Patterns of interstate migration in the United States from the survey of income and program participation

The authors describe the Survey of Income and Program Participation (SIPP) as a data source for migration studies. The SIPP is a panel dataset that provides information on income, employment outcomes, and participation in government programs. Survey participants are interviewed for up to four years even if they move to a new household or that household migrates within the United States. This unique longitudinal design gives the survey a strong advantage over traditional data sources. The authors illustrate differences in the propensity for interstate migration among different demographic groups over the 12-year period from 1996 to 2008. They also analyze the relationship between migration choices and life-changing events, such as becoming jobless or dissolution of a marriage. Their findings suggest that future research should consider the migration choices of individuals near retirement age.Demography ; Income ; Emigration and immigration

Forming a Primordial Star in a Relic HII Region

There has been considerable theoretical debate over whether photoionization and supernova feedback from the first Population III stars facilitate or suppress the formation of the next generation of stars. We present results from an Eulerian adaptive mesh refinement simulation demonstrating the formation of a primordial star within a region ionized by an earlier nearby star. Despite the higher temperatures of the ionized gas and its flow out of the dark matter potential wells, this second star formed within 23 million years of its neighbor's death. The enhanced electron fraction within the HII region catalyzes rapid molecular hydrogen formation that leads to faster cooling in the subsequent star forming halos than in the first halos. This "second generation" primordial protostar has a much lower accretion rate because, unlike the first protostar, it forms in a rotationally supported disk of approx. 10-100 solar masses. This is primarily due to the much higher angular momentum of the halo in which the second star forms. In contrast to previously published scenarios, such configurations may allow binaries or multiple systems of lower mass stars to form. These first high resolution calculations offer insight into the impact of feedback upon subsequent populations of stars and clearly demonstrate how primordial chemistry promotes the formation of subsequent generations of stars even in the presence of the entropy injected by the first stars into the IGM.Comment: 4 pages, 2 figures. Some revisions, including enhanced discussion of angular momentum issues. Asrophysical Journal, accepte

Radiation Hydrodynamical Instabilities in Cosmological and Galactic Ionization Fronts

Ionization fronts, the sharp radiation fronts behind which H/He ionizing photons from massive stars and galaxies propagate through space, were ubiquitous in the universe from its earliest times. The cosmic dark ages ended with the formation of the first primeval stars and galaxies a few hundred Myr after the Big Bang. Numerical simulations suggest that stars in this era were very massive, 25 - 500 solar masses, with H II regions of up to 30,000 light-years in diameter. We present three-dimensional radiation hydrodynamical calculations that reveal that the I-fronts of the first stars and galaxies were prone to violent instabilities, enhancing the escape of UV photons into the early intergalactic medium (IGM) and forming clumpy media in which supernovae later exploded. The enrichment of such clumps with metals by the first supernovae may have led to the prompt formation of a second generation of low-mass stars, profoundly transforming the nature of the first protogalaxies. Cosmological radiation hydrodynamics is unique because ionizing photons coupled strongly to both gas flows and primordial chemistry at early epochs, introducing a hierarchy of disparate characteristic timescales whose relative magnitudes can vary greatly throughout a given calculation. We describe the adaptive multistep integration scheme we have developed for the self-consistent transport of both cosmological and galactic ionization fronts.Comment: 6 pages, 4 figures, accepted for proceedings of HEDLA2010, Caltech, March 15 - 18, 201

Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells.

Endothelial cells (ECs) are critical determinants of vascular homeostasis and inflammation, but transcriptional mechanisms specifying their identities and functional states remain poorly understood. Here, we report a genome-wide assessment of regulatory landscapes of primary human aortic endothelial cells (HAECs) under basal and activated conditions, enabling inference of transcription factor networks that direct homeostatic and pro-inflammatory programs. We demonstrate that 43% of detected enhancers are EC-specific and contain SNPs associated to cardiovascular disease and hypertension. We provide evidence that AP1, ETS, and GATA transcription factors play key roles in HAEC transcription by co-binding enhancers associated with EC-specific genes. We further demonstrate that exposure of HAECs to oxidized phospholipids or pro-inflammatory cytokines results in signal-specific alterations in enhancer landscapes and associate with coordinated binding of CEBPD, IRF1, and NFκB. Collectively, these findings identify cis-regulatory elements and corresponding trans-acting factors that contribute to EC identity and their specific responses to pro-inflammatory stimuli

