432 research outputs found
Equivalence between two charged black holes in dynamics of orbits outside the event horizons
Using the FermiDirac distribution function, Balart and Vagenas gave a charged
spherically symmetric regular black hole, which is a solution of Einstein field
equations coupled to a nonlinear electrodynamics. In fact, the regular black
hole is a Reissner-Nordstrom (RN) black hole when a metric function is given a
Taylor expansion to first order approximations. It does not have a curvature
singularity at the origin,but the RN black hole does. Both black hole metrics
have horizons and similar asymptotic behaviors, and satisfy the weak energy
conditions everywhere. They are almost the same in photon effective potentials,
photon circular orbits and photon spheres outside the event horizons. There are
relatively minor differences between effective potentials, stable circular
orbits and innermost stable circular orbits of charged particles outside the
event horizons of the two black holes immersed in external magnetic fields.
Although the twomagnetized black holes allow different construction methods of
explicit symplectic integrators, they exhibit approximately consistent results
in the regular and chaotic dynamics of charged particles outside the event
horizons. Chaos gets strong as the magnetic field parameter or the magnitude of
negative Coulomb parameter increases, but becomes weak when the black hole
charge or the positive Coulomb parameter increases. A variation of dynamical
properties is not sensitive dependence on an appropriate increase of the black
hole charge. The basic equivalence between the two black hole gravitational
systems in the dynamics of orbits outside the event horizons is due to the two
metric functions having an extremely small difference. This implies that the RN
black hole is reasonably replaced by the regular black hole without curvature
singularity in many situations.Comment: 18 pages, 12 figure
Corporate Credit Rating: A Survey
Corporate credit rating (CCR) plays a very important role in the process of
contemporary economic and social development. How to use credit rating methods
for enterprises has always been a problem worthy of discussion. Through reading
and studying the relevant literature at home and abroad, this paper makes a
systematic survey of CCR. This paper combs the context of the development of
CCR methods from the three levels: statistical models, machine learning models
and neural network models, summarizes the common databases of CCR, and deeply
compares the advantages and disadvantages of the models. Finally, this paper
summarizes the problems existing in the current research and prospects the
future of CCR. Compared with the existing review of CCR, this paper expounds
and analyzes the progress of neural network model in this field in recent
years.Comment: 11 page
Spatio-Temporal Patterns and Climate Variables Controlling of Biomass Carbon Stock of Global Grassland Ecosystems from 1982 to 2006
Grassland ecosystems play an important role in subsistence agriculture and the global carbon cycle. However, the global spatio-temporal patterns and environmental controls of grassland biomass are not well quantified and understood. The goal of this study was to estimate the spatial and temporal patterns of the global grassland biomass and analyze their driving forces using field measurements, Normalized Difference Vegetation Index (NDVI) time series from satellite data, climate reanalysis data, and a satellite-based statistical model. Results showed that the NDVI-based biomass carbon model developed from this study explained 60% of the variance across 38 sites globally. The global carbon stock in grassland aboveground live biomass was 1.05 Pg·C, averaged from 1982 to 2006, and increased at a rate of 2.43 Tg·C·y−1 during this period. Temporal change of the global biomass was significantly and positively correlated with temperature and precipitation. The distribution of biomass carbon density followed the precipitation gradient. The dynamics of regional grassland biomass showed various trends largely determined by regional climate variability, disturbances, and management practices (such as grazing for meat production). The methods and results from this study can be used to monitor the dynamics of grassland aboveground biomass and evaluate grassland susceptibility to climate variability and change, disturbances, and management
Tuning Photophysical Properties And Improving Nonlinear Absorption Of Pt(ii) Diimine Complexes With Extended Pi-conjugation In The Acetylide Ligands
