Introduction to Human- and Task-Centered Assistance Systems Minitrack

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Volume Density Thresholds for Overall Star Formation imply Mass-Size Thresholds for Massive Star Formation

We aim at understanding the massive star formation (MSF) limit $m(r) = 870 M_{\odot} (r/pc)^{1.33}$ in the mass-size space of molecular structures recently proposed by Kauffmann & Pillai (2010). As a first step, we build on the hypothesis of a volume density threshold for overall star formation and the model of Parmentier (2011) to establish the mass-radius relations of molecular clumps containing given masses of star-forming gas. Specifically, we relate the mass $m_{clump}$, radius $r_{clump}$ and density profile slope $-p$ of molecular clumps which contain a mass $m_{th}$ of gas denser than a volume density threshold $\rho_{th}$. In a second step, we use the relation between the mass of embedded-clusters and the mass of their most-massive star to estimate the minimum mass of star-forming gas needed to form a $10\,M_{\odot}$ star. Assuming a star formation efficiency of $SFE \simeq 0.30$, this gives $m_{th,crit} \simeq 150 M_{\odot}$. In a third step, we demonstrate that, for sensible choices of the clump density index ($p \simeq 1.7$) and of the cluster formation density threshold ($n_{th} \simeq 10^4\,cm^{-3}$), the line of constant $m_{th,crit} \simeq 150 M_{\odot}$ in the mass-radius space of molecular structures equates with the MSF limit for spatial scales larger than 0.3\,pc. Hence, the observationally inferred MSF limit of Kauffmann & Pillai is consistent with a threshold in star-forming gas mass beyond which the star-forming gas reservoir is large enough to allow the formation of massive stars. For radii smaller than 0.3\,pc, the MSF limit is shown to be consistent with the formation of a $10\,M_{\odot}$ star out of its individual pre-stellar core of density threshold $n_{th} \simeq 10^5\,cm^{-3}$. The inferred density thresholds for the formation of star clusters and individual stars within star clusters match those previously suggested in the literature.Comment: 8 pages, 5 figs, accepted for publication in MNRA

MuBiTec : Musikalische Bildung mit mobilen Digitaltechnologien

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Neue Rechte und Universität

Prof. Dr. Jens Schröter, Dr. Pablo Abend und Prof. Dr. Benjamin Beil sind Herausgeber der Reihe. Die Herausgeber*innen der einzelnen Hefte sind renommierte Wissenschaftler*innen aus dem In- und Ausland. AG Siegen Denken: Pablo Abend, Armin Beverungen, Marcus Burkhardt, Timo Kaerlein, Tatjana Seitz, Nadine TahaIn dieser Ausgabe der "Navigationen" sammeln wir Ressourcen gegen die Vereinnahmung der Universität durch die so genannte Neue Rechte. Auslöser für das Themenheft sind die Geschehnisse rund um ein Seminar, das im Wintersemester 2018/19 unter dem Titel „Denken und Denken lassen. Zur Philosophie und Praxis der Meinungsfreiheit“ an der Universität Siegen angeboten wurde.Das Seminar wurde von einer Vorlesungsreihe flankiert, in der „dezidiert konservative oder rechte Denker“ eine Bühne bekamen, u.a. Marc Jongen von der AfD, und der Autor Thilo Sarrazin. Ein zentrales Anliegen dieser Ausgabe ist es, die Siegener Ereignisse zu dokumentieren, wissenschaftlich aufzuarbeiten und in verschiedenen Hinsichten zu kontextualisieren: diskursstrategisch, geographisch, historisch und politisch. Hierzu versammelt das Heft Beiträge diverser Forschungsdisziplinen – explizit auch von Vertreter*innen derjenigen Disziplinen, deren Existenzrecht von Teilen der Siegener Vortragenden in Zweifel gezogen wird. Um die Diversität der betroffenen Zugänge zu repräsentieren, sind über die Medienwissenschaft hinaus Beiträge aus der Islamwissenschaft, den Gender Studies, der Linguistik und der Soziologie im Heft vertreten

The risk of cryptorchidism among sons of women working in horticulture in Denmark: a cohort study

