to practice: a randomised controlled study of an evidenced based booklet targeted at breast care nurses in the United Kingdom

BACKGROUND: In the United Kingdom (UK), it was documented that a problem of knowledge transfer existed within the speciality of breast-cancer care, thus depriving patients of receiving optimal care. Despite increasingly robust research evidence indicating recommendation of whole body exercise for people affected by breast cancer, commensurate changes to practice were not noted amongst breast-care nurses (BCNs). AIM: To evaluate the effect of a targeted booklet, Exercise and Breast Cancer: A Booklet for Breast-Care Nurses, on changes in knowledge, reported practice, and attitudes of BCNs in the UK. METHOD: A prospective, experimental approach was used for designing a pre- and post-test randomised controlled study. Comparisons of knowledge, reported practice, and attitudes based on responses to a questionnaire were made at two time-points in two groups of BCNs (control and experimental). The unit of randomisation and analysis was hospital clusters of BCNs. The sample comprised 92 nurses from 62 hospitals. Analysis consisted of descriptive statistics and clustered regression techniques: clustered logistic regression for knowledge items, clustered linear regression for knowledge scores, ologit for attitude and reported practice items, and clustered multiple regression for paired and multiple variable analysis. RESULTS: A statistically significant increase in knowledge and changes in reported practice and attitudes were found. Robust variables affecting knowledge acquisition were: promotion of health, promotion of exercise, and understanding how exercise can reduce cancer-related fatigue. DISCUSSION: The study has shown that evidence-based printed material, such as an information booklet, can be used as an effective research dissemination method when developed for needs, values, and context of a target audience. CONCLUSIONS: This practical approach to research dissemination could be replicated and applied to other groups of nurses.</p

Cost-effectiveness of high-sensitive troponin assays for the early rule-out or diagnosis of acute myocardial infarction (AMI) in people with acute chest pain:A nice diagnostic assessment

Objectives: To assess cost-effectiveness of high sensitivity troponin (hs-cTn) assays for the management of adults presenting with acute chest pain at the emergency department. Methods: An economic model was constructed to estimate lifetime costs and QALYs of five hs-cTn strategies (differing according to manufacturer, timing of the test, number of tests and cutoff point for a positive test result) compared to standard troponin (sTn) testing at presentation and at 10-12 hours, which was considered the reference standard. In the base case, it was assumed that sTn testing had perfect accuracy for diagnosing AMI and only patients with a positive test for sTn were at increased risk for adverse events and would benefit from immediate treatment. In a secondary analysis, a proportion of patients with a positive hs-cTn test and a negative sTn test were at increased risk for adverse events and would benefit from immediate treatment. Results: Base case: Strategies considered cost-effective depending upon ICER thresholds were Abbott ARCHITECT hs-cTnI 99th centile (thresholds £103,194). Secondary analysis: Strategies considered cost-effective were Abbott ARCHITECT hs-cTnI 99th centile ( £14,992). STn was dominated. Sensitivity/subgroup analyses: Main drivers are: the difference in outcomes between treated and untreated patients, and treatment costs for patients testing false-positive. Hs-cTn testing is more cost-effective in younger age, pre-existing coronary artery disease, and symptom onset <3hrs ago. No testing is only cost-effective when pre-test prevalence is 1%. Conclusions: There is no strong evidence to prefer one hs-cTn testing strategy over another. Results do indicate that hs-cTn testing in general may be cost-effective compared to sTn testing, especially in the secondary analysis

Gravity wave analogs of black holes

It is demonstrated that gravity waves of a flowing fluid in a shallow basin can be used to simulate phenomena around black holes in the laboratory. Since the speed of the gravity waves as well as their high-wavenumber dispersion (subluminal vs. superluminal) can be adjusted easily by varying the height of the fluid (and its surface tension) this scenario has certain advantages over the sonic and dielectric black hole analogs, for example, although its use in testing quantum effects is dubious. It can be used to investigate the various classical instabilities associated with black (and white) holes experimentally, including positive and negative norm mode mixing at horizons. PACS: 04.70.-s, 47.90.+a, 92.60.Dj, 04.80.-y.Comment: 14 pages RevTeX, 5 figures, section VI modifie