Two new Pt(II) 4,4\u27-di(5,9-diethyltridecan-7-yl)-2,2\u27-bipyridine complexes (1 and 2,) bearing 9,9-diethyl-2-ethynyl-7-(2-(4-nitrophenyl)ethynyl)-9H-fluorene ligand and N-(4-(2-(9,9-diethyl-7-ethynyl-9H-fluoren-2-yl)ethynyl)phenyl)-N-phenylbenzeneamine ligand, respectively, were synthesized and characterized. Their photophysical properties were investigated systematically by UV vis absorption, emission, and transient absorption (TA) spectroscopy, and the nonlinear absorption was studied by nonlinear transmission technique. Theoretical TD-DFT calculations using the CAM-B3LYP functional were carried out to determine the nature of the singlet excited electronic states and to assist in the assignment of significant transitions observed in experiments. Complex 1 exhibits an intense, structureless absorption band at ca. 397 nm in CH2Cl2 solution, which is attributed to mixed metal-to-ligand charge transfer ((MLCT)-M-1)/ligand-to-ligand charge transfer ((LLCT)-L-1)/intraligand charge transfer ((ILCT)-I-1)/(1)pi,pi* transitions, and two (MLCT)-M-1/(LLCT)-L-1 transitions in the 300-350 nm spectral region. Complex 2 possesses an intense acetylide ligand localized (1)pi,pi* absorption band at ca. 373 nm and a moderately intense (MLCT)-M-1/(LLCT)-L-1 tail above 425 nm in CH2Cl2. Both complexes are emissive in solution at room temperature, with the emitting state being tentatively assigned to the predominant (3)pi,pi* state for 1, whereas the emitting state of 2 exhibits a switch from (3)pi,pi* state in high-polarity solvents to (MLCT)-M-3/(LLCT)-L-3 state in low-polarity solvents. Both 1 and 2 exhibit strong singlet excited-state TA in the visible to NIR region, where reverse saturable absorption (RSA) is feasible. The spectroscopic studies and theoretical calculations indicate that the photophysical properties of these Pt complexes can be tuned drastically by extending the pi-conjugation of the acetylide ligands. In addition, strong RSA was observed at 532 nm for nanosecond (ns) laser pulses from 1 and 2, demonstrating that the RSA of the Pt(II) diimine complexes can be improved by extending the pi-conjugation of the acetylide ligands
A Biodegradable Polyethylenimine-Based Vector Modified by Trifunctional Peptide R18 for Enhancing Gene Transfection Efficiency In Vivo
Lack of capacity to cross the nucleus membrane seems to be one of the main
reasons for the lower transfection efficiency of gene vectors observed in vivo
study than in vitro. To solve this problem, a new non-viral gene vector was
designed. First, a degradable polyethylenimine (PEI) derivate was synthesized
by crosslinking low-molecular-weight (LMW) PEI with N-octyl-N-quaternary
chitosan (OTMCS), and then adopting a designed trifunctional peptide (RGDC-
TAT-NLS) with good tumor targeting, cell uptake and nucleus transport
capabilities to modify OTMCS-PEI. The new gene vector was termed as OTMCS-
PEI-R18 and characterized in terms of its chemical structure and biophysical
parameters. Gene transfection efficiency and nucleus transport mechanism of
this vector were also evaluated. The polymer showed controlled degradation and
remarkable buffer capabilities with the particle size around 100–300 nm and
the zeta potential ranged from 5 mV to 40 mV. Agraose gel electrophoresis
showed that OTMCS-PEI-R18 could effectively condensed plasmid DNA at a ratio
of 1.0. Besides, the polymer was stable in the presence of sodium heparin and
could resist digestion by DNase I at a concentration of 63U DNase I/DNA.
OTMCS-PEI-R18 also showed much lower cytotoxicity and better transfection
rates compared to polymers OTMCS-PEI-R13, OTMCS-PEI and PEI 25 KDa in vitro
and in vivo. Furthermore, OTMCS-PEI-R18/DNA complexes could accumulate in the
nucleus well soon and not rely on mitosis absolutely due to the newly
incorporated ligand peptide NLS with the specific nuclear delivery pathway
indicating that the gene delivery system OTMCS-PEI-R18 could reinforce gene
transfection efficiency in vivo
Management of severe crush injury in a front-line tent ICU after 2008 Wenchuan earthquake in China: an experience with 32 cases
Study on Spatial Distribution of Soil Available Microelement in Qujing Tobacco Farming Area, China
AbstractDescriptive analysis characteristics and spatial variation characteristics of soil available microelements were studied based on SPSS and GIS Soil available microelements spatial distribution maps were created with ordinary Kriging method. The results indicate that, 7 available microelements in tobacco soil obey lognormal distribution, all the available microelements were intermediate variability; Anisotropic structure of available microelements of tobacco soil varies evidently, spatial variability of available B was mainly caused by random factors, and others’ spatial variability were caused by structural factors and random factors; Spatial distribution maps show that, available B was widely deficient in tobacco soil of Qujing farming area, ‘lower level’ and ‘low level’ taken 7.74% and 68.20%, respectively available Zn distribution was moderate, only 1.32% of the area lack of Zn, available Cu, available Fe and available Mn were extremely high in the whole extension, available Mo was deficient in part of the region with 28.38%, water soluble Cl was higher than critical value(30mgkg−1)in the most of Qujing farming area, which taken 38.86%
From a Spatial Structure Perspective : Spatial-Temporal Variation of Climate Redistribution of China Based on the Köppen–Geiger Classification
