6 research outputs found
Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage
- Author
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Summary Tissue homeostasis requires maintenance of functional integrity under stress. A central source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how the genome is protected against mechanical stress is unclear. We show that mechanical stretch deforms the nucleus, which cells initially counteract via a calcium-dependent nuclear softening driven by loss of H3K9me3-marked heterochromatin. The resulting changes in chromatin rheology and architecture are required to insulate genetic material from mechanical force. Failure to mount this nuclear mechanoresponse results in DNA damage. Persistent, high-amplitude stretch induces supracellular alignment of tissue to redistribute mechanical energy before it reaches the nucleus. This tissue-scale mechanoadaptation functions through a separate pathway mediated by cell-cell contacts and allows cells/tissues to switch off nuclear mechanotransduction to restore initial chromatin state. Our work identifies an unconventional role of chromatin in altering its own mechanical state to maintain genome integrity in response to deformation.Peer reviewe
Anthropometric Dividends of Czechoslovakia's Break Up
- Author
- A Alesina
- A Alesina
- A Chanda
- A E J M Cavelaars
- A Guntupalli
- A Hill
- A I Meszaros
- A Innes
- A J Stunkard
- A K Sen
- A Meisel
- A S Blinder
- Abel Bojar
- Alison &
- Anna S Burger
- B A&apos
- B Bogin
- B Heyns
- B Jann
- B Milanovic
- Bojan Bugari?
- C Bozzoli
- C J Murray
- C Lawson
- C Masseria
- C S Leff
- Christopher Wratil
- D C North
- D Filmer
- D Friedman
- D Olson
- D Wittman
- D&apos
- Daniel Innerarity
- David M Woodroof
- E Arcaleni
- E Giles
- E Ginter
- Eri Bertsou
- F Cizmecioglu
- F Peracchi
- G A Cornia
- G Heineck
- J Bartosova
- J Baten
- J Costa-Font
- J Hausner
- J Komlos
- J Komlos
- J Komlos
- J Komlos
- J Komlos
- J Komlos
- J Nobles
- J Svejnar
- J Tavares
- J Vignerov�
- Joan &
- Joan Costa-Font
- K Silventoinen
- K Silventoinen
- L Christiaensen
- L Fedorov
- L Szamuely
- Lucia Kossarova
- Luigi Guiso
- M Bobak
- M Ezzati
- M Hiermeyer
- M Potucek
- M Simai
- M Sunder
- M Z Bookman
- Marcus Haverland
- Monastiriotis
- N Persico
- O Adeyi
- P B Eveleth
- P B Eveleth
- P Bolton
- P Pavl�nek
- Przeworski
- R D Salvatore
- R H Steckel
- R H Steckel
- Ricardo &
- Riccardo Crescenzi
- Richard Akresh
- S J Kirschbaum
- S M Collins
- S Stillman
- S Whitefield
- S Wolchik
- Simon Glendinning
- Systemic Center
- T Cox
- T Cvrcek
- T I Garner
- T Inglot
- T Inglot
- Tatiana &
- W Kostecki
- Will Bartlett
- Z Janik
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Democratic Responsiveness in the European Union: The Case of the Council
- Author
- Abel Bojar
- Alison &
- Andrea Volkens
- Andreas Follesdal
- Andrew Healy
- Andrew Moravcsik
- Anke Hassel
- Anna Aspelund
- Anna S Burger
- B Kvaloy
- Benjamin I Page
- Bojan Bugari?
- Brandice Canes-Wrone
- Cees Van Der Eijk
- Christina Zimmer
- Christine Arnold
- Christopher Wlezien
- Christopher Wlezien
- Christopher Wratil
- Clifford J Carrubba
- D&apos
- Daniel Innerarity
- Daniel Stevens
- Daphne J Van Der Pas
- David M Woodroof
- De Vreese
- De Vries
- De Vries
- De Vries
- De Vries
- De Vries
- Dimiter Toshkov
- Edward G Carmines
- Eri Bertsou
- Eric C Chang
- Eric Neumayer
- Erik R Tillman
- F Franchino
- Ferguson
- Gary Marks
- Gary Marks
- Gregory A Huber
- Hajo G Boomgaarden
- Hajo G Boomgaarden
- Hajo G Boomgaarden
- Harald Schoen
- Hermann Schmitt
- Hulda Thorisdottir
- J Cohrs
- J Cohrs
- Jacques J A Thomassen
- James A Stimson
- James A Stimson
- James D Fearon
- James Gwartney
- James H Kuklinski
- James M Snyder
- Jane Mansbridge
- Jeffrey R Lax
- Joan &
- Johan Hellstr�m