Aerodynamic Simulation of Runback Ice Accretion

This report presents the results of recent investigations into the aerodynamics of simulated runback ice accretion on airfoils. Aerodynamic tests were performed on a full-scale model using a high-fidelity, ice-casting simulation at near-flight Reynolds (Re) number. The ice-casting simulation was attached to the leading edge of a 72-in. (1828.8-mm ) chord NACA 23012 airfoil model. Aerodynamic performance tests were conducted at the ONERA F1 pressurized wind tunnel over a Reynolds number range of 4.7?10(exp 6) to 16.0?10(exp 6) and a Mach (M) number ran ge of 0.10 to 0.28. For Re = 16.0?10(exp 6) and M = 0.20, the simulated runback ice accretion on the airfoil decreased the maximum lift coe fficient from 1.82 to 1.51 and decreased the stalling angle of attack from 18.1deg to 15.0deg. The pitching-moment slope was also increased and the drag coefficient was increased by more than a factor of two. In general, the performance effects were insensitive to Reynolds numb er and Mach number changes over the range tested. Follow-on, subscale aerodynamic tests were conducted on a quarter-scale NACA 23012 model (18-in. (457.2-mm) chord) at Re = 1.8?10(exp 6) and M = 0.18, using low-fidelity, geometrically scaled simulations of the full-scale castin g. It was found that simple, two-dimensional simulations of the upper- and lower-surface runback ridges provided the best representation of the full-scale, high Reynolds number iced-airfoil aerodynamics, whereas higher-fidelity simulations resulted in larger performance degrada tions. The experimental results were used to define a new subclassification of spanwise ridge ice that distinguishes between short and tall ridges. This subclassification is based upon the flow field and resulting aerodynamic characteristics, regardless of the physical size of the ridge and the ice-accretion mechanism

Physical Models for the Clustering of Obscured and Unobscured Quasars

Clustering measurements of obscured and unobscured quasars show that obscured quasars reside in more massive dark matter halos than their unobscured counterparts. These results are inconsistent with simple unified (torus) scenarios, but might be explained by models in which the distribution of obscuring material depends on Eddington ratio or galaxy stellar mass. We test these possibilities by constructing simple physical models to compare to observed AGN populations. We find that previously observed relationships between obscuration and Eddington ratio or stellar mass are not sufficient reproduce the observed quasar clustering results ($\langle \log M_{\text{halo}}/M_{\odot} \rangle = 12.94 ^{+ 0.10}_{- 0.11}$ and $\langle \log M_{\text{halo}}/M_{\odot} \rangle = 12.49 ^{+ 0.08}_{- 0.08}$ for obscured and unobscured populations, respectively) while maintaining the observed fraction of obscured quasars (30-65$\%$). This work suggests that evolutionary models, in which obscuration evolves on the typical timescale for black hole growth, are necessary to understand the observed clustering of mid-IR selected quasars.Comment: 14 pages, 10 figures, accepted for publication in Ap

Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: Potential role in liver fibrosis

Background The pro-inflammatory cytokines, tumor necrosis factor (TNF)-α, and interleukin (IL)-17, have been implicated in the pathogenesis of liver fibrosis. In this study, we investigated the role of TNFα and IL-17 toward induction of profibrotic factor, periostin. Methods HepG2 cells were cultured and treated with inflammatory cytokines, TNFα and IL-17. Computational promoter sequence analysis of the periostin promoter was performed to define the putative binding sites for transcription factors. Transcription factors were analyzed by Western blot and Chromatin Immunoprecipitation. Periostin and transcription factor expression analysis was performed by RT-PCR, Western blot, and fluorescence microscopy. Type I collagen expression from fibroblast cultures was analyzed by Western blot and Sircol soluble collagen assay. Results Activation of HepG2 Cells with TNFα and IL-17 enhanced the expression of periostin (3.5 and 4.4 fold, respectively p \u3c 0.05) compared to untreated cells. However, combined treatment with both TNFα and IL-17 at similar concentration demonstrated a 13.3 fold increase in periostin (p \u3c 0.01), thus suggesting a synergistic role of these cytokines. Periostin promoter analysis and specific siRNA knock-down revealed that TNFα induces periostin through cJun, while IL-17 induced periostin via STAT-3 signaling mechanisms. Treatment of the supernatant from the cytokine activated HepG2 cells on fibroblast cultures induced enhanced expression of type I collagen (\u3e9.1 fold, p \u3c 0.01), indicative of a direct fibrogenic effect of TNFα and IL-17. Conclusion TNFα and IL-17 induced fibrogenesis through cJun and STAT-3 mediated expression of profibrotic biomarker, periostin. Therefore, periostin might serve as a novel biomarker in early diagnosis of liver fibrosis

Cosmological radiative transfer comparison project - II. The radiation-hydrodynamic tests

The development of radiation hydrodynamical methods that are able to follow gas dynamics and radiative transfer (RT) self-consistently is key to the solution of many problems in numerical astrophysics. Such fluid flows are highly complex, rarely allowing even for approximate analytical solutions against which numerical codes can be tested. An alternative validation procedure is to compare different methods against each other on common problems, in order to assess the robustness of the results and establish a range of validity for the methods. Previously, we presented such a comparison for a set of pure RT tests (i.e. for fixed, non-evolving density fields). This is the second paper of the Cosmological Radiative Transfer Comparison Project, in which we compare nine independent RT codes directly coupled to gas dynamics on three relatively simple astrophysical hydrodynamics problems: (i) the expansion of an H ii region in a uniform medium, (ii) an ionization front in a 1/r2 density profile with a flat core and (iii) the photoevaporation of a uniform dense clump. Results show a broad agreement between the different methods and no big failures, indicating that the participating codes have reached a certain level of maturity and reliability. However, many details still do differ, and virtually every code has showed some shortcomings and has disagreed, in one respect or another, with the majority of the results. This underscores the fact that no method is universal and all require careful testing of the particular features which are most relevant to the specific problem at han