10 research outputs found
FDA safety warning on the cardiac effects of lamotrigine: an advisory from the Ad Hoc ILAE/AES Task Force
Paroxysmal Cerebral Disorder
The Galactic Environment of the Sun: Interstellar Material Inside and Outside of the Heliosphere
Measurement of the Positive Muon Anomalous Magnetic Moment to 0.46 ppm
We present the first results of the Fermilab Muon g-2 Experiment for the
positive muon magnetic anomaly . The anomaly is
determined from the precision measurements of two angular frequencies.
Intensity variation of high-energy positrons from muon decays directly encodes
the difference frequency between the spin-precession and cyclotron
frequencies for polarized muons in a magnetic storage ring. The storage ring
magnetic field is measured using nuclear magnetic resonance probes calibrated
in terms of the equivalent proton spin precession frequency
in a spherical water sample at 34.7C. The
ratio , together with known fundamental
constants, determines
(0.46\,ppm). The result is 3.3 standard deviations greater than the standard
model prediction and is in excellent agreement with the previous Brookhaven
National Laboratory (BNL) E821 measurement. After combination with previous
measurements of both and , the new experimental average of
(0.35\,ppm) increases the
tension between experiment and theory to 4.2 standard deviationsComment: 10 pages; 4 figure
Beta Blockade and Clinical Outcomes in Aneurysmal Subarachnoid Hemorrhage
BACKGROUND: Aneurysmal subarachnoid hemorrhages are frequently complicated by hypertension and neurogenic myocardial stunning. Beta blockers may be used for management of these complications. We sought to investigate sympathetic nervous system modulation by beta blockers and their effect on radiographic vasospasm, delayed cerebral infarction, discharge destination and death. METHODS: Retrospective chart review of 218 adults admitted to the ICU between 8/2004 and 9/2010 was performed. Groups were identified relevant to beta blockade: 77 were never beta blocked (No/No), 123 received post-admission beta blockers (No/Yes), and 18 were continued on their home beta blockers (Yes/Yes). Records were analyzed for baseline characteristics and the development of vasospasm, delayed cerebral infarction, discharge destination and death, expressed as adjusted odds ratio. RESULTS: Of the 218 patients 145 patients developed vasospasm, 47 consequently infarcted, and 53 died or required care in a long-term facility. When compared to No/No patients, No/Yes patients had significantly increased vasospasm (OR 2.11 (1.06-4.16)). However, these patients also had significantly fewer deaths or need for long term care (OR 0.17 (0.05-0.64)), with decreased tendency for infarcts (OR 0.70 (0.32-1.55)). When compared to No/No patients, Yes/Yes patients demonstrated a trend toward increased vasospasm (OR 1.61 (0.50-5.29)) that led to infarction (OR 1.51 (0.44-5.13)), but with decreased mortality or need for long term care in a facility (OR 0.13 (0.01-1.30)). CONCLUSION: Post-admission beta blockade in aneurysmal subarachnoid hemorrhage patients was associated with increased incidence of vasospasm. However, despite the increased occurrence of vasospasm, beta blockers were associated with improved discharge characteristics and fewer deaths
Detailed Report on the Measurement of the Positive Muon Anomalous Magnetic Moment to 0.20 ppm
We present details on a new measurement of the muon magnetic anomaly, . The result is based on positive muon data taken at Fermilab's Muon Campus during the 2019 and 2020 accelerator runs. The measurement uses GeV polarized muons stored in a -m-radius storage ring with a T uniform magnetic field. The value of is determined from the measured difference between the muon spin precession frequency and its cyclotron frequency. This difference is normalized to the strength of the magnetic field, measured using Nuclear Magnetic Resonance (NMR). The ratio is then corrected for small contributions from beam motion, beam dispersion, and transient magnetic fields. We measure (0.21 ppm). This is the world's most precise measurement of this quantity and represents a factor of improvement over our previous result based on the 2018 dataset. In combination, the two datasets yield (0.20 ppm). Combining this with the measurements from Brookhaven National Laboratory for both positive and negative muons, the new world average is (exp) (0.19 ppm)