- John D Huber
- John D Huber
- John D Skrentny
- John Ferejohn
- Jorgen Bolstad
- Kim Hill
- Lawrence R Jacobs
- Leonard Ray
- Luigi Guiso
- Marco R Steenbergen
- Marcus Haverland
- Mark Kayser
- Martin Gilens
- Michael M Bechtel
- Mikko Mattila
- Monastiriotis
- Oddbj�rn Knutsen
- Patricia A Hurley
- Paul Burstein
- Philippe Thalmann
- Piurko
- R Rogowski
- Regina Vetters
- Ren� Lindst�dt
- Ricardo &
- Riccardo Crescenzi
- Richard C Elling
- Robert Dahl
- Robert J Barro
- Robert Rohrschneider
- Robert S Erikson
- Robert Thomson
- Robert Thomson
- Robert Thomson
- Rory Costello
- Ryan Bakker
- Sara B Hobolt
- Sara B Hobolt
- Sara B Hobolt
- Seymur M Lipset
- Silke Adam
- Simon Glendinning
- Simon Hix
- Simon Hix
- Stefanie Bailer
- Stephanie J Rickard
- Stephen Whitefield
- Stuart N Soroka
- Stuart N Soroka
- Tanja A B�rzel
- Tanja A B�rzel
- Tatiana &
- Timothy Besley
- Torsten Persson
- Van Der Brug
- Will Bartlett
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Russia: The Long Road to Ratification. Internal Institution and Pressure Groups in the Kyoto Protocol's Adoption Process
- Author
- A L D Paulo
- A Markandya
- Alberini Anna
- Alberini Anna
- Amir Rabah
- Ana Mauleon
- Anastasios Xepapadeas
- Andrea Bigano
- Antoci Angelo
- Arenas �lex
- Aussenegg Wolfgang
- Barbara Buchner
- Barbara Buchner
- Bela Gy�rgyi
- Bellettini Giorgio
- Ben Slim
- Birol Ekin
- Bjarne Brendstrup
- Bjorndal Trond
- Bob Van Der Zwaan
- Bortolotti Bernardo
- Bosello Francesco
- Bosetti Valentina
- Boubakri Narjess
- Brusco Sandro
- Br�uer Ingo
- C W Maarten
- Candela Guido
- Caparr�s Alejandro
- Carlo Carraro
- Cartwright Edward
- Cavaliere Alberto
- Chaib Linda
- Conrad Klaus
- Crespi Francesco
- Currarini Sergio
- D I Adolfo
- Dedeurwaerdere ( Tom
- Del Massimo
- Deru Ljiljana
- Diermeier Daniel
- Dimitrov Dinko
- E C M
- E C M Ruijgrok
- Eckert Franca
- Edi Defrancesco
- Elbert Dijkgraaf
- Eliaz Kfir
- Englmaier Florian
- Environment Climateark
- Escrihuela- Marc
- Fernando Vega-Redondo
- Ferro Nicoletta
- Fibich Gadi
- Finus Michael
- Finus Michael
- Finus Michael
- Finus Micheal
- Francis Bloch
- Francis Bloch
- Frantz David
- Fujita Masahisa
- Furusawa Taiji
- Galeotti Marzio
- Galeotti Marzio
- Galeotti Marzio
- Garratt Rod
- Giannis Vardas
- Ginsburgh Victor
- Giorgio Bellettini
- Giorgio Busetti
- Giovannini Massimo
- Glachant Matthieu
- Goeschl Timo
- Goeschl Timo
- Goeschl Timo
- Goyal Sanjeev
- Gustavo Berganti�os
- Hamde ( Kiflemariam
- Horbach Jens
- I P Gianmarco
- I P Gianmarco
- Izmalkov ( Sergei
- Jacqueline M
- Javier Rey
- Jean-Jacques Nowak
- Joseph E Aldy
- Jouvet Pierre-Andr�
- Juan Luis
- Kadan Ohad
- Klepper Gernot
- Koen Smekens
- Kokorin A. -Rutland P
- Korppoo A
- Kristine Crane (lxii
- Kristine Crane (lxviii
- Lanza Alessandro
- Maignan Carole
- Marcus A
- Margarita Genius
- Markandya Anil
- Matoba ( Kazuma
- Matthew Haag
- Mburu John
- Merk ( Vincent
- Michele Moretto
- Millock Katrin
- Natalya V Taranova (lxii
- O Matthew
- Odunga Pius
- Oreffice Sonia
- P C Ordeshook
- Papyrakis Elissaios
- Papyrakis Elissaios
- Pearce Richard
- Perez Wilson
- Petrucci Alberto
- Pichler Pegaret
- Piras Romano
- R Finn
- R J Herman
- Ra�l Hern�ndez
- Rehdanz Katrin
- Reis Catarina
- Ricci Francesco
- Rob Dellink
- Rolf Golombek
- Rolf Golombek
- Rosella Levaggi
- Sade Orly
- Salvador Barber�
- Santiago Rubio
- Sch�b Ronnie
- Scott Barrett
- Sebastian Bervoets
- Shareef ( Riaz
- Siddhartha Bandyopadhyay
- Signe Anthon
- Silvia Dall'Olio
- Simonia N
- Snyder Lori
- Snyder Lori
- Stryszowska Marta
- Trond Bj�rndal
- Wallman ( Sandra
- Weber ( Marian
- Weikard Hans-Peter
- Whitefield S
- World
- Zhang Zhongxiang
- � L�szl�
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2004
- Field of study
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