2,718 research outputs found

    Genetic heterogeneity of residual variance in broiler chickens

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    Aims were to estimate the extent of genetic heterogeneity in environmental variance. Data comprised 99 535 records of 35-day body weights from broiler chickens reared in a controlled environment. Residual variance within dam families was estimated using ASREML, after fitting fixed effects such as genetic groups and hatches, for each of 377 genetically contemporary sires with a large number of progeny (>>100 males or females each). Residual variance was computed separately for male and female offspring, and after correction for sampling, strong evidence for heterogeneity was found, the standard deviation between sires in within variance amounting to 15–18% of its mean. Reanalysis using log-transformed data gave similar results, and elimination of 2–3% of outlier data reduced the heterogeneity but it was still over 10%. The correlation between estimates for males and females was low, however. The correlation between sire effects on progeny mean and residual variance for body weight was small and negative (-0.1). Using a data set bigger than any yet presented and on a trait measurable in both sexes, this study has shown evidence for heterogeneity in the residual variance, which could not be explained by segregation of major genes unless very few determined the trait

    None So Blind

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    Phase Transitions in the One-Dimensional Pair-Hopping Model: a Renormalization Group Study

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    The phase diagram of a one-dimensional tight-binding model with a pair-hopping term (amplitude V) has been the subject of some controvery. Using two-loop renormalization group equations and the density matrix renormalization group with lengths L<=60, we argue that no spin-gap transition occurs at half-filling for positive V, contrary to recent claims. However, we point out that away from half-filling, a *phase-separation* transition occurs at finite V. This transition and the spin-gap transition occuring at half-filling and *negative* V are analyzed numerically.Comment: 7 pages RevTeX, 6 uuencoded figures which can be (and by default are) directly included. Received by Phys. Rev. B 20 April 199

    On the Nagaoka polaron in the t-J model

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    It is widely believed that a single hole in the two (or three) dimensional t-J model, for sufficiently small exchange coupling J, creates a ferromagnetic bubble around itself, a finite J remnant of the ferromagnetic groundstate at J=0 (the infinite U Hubbard model), first established by Nagaoka. We investigate this phenomenon in two dimensions using the density matrix renormalization group, for system sizes up to 9x9. We find that the polaron forms for J/t<0.02-0.03 (a somewhat larger value than estimated previously). Although finite-size effects appear large, our data seems consistent with the expected 1.1(J/t)^{-1/4} variation of polarion radius. We also test the Brinkman-Rice model of non-retracing paths in a Neel background, showing that it is quite accurate, at larger J. Results are also presented in the case where the Heisenberg interaction is dropped (the t-J^z model). Finally we discuss a "dressed polaron" picture in which the hole propagates freely inside a finite region but makes only self-retracing excursions outside this region.Comment: 7 pages, 9 encapsulated figure

    A statistical development of fixed odds betting rules in soccer

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    Two simple but seemingly profitable betting rules for betting on the away win in association football are developed. One rule is consistent with avoiding those games in which there is a clear favourite. The second rule is based directly on modelling bookmaker odds and assessing the residuals under the fitted model. Contrary to previous research the betting rule using the residuals suggests avoiding betting on those games where there are large discrepancies between bookmaker odds and predicted-model odds

    Missing data in randomized controlled trials testing palliative interventions pose a significant risk of bias and loss of power: a systematic review and meta-analyses

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    Objectives To assess the risk posed by missing data (MD) to the power and validity of trials evaluating palliative interventions. Study Design and Setting A systematic review of MD in published randomized controlled trials (RCTs) of palliative interventions in participants with life-limiting illnesses was conducted, and random-effects meta-analyses and metaregression were performed. CENTRAL, MEDLINE, and EMBASE (2009-2014) were searched with no language restrictions. Results One hundred and eight RCTs representing 15,560 patients were included. The weighted estimate for MD at the primary endpoint was 23.1% (95% confidence interval [CI] 19.3, 27.4). Larger MD proportions were associated with increasing numbers of questions/tests requested (odds ratio [OR] , 1.19; 95% CI 1.05, 1.35) and with longer study duration (OR, 1.09; 95% CI 1.02, 1.17). Meta-analysis found evidence of differential rates of MD between trial arms, which varied in direction (OR, 1.04; 95% CI 0.90, 1.20; I 2 35.9, P = 0.001). Despite randomization, MD in the intervention arms (vs. control) were more likely to be attributed to disease progression unrelated to the intervention (OR, 1.31; 95% CI 1.02, 1.69). This was not the case for MD due to death (OR, 0.92; 95% CI 0.78, 1.08). Conclusion The overall proportion and differential rates and reasons for MD reduce the power and potentially introduce bias to palliative care trials

    Variance reduction in randomised trials by inverse probability weighting using the propensity score.

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    In individually randomised controlled trials, adjustment for baseline characteristics is often undertaken to increase precision of the treatment effect estimate. This is usually performed using covariate adjustment in outcome regression models. An alternative method of adjustment is to use inverse probability-of-treatment weighting (IPTW), on the basis of estimated propensity scores. We calculate the large-sample marginal variance of IPTW estimators of the mean difference for continuous outcomes, and risk difference, risk ratio or odds ratio for binary outcomes. We show that IPTW adjustment always increases the precision of the treatment effect estimate. For continuous outcomes, we demonstrate that the IPTW estimator has the same large-sample marginal variance as the standard analysis of covariance estimator. However, ignoring the estimation of the propensity score in the calculation of the variance leads to the erroneous conclusion that the IPTW treatment effect estimator has the same variance as an unadjusted estimator; thus, it is important to use a variance estimator that correctly takes into account the estimation of the propensity score. The IPTW approach has particular advantages when estimating risk differences or risk ratios. In this case, non-convergence of covariate-adjusted outcome regression models frequently occurs. Such problems can be circumvented by using the IPTW adjustment approach

    Dynamical Correlation Functions using the Density Matrix Renormalization Group

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    The density matrix renormalization group (DMRG) method allows for very precise calculations of ground state properties in low-dimensional strongly correlated systems. We investigate two methods to expand the DMRG to calculations of dynamical properties. In the Lanczos vector method the DMRG basis is optimized to represent Lanczos vectors, which are then used to calculate the spectra. This method is fast and relatively easy to implement, but the accuracy at higher frequencies is limited. Alternatively, one can optimize the basis to represent a correction vector for a particular frequency. The correction vectors can be used to calculate the dynamical correlation functions at these frequencies with high accuracy. By separately calculating correction vectors at different frequencies, the dynamical correlation functions can be interpolated and pieced together from these results. For systems with open boundaries we discuss how to construct operators for specific wavevectors using filter functions.Comment: minor revision, 10 pages, 15 figure
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