<p>Abstract</p> <p>Background</p> <p>Androgens are crucial for normal testicular descent. Studies show that some pesticides have estrogenic or antiandrogenic effects, and that female workers exposed to pesticides have increased risk of having a boy with cryptorchidism. The main objective of the present study was to investigate whether pregnant women exposed to pesticides due to their work in horticulture experience excess risk of having sons with cryptorchidism.</p> <p>Methods</p> <p>We conducted a cohort study of pregnant women working in horticulture using four cohorts including one cohort established with data from the departments of occupational medicine in Jutland and Funen and three existing mother-child cohorts (n = 1,468). A reference group was established from the entire Danish population of boys born in the period of 1986-2007 (n = 783,817). Nationwide Danish health registers provided information on birth outcome, cryptorchidism diagnosis and orchiopexy. The level of occupational exposure to pesticides was assessed by expert judgment blinded towards outcome status. Risk of cryptorchidism among exposed horticulture workers compared to the background population and to unexposed horticulture workers was assessed by Cox regression models.</p> <p>Results</p> <p>Pesticide exposed women employed in horticulture had a hazard ratio (HR) of having cryptorchid sons of 1.39 (95% CI 0.84; 2.31) and a HR of orchiopexy of 1.34 (0.72; 2.49) compared to the background population. Analysis divided into separate cohorts revealed a significantly increased risk of cryptorchidism in cohort 2: HR 2.58 (1.07;6.20) and increased risk of orchiopexy in cohort 4: HR 2.76 (1.03;7.35), but no significant associations in the other cohorts. Compared to unexposed women working in horticulture, pesticide exposed women had a risk of having sons with cryptorchidism of 1.34 (0.30; 5.96) and of orchiopexy of 1.93 (0.24;15.4).</p> <p>Conclusions</p> <p>The data are compatible with a slightly increased risk of cryptorchidism in sons of women exposed to pesticides by working in horticulture.</p

Ebola Virion Attachment and Entry into Human Macrophages Profoundly Effects Early Cellular Gene Expression

Zaire ebolavirus (ZEBOV) infections are associated with high lethality in primates. ZEBOV primarily targets mononuclear phagocytes, which are activated upon infection and secrete mediators believed to trigger initial stages of pathogenesis. The characterization of the responses of target cells to ZEBOV infection may therefore not only further understanding of pathogenesis but also suggest possible points of therapeutic intervention. Gene expression profiles of primary human macrophages exposed to ZEBOV were determined using DNA microarrays and quantitative PCR to gain insight into the cellular response immediately after cell entry. Significant changes in mRNA concentrations encoding for 88 cellular proteins were observed. Most of these proteins have not yet been implicated in ZEBOV infection. Some, however, are inflammatory mediators known to be elevated during the acute phase of disease in the blood of ZEBOV-infected humans. Interestingly, the cellular response occurred within the first hour of Ebola virion exposure, i.e. prior to virus gene expression. This observation supports the hypothesis that virion binding or entry mediated by the spike glycoprotein (GP1,2) is the primary stimulus for an initial response. Indeed, ZEBOV virions, LPS, and virus-like particles consisting of only the ZEBOV matrix protein VP40 and GP1,2 (VLPVP40-GP) triggered comparable responses in macrophages, including pro-inflammatory and pro-apoptotic signals. In contrast, VLPVP40 (particles lacking GP1,2) caused an aberrant response. This suggests that GP1,2 binding to macrophages plays an important role in the immediate cellular response

Microtomography of the Baltic amber tick Ixodes succineus reveals affinities with the modern Asian disease vector Ixodes ovatus

BACKGROUND: Fossil ticks are extremely rare and Ixodes succineus Weidner, 1964 from Eocene (ca. 44–49 Ma) Baltic amber is one of the oldest examples of a living hard tick genus (Ixodida: Ixodidae). Previous work suggested it was most closely related to the modern and widespread European sheep tick Ixodes ricinus (Linneaus, 1758). RESULTS: Restudy using phase contrast synchrotron x-ray tomography yielded images of exceptional quality. These confirm the fossil’s referral to Ixodes Latreille, 1795, but the characters resolved here suggest instead affinities with the Asian subgenus Partipalpiger Hoogstraal et al., 1973 and its single living (and medically significant) species Ixodes ovatus Neumann, 1899. We redescribe the amber fossil here as Ixodes (Partipalpiger) succineus. CONCLUSIONS: Our data suggest that Ixodes ricinus is unlikely to be directly derived from Weidner’s amber species, but instead reveals that the Partipalpiger lineage was originally more widely distributed across the northern hemisphere. The closeness of Ixodes (P.) succineus to a living vector of a wide range of pathogens offers the potential to correlate its spatial and temporal position (northern Europe, nearly 50 million years ago) with the estimated origination dates of various tick-borne diseases

Editor’s Note

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