Alcohol assessment and feedback by email for university students: main findings from a randomised controlled trial.

BACKGROUND: Brief interventions can be efficacious in changing alcohol consumption and increasingly take advantage of the internet to reach high-risk populations such as students. AIMS: To evaluate the effectiveness of a brief online intervention, controlling for the possible effects of the research process. METHOD: A three-arm parallel groups design was used to explore the magnitude of the feedback and assessment component effects. The three groups were: alcohol assessment and feedback (group 1); alcohol assessment only without feedback (group 2); and no contact, and thus neither assessment nor feedback (group 3). Outcomes were evaluated after 3 months via an invitation to participate in a brief cross-sectional lifestyle survey. The study was undertaken in two universities randomising the email addresses of all 14 910 students (the AMADEUS-1 study, trial registration: ISRCTN28328154). RESULTS: Overall, 52% (n = 7809) of students completed follow-up, with small differences in attrition between the three groups. For each of the two primary outcomes, there was one statistically significant difference between groups, with group 1 having 3.7% fewer risky drinkers at follow-up than group 3 (P = 0.006) and group 2 scoring 0.16 points lower than group 3 on the three alcohol consumption questions from the Alcohol Use Disorders Identification Test (AUDIT-C) (P = 0.039). CONCLUSIONS: This study provides some evidence of population-level benefit attained through intervening with individual students

Stochastic superspace phenomenology at the Large Hadron Collider

We analyse restrictions on the stochastic superspace parameter space arising from 1 fb$^{-1}$ of LHC data, and bounds on sparticle masses, cold dark matter relic density and the branching ratio of the process $B_s \rightarrow \mu^+ \mu^-$. A region of parameter space consistent with these limits is found where the stochasticity parameter, \xi, takes values in the range -2200 GeV < \xi < -900 GeV, provided the cutoff scale is $\mathcal{O}(10^{18})$ GeV.Comment: 9 pages, 13 figure

Women, Domestic Violence Service Providers, and Knowledge of Technology-Related Abuse

Many victims of domestic violence face continued exposure to abuse through technology because intimate partners may use technology as weapon against them. Some domestic violence service professionals lack necessary information or training to educate victims. The impact on victims has not been thoroughly examined. The purpose of this qualitative case study was to assess the impact on women when domestic violence service providers do not provide current information about technology-related abuse to promote safety when providing service to victims. The conceptual framework was the Duluth model of power and control and the feminist perspective on intimate partner violence. The primary research question centered on the impact of domestic violence service providers\u27 knowledge of trending issues with technology-facilitated violence on victims after they seek assistance. Another research question concerned the role that the victim\u27s level of education plays in making protective decisions when using technology. The analytical procedures included taking notes, developing codes, and identifying themes. A conclusion was that domestic violence service providers are not consistently soliciting information on technology-facilitated abuse at the point of service and that some victims are continuing to experience technology-facilitated abuse and subsequent emotional and psychological trauma. Additionally, a woman\u27s level of education is not associated with following proper safety protocols when using technology. Implications for social change include consistent legislation by policy makers and improved dissemination of information about technology-facilitated abuse by governments, courts, law enforcement, and advocacy groups

Alcohol assessment & feedback by e-mail for university student hazardous and harmful drinkers: study protocol for the AMADEUS-2 randomised controlled trial.

BACKGROUND: Alcohol is responsible for a large and growing proportion of the global burden of disease, as well as being the cause of social problems. Brief interventions are one component of comprehensive policy measures necessary to reduce these harms. Brief interventions increasingly take advantage of the Internet to reach large numbers of high risk groups such as students. The research literature on the efficacy and effectiveness of online interventions is developing rapidly. Although many studies show benefits in the form of reduced consumption, other intervention studies show no effects, for reasons that are unclear. Sweden became the first country in the world to implement a national system in which all university students are offered a brief online intervention via an e-mail. METHODS/DESIGN: This randomized controlled trial (RCT) aims to evaluate the effectiveness of this national system comprising a brief online intervention among university students who are hazardous and harmful drinkers. This study employs a conventional RCT design in which screening to determine eligibility precedes random allocation to immediate or delayed access to online intervention. The online intervention evaluated comprises three main components; assessment, normative feedback and advice on reducing drinking. Screening is confined to a single question in order to minimise assessment reactivity and to prevent contamination. Outcomes will be evaluated after 2 months, with total weekly alcohol consumption being the primary outcome measure. Invitations to participate are provided by e-mail to approximately 55,000 students in 9 Swedish universities. DISCUSSION: This RCT evaluates routine service provision in Swedish universities via a delay in offer of intervention to the control group. It evaluates effects in the key population for whom this intervention has been designed. Study findings will inform the further development of the national service provision. TRIAL REGISTRATION: ISRCTN02335307

Addressing Suicide in Entry-to-Practice Occupational Therapy Programs: A Canadian Picture

