2,348 research outputs found
Cutaneous eccrine glands of the foot pads of the rock hyrax (Procavia capensis, Hyracoidea, mammalia)
In order to find correlations between skin gland morphology and specific ethological features, the cutaneous glands of the foot pads of Procavia capensis were studied by histological and various histochemical methods and by electron microscopy. In the foot pads, abundant specific eccrine skin glands occur, which consist of coiled tubular secretory portions and coiled ducts. The wall of the secretory part is composed of cuboidal glandular cells and myoepithelial cells. Among the glandular cells two types occur: clear and dark cells. Clear cells have numerous mitochondria and form a basal labyrinth, indicating fluid transport. Dark cells, which stain strongly with periodic acid-Schiff, contain a highly developed perinuclear Golgi apparatus, large amounts of rough endoplasmic reticulum and many secretory granules indicating production of glycoproteins. Cytokeratin (CK) 19 was found in secretory compartments and ducts, CK14 only in duct cells. Single cells of the secretory coils and ducts may be stained with antibodies against antimicrobial peptides. Some glandular cells contain proliferating cell nuclear antigen-positive nuclei especially in the ducts indicating an increased cell proliferation. Terminal transferase (TdT)-mediated d-UTP nick-end labeling-positive nuclei can be detected predominantly in the secretory coils and rarely in the transitional portions between ducts and end pieces. We suppose that proliferating cells migrate from the ducts to the secretory coils. The secretory product of the eccrine cutaneous glands seems to improve the traction between the foot pads of these animals and the steep and smooth rock formations among which they live
Estimating Electric Fields from Vector Magnetogram Sequences
Determining the electric field (E-field) distribution on the Sun's
photosphere is essential for quantitative studies of how energy flows from the
Sun's photosphere, through the corona, and into the heliosphere. This E-field
also provides valuable input for data-driven models of the solar atmosphere and
the Sun-Earth system. We show how Faraday's Law can be used with observed
vector magnetogram time series to estimate the photospheric E-field, an
ill-posed inversion problem. Our method uses a "poloidal-toroidal
decomposition" (PTD) of the time derivative of the vector magnetic field. The
PTD solutions are not unique; the gradient of a scalar potential can be added
to the PTD E-field without affecting consistency with Faraday's Law. We present
an iterative technique to determine a potential function consistent with ideal
MHD evolution; but this E-field is also not a unique solution to Faraday's Law.
Finally, we explore a variational approach that minimizes an energy functional
to determine a unique E-field, similar to Longcope's "Minimum Energy Fit". The
PTD technique, the iterative technique, and the variational technique are used
to estimate E-fields from a pair of synthetic vector magnetograms taken from an
MHD simulation; and these E-fields are compared with the simulation's known
electric fields. These three techniques are then applied to a pair of vector
magnetograms of solar active region NOAA AR8210, to demonstrate the methods
with real data.Comment: 41 pages, 10 figure
The cyclic stress-strain behavior of PWA 1480 at 650 deg C
The monotonic plastic flow behavior of several single crystal nickel-base, superalloys has been shown to vary significantly with crystallographic orientation. In the present study, the cyclic plastic flow response of one such alloy, PWA 1480, was examined at 650 deg C in air. Single crystal specimens aligned near several crystallographic directions were tested in fully reversed, total-strain-controlled low cycle fatigue tests at a frequency of 0.1 Hz. The cyclic stress-strain response and general cyclic hardening behavior was analyzed as a function of crystallographic orientation and inelastic strain range
Development of Rebunching Cavities at IAP
A focus of work at IAP has been the development and optimization of spiral
loaded cavities since the 1970s [A. Schempp et al, NIM 135, 409 (1976)]. These
cavities feature a high efficiency, a compact design and a big variety of
possible fields of application. They find use both as bunchers and post
accelerators to vary the final energy of the beam. In comparison to other
available designs, the advantage of these structures lies in their small size.
Furthermore they can easily be tuned to the required resonance frequency by
varying the length of the spiral. Due to the small size of the cavities the
required budget can also be kept low. Here, two slightly different types of
spiral loaded cavities, which were built for the REX-ISOLDE project at CERN and
the intensity upgrade program at GSI are being discussed.Comment: 4 pages, 9 figures PRST-AB special LINAC 2000 edition with additional
information in comparison to the 3 pages LINAC paper physics/000708
Beam Dynamics Studies and Design Optimisation of New Low Energy Antiproton Facilities
Antiprotons, stored and cooled at low energies in a storage ring or at rest
in traps, are highly desirable for the investigation of a large number of basic
questions on fundamental interactions. This includes the static structure of
antiprotonic atomic systems and the time-dependent quantum dynamics of
correlated systems. The Antiproton Decelerator (AD) at CERN is currently the
worlds only low energy antiproton factory dedicated to antimatter experiments.
