251 research outputs found
Tema Con Variazioni: Quantum Channel Capacity
Channel capacity describes the size of the nearly ideal channels, which can
be obtained from many uses of a given channel, using an optimal error
correcting code. In this paper we collect and compare minor and major
variations in the mathematically precise statements of this idea which have
been put forward in the literature. We show that all the variations considered
lead to equivalent capacity definitions. In particular, it makes no difference
whether one requires mean or maximal errors to go to zero, and it makes no
difference whether errors are required to vanish for any sequence of block
sizes compatible with the rate, or only for one infinite sequence.Comment: 32 pages, uses iopart.cl
High-resolution cryo-EM structures of respiratory complex I : Mechanism, assembly, and disease
Respiratory complex I is a redox-driven proton pump, accounting for a large part of the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Complex I dysfunction is associated with severe human diseases. Assembly of the one-megadalton complex I in the inner mitochondrial membrane requires assembly factors and chaperones. We have determined the structure of complex I from the aerobic yeast Yarrowia lipolytica by electron cryo-microscopy at 3.2-angstrom resolution. A ubiquinone molecule was identified in the access path to the active site. The electron cryo-microscopy structure indicated an unusual lipid-protein arrangement at the junction of membrane and matrix arms that was confirmed by molecular simulations. The structure of a complex I mutant and an assembly intermediate provide detailed molecular insights into the cause of a hereditary complex I-linked disease and complex I assembly in the inner mitochondrial membrane.Peer reviewe
High-resolution cryo-EM structures of respiratory complex I : Mechanism, assembly, and disease
Respiratory complex I is a redox-driven proton pump, accounting for a large part of the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Complex I dysfunction is associated with severe human diseases. Assembly of the one-megadalton complex I in the inner mitochondrial membrane requires assembly factors and chaperones. We have determined the structure of complex I from the aerobic yeast Yarrowia lipolytica by electron cryo-microscopy at 3.2-angstrom resolution. A ubiquinone molecule was identified in the access path to the active site. The electron cryo-microscopy structure indicated an unusual lipid-protein arrangement at the junction of membrane and matrix arms that was confirmed by molecular simulations. The structure of a complex I mutant and an assembly intermediate provide detailed molecular insights into the cause of a hereditary complex I-linked disease and complex I assembly in the inner mitochondrial membrane.Peer reviewe
Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis
Chronic pulmonary infection is a hallmark of cystic fibrosis (CF) and requires continuous antibiotic treatment. In this context, Pseudomonas aeruginosa (Pa) is of special concern since colonizing strains frequently acquire multiple drug resistance (MDR). Bactericidal/permeability-increasing protein (BPI) is a neutrophil-derived, endogenous protein with high bactericidal potency against Gram-negative bacteria. However, a significant range of people with CF (PwCF) produce anti-neutrophil cytoplasmic antibodies against BPI (BPI-ANCA), thereby neutralizing its bactericidal function. In accordance with literature, we describe that 51.0% of a total of 39 PwCF expressed BPI-ANCA. Importantly, an orthologous protein to human BPI (huBPI) derived from the scorpionfish Sebastes schlegelii (scoBPI) completely escaped recognition by these autoantibodies. Moreover, scoBPI exhibited high anti-inflammatory potency towards Pa LPS and was bactericidal against MDR Pa derived from PwCF at nanomolar concentrations. In conclusion, our results highlight the potential of highly active orthologous proteins of huBPI in treatment of MDR Pa infections, especially in the presence of BPI-ANCA
Partial Anterior Cruciate Ligament Ruptures: Advantages by Intraligament Autologous Conditioned Plasma Injection and Healing Response TechniqueâMidterm Outcome Evaluation
