Hydroclimatic variability in loess delta D-wax records from the central Chinese Loess Plateau over the past 250 ka

This study reports hydrogen isotopic records from the central Chinese Loess Plateau (CLP) over the past 250 ka. After eliminating the influence of ice and local temperatures, the delta D-wax records extracted from two loess sites at Xifeng and Luochuan can be taken to represent arid/humid alternations in the hydrological environment in this marginal Asian Summer Monsoon (ASM) region; they also contain integrated information on summer precipitation patterns and the corresponding responses to these changes by predominant vegetation cover types. These arid/humid alternations show 100 ka, 40 ka and 20 ka cycles. An increase in precipitation in association with an enhanced summer monsoon has historically been taken to be the major factor driving a humid environment in the central CLP. However, hydroclimatic changes in delta D-wax records differ for the central CLP, central China and southern China. Over a 20 ka cycle, the influence of solar insolation on hydroclimatic changes can be shown to be consistent throughout the central CLP. However, changes in the relative location of the land and sea may have caused different hydroclimatic responses between southern China and the central CLP on a glacial-interglacial scale. The hydroclimatic variability in the central CLP would suggest that an enhanced summer monsoon due to climatic warming is the key to understanding decreased drought degree in this marginal monsoonal region

Expression of GSK-3β in renal allograft tissue and its significance in pathogenesis of chronic allograft dysfunction

<p>Abstract</p> <p>Objective</p> <p>To explore the expression of Glycogen synthase kinase 3 beta (GSK-3β) in renal allograft tissue and its significance in the pathogenesis of chronic allograft dysfunction.</p> <p>Methods</p> <p>Renal allograft biopsy was performed in all of the renal allograft recipients with proteinuria or increased serum creatinine level who came into our hospital from January 2007 to December 2009. Among them 28 cases was diagnosed as chronic allograft dysfunction based on pahtological observation, including 21 males with a mean age of 45 ± 10 years old and 7 females with a mean age of 42 ± 9 years old. The time from kidney transplantation to biopsy were 1-9 (3.5) years. Their serum creatinine level were 206 ± 122 umol/L. Immunohistochemical assay and computer-assisted genuine color image analysis system (imagepro-plus 6.0) were used to detect the expression of GSK-3β in the renal allografts of 28 cases of recipients with chronic allograft dysfunction. Mean area and mean integrated optical density of GSK-3β expression were calculated. The relationship between expression level of GSK-3β and either the grade of inflammatory cell infiltration or interstitial fibrosis/tubular atrophy in renal allograft was analyzed. Five specimens of healthy renal tissue were used as controls.</p> <p>Results</p> <p>The expression level of the GSK-3β was significantly increased in the renal allograft tissue of recipients with chronic allograft dysfunction, compared to normal renal tissues, and GSK-3β expression became stronger along with the increasing of the grade of either inflammatory cell infiltration or interstitial fibrosis/tubular atrophy in renal allograft tissue.</p> <p>Conclusion</p> <p>There might be a positive correlation between either inflammatory cell infiltration or interstitial fibrosis/tubular atrophy and high GSK-3β expression in renal allograft tissue.</p> <p>Virtual slides</p> <p>The virtual slide(s) for this article can be found here:</p> <p><url>http://www.diagnosticpathology.diagnomx.eu/vs/9924478946162998</url>.</p

Herbivores Alleviate the Negative Effects of Extreme Drought on Plant Community by Enhancing Dominant Species

Aims Both extreme drought and insect herbivores can suppress plant growth in grassland communities. However, most studies have examined extreme drought and insects in isolation, and there is reason to believe that insects might alter the ability of grasslands to withstand drought. Unfortunately, few studies have tested the interactive effects of extreme drought and insect herbivores in grassland communities. Methods Here, we tested the drought–herbivore interactions using a manipulative experiment that factorially crossed extreme drought with the exclusion of insect herbivores in a temperate semiarid grassland in Inner Mongolia. Important Findings Our results demonstrated that both extreme drought and insect herbivores separately decreased total plant cover. When combined, insect herbivores reduced the impact of drought on total cover by increasing the relative abundance of drought-resistant dominant species. Our results highlight that the negative effect of extreme drought on total plant cover could be alleviated by maintaining robust insect herbivore communities

