A Corpus-Based, Pilot Study of Lexical Stress Variation in American English

Phonological free variation describes the phenomenon of there being more than one pronunciation for a word without any change in meaning (e.g. because, schedule, vehicle). The term also applies to words that exhibit different stress patterns (e.g. academic, resources, comparable) with no change in meaning or grammatical category. A corpus-based analysis of free variation is a useful tool for testing the validity of surveys of speakers' pronunciation preferences for certain variants. The current paper presents the results of a corpus-based pilot study of American English, in an attempt to replicate Mompéan's 2009 study of British English

Computer aids for worst case electronic circuit design

Computer aids for worst case electronic circuit desig

Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor.

Signaling through growth factor receptors controls such diverse cell functions as proliferation, migration, and differentiation. A critical question has been how the activation of these receptors is regulated. Most, if not all, of the known ligands for these receptors are soluble factors. However, as matrix components are highly tissue-specific and change during development and pathology, it has been suggested that select growth factor receptors might be stimulated by binding to matrix components. Herein, we describe a new class of ligand for the epidermal growth factor (EGF) receptor (EGFR) found within the EGF-like repeats of tenascin-C, an antiadhesive matrix component present during organogenesis, development, and wound repair. Select EGF-like repeats of tenascin-C elicited mitogenesis and EGFR autophosphorylation in an EGFR-dependent manner. Micromolar concentrations of EGF-like repeats induced EGFR autophosphorylation and activated extracellular signal-regulated, mitogen-activated protein kinase to levels comparable to those induced by subsaturating levels of known EGFR ligands. EGFR-dependent adhesion was noted when the ligands were tethered to inert beads, simulating the physiologically relevant presentation of tenascin-C as hexabrachion, and suggesting an increase in avidity similar to that seen for integrin ligands upon surface binding. Specific binding to EGFR was further established by immunofluorescence detection of EGF-like repeats bound to cells and cross-linking of EGFR with the repeats. Both of these interactions were abolished upon competition by EGF and enhanced by dimerization of the EGF-like repeat. Such low affinity behavior would be expected for a matrix-tethered ligand; i.e., a ligand which acts from the matrix, presented continuously to cell surface EGF receptors, because it can neither diffuse away nor be internalized and degraded. These data identify a new class of insoluble growth factor ligands and a novel mode of activation for growth factor receptors

An experimental study of the temporal statistics of radio signals scattered by rain

A fixed-beam bistatic CW experiment designed to measure the temporal statistics of the volume reflectivity produced by hydrometeors at several selected altitudes, scattering angles, and at two frequencies (3.6 and 7.8 GHz) is described. Surface rain gauge data, local meteorological data, surveillance S-band radar, and great-circle path propagation measurements were also made to describe the general weather and propagation conditions and to distinguish precipitation scatter signals from those caused by ducting and other nonhydrometeor scatter mechanisms. The data analysis procedures were designed to provide an assessment of a one-year sample of data with a time resolution of one minute. The cumulative distributions of the bistatic signals for all of the rainy minutes during this period are presented for the several path geometries

Understanding the role of promoters in catalysis: operando XAFS/DRIFTS study of CeO_x/Pt/Al₂O₃ during CO oxidation

A combined operando XAFS/DRIFTS study on CeOx/Pt/Al2O3 catalysts has been performed during CO oxidation and provides insights into the changes in nanoparticle structure and adsorbed species during the reaction profile. The onset of CO2 formation is shown to be concurrent with a rapid re-oxidation of the Pt nanoparticles, evidenced by XAFS spectroscopy, and the loss of bridge bonded CO adsorbed on Pt, as shown by simultaneous DRIFTS acquisition. The continued appearance of linear bound CO on the catalyst surface is shown to remain long after catalytic light off. The interaction of Pt and CeOx is evidenced by the improved performance towards CO oxidation, compared to the non-CeOx modified Pt/Al2O3, and changes in the CO adsorption properties on Pt previously linked to Pt-CeO2 interfaces

Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb

Mice are one of the most commonly used laboratory animals, with an extensive array of disease models in existence, including for many neuromuscular diseases. The hindlimb is of particular interest due to several close muscle analogues/homologues to humans and other species. A detailed anatomical study describing the adult morphology is lacking, however. This study describes in detail the musculoskeletal geometry and skeletal muscle architecture of the mouse hindlimb and pelvis, determining the extent to which the muscles are adapted for their function, as inferred from their architecture. Using I2KI enhanced microCT scanning and digital segmentation, it was possible to identify 39 distinct muscles of the hindlimb and pelvis belonging to nine functional groups. The architecture of each of these muscles was determined through microdissections, revealing strong architectural specialisations between the functional groups. The hip extensors and hip adductors showed significantly stronger adaptations towards high contraction velocities and joint control relative to the distal functional groups, which exhibited larger physiological cross sectional areas and longer tendons, adaptations for high force output and elastic energy savings. These results suggest that a proximo-distal gradient in muscle architecture exists in the mouse hindlimb. Such a gradient has been purported to function in aiding locomotor stability and efficiency. The data presented here will be especially valuable to any research with a focus on the architecture or gross anatomy of the mouse hindlimb and pelvis musculature, but also of use to anyone interested in the functional significance of muscle design in relation to quadrupedal locomotion

