Rock CT Image Super-Resolution Using Residual Dual-Channel Attention Generative Adversarial Network

Because of its benefits in terms of high speed, non-destructiveness, and three-dimensionality, as well as ease of integration with computer simulation, computed tomography (CT) technology is widely applied in reservoir geology research. However, rock imaging is restricted by the device used as there is not a win–win for both the image receptive field and corresponding resolution. Convolutional neural network-based super-resolution reconstruction has become a hot topic in improving the performance of CT images. With the help of a convolution kernel, it can effectively extract characteristics and ignore disturbance information. The dismal truth is that convolutional neural networks still have numerous issues, particularly unclear texture details. To address these challenges, a generative adversarial network (RDCA-SRGAN) was designed to improve rock CT image resolution using the combination of residual learning and a dual-channel attention mechanism. Specifically, our generator employs residual attention to extract additional features; similarly, the discriminator builds on dual-channel attention and residual learning to distinguish generated contextual information and decrease computational consumption. Quantitative and qualitative analyses demonstrate that the proposed model is superior to earlier advanced frameworks and is capable to constructure visually indistinguishable high-frequency details. The quantitative analysis shows our model contributes the highest value of structural similarity, enriching the more detailed texture information. From the qualitative analysis, in enlarged details of the reconstructed images, the edges of the images generated by the RDCA-SRGAN can be shown to be clearer and sharper. Our model not only performs well in subtle coal cracks but also enriches more dissolved carbonate and carbon minerals. The RDCA-SRGAN has substantially enhanced the reconstructed image resolution and our model has great potential to be used in geomorphological study and exploration

Rock CT Image Super-Resolution Using Residual Dual-Channel Attention Generative Adversarial Network

Because of its benefits in terms of high speed, non-destructiveness, and three-dimensionality, as well as ease of integration with computer simulation, computed tomography (CT) technology is widely applied in reservoir geology research. However, rock imaging is restricted by the device used as there is not a win–win for both the image receptive field and corresponding resolution. Convolutional neural network-based super-resolution reconstruction has become a hot topic in improving the performance of CT images. With the help of a convolution kernel, it can effectively extract characteristics and ignore disturbance information. The dismal truth is that convolutional neural networks still have numerous issues, particularly unclear texture details. To address these challenges, a generative adversarial network (RDCA-SRGAN) was designed to improve rock CT image resolution using the combination of residual learning and a dual-channel attention mechanism. Specifically, our generator employs residual attention to extract additional features; similarly, the discriminator builds on dual-channel attention and residual learning to distinguish generated contextual information and decrease computational consumption. Quantitative and qualitative analyses demonstrate that the proposed model is superior to earlier advanced frameworks and is capable to constructure visually indistinguishable high-frequency details. The quantitative analysis shows our model contributes the highest value of structural similarity, enriching the more detailed texture information. From the qualitative analysis, in enlarged details of the reconstructed images, the edges of the images generated by the RDCA-SRGAN can be shown to be clearer and sharper. Our model not only performs well in subtle coal cracks but also enriches more dissolved carbonate and carbon minerals. The RDCA-SRGAN has substantially enhanced the reconstructed image resolution and our model has great potential to be used in geomorphological study and exploration

Inhibition of EZH2 alleviates SAHA-induced senescence-associated secretion phenotype in small cell lung cancer cells

Abstract Chemotherapy has been widely used in small cell lung cancer (SCLC) treatment in the past decades. However, SCLC is easy to recur after chemotherapy. The senescence of cancer cells during chemotherapy is one of the effective therapeutic strategies to inhibit the progression of cancer. Nevertheless, the senescence-associated secretion phenotype (SASP) promotes chronic inflammation of the cancer microenvironment and further accelerates the progression of tumors. Therefore, inducing the senescence of cancer cells and inhibiting the production of SASP factors during anticancer treatment have become effective therapeutic strategies to improve the anticancer effect of drugs. Here we reported that SCLC cells treated with an FDA-approved HDAC inhibitor SAHA underwent senescence and displayed remarkable SASP. In particular, SAHA promoted the formation of cytoplasmic chromatin fragments (CCFs) in SCLC cells. The increased CCFs in SAHA-treated SCLC cells were related to nuclear porin Tpr, which activated the cGAS-STING pathway, and promoted the secretion of SASP in cancer cells. Inhibition of EZH2 suppressed the increase of CCFs in SAHA-treated SCLC cells, weakened the production of SASP, and increased the antiproliferative effect of SAHA. Overall, our work affords new insight into the secretion of SASP in SCLC and establishes a foundation for constructing a new therapeutic strategy for SCLC patients