Mid-late Holocene temperature and precipitation variations in the Guanting Basin, upper reaches of the Yellow River

The reconstruction of prehistoric temperature and precipitation variations in the upper reaches of the Yellow River is essential for understanding the cultural evolution of the region, but related information is sparse due to the limitations of the available proxies. Recent studies have shown that microbial glycerol dialkyl glycerol tetraethers (GDGTs) are promising tools for reconstructing mean annual temperature (MAT) and mean annual precipitation (MAP) in terrestrial deposits. In this study, we reconstructed mid-late Holocene climatic changes using GDGT distributions in a loess-paleosol sequence in the Lajia Ruins of the Neolithic Qijia Culture, Guanting Basin, in the southwestern end of the Chinese Loess Plateau. Our GDGT records show that MAP decreased from ca. 600 mm to 430 mm, while MAT decreased from 11.9 degrees C to 8.0 degrees C, during the past ca. 7000 yr, and a drastic decline in MAP (70 mm), accompanied by a 0.8 degrees C decline in MAT, occurred at 3800-3400 yr BP. Our results provide direct evidence supporting a hypothesis that the flourishing (4200-4000 yr BP) and decline (4000-3600 yr BP) of the Qijia culture (mainly based on millets cultivation) and subsequent rise of the Xindian/Kayue culture (3600-2600 yr BP), based on mixed agriculture of sheep husbandry and millets cultivation were triggered by climate change

Ultrafast Melting of Superconductivity in an Iron-Based Superconductor

Intense debate has recently arisen regarding the photoinduced changes to the iron-chalcogenide superconductors, including the enhancement of superconductivity and a metastable state. Here, by employing high energy resolution, we directly observe the melting of superconductivity on ultrafast timescales. We demonstrate a distinctly nonequilibrium response on short timescales, where the gap fills in prior to the destruction of the superconducting peak, followed by a metastable response. We propose that the former is due to pair phase decoherence and speculate that the latter is due to the increase in double stripe correlations that are known to compete with superconductivity. Our results add to exciting new developments on the iron-based superconductors, indicating that the photoinduced metastable state possibly competes with superconductivity

Synthesis and Anticancer Activity Evaluation of Novel Phenanthridine Derivatives

Based on the structure of sanguinarine, fourteen phenanthridine derivatives were designed and synthesized in the current study. The cytotoxic activities of synthesized compounds were evaluated against five human cancer cell lines (MCF-7, PC3, Hela, A549, and HepG2 cell lines) via MTT assay. Among all the compounds tested, molecule 8a exhibited significant cytotoxic activity against MCF-7 cells with a IC50 value of 0.28 μM. A following up enzymatic assay indicated that compound 8a could inhibit the activity of DNA topoisomerase I/II. Further mechanistic studies performed in the MCF-7 cell line revealed that compound 8a could arrest cell cycle in S phase and induce cell apoptosis via downregulation of Bcl-2 and upregulation of Bax. Collectively, a potent DNA topoisomerase inhibitor (8a) was discovered, which exhibited potential as a candidate chemotherapeutic agent for the management of tumors in the present study

Origin and anatomy of two different types of mass-transport complexes: a 3D seismic case study from the northern South China Sea margin