https://doi.org/10.1029/2022GL099319Shifting climate zones are widely used to diagnose and predict regional climate change. However, few attempts have been made to measure the spatial redistribution of these climate zones from a spatial structure perspective. We investigated changes in spatial structure of Köppen climate landscape in China between 1963 and 2098 with a landscape aggregation index. Our results reveal an apparent signal from fragmentation to aggregation, accompanied by the intensification of areal dispersion between cold and warm climate types. Our attribution analysis indicates that anthropogenic forcings have a larger influence on changes of spatial structure than natural variation. We also found that topographical heterogeneity is likely to contribute to the regional spatial fragmentation, especially in the Qinghai-Tibet Plateau. However, we also found that the spatial fragmentation will be weakened around the mid-2040s. We argue that biodiversity is likely to be mediated by spatial structure of future climate landscapes in China.Peer reviewe
Concurrent nephrotic syndrome and acute renal failure caused by chronic lymphocytic leukemia (CLL): a case report and literature review
Kidney injury associated with lymphocytic leukemia (CLL) is typically caused by direct tumor infiltration which occasionally results in acute renal failure. Glomerular involvement presenting as proteinuria or even nephrotic syndrome is exceptionally rare. Here we report a case of 54-year-old male CLL patient with nephrotic syndrome and renal failure. The lymph node biopsy confirmed that the patients had CLL with remarkable immunoglobulin light chain amyloid deposition. The renal biopsy demonstrated the concurrence of AL amyloidosis and neoplastic infiltration. Combined treatment of fludarabine, cyclophosphamide and rituximab resulted in remission of CLL, as well as the renal disfunction and nephrotic syndrome, without recurrence during a 12-month follow-up. To our knowledge, this is the first case of CLL patient showing the nephrotic syndrome and acute renal failure caused by AL amyloidosis and neoplastic infiltration. Though AL amyloidosis caused by plasma cell dyscrasia usually responses poorly to chemotherapy, this patient exhibited a satisfactory clinical outcome due to successful inhibition of the production of amylodogenic light chains by combined chemotherapy
Xinfeng capsule improves pulmonary function in ankylosing spondylitis patients via NF-κB-iNOS-NO signaling pathway
AbstractObjectiveTo study changes in the nuclear factor-κB p65 (NF-κB p65)-inducible nitric oxide synthase (iNOS)-nitric oxide (NO) signaling pathway and the effects of Xinfeng capsules (XFC) in patients with ankylosing spondylitis (AS)MethodsOne hundred twenty patients with AS were randomly divided into an XFC group and a Salazopyrin group. Sixty health subjects were included as a normal control group. In the two treatment groups, pulmonary functional parameters, forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), maximal voluntary ventilation (MVV), peak expiratory flow (PEF), forced expiratory flow at 25% of forced vital capacity (FEF25), forced expiratory flow at 50% of forced vital capacity (FEF50), and forced expiratory flow at 75% of forced vital capacity (FEF75) were determined. Enzyme linked immunosorbent assays were used for detection of the serum oxidative stress indexes, NF-κB p65, iNOS, NO, reactive oxygen species (ROS), reactive nitrogen species (RNS), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), total antioxidative capacity (TAOC) and interleukin-4 (IL-4), IL-10, IL-1β, and tumor necrosis factor-α (TNF-α) contents. Westergren's method was used for determination of erythrocyte sedimentation rate (ESR). High-sensitivity C-reactive protein (Hs-CRP) was detected with a 7060 full-automatic biochemical analyzer (Hitachi, Japan).ResultsThe clinical therapeutic effect in the XFC group was significantly superior to that in the Salazopyrin group (P<0.01). Compared with the normal control group, FEV1, MVV, PEF, FEF50, FEF75, SOD, CAT, TAOC, IL-4, IL-10 were significantly lower, and NF-κB p65, iNOS, NO, ROS, RNS, MDA, IL-1β, TNF-α, ESR, and Hs-CRP significantly higher in patients with AS (P<0.01 or P<0.05). Compared with before treatment, FEV1, MVV, PEF, FEF50, FEF75, SOD, CAT, TAOC, IL-4, and IL-10 were significantly increased, and NF-κB p65, iNOS, NO, ROS, RNS, MDA, IL-1β, TNF-α, ESR, CRP, visual analog scales (VAS), Bath ankylosing spondylitis disease active index, Bath ankylosing spondylitis functional index, and Bath ankylosing spondylitis global index significantly decreased in the two treatment groups after treatment (P< 0.01 or P<0.05), with significant differences between the XFC and Salazopyrin groups (P<0.01 or P<0.05). Spearman correlation analysis indicated that FEV1, MVV, PEF, FEF50, and FEF75 were positively correlated with SOD, CAT, TAOC, IL-4, and IL-10, and were negatively correlated with NF-κB p65, iNOS, NO, ROS, RNS, MDA, IL-1β, TNF-α, ESR, and CRP.ConclusionPatients with AS have local pathologic changes in the spinal cord and other joints. They also have decreased pulmonary function, which is negatively correlated with the NF-κB-iNOS-NO signaling pathway, oxidative indexes, and inflammatory factors. XFC improves rigidity and pain in spinal joints and other symptoms, laboratory indexes, and pulmonary function. The mechanism is possibly related to inhibition of the NF-κB-iNOS-NO signaling pathway
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