824 research outputs found
A squeezed state source using radiation pressure induced rigidity
We propose an experiment to extract ponderomotive squeezing from an
interferometer with high circulating power and low mass mirrors. In this
interferometer, optical resonances of the arm cavities are detuned from the
laser frequency, creating a mechanical rigidity that dramatically suppresses
displacement noise. After taking into account imperfection of optical elements,
laser noise, and other technical noise consistent with existing laser and
optical technologies and typical laboratory environments, we expect the output
light from the interferometer to have measurable squeezing of ~5 dB, with a
frequency-independent squeeze angle for frequencies below 1 kHz. This squeeze
source is well suited for injection into a gravitational-wave interferometer,
leading to improved sensitivity from reduction in the quantum noise.
Furthermore, this design provides an experimental test of quantum-limited
radiation pressure effects, which have not previously been tested.Comment: 15 pages, 6 figures, submitted to Phys. Rev.
The Effect of Tropical Storm Agnes on Oysters, Hard Clams, Soft Clams, and Oyster Drills in VIrginia
Tropical Storm Agnes had a major effect on the molluscan fisheries of Virginia. One effect was the direct mortality of oysters, Crassostrea virginiaa, in the upper parts of many estuaries. Typical losses on leased bottoms were: the James River, 10%; the York River, 2%; the Rappahannock River, 50%; and the Potomac River tributaries (Virginia) 70%. Economic loss was in excess of 7.9 million dollars. There was a nearly complete absence of oyster larvae attachment (setting) in 1972. Other effects of Agnes included a nearly complete loss of soft clams, Mya arenaria, in the Rappahannock River. Hard clams, Meraenaria meraenaria, were killed in the upper part of the York River. Oyster drills, Urosalpinx ainerea, were eliminated from the Rappahannock and reduced greatly in numbers in the York and James Rivers.https://scholarworks.wm.edu/vimsbooks/1074/thumbnail.jp
Transient ultrasound stimulation has lasting effects on neuronal excitability
Background
Transcranial ultrasound stimulation can acutely modulate brain activity, but the lasting effects on neurons are unknown.
Objective
To assess the excitability profile of neurons in the hours following transient ultrasound stimulation.
Methods
Primary rat cortical neurons were stimulated with a 40 s, 200 kHz pulsed ultrasound stimulation or sham-stimulation. Intrinsic firing properties were investigated through whole-cell patch-clamp recording by evoking action potentials in response to somatic current injection. Recordings were taken at set timepoints following ultrasound stimulation: 0–2 h, 6–8 h, 12–14 h and 24–26 h. Transmission electron microscopy was used to assess synaptic ultrastructure at the same timepoints.
Results
In the 0–2 h window, neurons stimulated with ultrasound displayed an increase in the mean frequency of evoked action potentials of 32% above control cell levels (p = 0.023). After 4–6 h this increase was measured as 44% (p = 0.0043). By 12–14 h this effect was eliminated and remained absent 24–26 h post-stimulation. These changes to action potential firing occurred in conjunction with statistically significant differences between control and ultrasound-stimulated neurons in action potential half-width, depolarisation rate, and repolarisation rate, that were similarly eliminated by 24 h following stimulation. These effects occurred in the absence of alterations to intrinsic membrane properties or synaptic ultrastructure.
Conclusion
We report that stimulating neurons with 40 s of ultrasound enhances their excitability for up to 8 h in conjunction with modifications to action potential kinetics. This occurs in the absence of major ultrastructural change or modification of intrinsic membrane properties. These results can inform the application of transcranial ultrasound in experimental and therapeutic settings
Lipid Adjustment in the Analysis of Environmental Contaminants and Human Health Risks
The literature on exposure to lipophilic agents such as polychlorinated biphenyls (PCBs) is conflicting, posing challenges for the interpretation of potential human health risks. Laboratory variation in quantifying PCBs may account for some of the conflicting study results. For example, for quantification purposes, blood is often used as a proxy for adipose tissue, which makes it necessary to model serum lipids when assessing health risks of PCBs. Using a simulation study, we evaluated four statistical models (unadjusted, standardized, adjusted, and two-stage) for the analysis of PCB exposure, serum lipids, and health outcome risk (breast cancer). We applied eight candidate true causal scenarios, depicted by directed acyclic graphs, to illustrate the ramifications of misspecification of underlying assumptions when interpreting results. Statistical models that deviated from underlying causal assumptions generated biased results. Lipid standardization, or the division of serum concentrations by serum lipids, was observed to be highly prone to bias. We conclude that investigators must consider biology, biologic medium (e.g., nonfasting blood samples), laboratory measurement, and other underlying modeling assumptions when devising a statistical plan for assessing health outcomes in relation to environmental exposures
Training of Instrumentalists and Development of New Technologies on SOFIA
This white paper is submitted to the Astronomy and Astrophysics 2010 Decadal
Survey (Astro2010)1 Committee on the State of the Profession to emphasize the
potential of the Stratospheric Observatory for Infrared Astronomy (SOFIA) to
contribute to the training of instrumentalists and observers, and to related
technology developments. This potential goes beyond the primary mission of
SOFIA, which is to carry out unique, high priority astronomical research.
SOFIA is a Boeing 747SP aircraft with a 2.5 meter telescope. It will enable
astronomical observations anywhere, any time, and at most wavelengths between
0.3 microns and 1.6 mm not accessible from ground-based observatories. These
attributes, accruing from the mobility and flight altitude of SOFIA, guarantee
a wealth of scientific return. Its instrument teams (nine in the first
generation) and guest investigators will do suborbital astronomy in a
shirt-sleeve environment. The project will invest $10M per year in science
instrument development over a lifetime of 20 years. This, frequent flight
opportunities, and operation that enables rapid changes of science instruments
and hands-on in-flight access to the instruments, assure a unique and extensive
potential - both for training young instrumentalists and for encouraging and
deploying nascent technologies. Novel instruments covering optical, infrared,
and submillimeter bands can be developed for and tested on SOFIA by their
developers (including apprentices) for their own observations and for those of
guest observers, to validate technologies and maximize observational
effectiveness.Comment: 10 pages, no figures, White Paper for Astro 2010 Survey Committee on
State of the Professio
Observational Limit on Gravitational Waves from Binary Neutron Stars in the Galaxy
Using optimal matched filtering, we search 25 hours of data from the LIGO
40-meter prototype laser interferometric gravitational-wave detector for
gravitational-wave chirps emitted by coalescing binary systems within our
Galaxy. This is the first test of this filtering technique on real
interferometric data. An upper limit on the rate R of neutron star binary
inspirals in our Galaxy is obtained: with 90% confidence, R< 0.5/hour. Similar
experiments with LIGO interferometers will provide constraints on the
population of tight binary neutron star systems in the Universe.Comment: RevTeX, minor revisions, exactly as published in PRL 83 (1999) p1498,
4 pages, 2 figures include
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