New antiproton facilities, such as the Extra Low ENergy Antiproton ring (ELENA)
at CERN and the Ultra-low energy Storage Ring (USR) at FLAIR, will open unique
possibilities. They will provide cooled, high quality beams of extra-low energy
antiprotons at intensities exceeding those achieved presently at the AD by
factors of ten to one hundred. These facilities, operating in the energy regime
between 100 keV down to 20 keV, face several design and beam dynamics
challenges, for example nonlinearities, space charge and scattering effects
limiting beam life time. Detailed investigations into the low energy and long
term beam dynamics have been carried out to address many of those challenges
towards the design optimisation. Results from these studies are presented in
this contribution, showing some examples for ELENA.Comment: 6 pages, 4 figures, 12th International Conference on Low Energy
Antiproton Physics, LEAP 2016. Submitted to JPS Conference Proceeding
Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers
Objectives: Our study sought to elucidate the role of oxidative stress for shedding of tumor necrosis factor-α (TNF-α) and for activating TNF-α-converting enzyme (TACE). Background: TNF-α, a central inflammatory cytokine, is discussed as one of the mediators of reperfusion injury. Shedding of membrane-bound pro-TNF-α is thought to be largely due to TNF-α-converting enzyme (TACE). Methods: Release of TNF-α and TACE dependency were studied in isolated rat hearts and in the human mast cell line HMC-1. Results: In reperfused hearts, interstitial release of TNF-α occurred in two phases (2–10 and >45 min). It depended on the presence of oxygen during reperfusion and was attenuated by reduced glutathione. Infusion of the oxidants H2O2 or HOCl elicited release in non-ischemic hearts. TNF-α release was inhibited in hearts treated with degranulation inhibitors ketotifen or cromoglycate, suggesting mast cells as major source for myocardial TNF-α. This was confirmed by tissue staining. Post-ischemic release of histamine, however, did not parallel that of TNF-α. Heart tissue contained mainly mature TACE. HMC-1 expressed abundant pro-TACE and cleaved the pro-TNF-α-peptide Ac-SPLAQAVRSSSR-NH2. However, cleavage was nonspecific and only partly inhibited by TACE inhibitor TAPI-2 (10–100 μmol/l), while it was stimulated by H2O2 and HOCl and fully blocked by the nonspecific metalloprotease inhibitor o-phenanthroline. Conclusions: The mechanism underlying TNF-α release from post-ischemic myocardium is oxidation-dependent but largely independent of activation of TACE. Mast cell stabilizers may be useful in preventing TNF-α release during reperfusion
Conditional quantum-state transformation at a beam splitter
Using conditional measurement on a beam splitter, we study the transformation
of the quantum state of the signal mode within the concept of two-port
non-unitary transformation. Allowing for arbitrary quantum states of both the
input reference mode and the output reference mode on which the measurement is
performed, we show that the non-unitary transformation operator can be given as
an -ordered operator product, where the value of is entirely determined
by the absolute value of the beam splitter reflectance (or transmittance). The
formalism generalizes previously obtained results that can be recovered by
simple specification of the non-unitary transformation operator. As an
application, we consider the generation of Schr\"odinger-cat-like states. An
extension to mixed states and imperfect detection is outlined.Comment: 7 Postscript figures, using Late
Histological investigations on the thyroid glands of marine mammals (Phoca vitulina, Phocoena phocoena) and the possible implications of marine pollution
In 1988 and 1989, thousands of harbor seals (Phoca vitulina) died in the North Sea from phocine distemper infection. The morphology of thyroid glands from 40 harbor seals found dead on the North Sea coastlines of Schleswig-Holstein, Federal Republic of Germany, during an epizootic of phocine distemper, was compared with the morphology of thyroid glands from five healthy harbor seals collected in Iceland. Thyroid glands from seven harbor porpoises (Phocoena phocoena) found dead in 1990 on the North Sea coastlines also were evaluated. Colloid depletion and fibrosis were found in the thyroid glands of harbor seals which died during the epizootic, but not in animals from Iceland. Thyroid glands of the porpoises showed similar lesions, but to a lesser degree, than those observed in the North Sea seals
Determination of quantum-noise parameters of realistic cavities
A procedure is developed which allows one to measure all the parameters
occurring in a complete model [A.A. Semenov et al., Phys. Rev. A 74, 033803
(2006); quant-ph/0603043] of realistic leaky cavities with unwanted noise. The
method is based on the reflection of properly chosen test pulses by the cavity.Comment: 5 pages, 2 figure
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