Cosmic Strings from Supersymmetric Flat Directions

Flat directions are a generic feature of the scalar potential in supersymmetric gauge field theories. They can arise, for example, from D-terms associated with an extra abelian gauge symmetry. Even when supersymmetry is broken softly, there often remain directions in the scalar field space along which the potential is almost flat. Upon breaking a gauge symmetry along one of these almost flat directions, cosmic strings may form. Relative to the standard cosmic string picture based on the abelian Higgs model, these flat-direction cosmic strings have the extreme Type-I properties of a thin gauge core surrounded by a much wider scalar field profile. We perform a comprehensive study of the microscopic, macroscopic, and observational characteristics of this class of strings. We find many differences from the standard string scenario, including stable higher winding mode strings, the dynamical formation of higher mode strings from lower ones, and a resultant multi-tension scaling string network in the early universe. These strings are only moderately constrained by current observations, and their gravitational wave signatures may be detectable at future gravity wave detectors. Furthermore, there is the interesting but speculative prospect that the decays of cosmic string loops in the early universe could be a source of ultra-high energy cosmic rays or non-thermal dark matter. We also compare the observational signatures of flat-direction cosmic strings with those of ordinary cosmic strings as well as (p,q) cosmic strings motivated by superstring theory.Comment: 58 pages, 16 figures, v2. accepted to PRD, added comments about baryogenesis and boosted decay products from cusp annihilatio

Pulmonary vasospasm in systemic sclerosis: noninvasive techniques for detection

In a subgroup of patients with systemic sclerosis (SSc), vasospasm affecting the pulmonary circulation may contribute to worsening respiratory symptoms, including dyspnea. Noninvasive assessment of pulmonary blood flow (PBF), utilizing inert-gas rebreathing (IGR) and dual-energy computed-tomography pulmonary angiography (DE-CTPA), may be useful for identifying pulmonary vasospasm. Thirty-one participants (22 SSc patients and 9 healthy volunteers) underwent PBF assessment with IGR and DE-CTPA at baseline and after provocation with a cold-air inhalation challenge (CACh). Before the study investigations, participants were assigned to subgroups: group A included SSc patients who reported increased breathlessness after exposure to cold air (n = 11), group B included SSc patients without cold-air sensitivity (n = 11), and group C patients included the healthy volunteers. Median change in PBF from baseline was compared between groups A, B, and C after CACh. Compared with groups B and C, in group A there was a significant decline in median PBF from baseline at 10 minutes (−10%; range: −52.2% to 4.0%; P < 0.01), 20 minutes (−17.4%; −27.9% to 0.0%; P < 0.01), and 30 minutes (−8.5%; −34.4% to 2.0%; P < 0.01) after CACh. There was no significant difference in median PBF change between groups B or C at any time point and no change in pulmonary perfusion on DE-CTPA. Reduction in pulmonary blood flow following CACh suggests that pulmonary vasospasm may be present in a subgroup of patients with SSc and may contribute to worsening dyspnea on exposure to cold

Wind tunnel and analytical investigation of over-the-wing propulsion/air frame interferences for a short-haul aircraft at Mach numbers from 0.6 to 0.78

Results of analytical calculations and wind tunnel tests at cruise speeds of a representative four engine short haul aircraft employing upper surface blowing (USB) with a supercritical wing are discussed. Wind tunnel tests covered a range of Mach number M from 0.6 to 0.78. Tests explored the use of three USB nozzle configurations. Results are shown for the isolated wing body and for each of the three nozzle types installed. Experimental results indicate that a low angle nacelle and streamline contoured nacelle yielded the same interference drag at the design Mach number. A high angle powered lift nacelle had higher interference drag primarily because of nacelle boattail low pressures and flow separation. Results of varying the spacing between the nacelles and the use of trailing edge flap deflections, wing upper surface contouring, and a convergent-divergent nozzle to reduce potential adverse jet effects were also discussed. Analytical comparisons with experimental data, made for selected cases, indicate favorable agreement