Worldwide, over 800,000 people die each year by suicide, leaving many behind to grieve the loss. Preventing suicide involves reaching people before they are in crisis (prevention), helping them to navigate a crisis that could result in suicide (intervention), and addressing the aftermath of a suicide loss or attempt (postvention). Healthcare professionals, including occupational therapists, unitedly acknowledge the lack of skills, knowledge, and competence in all facets of suicide awareness and prevention in their professional training and in practice. To improve this situation, suicide prevention skills must be taught in entry to practice programs, so they will filter into the practice of all occupational therapists. Thus, the purpose of this study was to discover how competencies related to suicide prevention are currently taught to student occupational therapists in Canadian universities. A cross-sectional descriptive design was used to survey the 14 Canadian university occupational therapy programs. 12/14 programs responded. All endorsed the use of a range of pedagogical approaches, but there was little similarity from one university to another. Learning activities mainly related to mitigating imminent suicide risk (intervention) and illustrated a lack of attention to the continuum of suicidal behavior (prevention, intervention, and postvention). All universities showed a clear willingness to improve their approach, but there is no current gold standard to strive for. Future initiatives can support research in this regard to ensure student occupational therapists are better prepared to address the full continuum of prevention, intervention, and postvention with explicit attention to an occupational perspective

Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2–dependent RNA granules

Central nervous system myelination requires the synthesis of large amounts of myelin basic protein (MBP) at the axon–glia contact site. MBP messenger RNA (mRNA) is transported in RNA granules to oligodendroglial processes in a translationally silenced state. This process is regulated by the trans-acting factor heterogeneous nuclear ribonucleoprotein (hnRNP) A2 binding to the cis-acting A2 response element (A2RE). Release of this repression of MBP mRNA translation is thus essential for myelination. Mice deficient in the Src family tyrosine kinase Fyn are hypomyelinated and contain reduced levels of MBP. Here, we identify hnRNP A2 as a target of activated Fyn in oligodendrocytes. We show that active Fyn phosphorylates hnRNP A2 and stimulates translation of an MBP A2RE–containing reporter construct. Neuronal adhesion molecule L1 binding to oligodendrocytes results in Fyn activation, which leads to an increase in hnRNP A2 phosphorylation. These results suggest that Fyn kinase activation results in the localized translation of MBP mRNA at sites of axon–glia contact and myelin deposition

Stable and Unstable Regimes of Mass Accretion onto RW Aur A

We present monitoring observations of the active T Tauri star RW Aur, from 2010 October to 2015 January, using optical high-resolution (R>10000) spectroscopy with CFHT-ESPaDOnS. Optical photometry in the literature shows bright, stable fluxes over most of this period, with lower fluxes (by 2-3 mag.) in 2010 and 2014. In the bright period our spectra show clear photospheric absorption, complicated variation in the Ca II 8542 A emission}profile shapes, and a large variation in redshifted absorption in the O I 7772 and 8446 A and He I 5876 A lines, suggesting unstable mass accretion during this period. In contrast, these line profiles are relatively uniform during the faint periods, suggesting stable mass accretion. During the faint periods the photospheric absorption lines are absent or marginal, and the averaged Li I profile shows redshifted absorption due to an inflow. We discuss (1) occultation by circumstellar material or a companion and (2) changes in the activity of mass accretion to explain the above results, together with near-infrared and X-ray observations from 2011-2015. Neither scenario can simply explain all the observed trends, and more theoretical work is needed to further investigate their feasibilities.Comment: 23 pages, 11 figures, 4 tables, accepted by Astrophysical Journal; some typos corrected on 4/18/201

Use of multiple covariates in assessing treatment-effect modifiers: A methodological review of individual participant data meta-analyses

Individual participant data (IPD) meta-analyses of randomised trials are considered a reliable way to assess participant-level treatment effect modifiers but may not make the best use of the available data. Traditionally, effect modifiers are explored one covariate at a time, which gives rise to the possibility that evidence of treatment-covariate interaction may be due to confounding from a different, related covariate. We aimed to evaluate current practice when estimating treatment-covariate interactions in IPD meta-analysis, specifically focusing on involvement of additional covariates in the models. We reviewed 100 IPD meta-analyses of randomised trials, published between 2015 and 2020, that assessed at least one treatment-covariate interaction. We identified four approaches to handling additional covariates: (1) Single interaction model (unadjusted): No additional covariates included (57/100 IPD meta-analyses); (2) Single interaction model (adjusted): Adjustment for the main effect of at least one additional covariate (35/100); (3) Multiple interactions model: Adjustment for at least one two-way interaction between treatment and an additional covariate (3/100); and (4) Three-way interaction model: Three-way interaction formed between treatment, the additional covariate and the potential effect modifier (5/100). IPD is not being utilised to its fullest extent. In an exemplar dataset, we demonstrate how these approaches lead to different conclusions. Researchers should adjust for additional covariates when estimating interactions in IPD meta-analysis providing they adjust their main effects, which is already widely recommended. Further, they should consider whether more complex approaches could provide better information on who might benefit most from treatments, improving patient choice and treatment policy and practice