The historical treatment options for partial anterior cruciate ligament (ACL) ruptures were conservative therapy or ACL reconstruction by injured bundle or entire ACL replacement. In awareness of the regenerative potential of biologic agents such as mesenchymal stem cells or platelet rich plasma (PRP), the healing response technique was developed to preserve the injured ACL with belter outcomes lhan ihe conservative therapy. Further improvement of this technique seems to be obtained by the additional application of PRP products. Thus, the aim of this study was to evaluate the midterm outcome after intraligament autologous conditioned plasma (ACP) by a clinical, scoring, and functional performance assessment. 42 patients were evaluated in this study. The failure rate was 9.5%. Outcome evaluation showed good to excellent results. The scores were IKDC subjective 83.2 (SD 14.5), Lysholm 85.5 (SD 15.5), Tegner 4.7 (SD 1.7), and Cincinnati 85.4 (SD 15.5) afler a mean follow-up of 33 months. Clinical examination showed stable Lachman tesl, negative pivot shift phenomenon, and a significant reduction in AP-laxity compared to preoperative status (rolimeter preoperative: 1.9 (SD1.4); postoperative 0.6 (SD1.8), p=0.001) in all patients. Functional performance testing showed no significant differences between the injured and healthy side. Return to sport was achieved after a mean of 5.8 months (SD 3.6) in 71.1% of the included patients. In summary, this new treatment option revealed in midterm follow-up promising results to treat partial ACL lesions with a reduced need for conversion to ACL reconstruction and with a high percentage of return to preinjury sport activity
Determination of the Michel Parameters rho, xi, and delta in tau-Lepton Decays with tau --> rho nu Tags
Using the ARGUS detector at the storage ring DORIS II, we have
measured the Michel parameters , , and for
decays in -pair events produced at
center of mass energies in the region of the resonances. Using
as spin analyzing tags, we find , , , , and . In addition, we report
the combined ARGUS results on , , and using this work
und previous measurements.Comment: 10 pages, well formatted postscript can be found at
http://pktw06.phy.tu-dresden.de/iktp/pub/desy97-194.p
New Philharmonia Chorus, de Londres, director adjunto: Russell Burgess, Orquesta Nacional, Rafael FrĂŒbeck de Burgos director
Programa dels concerts que va dur a terme l'Orquestra Nacional d'Espanya amb el New Philharmonia Chorus de Londres, dirigits per R. FrĂŒhbeck de Burgos i R. Burgess respectivament. En primer lloc van interpretar "Elies" de F. Mendelssohn, amb E. Speiser, N. Procter, W. Hollweg i H. Hagegard com a solistes, i amb M. Torrent a l'orgue. El proper concert van interpretar "La CreaciĂł" de J. Haydn, amb H. Donath, W. Hollweg i S. Nimsgern com a solistes. Els concerts es van celebrar en el marc de la XIV temporada musical del patronat pro musica de Barcelon
A Search for the Electric Dipole Moment of the Tau-Lepton
Using the ARGUS detector at the e+e- storage ring DORIS II, we have searched
for the real and imaginary part of the electric dipole formfactor d_tau of the
tau lepton in the production of tau pairs at q^2=100 GeV^2. This is the first
direct measurement of this CP violating formfactor. We applied the method of
optimised observables which takes into account all available information on the
observed tau decay products. No evidence for CP violation was found, and we
derive the following results: Re(d_tau)=(1.6+-.9)*10^(-16) ecm and
Im(d_tau)=(-0.2+-0.8)*10^(-16) ecm, where statistical and systematic errors
have been combined.Comment: 8 pages, 5 figures (10 subfigures
Fast Amplification of the Low Density Lipoprotein Receptor Gene and Detection of a Large Deletion by Means of Long Polymerase Chain Reaction
Peer Reviewe
Pharmacokinetic Modeling of Ketamine Enantiomers and Their Metabolites After Administration of ProlongedâRelease Ketamine With Emphasis on 2,6âHydroxynorketamines
Abstract
Modeling of metabolite kinetics after oral administration of ketamine is of special interest because of the higher concentrations of active metabolites because of the hepatic firstâpass effect. This holds especially in view of the potential analgesic and antidepressant effects of 2R,6Râ and 2S,6Sâhydroxynorketamine at low doses of ketamine. Therefore, a 9âcompartment model was developed to analyze the pharmacokinetics of ketamine enantiomers and their metabolites after racemic ketamine administered intravenously (5 mg) and as 4 doses (10, 20, 40, and 80 mg) of a prolongedârelease formulation (PRâketamine). Using a population approach, the serum concentrationâtime data of the enantiomers of ketamine, norketamine, dehydronorketamine, and 2,6âhydroxynorketamine obtained in 15 healthy volunteers could be adequately fitted. The estimated model parameters were used to simulate serum concentrationâtime profiles; after multiple dosing of PRâketamine (2 daily doses of 20 mg), the steadyâstate concentrations of Râ and Sâketamine were 1.4 and 1.3 ng/mL, respectively. The steadyâstate concentration of 2R,6Râhydroxynorketamine exceeded those of Rânorketamine (4âfold), Râdehydonorketamine (8âfold), and Râketamine (46âfold), whereas that of 2S,6Sâhydroxynorketamine exceeded that of Sâketamine by 14âfold. The model may be useful for identifying dosing regimens aiming at optimal plasma concentrations of 2,6âhydroxynorketamines
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