The value of dual-energy spectral CT in differentiating solitary pulmonary tuberculosis and solitary lung adenocarcinoma

BackgroundTo explore the value of dual-energy spectral CT in distinguishing solitary pulmonary tuberculosis (SP-TB) from solitary lung adenocarcinoma (S-LUAD).MethodsA total of 246 patients confirmed SP-TB (n = 86) or S-LUAD (n = 160) were retrospectively included. Spectral CT parameters include CT40keV value, CT70keV value, iodine concentration (IC), water concentration (WC), effective atomic number (Zeff), and spectral curve slope (λ70keV). Data were measured during the arterial phase (AP) and venous phase (VP). Chi-square test was used to compare categorical variables, Wilcoxon rank-sum test was used to compare continuous variables, and a two-sample t-test was used to compare spectral CT parameters. ROC curves were used to calculate diagnostic efficiency.ResultsThere were significant differences in spectral CT quantitative parameters (including CT40keV value [all P< 0.001] , CT70keV value [all P< 0.001], λ70keV [P< 0.001, and P = 0.027], Zeff [P =0.015, and P = 0.001], and IC [P =0.002, and P = 0.028]) between the two groups during the AP and VP. However, WC (P = 0.930, and P = 0.823) was not statistically different between the two groups. The ROC curve analysis showed that the AUC in the AP and VP was 90.9% (95% CI, 0.873-0.945) and 83.4% (95% CI, 0.780-0.887), respectively. The highest diagnostic performance (AUC, 97.6%; 95% CI, 0.961-0.991) was achieved when all spectral CT parameters were combined with clinical variables.ConclusionDual-energy spectral CT has a significant value in distinguishing SP-TB from S-LUAD

Development of a Nomogram Based on 3D CT Radiomics Signature to Predict the Mutation Status of EGFR Molecular Subtypes in Lung Adenocarcinoma: A Multicenter Study

BackgroundThis study aimed to noninvasively predict the mutation status of epidermal growth factor receptor (EGFR) molecular subtype in lung adenocarcinoma based on CT radiomics features.MethodsIn total, 728 patients with lung adenocarcinoma were included, and divided into three groups according to EGFR mutation subtypes. 1727 radiomics features were extracted from the three-dimensional images of each patient. Wilcoxon test, least absolute shrinkage and selection operator regression, and multiple logistic regression were used for feature selection. ROC curve was used to evaluate the predictive performance of the model. Nomogram was constructed by combining radiomics features and clinical risk factors. Calibration curve was used to evaluate the goodness of fit of the model. Decision curve analysis was used to evaluate the clinical applicability of the model.ResultsThere were three, two, and one clinical factor and fourteen, thirteen, and four radiomics features, respectively, which were significantly related to each EGFR molecular subtype. Compared with the clinical and radiomics models, the combined model had the highest predictive performance in predicting EGFR molecular subtypes [Del-19 mutation vs. wild-type, AUC=0.838 (95% CI, 0.799-0.877); L858R mutation vs. wild-type, AUC=0.855 (95% CI, 0.817-0.894); and Del-19 mutation vs. L858R mutation, AUC=0.906 (95% CI, 0.869-0.943), respectively], and it has a stable performance in the validation set [AUC was 0.813 (95% CI, 0.740-0.886), 0.852 (95% CI, 0.790-0.913), and 0.875 (95% CI, 0.781-0.929), respectively].ConclusionOur combined model showed good performance in predicting EGFR molecular subtypes in patients with lung adenocarcinoma. This model can be applied to patients with lung adenocarcinoma

Correction: A disorder-free conformation boosts phonon and charge transfer in an electron-deficient-core-based non-fullerene acceptor (vol 8, pg 8566, 2020)

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