Integration of 2D and 3D seismic data from the Qiongdongnan Basin along the northwestern South China Sea margin has enabled the seismic stratigraphy, seismic geomorphology and emplacement mechanisms of eight separate, previously undocumented, mass-transport complexes (MTCs) to be characterized. These eight MTCs can be grouped into two types:. (1) Localized detached MTCs, which are confined to submarine canyons and cover hundreds of km, consist of a few tens of km remobilized sediments and show long striations at their base. They resulted from small-scale mass-wasting processes induced by regional tectonic events and gravitational instabilities on canyon margins.(2) Regional attached MTCs, which occur within semi-confined or unconfined settings and are distributed roughly perpendicular to the strike of the regional slope. Attached MTCs occupy hundreds to thousands of km and are composed of tens to hundreds of km of remobilized sediments. They contain headwall escarpments, translated blocks, remnant blocks, pressure ridges, and basal striations and cat-claw grooves. They were created by large-scale mass-wasting processes triggered by high sedimentation rates, slope oversteepening by shelf-edge deltas, and seismicity.Our results show that MTCs may act as both lateral and top seals for underlying hydrocarbon reservoirs and could create MTC-related stratigraphic traps that represent potential drilling targets on continental margins, helping to identify MTC-related hydrocarbon traps

The Sihailongwan Maar Lake, northeastern China as a candidate Global Boundary Stratotype Section and Point for the Anthropocene Series

Sihailongwan Maar Lake, located in Northeast China, is a candidate Global boundary Stratotype Section and Point (GSSP) for demarcation of the Anthropocene. The lake’s varved sediments are formed by alternating allogenic atmospheric inputs and authigenic lake processes and store a record of environmental and human impacts at a continental-global scale. Varve counting and radiometric dating provided a precise annual-resolution sediment chronology for the site. Time series records of radioactive (239,240Pu, 129I and soot 14C), chemical (spheroidal carbonaceous particles, polycyclic aromatic hydrocarbons, soot, heavy metals, δ13C, etc), physical (magnetic susceptibility and grayscale) and biological (environmental DNA) indicators all show rapid changes in the mid-20th century, coincident with clear lithological changes of the sediments. Statistical analyses of these proxies show a tipping point in 1954 CE. 239,240Pu activities follow a typical unimodal globally-distributed profile, and are proposed as the primary marker for the Anthropocene. A rapid increase in 239,240Pu activities at 88 mm depth in core SHLW21-Fr-13 (1953 CE) is synchronous with rapid changes of other anthropogenic proxies and the Great Acceleration, marking the onset of the Anthropocene. The results indicate that Sihailongwan Maar Lake is an ideal site for the Anthropocene GSSP

Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi Metarhizium anisopliae and M. acridum

Metarhizium spp. are being used as environmentally friendly alternatives to chemical insecticides, as model systems for studying insect-fungus interactions, and as a resource of genes for biotechnology. We present a comparative analysis of the genome sequences of the broad-spectrum insect pathogen Metarhizium anisopliae and the acridid-specific M. acridum. Whole-genome analyses indicate that the genome structures of these two species are highly syntenic and suggest that the genus Metarhizium evolved from plant endophytes or pathogens. Both M. anisopliae and M. acridum have a strikingly larger proportion of genes encoding secreted proteins than other fungi, while ∼30% of these have no functionally characterized homologs, suggesting hitherto unsuspected interactions between fungal pathogens and insects. The analysis of transposase genes provided evidence of repeat-induced point mutations occurring in M. acridum but not in M. anisopliae. With the help of pathogen-host interaction gene database, ∼16% of Metarhizium genes were identified that are similar to experimentally verified genes involved in pathogenicity in other fungi, particularly plant pathogens. However, relative to M. acridum, M. anisopliae has evolved with many expanded gene families of proteases, chitinases, cytochrome P450s, polyketide synthases, and nonribosomal peptide synthetases for cuticle-degradation, detoxification, and toxin biosynthesis that may facilitate its ability to adapt to heterogenous environments. Transcriptional analysis of both fungi during early infection processes provided further insights into the genes and pathways involved in infectivity and specificity. Of particular note, M. acridum transcribed distinct G-protein coupled receptors on cuticles from locusts (the natural hosts) and cockroaches, whereas M. anisopliae transcribed the same receptor on both hosts. This study will facilitate the identification of virulence genes and the development of improved biocontrol strains with customized properties