60 research outputs found

    Coastal Archaeology and Climate Change in the Middle East and North Africa: Contextualizing Global Projections

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    Recent global projections of climate change highlight alarming rates of flooding and erosion on the coastlines of the Middle East and North Africa (MENA). Though there are indisputable links between climate change and the deterioration of maritime cultural heritage (particularly coastal archaeology), deterioration is often the result of multiple compounding factors, central among which are anthropogenic landscape alterations. In this article the authors attempt to disentangle these factors at a small scale, using the Gaza Strip, Libya, and Oman as case studies. They examine the impact of accelerating coastal erosion, flooding, and increasing frequency of tropical cyclones to question predominant discussions on the impact of climate change on heritage. They emphasize methods and practices for the identification of sites that can expand and refine climate change research (often reliant on data from the twentieth and twenty-first centuries) through the long-term perspective archaeology is uniquely placed to offer

    Maritime Cultural Heritage and Urbanisation in the Middle East and North Africa

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    Urbanisation, comprising development, land reclamation and population growth along coastal margins, continues to place significant pressure on the maritime cultural heritage (MCH), particularly in the Middle East and North Africa (MENA) region. Thus, there is a growing need for ascertaining the extent of the affected MCH resource and its condition. One such assessment is being undertaken by the Maritime Endangered Archaeology (MarEA) project, which is generating a unique informed database of the maritime resource in the MENA region. Through a regional overview combined with focused assessment on two case studies – Marsa Matruh (Egypt) and Bahrain – this paper demonstrates the threat urbanisation poses and the damage it has inflicted on MCH. The analyses and documentation that MarEA produces via remote sensing, deskbased and field-based assessments, constitutes a valuable resource that, at the very least, exists in digital perpetuity. It establishes a record that can be drawn upon to formulate targeted strategies and initiatives inclusive of the maritime cultural heritage resource

    Interacting galaxies in the IllustrisTNG simulations - I : Triggered star formation in a cosmological context

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    We use the IllustrisTNG cosmological hydrodynamical simulations to investigate how the specific star formation rates (sSFRs) of massive galaxies (M-* > 10(10) M-circle dot) depend on the distance to their closest companions. We estimate sSFR enhancements by comparing with control samples that are matched in redshift, stellar mass, local density, and isolation, and we restrict our analysis to pairs with stellar mass ratios of 0.1 to 10. At small separations (similar to 15 kpc), the mean sSFR is enhanced by a factor of 2.0 +/- 0.1 in the flagship (110.7Mpc)(3) simulation (TNG100-1). Statistically significant enhancements extend out to 3D separations of 280 kpc in the (302.6Mpc)(3) simulation (TNG300-1). We find similar trends in the EAGLE and Illustris simulations, although their sSFR enhancements are lower than those in TNG100-1 by about a factor of two. Enhancements in IllustrisTNG galaxies are seen throughout the redshift range explored (0Peer reviewe

    Of time and tide: the complex impacts of climate change on coastal and underwater cultural heritage

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    The Intergovernmental Panel on Climate Change has documented wide-ranging changes to the world’s coasts and oceans, with significant further change predicted. Impacts on coastal and underwater heritage sites, however, remain relatively poorly understood. The authors draw on 30 years of research into coastal and underwater archaeological sites to highlight some of the interrelated processes of deterioration and damage. Emphasising the need for closer collaboration between, on one hand, archaeologists and cultural resource managers and, on the other, climate and marine scientists, this article also discusses research from other disciplines that informs understanding of the complexity of the interaction of natural and anthropogenic processes and their impacts on cultural heritage

    Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

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    Background Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. Methods RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047. Findings Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths. Interpretation Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population
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